{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T12:01:17Z","timestamp":1775131277775,"version":"3.50.1"},"reference-count":37,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.3892\/ijmm.2015.2252","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T10:22:24Z","timestamp":1434622944000},"page":"541-550","source":"Crossref","is-referenced-by-count":5,"title":["Molecular characterization and expression analysis of mouse epidermal growth factor-like domain 8"],"prefix":"10.3892","volume":"36","author":[{"given":"IK-JIN","family":"SONG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MUHAMMAD","family":"IKRAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FAZLI","family":"SUBHAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DA-JEONG","family":"CHOI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JA-RANG","family":"LEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HEUI-SOO","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOUNG-TAK","family":"LIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SIK","family":"YOON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"key20180107232912_b1-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/dvdy.20063","article-title":"Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells","volume":"230","author":"Fitch","year":"2004","journal-title":"Dev Dyn"},{"key":"key20180107232912_b2-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"10933","DOI":"10.1021\/bi8008278","article-title":"Mutations in the fourth EGF-like domain affect thrombomodulin-induced changes in the active site of thrombin","volume":"47","author":"Koeppe","year":"2008","journal-title":"Biochemistry"},{"key":"key20180107232912_b3-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"e51647","DOI":"10.1371\/journal.pone.0051647","article-title":"The epidermal growth factor-like domain of CD93 is a potent angiogenic factor","volume":"7","author":"Kao","year":"2012","journal-title":"PLoS One"},{"key":"key20180107232912_b4-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cell.2009.09.025","article-title":"Gabapentin receptor \u03b12\u03b4-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis","volume":"139","author":"Eroglu","year":"2009","journal-title":"Cell"},{"key":"key20180107232912_b5-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.biocel.2007.06.024","article-title":"Thrombomodulin: From haemostasis to inflammation and tumourigenesis","volume":"40","author":"Koutsi","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"key20180107232912_b6-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0301-472X(01)00676-2","article-title":"Notch receptors and hematopoiesis","volume":"29","author":"Kojika","year":"2001","journal-title":"Exp Hematol"},{"key":"key20180107232912_b7-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/jnnp.72.3.382","article-title":"Notch3 gene polymorphism and ischaemic cerebro-vascular disease","volume":"72","author":"Ito","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key20180107232912_b8-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0002-9440(10)62972-0","article-title":"EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury","volume":"167","author":"Campagnolo","year":"2005","journal-title":"Am J Pathol"},{"key":"key20180107232912_b9-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.1182\/blood-2010-03-274860","article-title":"Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7","volume":"116","author":"Nichol","year":"2010","journal-title":"Blood"},{"key":"key20180107232912_b10-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood-2011-10-322446","article-title":"EGFL7: A unique angiogenic signaling factor in vascular development and disease","volume":"119","author":"Nichol","year":"2012","journal-title":"Blood"},{"key":"key20180107232912_b11-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nature02416","article-title":"The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation","volume":"428","author":"Parker","year":"2004","journal-title":"Nature"},{"key":"key20180107232912_b12-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/bies.200900140","article-title":"Notch: Implications of endogenous inhibitors for therapy","volume":"32","author":"Dikic","year":"2010","journal-title":"BioEssays"},{"key":"key20180107232912_b13-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4161\/onci.18964","article-title":"Egfl7 promotes tumor escape from immunity","volume":"1","author":"Pinte","year":"2012","journal-title":"Oncoimmunology"},{"key":"key20180107232912_b14-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/ncb1896","article-title":"Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal","volume":"11","author":"Schmidt","year":"2009","journal-title":"Nat Cell Biol"},{"key":"key20180107232912_b15-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11010-010-0521-7","article-title":"EGFL6 is increasingly expressed in human obesity and promotes proliferation of adipose tissue-derived stromal vascular cells","volume":"343","author":"Oberauer","year":"2010","journal-title":"Mol Cell Biochem"},{"key":"key20180107232912_b16-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"e52707","DOI":"10.1371\/journal.pone.0052707","article-title":"Analysis of gene expression profiling in meningioma: Deregulated signaling pathways associated with meningioma and EGFL6 overexpression in benign meningioma tissue and serum","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"key20180107232912_b17-ijmm-36-02-0541","first-page":"3377","article-title":"Down-regulation of EGFL8: A novel