{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:37:11Z","timestamp":1791920231021,"version":"4.3.4"},"reference-count":114,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.3892\/ijmm.2015.2428","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T06:05:23Z","timestamp":1449727523000},"page":"271-283","source":"Crossref","is-referenced-by-count":68,"title":["Experimental models of Alzheimer's disease for deciphering the pathogenesis and therapeutic screening (Review)"],"prefix":"10.3892","volume":"37","author":[{"given":"XUEYUAN","family":"LI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XINJIE","family":"BAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RENZHI","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"key20180107234443_b1-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/jnr.23555","article-title":"Potential of neural stem cell-based therapies for Alzheimer's disease","volume":"93","author":"Li","year":"2015","journal-title":"J Neurosci Res"},{"key":"key20180107234443_b2-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N Engl J Med"},{"key":"key20180107234443_b3-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1474-4422(12)70227-2","article-title":"Florbetapir PET analysis of amyloid-\u03b2 deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study","volume":"11","author":"Fleisher","year":"2012","journal-title":"Lancet Neurol"},{"key":"key20180107234443_b4-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1750-1326-8-37","article-title":"Modeling Alzheimer's disease in transgenic rats","volume":"8","author":"Do Carmo","year":"2013","journal-title":"Mol Neurodegener"},{"key":"key20180107234443_b5-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/msj.20159","article-title":"Transgenic mouse models of Alzheimer's disease","volume":"77","author":"Elder","year":"2010","journal-title":"Mt Sinai J Med"},{"key":"key20180107234443_b6-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2012.06.011","article-title":"Is there a relation between extremely low frequency magnetic field exposure, inflammation and neurodegenerative diseases? A review of in vivo and in vitro experimental evidence","volume":"301","author":"Mattsson","year":"2012","journal-title":"Toxicology"},{"key":"key20180107234443_b7-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.2218531","article-title":"Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides","volume":"250","author":"Yankner","year":"1990","journal-title":"Science"},{"key":"key20180107234443_b8-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s11064-013-1108-y","article-title":"Effects of amyloid \u03b2-peptides and gangliosides on mouse neural stem cells","volume":"38","author":"Itokazu","year":"2013","journal-title":"Neurochem Res"},{"key":"key20180107234443_b9-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1474-9728.2004.00101.x","article-title":"How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes","volume":"3","author":"Blasko","year":"2004","journal-title":"Aging Cell"},{"key":"key20180107234443_b10-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2353\/ajpath.2006.060002","article-title":"Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits","volume":"169","author":"Schindowski","year":"2006","journal-title":"Am J Pathol"},{"key":"key20180107234443_b11-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann Neurol"},{"key":"key20180107234443_b12-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(00)80108-7","article-title":"Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme","volume":"16","author":"Inestrosa","year":"1996","journal-title":"Neuron"},{"key":"key20180107234443_b13-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1006\/jmbi.1997.1245","article-title":"Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils","volume":"272","author":"Alvarez","year":"1997","journal-title":"J Mol Biol"},{"key":"key20180107234443_b14-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1523\/JNEUROSCI.18-09-03213.1998","article-title":"Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils","volume":"18","author":"Alvarez","year":"1998","journal-title":"J Neurosci"},{"key":"key20180107234443_b15-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0163-7258(00)00081-4","article-title":"Animal models of Alzheimer's disease and evaluation of anti-dementia drugs","volume":"88","author":"Yamada","year":"2000","journal-title":"Pharmacol Ther"},{"key":"key20180107234443_b16-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/353844a0","article-title":"Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene","volume":"353","author":"Chartier-Harlin","year":"1991","journal-title":"Nature"},{"key":"key20180107234443_b17-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","article-title":"Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"key20180107234443_b18-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.7638621","article-title":"A familial Alzheimer's disease locus on chromosome 1","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"key20180107234443_b19-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0925-4439(00)00037-5","article-title":"Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease","volume":"1502","author":"Goedert","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"key20180107234443_b20-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/ana.410380420","article-title":"Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease","volume":"38","author":"Levy-Lahad","year":"1995","journal-title":"Ann