{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:56:58Z","timestamp":1784599018099,"version":"3.55.0"},"reference-count":27,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.3892\/ijmm.2015.2251","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T10:32:32Z","timestamp":1434537152000},"page":"363-368","source":"Crossref","is-referenced-by-count":23,"title":["Recombinant human lactoferrin enhances the efficacy of triple therapy in mice infected with Helicobacter pylori"],"prefix":"10.3892","volume":"36","author":[{"given":"YUPING","family":"YUAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QINYI","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUOXIANG","family":"CHENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XUEFANG","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SIGUO","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUAN","family":"LUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AIMIN","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LI","family":"BIAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIANQUAN","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIAJUN","family":"LV","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIANGQIAN","family":"DONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GANG","family":"YANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUNZHEN","family":"ZHU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LANQING","family":"MA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,6,17]]},"reference":[{"key":"key20180107232938_b1-ijmm-36-02-0363","first-page":"C4271","article-title":"Diagnosis and treatment of Helicobacter pylori infection","volume":"58","author":"Bytzer","year":"2011","journal-title":"Dan Med Bull"},{"key":"key20180107232938_b2-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0300-1652.108884","article-title":"Helicobacter pylori eradication therapy: A review of current trends","volume":"54","author":"Olokoba","year":"2013","journal-title":"Niger Med J"},{"key":"key20180107232938_b3-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1002\/hep.27193","article-title":"Association of seropositivity to Helicobacter species and biliary tract cancer in the ATBC study","volume":"60","author":"Murphy","year":"2014","journal-title":"Hepatology"},{"key":"key20180107232938_b4-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11938-002-0060-8","article-title":"Rescue therapy for Helicobacter pylori","volume":"5","author":"Leung","year":"2002","journal-title":"Curr Treat Options Gastroenterol"},{"key":"key20180107232938_b5-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1046\/j.1365-2036.2002.01276.x","article-title":"Review article: Helicobacter pylori \u2018rescue\u2019 regimen when proton pump inhibitor-based triple therapies fail","volume":"16","author":"Gisbert","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"key20180107232938_b6-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/00007611-199608000-00004","article-title":"Efficacy of ciprofloxacin in the eradication of Helicobacter pylori","volume":"89","author":"Dresner","year":"1996","journal-title":"South Med J"},{"key":"key20180107232938_b7-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1111\/j.1572-0241.1999.1983a.x","article-title":"Decrease in serum concentrations of Helicobacter pylori IgG antibodies during antituberculosis therapy: the possible eradication by rifampicin and streptomycin","volume":"94","author":"Sanaka","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"key20180107232938_b8-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1128\/CMR.00054-05","article-title":"Pathogenesis of Helicobacter pylori infection","volume":"19","author":"Kusters","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"key20180107232938_b9-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1699-0463.1999.tb01499.x","article-title":"Lactoferrin: a multifunctional glycoprotein","volume":"107","author":"Vorland","year":"1999","journal-title":"APMIS"},{"key":"key20180107232938_b10-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0161-5890(03)00152-4","article-title":"Lactoferrin: a multifunctional protein with antimicrobial properties","volume":"40","author":"Farnaud","year":"2003","journal-title":"Mol Immunol"},{"key":"key20180107232938_b11-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0168-1702(99)00121-5","article-title":"Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells","volume":"66","author":"Ikeda","year":"2000","journal-title":"Virus Res"},{"key":"key20180107232938_b12-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1128\/IAI.56.11.2774-2781.1988","article-title":"Damage of the outer membrane of enteric Gram-negative bacteria by lactoferrin and transferrin","volume":"56","author":"Ellison","year":"1988","journal-title":"Infect Immun"},{"key":"key20180107232938_b13-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2011.11.002","article-title":"Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects","volume":"12","author":"Drago-Serrano","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"key20180107232938_b14-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00004836-200305000-00006","article-title":"Use of lactoferrin for Helicobacter pylori eradication. Preliminary results","volume":"36","author":"Di Mario","year":"2003","journal-title":"J Clin Gastroenterol"},{"key":"key20180107232938_b15-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1365-2036.2009.03934.x","article-title":"Meta-analysis: efficacy of bovine lacto-ferrin in Helicobacter pylori eradication","volume":"29","author":"Sachdeva","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"key20180107232938_b16-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1572-0241.2007.01085.x","article-title":"Helicobacter pylori eradication: a randomized prospective study of triple therapy versus triple therapy plus lactoferrin and probiotics","volume":"102","author":"de Bortoli","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"key20180107232938_b17-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1365-2036.2003.01395.x","article-title":"Human recombinant lactoferrin is ineffective in the treatment of human Helicobacter pylori infection","volume":"17","author":"Guttner","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"key20180107232938_b18-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1128\/JCM.34.10.2593-2594.1996","article-title":"Direct activity of recombinant human lactoferrin against Helicobacter pylori","volume":"34","author":"Miehlke","year":"1996","journal-title":"J Clin Microbiol"},{"key":"key20180107232938_b19-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc703","article-title":"Helicobacter pylori and gastrointestinal tract adenocarcinomas","volume":"2","author":"Peek","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"key20180107232938_b20-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1046\/j.1365-2036.2003.01746.x","article-title":"Meta-analysis: comparative efficacy of different proton-pump inhibitors in triple therapy for Helicobacter pylori eradication","volume":"18","author":"Vergara","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"key20180107232938_b21-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3748\/wjg.v10.i11.1656","article-title":"Maastricht II treatment scheme and efficacy of different proton pump inhibitors in eradicating Helicobacter pylori","volume":"10","author":"Altintas","year":"2004","journal-title":"World J Gastroenterol"},{"key":"key20180107232938_b22-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1023\/A:1026675916421","article-title":"Antibiotic properties of bovine lactoferrin on Helicobacter pylori","volume":"43","author":"Dial","year":"1998","journal-title":"Dig Dis Sci"},{"key":"key20180107232938_b23-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"14648","DOI":"10.1073\/pnas.93.25.14648","article-title":"cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors","volume":"93","author":"Censini","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107232938_b24-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0966-842X(00)01792-3","article-title":"Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells","volume":"8","author":"Christie","year":"2000","journal-title":"Trends Microbiol"},{"key":"key20180107232938_b25-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1046\/j.1365-2958.2001.02714.x","article-title":"Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8","volume":"42","author":"Fischer","year":"2001","journal-title":"Mol Microbiol"},{"key":"key20180107232938_b26-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1172\/JCI2764","article-title":"Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin","volume":"102","author":"Papini","year":"1998","journal-title":"J Clin Invest"},{"key":"key20180107232938_b27-ijmm-36-02-0363","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nrmicro1095","article-title":"Helicobacter pylori VacA, a paradigm for toxin multifunctionality","volume":"3","author":"Cover","year":"2005","journal-title":"Nat Rev Microbiol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2015.2251\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T17:08:41Z","timestamp":1599152921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2015.2251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,17]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,6,17]]},"published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.3892\/ijmm.2015.2251"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2015.2251","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,17]]}}}