biomarker for advanced gastric cancer","volume":"31","author":"Wu","year":"2011","journal-title":"Anticancer Res"},{"key":"key20180107232912_b18-ijmm-36-02-0541","first-page":"2249","article-title":"Down-regulation of EGFL8: A novel prognostic biomarker for patients with colorectal cancer","volume":"31","author":"Wu","year":"2011","journal-title":"Anticancer Res"},{"key":"key20180107232912_b19-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbrc.2012.07.076","article-title":"Regulatory role of mouse epidermal growth factor-like protein 8 in thymic epithelial cells","volume":"425","author":"Choi","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107232912_b20-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3892\/ijmm.2013.1448","article-title":"Epidermal growth factor-like domain 8 inhibits the survival and proliferation of mouse thymocytes","volume":"32","author":"Subhan","year":"2013","journal-title":"Int J Mol Med"},{"key":"key20180107232912_b21-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/eji.1830230602","article-title":"Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells","volume":"23","author":"Faas","year":"1993","journal-title":"Eur J Immunol"},{"key":"key20180107232912_b22-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/(SICI)1097-0134(199707)28:3<405::AID-PROT10>3.0.CO;2-L","article-title":"Pfam: A comprehensive database of protein domain families based on seed alignments","volume":"28","author":"Sonnhammer","year":"1997","journal-title":"Proteins"},{"key":"key20180107232912_b23-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0968-0004(94)90153-8","article-title":"A new generation of information retrieval tools for biologists: The example of the ExPASy WWW server","volume":"19","author":"Appel","year":"1994","journal-title":"Trends Biochem Sci"},{"key":"key20180107232912_b24-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura","year":"2011","journal-title":"Mol Biol Evol"},{"key":"key20180107232912_b25-ijmm-36-02-0541","first-page":"406","article-title":"The neighbor-joining method: A new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol Biol Evol"},{"key":"key20180107232912_b26-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"key20180107232912_b27-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: A new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"key20180107232912_b28-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nprot.2007.131","article-title":"Locating proteins in the cell using TargetP, SignalP and related tools","volume":"2","author":"Emanuelsson","year":"2007","journal-title":"Nat Protoc"},{"key":"key20180107232912_b29-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/0092-8674(95)90294-5","article-title":"Jagged: A mammalian ligand that activates Notch1","volume":"80","author":"Lindsell","year":"1995","journal-title":"Cell"},{"key":"key20180107232912_b30-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0092-8674(00)81259-3","article-title":"Solution structure of a pair of calcium-binding epidermal growth factor-like domains: Implications for the Marfan syndrome and other genetic disorders","volume":"85","author":"Downing","year":"1996","journal-title":"Cell"},{"key":"key20180107232912_b31-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1002\/j.1460-2075.1994.tb06658.x","article-title":"Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4","volume":"13","author":"Nagata","year":"1994","journal-title":"EMBO J"},{"key":"key20180107232912_b32-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.4049\/jimmunol.1302259","article-title":"An overview of the intrathymic intricacies of T cell development","volume":"192","author":"Shah","year":"2014","journal-title":"J Immunol"},{"key":"key20180107232912_b33-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nrd4252","article-title":"Therapeutic modulation of Notch signalling - are we there yet?","volume":"13","author":"Andersson","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"key20180107232912_b34-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1182\/blood-2013-08-355818","article-title":"Notch signaling: Switching an oncogene to a tumor suppressor","volume":"123","author":"Lobry","year":"2014","journal-title":"Blood"},{"key":"key20180107232912_b35-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fped.2014.00054","article-title":"The challenge of targeting notch in hematologic malignancies","volume":"2","author":"Hernandez Tejada","year":"2014","journal-title":"Front Pediatr"},{"key":"key20180107232912_b36-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2174\/15680096113136660101","article-title":"Regulation of EMT by Notch signaling pathway in tumor progression","volume":"13","author":"Li","year":"2013","journal-title":"Curr Cancer Drug Targets"},{"key":"key20180107232912_b37-ijmm-36-02-0541","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.4291","article-title":"In brief: Notch signalling in health and disease","volume":"232","author":"Aster","year":"2014","journal-title":"J Pathol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2015.2252\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T06:36:43Z","timestamp":1566887803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2015.2252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,18]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,6,18]]},"published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.3892\/ijmm.2015.2252"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2015.2252","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,18]]}}}