{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:48:03Z","timestamp":1792673283535,"version":"4.5.0"},"reference-count":31,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.3892\/ijmm.2015.2299","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T07:19:21Z","timestamp":1438327161000},"page":"985-991","source":"Crossref","is-referenced-by-count":51,"title":["Shikonin reduces TGF-\u03b21-induced collagen production and contraction in hypertrophic scar-derived human skin fibroblasts"],"prefix":"10.3892","volume":"36","author":[{"given":"CHEN","family":"FAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YING","family":"DONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YAN","family":"XIE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YONGHUA","family":"SU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XUFANG","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID","family":"LEAVESLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZEE","family":"UPTON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"key20180107232801_b1-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"e234","DOI":"10.1371\/journal.pmed.0040234","article-title":"Hypertrophic scar formation following burns and trauma: New approaches to treatment","volume":"4","author":"Aarabi","year":"2007","journal-title":"PLoS Med"},{"key":"key20180107232801_b2-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/s00266-011-9690-3","article-title":"Botulinum toxin type a inhibits connective tissue growth factor expression in fibroblasts derived from hypertrophic scar","volume":"35","author":"Xiao","year":"2011","journal-title":"Aesthetic Plast Surg"},{"key":"key20180107232801_b3-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11010-011-0736-2","article-title":"shRNA targeting SFRP2 promotes the apoptosis of hypertrophic scar fibroblast","volume":"352","author":"Sun","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"key20180107232801_b4-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/jid.2012.486","article-title":"Xiamenmycin attenuates hypertrophic scars by suppressing local inflammation and the effects of mechanical stress","volume":"133","author":"Liu","year":"2013","journal-title":"J Invest Dermatol"},{"key":"key20180107232801_b5-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.3760\/cma.j.issn.0366-6999.20130833","article-title":"Pressure therapy upregulates matrix metalloproteinase expression and downregulates collagen expression in hypertrophic scar tissue","volume":"126","author":"Huang","year":"2013","journal-title":"Chin Med J (Engl)"},{"key":"key20180107232801_b6-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2119\/molmed.2009.00153","article-title":"Hypertrophic scarring and keloids: Pathomechanisms and current and emerging treatment strategies","volume":"17","author":"Gauglitz","year":"2011","journal-title":"Mol Med"},{"key":"key20180107232801_b7-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3892\/ijmm.2013.1442","article-title":"Smac\/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts","volume":"32","author":"Liu","year":"2013","journal-title":"Int J Mol Med"},{"key":"key20180107232801_b8-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.burns.2011.09.001","article-title":"Enhanced secretion of TIMP-1 by human hypertrophic scar keratinocytes could contribute to fibrosis","volume":"38","author":"Simon","year":"2012","journal-title":"Burns"},{"key":"key20180107232801_b9-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1016\/j.biomaterials.2013.12.015","article-title":"The use of gene activated matrix to mediate effective SMAD2 gene silencing against hypertrophic scar","volume":"35","author":"Yin","year":"2014","journal-title":"Biomaterials"},{"key":"key20180107232801_b10-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1038\/jid.2014.169","article-title":"Mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis","volume":"134","author":"Liu","year":"2014","journal-title":"J Invest Dermatol"},{"key":"key20180107232801_b11-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1524-475x.2000.00128.x","article-title":"Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells","volume":"8","author":"Wang","year":"2000","journal-title":"Wound Repair Regen"},{"key":"key20180107232801_b12-ijmm-36-04-0985","first-page":"105","article-title":"Morphological and immunochemical differences between keloid and hypertrophic scar","volume":"145","author":"Ehrlich","year":"1994","journal-title":"Am J Pathol"},{"key":"key20180107232801_b13-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1172\/JCI31139","article-title":"Systemic sclerosis: A prototypic multi-system fibrotic disorder","volume":"117","author":"Varga","year":"2007","journal-title":"J Clin Invest"},{"key":"key20180107232801_b14-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1097\/01.prs.0000182343.99694.28","article-title":"Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation","volume":"116","author":"Colwell","year":"2005","journal-title":"Plast