{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:57:54Z","timestamp":1792706274497,"version":"4.5.0"},"reference-count":36,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.3892\/ijmm.2016.2561","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T11:28:50Z","timestamp":1460460530000},"page":"1465-1474","source":"Crossref","is-referenced-by-count":12,"title":["Effect of CD16a, the surface receptor of Kupffer cells, on the growth of hepatocellular carcinoma cells"],"prefix":"10.3892","volume":"37","author":[{"given":"XIU-YUN","family":"LI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUN","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHENG-WEI","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WEN-BO","family":"ZHOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MENG-YUAN","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUO-QING","family":"ZUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHANG-AN","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIONG","family":"DING","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,4,12]]},"reference":[{"key":"key20180107234607_b1-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.soc.2014.09.001","article-title":"Epidemiology of hepatocellular carcinoma","volume":"24","author":"Lafaro","year":"2015","journal-title":"Surg Oncol Clin N Am"},{"key":"key20180107234607_b2-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.freeradbiomed.2015.03.028","article-title":"Transforming growth factor \u03b2-interacting factor-induced malignant progression of hepatocellular carcinoma cells depends on superoxide production from Nox4","volume":"84","author":"Liu","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"key20180107234607_b3-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.addr.2012.04.001","article-title":"Therapeutic strategies for controlling the metastasis and recurrence of cancers: contribution of drug delivery technologies","volume":"64","author":"Kaneda","year":"2012","journal-title":"Adv Drug Deliv Rev"},{"key":"key20180107234607_b4-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.molimm.2010.11.019","article-title":"A standardized conversion of IgG antibody to bispecific form with inversely altered affinities for Fc\u03b3-receptors II and III","volume":"48","author":"Leong","year":"2011","journal-title":"Mol Immunol"},{"key":"key20180107234607_b5-ijmm-37-06-1465","article-title":"Role of chemokine pathways in hepatobiliary cancer","author":"Ehling","year":"2015","journal-title":"Cancer Lett"},{"key":"key20180107234607_b6-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/toxsci\/kfr278","article-title":"Nonclinical evaluation of GMA161 - an antihuman CD16 (Fc\u03b3RIII) monoclonal antibody for treatment of autoimmune disorders in CD16 transgenic mice","volume":"125","author":"Flaherty","year":"2012","journal-title":"Toxicol Sci"},{"key":"key20180107234607_b7-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.4049\/jimmunol.1301249","article-title":"Glycoengineering of therapeutic antibodies enhances monocyte\/macrophage-mediated phagocytosis and cytotoxicity","volume":"192","author":"Herter","year":"2014","journal-title":"J Immunol"},{"key":"key20180107234607_b8-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.imlet.2014.05.004","article-title":"Antibody-dependent cellular cytotoxicity and cytokine\/chemokine secretion by KHYG-1 cells stably expressing Fc\u03b3RIIIA","volume":"161","author":"Kobayashi","year":"2014","journal-title":"Immunol Lett"},{"key":"key20180107234607_b9-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.abb.2012.05.010","article-title":"Correlation between CD16a binding and immuno effector functionality of an antigen specific immunoglobulin Fc fragment (Fcab)","volume":"526","author":"Kainer","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"key20180107234607_b10-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1126\/science.1240094","article-title":"Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D","volume":"341","author":"Chaigne-Delalande","year":"2013","journal-title":"Science"},{"key":"key20180107234607_b11-ijmm-37-06-1465","first-page":"1370","article-title":"Prospective study of liver parenchyma volume in hepatectomy of primary liver cancer","volume":"43","author":"Zhou","year":"2005","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"key20180107234607_b12-ijmm-37-06-1465","first-page":"880","article-title":"Relationship between Kuppfer cells, inflammation, and fibrosis in chronic hepatitis B and C","volume":"117","author":"St\u0103ncule\u0163","year":"2013","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"key20180107234607_b13-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jss.2007.12.759","article-title":"Up-regulation of IRAK-M is essential for endotoxin tolerance induced by a low dose of lipopolysaccharide in Kupffer cells","volume":"150","author":"Liu","year":"2008","journal-title":"J Surg Res"},{"key":"key20180107234607_b14-ijmm-37-06-1465","first-page":"1269","article-title":"Influence of Fc\u03b3RIIIa polymorphism on rituximab-dependent NK cell-mediated cytotoxicity to Raji cells","volume":"18","author":"Qu","year":"2010","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"key20180107234607_b15-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12876-015-0380-5","article-title":"Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine (DMN)-induced liver fibrosis in rats","volume":"15","author":"Liu","year":"2015","journal-title":"BMC Gastroenterol"},{"key":"key20180107234607_b16-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00441-015-2252-2","article-title":"Kupffer-cell-expressed trans-membrane TNF-\u03b1 is a major contributor to lipopolysaccharide and D-galactosamine-induced liver injury","volume":"363","author":"Yang","year":"2016","journal-title":"Cell Tissue