{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:40:40Z","timestamp":1780083640671,"version":"3.54.0"},"reference-count":55,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.3892\/ijmm.2015.2098","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T08:56:13Z","timestamp":1423731373000},"page":"1042-1050","source":"Crossref","is-referenced-by-count":20,"title":["Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K\/Akt pathway"],"prefix":"10.3892","volume":"35","author":[{"given":"SO YOUNG","family":"KIM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MOO YEOL","family":"HYUN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KYUNG CHAN","family":"GO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOS C.","family":"ZOUBOULIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BEOM JOON","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"key20180107230401_b1-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.clindermatol.2004.03.004","article-title":"Acne and sebaceous gland function","volume":"22","author":"Zouboulis","year":"2004","journal-title":"Clin Dermatol"},{"key":"key20180107230401_b2-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"R132","DOI":"10.1016\/j.cub.2008.12.005","article-title":"The hair follicle as a dynamic miniorgan","volume":"19","author":"Schneider","year":"2009","journal-title":"Curr Biol"},{"key":"key20180107230401_b3-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1523-1747.1998.00264.x","article-title":"Lipogenesis in the human sebaceous gland: glycogen and glycerophosphate are substrates for the synthesis of sebum lipids","volume":"111","author":"Downie","year":"1998","journal-title":"J Invest Dermatol"},{"key":"key20180107230401_b4-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1128\/IAI.73.8.4512-4521.2005","article-title":"A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria","volume":"73","author":"Georgel","year":"2005","journal-title":"Infect Immun"},{"key":"key20180107230401_b5-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1194\/jlr.R700015-JLR200","article-title":"Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?","volume":"49","author":"Smith","year":"2008","journal-title":"J Lipid Res"},{"key":"key20180107230401_b6-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.biocel.2009.11.017","article-title":"Sebocytes, multifaceted epithelial cells: lipid production and holocrine secretion","volume":"42","author":"Schneider","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"key20180107230401_b7-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jaad.2008.05.029","article-title":"Acne scarring: a review and current treatment modalities","volume":"59","author":"Rivera","year":"2008","journal-title":"J Am Acad Dermatol"},{"issue":"4 Pt 2 Suppl","key":"key20180107230401_b8-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0190-9622(82)70066-0","article-title":"Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion","volume":"6","author":"Goldstein","year":"1982","journal-title":"J Am Acad Dermatol"},{"key":"key20180107230401_b9-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1055\/s-2007-961807","article-title":"Sexual hormones in human skin","volume":"39","author":"Zouboulis","year":"2007","journal-title":"Horm Metab Res"},{"key":"key20180107230401_b10-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/sj.jid.5700289","article-title":"13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes","volume":"126","author":"Nelson","year":"2006","journal-title":"J Invest Dermatol"},{"key":"key20180107230401_b11-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1046\/j.1523-1747.1999.00487.x","article-title":"Rat preputial sebocyte differentiation involves peroxisome proliferator-activated receptors","volume":"112","author":"Rosenfield","year":"1999","journal-title":"J Invest Dermatol"},{"key":"key20180107230401_b12-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"163631","DOI":"10.1155\/2011\/163631","article-title":"Unique mode of lipogenic activation in rat preputial sebocytes","volume":"2011","author":"Deplewski","year":"2011","journal-title":"J Nutr Metab"},{"key":"key20180107230401_b13-ijmm-35-04-1042","first-page":"269","article-title":"Peroxisome proliferator-activated receptors and skin development","volume":"54","author":"Rosenfield","year":"2000","journal-title":"Horm Res"},{"key":"key20180107230401_b14-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1210\/edrv.21.4.0404","article-title":"Role of hormones in pilosebaceous unit development","volume":"21","author":"Deplewski","year":"2000","journal-title":"Endocr Rev"},{"key":"key20180107230401_b15-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/sj.jid.5700278","article-title":"Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1","volume":"126","author":"Smith","year":"2006","journal-title":"J Invest Dermatol"},{"key":"key20180107230401_b16-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/sj.jid.5701155","article-title":"IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase\/Akt pathway","volume":"128","author":"Smith","year":"2008","journal-title":"J Invest Dermatol"},{"key":"key20180107230401_b17-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"32587","DOI":"10.1074\/jbc.M111106200","article-title":"Insulin-like growth factor-1-mediated AKT activation postpones the onset of ultraviolet B-induced apoptosis, providing more time