Neurol"},{"key":"key20180107234443_b21-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.lfs.2014.05.017","article-title":"Animal models of dementia and cognitive dysfunction","volume":"109","author":"Neha","year":"2014","journal-title":"Life Sci"},{"key":"key20180107234443_b22-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/7.12.1953","article-title":"Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease","volume":"7","author":"Liao","year":"1998","journal-title":"Hum Mol Genet"},{"key":"key20180107234443_b23-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/1531-8249(199910)46:4<664::AID-ANA18>3.0.CO;2-J","article-title":"Association between Alzheimer's disease and the NOS3 gene","volume":"46","author":"Dahiyat","year":"1999","journal-title":"Ann Neurol"},{"key":"key20180107234443_b24-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2174\/156720511798192736","article-title":"Transgenic mice as a model for Alzheimer's disease","volume":"8","author":"Lithner","year":"2011","journal-title":"Curr Alzheimer Res"},{"key":"key20180107234443_b25-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/352239a0","article-title":"Formation of beta-amyloid protein deposits in brains of transgenic mice","volume":"352","author":"Quon","year":"1991","journal-title":"Nature"},{"key":"key20180107234443_b26-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1073\/pnas.92.10.4402","article-title":"Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751","volume":"92","author":"Higgins","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107234443_b27-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/373523a0","article-title":"Alzheimer-type neuropathology in transgenic mice overex-pressing V717F beta-amyloid precursor protein","volume":"373","author":"Games","year":"1995","journal-title":"Nature"},{"key":"key20180107234443_b28-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"key20180107234443_b29-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/27351","article-title":"Neuron loss in APP transgenic mice","volume":"395","author":"Calhoun","year":"1998","journal-title":"Nature"},{"key":"key20180107234443_b30-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1523\/JNEUROSCI.23-26-08989.2003","article-title":"PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation","volume":"23","author":"Richards","year":"2003","journal-title":"J Neurosci"},{"key":"key20180107234443_b31-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00702-011-0731-5","article-title":"Recent rodent models for Alzheimer's disease: clinical implications and basic research","volume":"119","author":"Braidy","year":"2012","journal-title":"J Neural Transm"},{"key":"key20180107234443_b32-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1126\/science.1058189","article-title":"Enhanced neuro-fibrillary degeneration in transgenic mice expressing mutant tau and APP","volume":"293","author":"Lewis","year":"2001","journal-title":"Science"},{"key":"key20180107234443_b33-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/j.1460-2075.1995.tb07116.x","article-title":"Somatodendritic localization and hyperphos-phorylation of tau protein in transgenic mice expressing the longest human brain tau isoform","volume":"14","author":"G\u00f6tz","year":"1995","journal-title":"EMBO J"},{"key":"key20180107234443_b34-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0197-4580(95)02068-3","article-title":"Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine\/threonine kinase Mos","volume":"17","author":"James","year":"1996","journal-title":"Neurobiol Aging"},{"key":"key20180107234443_b35-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"9340","DOI":"10.1523\/JNEUROSCI.22-21-09340.2002","article-title":"Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein","volume":"22","author":"Allen","year":"2002","journal-title":"J Neurosci"},{"key":"key20180107234443_b36-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1523\/JNEUROSCI.0081-05.2005","article-title":"Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration","volume":"25","author":"Forman","year":"2005","journal-title":"J Neurosci"},{"key":"key20180107234443_b37-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"9434","DOI":"10.1523\/JNEUROSCI.2691-05.2005","article-title":"Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies","volume":"25","author":"Higuchi","year":"2005","journal-title":"J Neurosci"},{"key":"key20180107234443_b38-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.nbd.2005.05.027","article-title":"Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP\/tau transgenic mice","volume":"20","author":"Rib\u00e9","year":"2005","journal-title":"Neurobiol Dis"},{"key":"key20180107234443_b39-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.1062097","article-title":"Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils","volume":"293","author":"G\u00f6tz","year":"2001","journal-title":"Science"},{"key":"key20180107234443_b40-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"key20180107234443_b41-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-2094-2-23","article-title":"Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice","volume":"2","author":"Janelsins","year":"2005","journal-title":"J