{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:08:57Z","timestamp":1787738937947,"version":"build-2784847793"},"reference-count":39,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.3892\/ijmm.2016.2594","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T12:45:38Z","timestamp":1463489138000},"page":"75-82","source":"Crossref","is-referenced-by-count":55,"title":["Involvement of NADPH oxidases in alkali burn-induced corneal injury"],"prefix":"10.3892","volume":"38","author":[{"given":"XUE-JUN","family":"GU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIAN","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YING-YING","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YAO","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAN","family":"XU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIAO-JIAN","family":"HAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QIU-PING","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JING-LIN","family":"YI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JING-MING","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"key20180107232443_b1-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0039-6257(96)00007-0","article-title":"Chemical injuries of the eye: current concepts in pathophysiology and therapy","volume":"41","author":"Wagoner","year":"1997","journal-title":"Surv Ophthalmol"},{"key":"key20180107232443_b2-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1167\/iovs.10-6167","article-title":"Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model","volume":"52","author":"Kubota","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180107232443_b3-ijmm-38-01-0075","first-page":"1963","article-title":"Alkali burn-induced synthesis of inflammatory eicosanoids in rabbit corneal epithelium","volume":"38","author":"Conners","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180107232443_b4-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0955-0674(03)00002-4","article-title":"Oxidant signals and oxidative stress","volume":"15","author":"Finkel","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"key20180107232443_b5-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.diabres.2009.11.018","article-title":"Molecular pathology of oxidative stress in diabetic angiopathy: role of mitochondrial and cellular pathways","volume":"87","author":"Mokini","year":"2010","journal-title":"Diabetes Res Clin Pract"},{"key":"key20180107232443_b6-ijmm-38-01-0075","first-page":"RA37","article-title":"Role of oxidative stress in diabetic kidney disease","volume":"16","author":"Hakim","year":"2010","journal-title":"Med Sci Monit"},{"key":"key20180107232443_b7-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"768026","DOI":"10.1155\/2014\/768026","article-title":"Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration","volume":"2014","author":"Blasiak","year":"2014","journal-title":"BioMed Res Int"},{"key":"key20180107232443_b8-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.freeradbiomed.2008.07.021","article-title":"Oxidative stress in diseases of the human cornea","volume":"45","author":"Shoham","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"key20180107232443_b9-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0002-9440(10)62357-7","article-title":"Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice","volume":"166","author":"Saika","year":"2005","journal-title":"Am J Pathol"},{"key":"key20180107232443_b10-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000353437","article-title":"KH902, a recombinant human VEGF receptor fusion protein, reduced the level of placental growth factor in alkali burn induced-corneal neovascularization","volume":"50","author":"Zhou","year":"2013","journal-title":"Ophthalmic Res"},{"key":"key20180107232443_b11-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1097\/ICO.0b013e31814b8a28","article-title":"Expression of matrix metalloproteinase 2 and 9 in experimentally wounded canine corneas and spontaneous chronic corneal epithelial defects","volume":"26","author":"Carter","year":"2007","journal-title":"Cornea"},{"key":"key20180107232443_b12-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bbrc.2005.08.210","article-title":"Molecular composition and regulation of the Nox family NAD(P)H oxidases","volume":"338","author":"Sumimoto","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107232443_b13-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"key":"key20180107232443_b14-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1089\/ars.2010.3635","article-title":"NOX2 complex-derived ROS as immune regulators","volume":"15","author":"Sareila","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"key20180107232443_b15-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1021\/bi500331y","article-title":"Nox4: a hydrogen peroxide-generating oxygen sensor","volume":"53","author":"Nisimoto","year":"2014","journal-title":"Biochemistry"},{"key":"key20180107232443_b16-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"8010","DOI":"10.1073\/pnas.130135897","article-title":"Identification of renox, an NAD(P)H oxidase in kidney","volume":"97","author":"Geiszt","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107232443_b17-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.ATV.0000112024.13727.2c","article-title":"Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells","volume":"24","author":"Hilenski","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20180107232443_b18-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1365-2443.2005.00907.x","article-title":"The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells","volume":"10","author":"Kuroda","year":"2005","journal-title":"Genes Cells"},{"key":"key20180107232443_b19-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0891-5849(97)00202-5","article-title":"Increased NADH oxidase activity in the retina of the BBZ\/Wor diabetic rat","volume":"24","author":"Ellis","year":"1998","journal-title":"Free Radic Biol