for cyclobutane thymine dimer removal in primary human keratinocytes","volume":"277","author":"Decraene","year":"2002","journal-title":"J Biol Chem"},{"key":"key20180107230401_b18-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0968-0004(94)90147-3","article-title":"Diversity in function and regulation of MAP kinase pathways","volume":"19","author":"Blumer","year":"1994","journal-title":"Trends Biochem Sci"},{"key":"key20180107230401_b19-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0092-8674(00)81883-8","article-title":"PI3K: downstream AKTion blocks apoptosis","volume":"88","author":"Franke","year":"1997","journal-title":"Cell"},{"key":"key20180107230401_b20-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jdermsci.2011.11.005","article-title":"TNF-\u03b1 increases lipogenesis via JNK and PI3K\/Akt pathways in SZ95 human sebocytes","volume":"65","author":"Choi","year":"2012","journal-title":"J Dermatol Sci"},{"key":"key20180107230401_b21-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0009-9120(96)00155-5","article-title":"Resveratrol: a molecule whose time has come? And gone?","volume":"30","author":"Soleas","year":"1997","journal-title":"Clin Biochem"},{"key":"key20180107230401_b22-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.275.5297.218","article-title":"Cancer chemopreventive activity of resveratrol, a natural product derived from grapes","volume":"275","author":"Jang","year":"1997","journal-title":"Science"},{"key":"key20180107230401_b23-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1182\/blood.V92.3.996","article-title":"Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells","volume":"92","author":"Clement","year":"1998","journal-title":"Blood"},{"key":"key20180107230401_b24-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0304-3835(00)00658-3","article-title":"Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells","volume":"163","author":"Park","year":"2001","journal-title":"Cancer Lett"},{"key":"key20180107230401_b25-ijmm-35-04-1042","first-page":"2596","article-title":"Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1\/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2","volume":"59","author":"Hsieh","year":"1999","journal-title":"Cancer Res"},{"key":"key20180107230401_b26-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1006\/bbrc.1998.9263","article-title":"Resveratrol arrests the cell division cycle at S\/G2 phase transition","volume":"250","author":"Ragione","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107230401_b27-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/jn\/131.8.2197","article-title":"Downregulation of the cyclin D1\/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines","volume":"131","author":"Wolter","year":"2001","journal-title":"J Nutr"},{"key":"key20180107230401_b28-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1039\/c2mb05486h","article-title":"Resveratrol downregulates Akt\/GSK and ERK signalling pathways in OVCAR-3 ovarian cancer cells","volume":"8","author":"Vergara","year":"2012","journal-title":"Mol Biosyst"},{"key":"key20180107230401_b29-ijmm-35-04-1042","first-page":"647","article-title":"Suppression of mitogenesis and regulation of cell cycle traverse by resveratrol in cultured smooth muscle cells","volume":"15","author":"Zou","year":"1999","journal-title":"Int J Oncol"},{"key":"key20180107230401_b30-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jcb.1085","article-title":"Resveratrol inhibits the proliferation of normal human keratinocytes in vitro","volume":"36","author":"Holian","year":"2001","journal-title":"J Cell Biochem Suppl (Suppl)"},{"key":"key20180107230401_b31-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/ptr.2503","article-title":"Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes","volume":"22","author":"Rayalam","year":"2008","journal-title":"Phytother Res"},{"key":"key20180107230401_b32-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1248\/cpb.30.1766","article-title":"Effects of stilbene components of the roots of Polygonum cuspidatum Sieb et Zucc on lipid metabolism","volume":"30","author":"Arichi","year":"1982","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"key20180107230401_b33-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nature02583","article-title":"Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma","volume":"429","author":"Picard","year":"2004","journal-title":"Nature"},{"key":"key20180107230401_b34-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1046\/j.1523-1747.1999.00771.x","article-title":"Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)","volume":"113","author":"Zouboulis","year":"1999","journal-title":"J Invest Dermatol"},{"issue":"Suppl 4","key":"key20180107230401_b35-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-0625.2004.00255.x","article-title":"Androgen action on human skin-from basic research to clinical significance","volume":"13","author":"Zouboulis","year":"2004","journal-title":"Exp Dermatol"},{"key":"key20180107230401_b36-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00403-008-0879-5","article-title":"The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne","volume":"300","author":"Zouboulis","year":"2008","journal-title":"Arch Dermatol Res"},{"key":"key20180107230401_b37-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1523-1747.2003.12029.x","article-title":"Differentiation and