Neuroinflammation"},{"key":"key20180107234443_b42-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.nbd.2008.10.006","article-title":"Impairments in remote memory stabi-lization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model","volume":"33","author":"Kimura","year":"2009","journal-title":"Neurobiol Dis"},{"key":"key20180107234443_b43-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"key":"key20180107234443_b44-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1111\/j.1460-9568.2007.05807.x","article-title":"Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats","volume":"26","author":"Clarke","year":"2007","journal-title":"Eur J Neurosci"},{"key":"key20180107234443_b45-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.neurobiolaging.2007.10.006","article-title":"A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition","volume":"30","author":"Flood","year":"2009","journal-title":"Neurobiol Aging"},{"key":"key20180107234443_b46-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2119\/2003-00044.Herrera","article-title":"Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats","volume":"10","author":"Ruiz-Opazo","year":"2004","journal-title":"Mol Med"},{"key":"key20180107234443_b47-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.neurobiolaging.2010.10.015","article-title":"First transgenic rat model developing progressive cortical neurofibrillary tangles","volume":"33","author":"Filipcik","year":"2012","journal-title":"Neurobiol Aging"},{"key":"key20180107234443_b48-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1476-5381.2011.01299.x","article-title":"Animal models in the drug discovery pipeline for Alzheimer's disease","volume":"164","author":"Van Dam","year":"2011","journal-title":"Br J Pharmacol"},{"key":"key20180107234443_b49-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/77399","article-title":"Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition","volume":"6","author":"Iwata","year":"2000","journal-title":"Nat Med"},{"key":"key20180107234443_b50-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1523\/JNEUROSCI.20-05-01657.2000","article-title":"Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme","volume":"20","author":"Vekrellis","year":"2000","journal-title":"J Neurosci"},{"key":"key20180107234443_b51-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1460-9568.1993.tb00931.x","article-title":"Beta APP gene expression is increased in the rat brain after motor neuron axotomy","volume":"5","author":"Sol\u00e0","year":"1993","journal-title":"Eur J Neurosci"},{"key":"key20180107234443_b52-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0891-0618(03)00046-2","article-title":"Effects of beta-amyloid protein on serotoninergic, noradrenergic, and cholinergic markers in neurons of the pontomesencephalic tegmentum in the rat","volume":"26","author":"Gonzalo-Ruiz","year":"2003","journal-title":"J Chem Neuroanat"},{"key":"key20180107234443_b53-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1124\/jpet.106.114561","article-title":"Dominance of amyloid precursor protein sequence over host cell secretases in determining beta-amyloid profiles studies of interspecies variation and drug action by internally standardized immunoprecipitation\/mass spectrometry","volume":"320","author":"Du","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"key20180107234443_b54-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1023\/A:1022850113083","article-title":"Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo","volume":"28","author":"Beck","year":"2003","journal-title":"Neurochem Res"},{"key":"key20180107234443_b55-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2014.01.005","article-title":"\u03b2-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice","volume":"1552","author":"Chen","year":"2014","journal-title":"Brain Res"},{"key":"key20180107234443_b56-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0047-6374(81)90084-1","article-title":"A new murine model of accelerated senescence","volume":"17","author":"Takeda","year":"1981","journal-title":"Mech Ageing Dev"},{"key":"key20180107234443_b57-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0149-7634(96)00063-2","article-title":"Learning and memory in the SAMP8 mouse","volume":"22","author":"Flood","year":"1998","journal-title":"Neurosci Biobehav Rev"},{"key":"key20180107234443_b58-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"898","DOI":"10.4161\/cc.28255","article-title":"Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease","volume":"13","author":"Stefanova","year":"2014","journal-title":"Cell Cycle"},{"key":"key20180107234443_b59-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3233\/JAD-131034","article-title":"Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1","volume":"38","author":"Stefanova","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"key20180107234443_b60-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/gerona\/59.5.M478","article-title":"Free radicals: key to brain aging and heme oxygenase as a cellular response to oxidative stress","volume":"59","author":"Poon","year":"2004","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key20180107234443_b61-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2174\/156720512800107546","article-title":"Dogs