{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:14:36Z","timestamp":1782476076132,"version":"3.54.5"},"reference-count":43,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.3892\/ijmm.2016.2771","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T05:48:15Z","timestamp":1476424095000},"page":"1683-1692","source":"Crossref","is-referenced-by-count":38,"title":["Effect of endotoxemia in mice genetically deficient in cystathionine-\u03b3-lyase, cystathionine-\u03b2-synthase or 3-mercaptopyruvate sulfurtransferase"],"prefix":"10.3892","volume":"38","author":[{"given":"Akbar","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domokos","family":"Ger\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Olah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,10,14]]},"reference":[{"key":"key20180107232537_b1-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/j.gastro.2006.02.033","article-title":"The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver","volume":"131","author":"Fiorucci","year":"2006","journal-title":"Gastroenterology"},{"key":"key20180107232537_b2-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szab\u00f3","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"key20180107232537_b3-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol Rev"},{"key":"key20180107232537_b4-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/ars.2012.4612","article-title":"Hydrogen sulfide in biochemistry and medicine","volume":"17","author":"Predmore","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"key20180107232537_b5-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00109-012-0873-4","article-title":"Hydrogen sulfide: A gasotransmitter of clinical relevance","volume":"90","author":"Vandiver","year":"2012","journal-title":"J Mol Med (Berl)"},{"key":"key20180107232537_b6-ijmm-38-06-1683","first-page":"208","article-title":"Potential role of hydrogen sulfide in the pathogenesis of vascular dysfunction in septic shock","volume":"11","author":"Coletta","year":"2013","journal-title":"Curr Vasc Pharmacol"},{"key":"key20180107232537_b7-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1111\/bph.12369","article-title":"Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms","volume":"171","author":"Szabo","year":"2014","journal-title":"Br J Pharmacol"},{"key":"key20180107232537_b8-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.niox.2014.03.163","article-title":"H2S during circulatory shock: Some unresolved questions","volume":"41","author":"McCook","year":"2014","journal-title":"Nitric Oxide"},{"key":"key20180107232537_b9-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1089\/ars.2014.5869","article-title":"Signaling molecules: Hydrogen sulfide and polysulfide","volume":"22","author":"Kimura","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"key20180107232537_b10-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-18144-8_1","article-title":"2S synthesizing enzymes: Biochemistry and molecular aspects","volume":"230","author":"Huang","year":"2015","journal-title":"Handb Exp Pharmacol"},{"key":"key20180107232537_b11-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.freeradbiomed.2009.04.014","article-title":"GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat","volume":"47","author":"Li","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"key20180107232537_b12-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1089\/ars.2011.4363","article-title":"Inhaled hydrogen sulfide prevents endotoxin-induced systemic inflammation and improves survival by altering sulfide metabolism in mice","volume":"17","author":"Tokuda","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"key20180107232537_b13-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cyto.2012.11.018","article-title":"A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion","volume":"61","author":"Aslami","year":"2013","journal-title":"Cytokine"},{"key":"key20180107232537_b14-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3892\/etm.2014.1781","article-title":"Hydrogen sulfide reduces kidney injury due to urinary-derived sepsis by inhibiting NF-\u03baB expression, decreasing TNF-\u03b1 levels and increasing IL-10 levels","volume":"8","author":"Chen","year":"2014","journal-title":"Exp Ther Med"},{"key":"key20180107232537_b15-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.4049\/jimmunol.1300835","article-title":"Hydrogen sulfide [corrected] increases survival during sepsis: Protective effect of CHOP inhibition","volume":"192","author":"Ferlito","year":"2014","journal-title":"J Immunol"},{"key":"key20180107232537_b16-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/SHK.0000000000000589","article-title":"Delayed treatment with sodium hydrosulfide improves regional blood flow and alleviates cecal ligation and puncture (CLP)-induced septic shock","volume":"46","author":"Ahmad","year":"2016","journal-title":"Shock"},{"key":"key20180107232537_b17-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/sj.bjp.0706367","article-title":"Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia","volume":"146","author":"Collin","year":"2005","journal-title":"Br J Pharmacol"},{"key":"key20180107232537_b18-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J"},{"key":"key20180107232537_b19-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"L960","DOI":"10.1152\/ajplung.00388.2006","article-title":"Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB","volume":"292","author":"Zhang","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key20180107232537_b20-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.4049\/jimmunol.181.6.4320","article-title":"Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis","volume":"181","author":"Zhang","year":"2008","journal-title":"J Immunol"},{"key":"key20180107232537_b21-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.rvsc.2012.10.009","article-title":"Endogenous hydrogen sulfide formation mediates the liver damage in endotoxemic rats","volume":"94","author":"Yan","year":"2013","journal-title":"Res Vet Sci"},{"key":"key20180107232537_b22-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1089\/ars.2013.5354","article-title":"Cystathionine \u03b3-lyase deficiency protects mice from galactosamine\/lipopolysaccharide-induced acute liver failure","volume":"20","author":"Shirozu","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"key20180107232537_b23-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12038-016-9598-9","article-title":"Cys