apoptosis in human immortalized sebocytes","volume":"120","author":"Wr\u00f3bel","year":"2003","journal-title":"J Invest Dermatol"},{"key":"key20180107230401_b38-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.0022-202X.2005.23866.x","article-title":"Augmentation of lipogenesis by 15-deoxy-Delta12, 14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12, 14-prostaglandin J2 production","volume":"125","author":"Iwata","year":"2005","journal-title":"J Invest Dermatol"},{"key":"key20180107230401_b39-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/jnci\/89.24.1881","article-title":"Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells","volume":"89","author":"Ahmad","year":"1997","journal-title":"J Natl Cancer Inst"},{"key":"key20180107230401_b40-ijmm-35-04-1042","first-page":"3099","article-title":"Mutant p53 mediated induction of cell cycle arrest and apoptosis at G1 phase by 9-hydroxyellipticine","volume":"19","author":"Sugikawa","year":"1999","journal-title":"Anticancer Res"},{"key":"key20180107230401_b41-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2184.2003.00266.x","article-title":"The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer","volume":"36","author":"Vermeulen","year":"2003","journal-title":"Cell Prolif"},{"key":"key20180107230401_b42-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0304-3835(99)00335-3","article-title":"p21 expression is a prognostic factor in patients with p53-negative gastric cancer","volume":"148","author":"Xiangming","year":"2000","journal-title":"Cancer Lett"},{"key":"key20180107230401_b43-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1093\/carcin\/21.8.1619","article-title":"Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression","volume":"21","author":"Tessitore","year":"2000","journal-title":"Carcinogenesis"},{"key":"key20180107230401_b44-ijmm-35-04-1042","first-page":"1466","article-title":"Resveratrol causes WAF-1\/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells","volume":"7","author":"Ahmad","year":"2001","journal-title":"Clin Cancer Res"},{"key":"key20180107230401_b45-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"key20180107230401_b46-ijmm-35-04-1042","first-page":"L558","article-title":"MEK1 is required for PDGF-induced ERK activation and DNA synthesis in tracheal myocytes","volume":"272","author":"Karpova","year":"1997","journal-title":"AmXJ Physiol"},{"key":"key20180107230401_b47-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jdermsci.2014.03.004","article-title":"Resveratrol inhibition of human keratinocyte proliferation via SIRT1\/ARNT\/ERK dependent downregulation of aquaporin 3","volume":"75","author":"Wu","year":"2014","journal-title":"J Dermatol Sci"},{"key":"key20180107230401_b48-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1365-2133.2010.10037.x","article-title":"Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne?","volume":"164","author":"Schuster","year":"2011","journal-title":"Br J Dermatol"},{"key":"key20180107230401_b49-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80211-7","article-title":"PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro","volume":"4","author":"Rosen","year":"1999","journal-title":"Mol Cell"},{"key":"key20180107230401_b50-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000017864","article-title":"Mechanisms of androgen induction of sebocyte differentiation","volume":"196","author":"Rosenfield","year":"1998","journal-title":"Dermatology"},{"key":"key20180107230401_b51-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbrc.2010.07.038","article-title":"Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation","volume":"399","author":"Kim","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"7 Suppl 1","key":"key20180107230401_b52-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.metabol.2008.04.006","article-title":"Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol","volume":"57","author":"Floyd","year":"2008","journal-title":"Metabolism"},{"key":"key20180107230401_b53-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/jac\/dkm099","article-title":"Resveratrol inhibition of Propionibacterium acnes","volume":"59","author":"Docherty","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"key20180107230401_b54-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-5945-13-2","article-title":"TGF\u03b2 signaling regulates lipogenesis in human sebaceous glands cells","volume":"13","author":"McNairn","year":"2013","journal-title":"BMC Dermatol"},{"key":"key20180107230401_b55-ijmm-35-04-1042","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/jid.2013.413","article-title":"PPAR\u03b3-mediated and arachidonic acid-dependent signaling is involved in differentiation and lipid production of human sebocytes","volume":"134","author":"Dozsa","year":"2014","journal-title":"J Invest Dermatol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2015.2098\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T23:10:29Z","timestamp":1598742629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2015.2098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,12]]},"references-count":55,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,2,12]]},"published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.3892\/ijmm.2015.2098"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2015.2098","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,12]]}}}