with cognitive dysfunction syndrome: A natural model of Alzheimer's disease","volume":"9","author":"Bosch","year":"2012","journal-title":"Curr Alzheimer Res"},{"key":"key20180107234443_b62-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0197-4580(98)00084-0","article-title":"Visual-discrimination learning ability and beta-amyloid accumulation in the dog","volume":"19","author":"Head","year":"1998","journal-title":"Neurobiol Aging"},{"key":"key20180107234443_b63-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0197-4580(00)00093-2","article-title":"Region-specific age at onset of beta-amyloid in dogs","volume":"21","author":"Head","year":"2000","journal-title":"Neurobiol Aging"},{"key":"key20180107234443_b64-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1097\/00001756-199703030-00038","article-title":"Distribution of beta-amyloid in the canine brain","volume":"8","author":"Hou","year":"1997","journal-title":"Neuroreport"},{"key":"key20180107234443_b65-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0006-8993(97)81684-8","article-title":"The progression of beta-amyloid deposition in the frontal cortex of the aged canine","volume":"774","author":"Satou","year":"1997","journal-title":"Brain Res"},{"key":"key20180107234443_b66-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00216-007-1761-6","article-title":"Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development","volume":"390","author":"Cuyckens","year":"2008","journal-title":"Anal Bioanal Chem"},{"key":"key20180107234443_b67-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1196\/annals.1396.004","article-title":"Combining an antioxidant-fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging","volume":"1114","author":"Head","year":"2007","journal-title":"Ann NY Acad Sci"},{"key":"key20180107234443_b68-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/13506120108993810","article-title":"Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques","volume":"8","author":"Papaioannou","year":"2001","journal-title":"Amyloid"},{"key":"key20180107234443_b69-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00401-006-0087-3","article-title":"Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits","volume":"112","author":"Pugliese","year":"2006","journal-title":"Acta Neuropathol"},{"key":"key20180107234443_b70-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.arr.2011.07.001","article-title":"The grey mouse lemur: a non-human primate model for ageing studies","volume":"11","author":"Languille","year":"2012","journal-title":"Ageing Res Rev"},{"key":"key20180107234443_b71-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1601-183X.2005.00149.x","article-title":"Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease?","volume":"5","author":"Bons","year":"2006","journal-title":"Genes Brain Behav"},{"key":"key20180107234443_b72-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.neurobiolaging.2009.05.018","article-title":"Age-associated cerebral atrophy in mouse lemur primates","volume":"32","author":"Kraska","year":"2011","journal-title":"Neurobiol Aging"},{"key":"key20180107234443_b73-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s004010050684","article-title":"Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus","volume":"94","author":"Giannakopoulos","year":"1997","journal-title":"Acta Neuropathol"},{"key":"key20180107234443_b74-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"e319","DOI":"10.1016\/j.ddtec.2012.04.001","article-title":"Animal models of Alzheimer's disease and drug development","volume":"10","author":"Laurijssens","year":"2013","journal-title":"Drug Discov Today Technol"},{"key":"key20180107234443_b75-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.neurobiolaging.2005.09.028","article-title":"DHEA improves symptomatic treatment of moderately and severely impaired MPTP monkeys","volume":"27","author":"B\u00e9langer","year":"2006","journal-title":"Neurobiol Aging"},{"key":"key20180107234443_b76-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.neurobiolaging.2014.01.139","article-title":"Age-associated changes of cerebrospinal fluid amyloid-\u03b2 and tau in cynomolgus monkeys","volume":"35","author":"Yue","year":"2014","journal-title":"Neurobiol Aging"},{"key":"key20180107234443_b77-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0306-4522(02)00123-9","article-title":"A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning","volume":"112","author":"Molteni","year":"2002","journal-title":"Neuroscience"},{"key":"key20180107234443_b78-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s10522-013-9479-7","article-title":"Alzheimer's as a metabolic disease","volume":"14","author":"Demetrius","year":"2013","journal-title":"Biogerontology"},{"key":"key20180107234443_b79-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3233\/JAD-2012-121324","article-title":"\u03b2-alanyl-L-histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer's disease","volume":"33","author":"Herculano","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"key20180107234443_b80-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1001\/archneur.57.10.1410","article-title":"Is there a connection between the concentration of cholesterol circulating in plasma and the rate of neuritic plaque formation in Alzheimer