tathionine-\u03b3-lyase gene silencing with siRNA in monocytes\/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse","volume":"41","author":"Badiei","year":"2016","journal-title":"J Biosci"},{"key":"key20180107232537_b24-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1073\/pnas.92.5.1585","article-title":"Mice deficient in cystathionine beta-synthase: Animal models for mild and severe homocyst(e) inemia","volume":"92","author":"Watanabe","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107232537_b25-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"key20180107232537_b26-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.niox.2015.02.086","article-title":"3-Mercaptopyruvate sulfurtransferase deficient mice show accelerated glucose uptake and a dysregulated metabolic profile","volume":"47","author":"Gero","year":"2015","journal-title":"Nitric Oxide"},{"key":"key20180107232537_b27-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/00003246-200205000-00019","article-title":"Novel phenanthridinone inhibitors of poly (adenosine 5\u2032-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents","volume":"30","author":"Jagtap","year":"2002","journal-title":"Crit Care Med"},{"key":"key20180107232537_b28-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"e67419","DOI":"10.1371\/journal.pone.0067419","article-title":"Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice","volume":"8","author":"Namas","year":"2013","journal-title":"PLoS One"},{"key":"key20180107232537_b29-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"e79037","DOI":"10.1371\/journal.pone.0079037","article-title":"Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-\u03b1 antibodies","volume":"8","author":"Bhargava","year":"2013","journal-title":"PLoS One"},{"key":"key20180107232537_b30-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"e0152289","DOI":"10.1371\/journal.pone.0152289","article-title":"Differential expression of inflammatory cytokines and stress genes in male and female mice in response to a lipopolysaccharide challenge","volume":"11","author":"Everhardt Queen","year":"2016","journal-title":"PLoS One"},{"key":"key20180107232537_b31-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2119\/molmed.2010.00027","article-title":"Role of hydrogen sulfide in severe burn injury-induced inflammation in mice","volume":"16","author":"Zhang","year":"2010","journal-title":"Mol Med"},{"key":"key20180107232537_b32-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.pharep.2014.05.014","article-title":"Propargylglycine aggravates liver damage in LPS-treated rats: Possible relation of nitrosative stress with the inhibition of H2S formation","volume":"66","author":"Bekpinar","year":"2014","journal-title":"Pharmacol Rep"},{"key":"key20180107232537_b33-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1111\/bph.12368","article-title":"Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects","volume":"171","author":"M\u00f3dis","year":"2014","journal-title":"Br J Pharmacol"},{"key":"key20180107232537_b34-ijmm-38-06-1683","article-title":"Upregulation and mitochondrial sequestration of hemoglobins occurs in circulating leukocytes during critical illness, conferring a cytoprotective phenotype","author":"Brunyanszki","journal-title":"Mol Med"},{"key":"key20180107232537_b35-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","article-title":"Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia","volume":"100","author":"Hu","year":"2007","journal-title":"J Neurochem"},{"key":"key20180107232537_b36-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.archoralbio.2014.05.022","article-title":"Hydrogen sulfide synergistically upregulates Porphyromonas gingivalis lipopolysaccharide-induced expression of IL-6 and IL-8 via NF-\u03baB signalling in periodontal fibroblasts","volume":"59","author":"Chi","year":"2014","journal-title":"Arch Oral Biol"},{"key":"key20180107232537_b37-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.3892\/ijmm.2015.2176","article-title":"Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling","volume":"35","author":"Rios","year":"2015","journal-title":"Int J Mol Med"},{"key":"key20180107232537_b38-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3892\/ijmm.2014.2036","article-title":"Diallyl trisulfide exerts anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 macrophages by suppressing the Toll-like receptor 4\/nuclear factor-\u03baB pathway","volume":"35","author":"Lee","year":"2015","journal-title":"Int J Mol Med"},{"key":"key20180107232537_b39-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1084\/jem.20141318","article-title":"MD-2 is required for disulfide HMGB1-dependent TLR4 signaling","volume":"212","author":"Yang","year":"2015","journal-title":"J Exp Med"},{"key":"key20180107232537_b40-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.1321871111","article-title":"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent","volume":"111","author":"King","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107232537_b41-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"e12251","DOI":"10.14814\/phy2.12251","article-title":"Downregulation of cystathionine \u03b2-synthase and cystathionine \u03b3-lyase expression stimulates inflammation in kidney ischemia-reperfusion injury","volume":"2","author":"Wang","year":"2014","journal-title":"Physiol Rep"},{"key":"key20180107232537_b42-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/hmg\/ddi224","article-title":"Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model","volume":"14","author":"Wang","year":"2005","journal-title":"Hum Mol Genet"},{"key":"key20180107232537_b43-ijmm-38-06-1683","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1038\/srep01986","article-title":"Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: A model for human mercaptolactate-cysteine disulfiduria","volume":"3","author":"Nagahara","year":"2013","journal-title":"Sci Rep"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2016.2771\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T12:01:35Z","timestamp":1568462495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2016.2771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,14]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,10,14]]},"published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.3892\/ijmm.2016.2771"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2016.2771","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,14]]}}}