Res"},{"key":"key20180107234607_b17-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.amjsurg.2007.09.045","article-title":"Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells","volume":"196","author":"Xu","year":"2008","journal-title":"Am J Surg"},{"key":"key20180107234607_b18-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.3748\/wjg.v9.i9.1946","article-title":"Pathomorphological study on location and distribution of Kupffer cells in hepatocellular carcinoma","volume":"9","author":"Liu","year":"2003","journal-title":"World J Gastroenterol"},{"key":"key20180107234607_b19-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/hep.510240409","article-title":"Pathomorphological study of Kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver","volume":"24","author":"Tanaka","year":"1996","journal-title":"Hepatology"},{"key":"key20180107234607_b20-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"key20180107234607_b21-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/carcin\/bgu060","article-title":"Tumor-associated macrophages promote the metastatic potential of thyroid papillary cancer by releasing CXCL8","volume":"35","author":"Fang","year":"2014","journal-title":"Carcinogenesis"},{"key":"key20180107234607_b22-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"831387","DOI":"10.1155\/2013\/831387","article-title":"Collaborating with the enemy: function of macrophages in the development of neoplastic disease","volume":"2013","author":"Eljaszewicz","year":"2013","journal-title":"Mediators Inflamm"},{"key":"key20180107234607_b23-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.immuni.2012.10.015","article-title":"Angiotensin II drives the production of tumor-promoting macrophages","volume":"38","author":"Cortez-Retamozo","year":"2013","journal-title":"Immunity"},{"key":"key20180107234607_b24-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.exphem.2014.07.260","article-title":"Anti-tumor effects of anti-T-cell globulin","volume":"42","author":"Westphal","year":"2014","journal-title":"Exp Hematol"},{"key":"key20180107234607_b25-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"7535","DOI":"10.1074\/jbc.M114.620260","article-title":"A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism","volume":"290","author":"Liu","year":"2015","journal-title":"J Biol Chem"},{"key":"key20180107234607_b26-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"e62932","DOI":"10.1371\/journal.pone.0062932","article-title":"Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells","volume":"8","author":"Poggi","year":"2013","journal-title":"PLoS One"},{"key":"key20180107234607_b27-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"key20180107234607_b28-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.taap.2012.02.008","article-title":"Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria","volume":"260","author":"Tseng","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"key20180107234607_b29-ijmm-37-06-1465","first-page":"1129","article-title":"Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo","volume":"8","author":"Chen","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"key20180107234607_b30-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1002\/ijc.23870","article-title":"Selective expression of inhibitory Fcgamma receptor by metastatic melanoma impairs tumor susceptibility to IgG-dependent cellular response","volume":"123","author":"Cassard","year":"2008","journal-title":"Int J Cancer"},{"key":"key20180107234607_b31-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s00210-004-0877-x","article-title":"Intravenous immunoglobulin inhibits NF-kappaB activation and affects Fcgamma receptor expression in monocytes\/macrophages","volume":"369","author":"Ichiyama","year":"2004","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"key20180107234607_b32-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1182\/blood-2014-04-569061","article-title":"Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells","volume":"124","author":"Romain","year":"2014","journal-title":"Blood"},{"key":"key20180107234607_b33-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.imbio.2012.02.013","article-title":"A defect of CD16-positive monocytes can occur without disease","volume":"218","author":"Frankenberger","year":"2013","journal-title":"Immunobiology"},{"key":"key20180107234607_b34-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.3899\/jrheum.110980","article-title":"FCGR2A\/CD32A and FCGR3A\/CD16A variants and EULAR response to tumor necrosis factor-\u03b1 blockers in psoriatic arthritis: a longitudinal study with 6 months of followup","volume":"39","author":"Ram\u00edrez","year":"2012","journal-title":"J Rheumatol"},{"key":"key20180107234607_b35-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1074\/jbc.M113.513366","article-title":"Asymmetrical Fc engineering greatly enhances antibody-dependent cellular cytotoxicity (ADCC) effector function and stability of the modified antibodies","volume":"289","author":"Liu","year":"2014","journal-title":"J Biol Chem"},{"key":"key20180107234607_b36-ijmm-37-06-1465","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/infdis\/jis027","article-title":"Genetically associated CD16(+)56(\u2212) natural killer cell interferon (IFN)-\u03b1R expression regulates signaling and is implicated in IFN-\u03b1-induced hepatitis C virus decline","volume":"205","author":"Conry","year":"2012","journal-title":"J Infect Dis"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2016.2561\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:21:34Z","timestamp":1515370894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2016.2561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,12]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,4,12]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.3892\/ijmm.2016.2561"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2016.2561","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,12]]}}}