disease?","volume":"57","author":"Haley","year":"2000","journal-title":"Arch Neurol"},{"key":"key20180107234443_b81-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0005-2736(03)00025-7","article-title":"Amyloid beta-protein interactions with membranes and cholesterol: Causes or casualties of Alzheimer's disease","volume":"1610","author":"Gibson Wood","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"key20180107234443_b82-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3233\/JAD-130521","article-title":"Lithium attenuates scopolamine-induced memory deficits with inhibition of GSK-3\u03b2 and preservation of post-synaptic components","volume":"37","author":"Wu","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"key20180107234443_b83-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.2337\/db14-0375","article-title":"Insulin reverses the high-fat diet-induced increase in brain A\u03b2 and improves memory in an animal model of Alzheimer disease","volume":"63","author":"Vandal","year":"2014","journal-title":"Diabetes"},{"key":"key20180107234443_b84-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jnutbio.2012.06.012","article-title":"Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer's type model in rats","volume":"24","author":"Pinton","year":"2013","journal-title":"J Nutr Biochem"},{"key":"key20180107234443_b85-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0006-8993(01)02704-4","article-title":"Progressive brain dysfunction following intracerebroventricular infusion of beta(1-42)-amyloid peptide","volume":"912","author":"Nakamura","year":"2001","journal-title":"Brain Res"},{"key":"key20180107234443_b86-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF02245626","article-title":"Cholinergic modulation of a decrement in social investigation following repeated contacts between mice","volume":"121","author":"Winslow","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"key":"key20180107234443_b87-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.neuroscience.2011.07.002","article-title":"Pharmacological investigations on potential of peroxisome proliferator-activated receptor-gamma agonists in hyperhomocysteinemia-induced vascular dementia in rats","volume":"192","author":"Sain","year":"2011","journal-title":"Neuroscience"},{"key":"key20180107234443_b88-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neuro.2013.05.002","article-title":"Okadaic acid induced neuro-toxicity: An emerging tool to study Alzheimer's disease pathology","volume":"37","author":"Kamat","year":"2013","journal-title":"Neurotoxicology"},{"key":"key20180107234443_b89-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"e56658","DOI":"10.1371\/journal.pone.0056658","article-title":"Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"key20180107234443_b90-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1039\/c0mt00074d","article-title":"Role of metal dyshomeostasis in Alzheimer's disease","volume":"3","author":"Bonda","year":"2011","journal-title":"Metallomics"},{"key":"key20180107234443_b91-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0166-2236(88)90144-0","article-title":"Memory: Brain systems and behavior","volume":"11","author":"Squire","year":"1988","journal-title":"Trends Neurosci"},{"key":"key20180107234443_b92-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2009.09.020","article-title":"Effects of NT-4 gene modified fibroblasts transplanted into AD rats","volume":"466","author":"Liu","year":"2009","journal-title":"Neurosci Lett"},{"key":"key20180107234443_b93-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0166-4328(97)80983-7","article-title":"The effects of lesions to thalamic lateral internal medullary lamina and posterior nuclei on learning, memory and habituation in the rat","volume":"82","author":"Savage","year":"1997","journal-title":"Behav Brain Res"},{"key":"key20180107234443_b94-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1002\/stem.1823","article-title":"Optogenetics reveal delayed afferent synaptogenesis on grafted human-induced pluripotent stem cell-derived neural progenitors","volume":"32","author":"Avaliani","year":"2014","journal-title":"Stem Cells"},{"key":"key20180107234443_b95-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/978-1-4020-6191-2_19","article-title":"Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models","volume":"45","author":"Green","year":"2007","journal-title":"Subcell Biochem"},{"key":"key20180107234443_b96-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"8576","DOI":"10.1021\/jm5010804","article-title":"Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-\u03b2 aggregation and to exert anticholinesterase and antioxidant effects","volume":"57","author":"Nepovimova","year":"2014","journal-title":"J Med Chem"},{"key":"key20180107234443_b97-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"10812","DOI":"10.1074\/jbc.M113.519355","article-title":"The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in \u03b2-amyloid-induced neuron death","volume":"289","author":"Akhter","year":"2014","journal-title":"J Biol Chem"},{"key":"key20180107234443_b98-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1073\/pnas.1402228111","article-title":"Clioquinol promotes the degradation of metal-dependent amyloid-\u03b2 (A\u03b2) oligomers to restore endocytosis and ameliorate