{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:35:05Z","timestamp":1772130905733,"version":"3.50.1"},"reference-count":31,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.3892\/ijmm.2015.2138","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T12:59:59Z","timestamp":1426251599000},"page":"1230-1236","source":"Crossref","is-referenced-by-count":6,"title":["Ser341Pro MYOC gene mutation in a family with primary open-angle glaucoma"],"prefix":"10.3892","volume":"35","author":[{"given":"FENGYUN","family":"WANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YANG","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAN","family":"LAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BO","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LI","family":"LIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIAOHE","family":"LU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIPING","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"key20180107230500_b1-ijmm-35-05-1230","first-page":"1793","article-title":"Identification and functional characterization of a novel MYOC mutation in two primary open angle glaucoma families from The Netherlands","volume":"13","author":"Hogewind","year":"2007","journal-title":"Mol Vis"},{"key":"key20180107230500_b2-ijmm-35-05-1230","first-page":"706","article-title":"Genetic and environmental risk factors for primary open-angle glaucoma","volume":"117","author":"Fan","year":"2004","journal-title":"Chin Med J (Engl)"},{"key":"key20180107230500_b3-ijmm-35-05-1230","first-page":"192","article-title":"Glaucoma research progress and development trend","volume":"36","author":"Ge","year":"2000","journal-title":"Chin J Ophthalmol"},{"key":"key20180107230500_b4-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1001\/archopht.118.8.1105","article-title":"The prevalence of glaucoma in Chinese residents of Singapore: a cross-sectional population survey of the Tanjong Pagar district","volume":"118","author":"Foster","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"key20180107230500_b5-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/archopht.116.12.1640","article-title":"Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study","volume":"116","author":"Wolfs","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"key20180107230500_b6-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.275.5300.668","article-title":"Identification of a gene that causes primary open angle glaucoma","volume":"275","author":"Stone","year":"1997","journal-title":"Science"},{"key":"key20180107230500_b7-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.clinbiochem.2005.11.001","article-title":"Gene mapping for primary open angle glaucoma","volume":"39","author":"Fan","year":"2006","journal-title":"Clin Biochem"},{"key":"key20180107230500_b8-ijmm-35-05-1230","first-page":"1945","article-title":"The novel Y371D myocilin mutation causes an aggressive form of juvenile open-angle glaucoma in a Caucasian family from the Middle-East","volume":"15","author":"Avisar","year":"2009","journal-title":"Mol Vis"},{"key":"key20180107230500_b9-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1074\/jbc.273.11.6341","article-title":"Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells","volume":"273","author":"Nguyen","year":"1998","journal-title":"J Biol Chem"},{"key":"key20180107230500_b10-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/humu.20634","article-title":"Myocilin allele-specific glaucoma phenotype database","volume":"29","author":"Hewitt","year":"2008","journal-title":"Hum Mutat"},{"key":"key20180107230500_b11-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5005\/jp-journals-10008-1097","article-title":"Genetic Complexity of primary open-angle glaucoma","volume":"5","author":"Mohanty","year":"2011","journal-title":"JOCGP"},{"key":"key20180107230500_b12-ijmm-35-05-1230","first-page":"439","article-title":"Correlation analysis of some physial chemistry properties among genetic codons and amino acids","volume":"30","author":"Ma","year":"2003","journal-title":"J Anhui Agric Univ"},{"key":"key20180107230500_b13-ijmm-35-05-1230","first-page":"1666","article-title":"Two novel myocilin mutations in a Chinese family with primary open-angle glaucoma","volume":"14","author":"Xie","year":"2008","journal-title":"Mol Vis"},{"key":"key20180107230500_b14-ijmm-35-05-1230","first-page":"75","article-title":"Investigation on the mutation of MYOC gene in two family pedigrees with primary open-angle glaucoma in Shanxi","volume":"23","author":"Qin","year":"2007","journal-title":"Yan Ke Xue Bao"},{"issue":"Spec 1","key":"key20180107230500_b15-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"R91","DOI":"10.1093\/hmg\/ddh074","article-title":"Genetic dissection of myocilin