Med"},{"key":"key20180107232443_b20-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1089\/ars.2006.8.1473","article-title":"NOX2 and NOX4 mediate proliferative response in endothelial cells","volume":"8","author":"Petry","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"key20180107232443_b21-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbrc.2010.05.019","article-title":"Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-kappaB in human aortic smooth muscle cells","volume":"396","author":"Manea","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107232443_b22-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1182\/blood-2004-02-0665","article-title":"Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species","volume":"104","author":"Deem","year":"2004","journal-title":"Blood"},{"key":"key20180107232443_b23-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2337\/db09-1057","article-title":"Inhibition of reactive oxygen species by Lovastatin down-regulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db\/db mice: role of NADPH oxidase 4","volume":"59","author":"Li","year":"2010","journal-title":"Diabetes"},{"key":"key20180107232443_b24-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1167\/iovs.05-1063","article-title":"Expression of NADPH oxidase in rabbit corneal epithelial and stromal cells in culture","volume":"47","author":"O'Brien","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180107232443_b25-ijmm-38-01-0075","first-page":"2535","article-title":"NADPH oxidase expression and production of superoxide by human corneal stromal cells","volume":"15","author":"O'Brien","year":"2009","journal-title":"Mol Vis"},{"key":"key20180107232443_b26-ijmm-38-01-0075","first-page":"1076","article-title":"Selection of housekeeping genes for use in quantitative reverse transcription PCR assays on the murine cornea","volume":"16","author":"Ren","year":"2010","journal-title":"Mol Vis"},{"key":"key20180107232443_b27-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ejphar.2007.10.043","article-title":"Inhibition of NADPH oxidase by apocynin inhibits lipopolysaccharide (LPS) induced up-regulation of arginase in rat alveolar macrophages","volume":"579","author":"Matthiesen","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"key20180107232443_b28-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.humimm.2013.06.009","article-title":"3-Nitrotyrosine: A biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions","volume":"74","author":"Ahsan","year":"2013","journal-title":"Hum Immunol"},{"key":"key20180107232443_b29-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jfo.2013.03.002","article-title":"Corneal neovascularization: epidemiological, physiopathological, and clinical features","volume":"36","author":"Benayoun","year":"2013","journal-title":"J Fr Ophtalmol"},{"key":"key20180107232443_b30-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/IIO.0b013e31829ceefa","article-title":"Corneal alkali burns: a review of the literature and proposed protocol for evaluation and treatment","volume":"53","author":"Hamill","year":"2013","journal-title":"Int Ophthalmol Clin"},{"key":"key20180107232443_b31-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.exer.2013.10.002","article-title":"Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface","volume":"116","author":"Cejkova","year":"2013","journal-title":"Exp Eye Res"},{"key":"key20180107232443_b32-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1124\/pr.110.002980","article-title":"NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair","volume":"63","author":"Jiang","year":"2011","journal-title":"Pharmacol Rev"},{"key":"key20180107232443_b33-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1076\/ceyr.16.7.670.5057","article-title":"Cytokine expression in the alkali-burned cornea","volume":"16","author":"Sotozono","year":"1997","journal-title":"Curr Eye Res"},{"key":"key20180107232443_b34-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.cardiores.2006.04.015","article-title":"Redox signaling in angiogenesis: role of NADPH oxidase","volume":"71","author":"Ushio-Fukai","year":"2006","journal-title":"Cardiovasc Res"},{"key":"key20180107232443_b35-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2174\/187221309789257450","article-title":"Corneal neovascularization: molecular events and therapeutic options","volume":"3","author":"Shakiba","year":"2009","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"key":"key20180107232443_b36-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/ATVBAHA.108.181610","article-title":"NADPH oxidases: functions and pathologies in the vasculature","volume":"30","author":"Lass\u00e8gue","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20180107232443_b37-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1089\/ars.2013.5703","article-title":"New insights on NOX enzymes in the central nervous system","volume":"20","author":"Nayernia","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"key20180107232443_b38-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1111\/j.1743-6109.2012.02716.x","article-title":"Role of oxidative stress in a rat model of radiation-induced erectile dysfunction","volume":"9","author":"Kimura","year":"2012","journal-title":"J Sex Med"},{"key":"key20180107232443_b39-ijmm-38-01-0075","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1021\/bi401719r","article-title":"The basic biology of redoxosomes in cytokine-mediated signal transduction and implications for disease-specific therapies","volume":"53","author":"Spencer","year":"2014","journal-title":"Biochemistry"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2016.2594\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T23:52:50Z","timestamp":1515369170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2016.2594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,5,17]]},"published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.3892\/ijmm.2016.2594"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2016.2594","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]}}}