A\u03b2 toxicity","volume":"111","author":"Matlack","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107234443_b99-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S1385-299X(00)00046-5","article-title":"Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain","volume":"6","author":"Gong","year":"2001","journal-title":"Brain Res Brain Res Protoc"},{"key":"key20180107234443_b100-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0306-4522(03)00381-6","article-title":"Electrophysiological studies on the hippocampus and prefrontal cortex assessing the effects of amyloidosis in amyloid precursor protein 23 transgenic mice","volume":"120","author":"Roder","year":"2003","journal-title":"Neuroscience"},{"key":"key20180107234443_b101-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.febslet.2004.04.047","article-title":"Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration","volume":"566","author":"Li","year":"2004","journal-title":"FEBS Lett"},{"key":"key20180107234443_b102-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3858\/emm.2012.44.3.015","article-title":"Disease-specific induced pluripotent stem cells: A platform for human disease modeling and drug discovery","volume":"44","author":"Jang","year":"2012","journal-title":"Exp Mol Med"},{"key":"key20180107234443_b103-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1093\/hmg\/ddr394","article-title":"Modeling familial Alzheimer's disease with induced pluripotent stem cells","volume":"20","author":"Yagi","year":"2011","journal-title":"Hum Mol Genet"},{"key":"key20180107234443_b104-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature10821","article-title":"Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells","volume":"482","author":"Israel","year":"2012","journal-title":"Nature"},{"key":"key20180107234443_b105-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.stem.2013.01.009","article-title":"Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular A\u03b2 and differential drug responsiveness","volume":"12","author":"Kondo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"key20180107234443_b106-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jneumeth.2013.11.024","article-title":"A cellular model of amyloid precursor protein processing and amyloid-\u03b2 peptide production","volume":"223","author":"Macias","year":"2014","journal-title":"J Neurosci Methods"},{"key":"key20180107234443_b107-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2014.12.003","article-title":"Carnosic acid attenuates apoptosis induced by amyloid-\u03b2 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells","volume":"94","author":"Meng","year":"2015","journal-title":"Neurosci Res"},{"key":"key20180107234443_b108-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.biocel.2014.07.009","article-title":"Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride","volume":"54","author":"Giunta","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"key":"key20180107234443_b109-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.mehy.2013.09.008","article-title":"Alzheimer's disease: A gas model. The NADPH oxidase-Nitric Oxide system as an antibubble biomachinery","volume":"81","author":"Denis","year":"2013","journal-title":"Med Hypotheses"},{"key":"key20180107234443_b110-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"11242","DOI":"10.1074\/jbc.M113.537472","article-title":"Computational and experimental studies on \u03b2-sheet breakers targeting A\u03b21-40 fibrils","volume":"289","author":"Minicozzi","year":"2014","journal-title":"J Biol Chem"},{"key":"key20180107234443_b111-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nrn2420","article-title":"Animal models of Alzheimer's disease and frontotemporal dementia","volume":"9","author":"G\u00f6tz","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"key20180107234443_b112-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"e79151","DOI":"10.1371\/journal.pone.0079151","article-title":"Discovery of dihydrochalcone as potential lead for Alzheimer's disease: In silico and in vitro study","volume":"8","author":"Viet","year":"2013","journal-title":"PLoS One"},{"key":"key20180107234443_b113-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3233\/JAD-122296","article-title":"Amyloid and tau neuro-pathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease","volume":"37","author":"Lo","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"key20180107234443_b114-ijmm-37-02-0271","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1254\/jjp.78.399","article-title":"Senescence-accelerated mouse (SAM) as an animal model of senile dementia: pharmacological, neurochemical and molecular biological approach","volume":"78","author":"Okuma","year":"1998","journal-title":"Jpn J Pharmacol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2015.2428\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T05:29:50Z","timestamp":1567402190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2015.2428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,10]]},"references-count":114,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,12,10]]},"published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.3892\/ijmm.2015.2428"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2015.2428","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,10]]}}}