glaucoma","volume":"13","author":"Gong","year":"2004","journal-title":"Hum Mol Genet"},{"key":"key20180107230500_b16-ijmm-35-05-1230","first-page":"360","article-title":"Presymptomatic genetic diagnosis for consulters from a large Chinese family with juvenile open angle glaucoma","volume":"12","author":"Chen","year":"2006","journal-title":"Mol Vis"},{"key":"key20180107230500_b17-ijmm-35-05-1230","first-page":"1533","article-title":"Pro370Leu MYOC gene mutation in a large Chinese family with juvenile-onset open angle glaucoma: correlation between genotype and phenotype","volume":"14","author":"Zhuo","year":"2008","journal-title":"Mol Vis"},{"key":"key20180107230500_b18-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1001\/archopht.124.1.102","article-title":"Novel myocilin mutation in a Chinese family with juvenile-onset open-angle glaucoma","volume":"124","author":"Fan","year":"2006","journal-title":"Arch Ophthalmol"},{"key":"key20180107230500_b19-ijmm-35-05-1230","first-page":"625","article-title":"SNPs and interaction analyses of myocilin, optineurin, and aplipoprotein E in primary open angle glaucoma patients","volume":"11","author":"Fan","year":"2005","journal-title":"Mol Vis"},{"key":"key20180107230500_b20-ijmm-35-05-1230","first-page":"3231","article-title":"TIGR\/MYOC gene sequence alterations in individuals with and without primary open-angle glaucoma","volume":"43","author":"Pang","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180107230500_b21-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1086\/338709","article-title":"Digenic Inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene","volume":"70","author":"Vincent","year":"2002","journal-title":"Am J Hum Genet"},{"key":"key20180107230500_b22-ijmm-35-05-1230","first-page":"629","article-title":"A novel mutation in the myocilin gene identified in a Chinese primary open angle glaucoma family","volume":"24","author":"Tian","year":"2007","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"key20180107230500_b23-ijmm-35-05-1230","first-page":"1386","article-title":"Truncations in the TIGR gene in individuals with and without primary open-angle glaucoma","volume":"41","author":"Lam","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180107230500_b24-ijmm-35-05-1230","first-page":"1728","article-title":"Identification a novel MYOC gene mutation in a Chinese family with juvenile-onset open angle glaucoma","volume":"16","author":"Zhao","journal-title":"Mol Vis"},{"key":"key20180107230500_b25-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1167\/iovs.06-0179","article-title":"A genome-wide scan maps a novel juvenile-onset primary open-angle glaucoma locus to 15q","volume":"47","author":"Wang","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180107230500_b26-ijmm-35-05-1230","first-page":"85","article-title":"A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q","volume":"12","author":"Pang","year":"2006","journal-title":"Mol Vis"},{"key":"key20180107230500_b27-ijmm-35-05-1230","first-page":"739","article-title":"A genome-wide scan maps a novel autosomal dominant juvenile-onset open-angle glaucoma locus to 2p15\u201316","volume":"14","author":"Lin","year":"2008","journal-title":"Mol Vis"},{"key":"key20180107230500_b28-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0002-9394(00)00536-5","article-title":"Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma","volume":"130","author":"Shimizu","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"key20180107230500_b29-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/00061198-199904000-00012","article-title":"A GLC1A gene Gln368Stop mutation in a patient with normal-tension open-angle glaucoma","volume":"8","author":"Mardin","year":"1999","journal-title":"J Glaucoma"},{"key":"key20180107230500_b30-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ajo.2004.11.061","article-title":"The Q368STOP myocilin mutation in a population-based cohort: the Blue Mountains Eye Study","volume":"139","author":"Baird","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"key20180107230500_b31-ijmm-35-05-1230","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0039-6257(02)00353-3","article-title":"Myocilin glaucoma","volume":"47","author":"Fingert","year":"2002","journal-title":"Surv Ophthalmol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2015.2138\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T23:19:22Z","timestamp":1515367162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2015.2138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,13]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,3,13]]},"published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.3892\/ijmm.2015.2138"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2015.2138","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,13]]}}}