Reconstr Surg"},{"key":"key20180107232801_b15-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ptr.1100","article-title":"Cellular pharmacology studies of shikonin derivatives","volume":"16","author":"Chen","year":"2002","journal-title":"Phytother Res"},{"key":"key20180107232801_b16-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0022-1759(01)00404-5","article-title":"Sensitive determination of cell number using the CyQUANT cell proliferation assay","volume":"254","author":"Jones","year":"2001","journal-title":"J Immunol Methods"},{"key":"key20180107232801_b17-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/01902149509031745","article-title":"Advantages of Sirius Red staining for quantitative morphometric collagen measurements in lungs","volume":"21","author":"Malkusch","year":"1995","journal-title":"Exp Lung Res"},{"key":"key20180107232801_b18-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"Singer","year":"1999","journal-title":"N Engl J Med"},{"key":"key20180107232801_b19-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1085-5629(99)80040-6","article-title":"Keloids and hypertrophic scars: Review and treatment strategies","volume":"18","author":"Urioste","year":"1999","journal-title":"Semin Cutan Med Surg"},{"key":"key20180107232801_b20-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1242\/jcs.112.24.4557","article-title":"TGF-(beta) type I receptor\/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells","volume":"112","author":"Piek","year":"1999","journal-title":"J Cell Sci"},{"key":"key20180107232801_b21-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1359-6101(99)00024-6","article-title":"The Smad pathway","volume":"11","author":"Wrana","year":"2000","journal-title":"Cytokine Growth Factor Rev"},{"key":"key20180107232801_b22-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1101\/gad.1167003","article-title":"Integration of Smad and MAPK pathways: A link and a linker revisited","volume":"17","author":"Massague","year":"2003","journal-title":"Genes Dev"},{"key":"key20180107232801_b23-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1042\/BJ20042133","article-title":"Linking Smads and transcriptional activation","volume":"386","author":"Inman","year":"2005","journal-title":"Biochem J"},{"key":"key20180107232801_b24-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"e42513","DOI":"10.1371\/journal.pone.0042513","article-title":"Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling","volume":"7","author":"Hough","year":"2012","journal-title":"PLoS One"},{"key":"key20180107232801_b25-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"key20180107232801_b26-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-2184.2010.00682.x","article-title":"MEK\/ERK and p38 MAPK regulate chondrogenesis of rat bone marrow mesenchymal stem cells through delicate interaction with TGF-beta1\/Smads pathway","volume":"43","author":"Li","year":"2010","journal-title":"Cell Prolif"},{"key":"key20180107232801_b27-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0074-7696(07)57004-X","article-title":"Fibroblast differentiation in wound healing and fibrosis","volume":"257","author":"Darby","year":"2007","journal-title":"Int Rev Cytol"},{"key":"key20180107232801_b28-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.burns.2008.08.021","article-title":"Recombinant human decorin inhibits TGF-\u03b21-induced contraction of collagen lattice by hypertrophic scar fibroblasts","volume":"35","author":"Zhang","year":"2009","journal-title":"Burns"},{"key":"key20180107232801_b29-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00418-009-0559-3","article-title":"Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma","volume":"131","author":"Franz","year":"2009","journal-title":"Histochem Cell Biol"},{"key":"key20180107232801_b30-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/wrr.12238","article-title":"A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies","volume":"22","author":"Ibrahim","year":"2014","journal-title":"Wound Repair Regen"},{"key":"key20180107232801_b31-ijmm-36-04-0985","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/labinvest.2008.101","article-title":"Deep dermal fibroblasts contribute to hypertrophic scarring","volume":"88","author":"Wang","year":"2008","journal-title":"Lab Invest"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2015.2299\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T08:42:36Z","timestamp":1718008956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2015.2299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,7,31]]},"published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.3892\/ijmm.2015.2299"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2015.2299","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]}}}