{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:18:31Z","timestamp":1788848311813,"version":"build-2803163510"},"reference-count":44,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.3892\/ijmm.2017.2941","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T13:34:47Z","timestamp":1491312887000},"page":"1072-1082","source":"Crossref","is-referenced-by-count":61,"title":["A heptameric peptide purified from Spirulina sp. gastrointestinal hydrolysate inhibits angiotensin I-converting enzyme- and angiotensin II-induced vascular dysfunction in human endothelial cells"],"prefix":"10.3892","volume":"39","author":[{"given":"Seong-Yeong","family":"Heo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Chun","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gun-Woo","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomi","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Ji","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geunhyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Sun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Whan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Tuong Vy","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Jin","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Hyung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myunggi","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Kyo","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"key20180107234905_b1-ijmm-39-05-1072","first-page":"83","article-title":"Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals","volume":"21","author":"Yamada","year":"2008","journal-title":"Int J Mol Med"},{"key":"key20180107234905_b2-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jff.2015.07.003","article-title":"Angio-tensin I-converting enzyme (ACE) inhibition and nitric oxide (NO)-mediated antihypertensive effect of octaphlorethol A isolated from Ishige sinicola: in vitro molecular mechanism and in vivo SHR model","volume":"18","author":"Ko","year":"2016","journal-title":"J Funct Foods"},{"key":"key20180107234905_b3-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1021\/jf3041066","article-title":"Green asparagus (Asparagus officinalis) prevented hypertension by an inhibitory effect on angiotensin-converting enzyme activity in the kidney of spontaneously hypertensive rats","volume":"61","author":"Sanae","year":"2013","journal-title":"J Agric Food Chem"},{"key":"key20180107234905_b4-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1016\/j.procbio.2012.08.019","article-title":"Angiotensin I converting enzyme (ACE) inhibitory peptides from salmon byproduct protein hydrolysate by alcalase hydrolysis","volume":"47","author":"Ahn","year":"2012","journal-title":"Process Biochem"},{"key":"key20180107234905_b5-ijmm-39-05-1072","first-page":"571","article-title":"Improvement of organ damage by a non-depressor dose of imidapril in diabetic spontaneously hypertensive rats","volume":"19","author":"Tomita","year":"2007","journal-title":"Int J Mol Med"},{"key":"key20180107234905_b6-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.procbio.2012.07.015","article-title":"A novel angiotensin I-converting enzyme (ACE) inhibitory peptide from a marine Chlorella ellipsoidea and its antihypertensive effect in spontaneously hypertensive rats","volume":"47","author":"Ko","year":"2012","journal-title":"Process Biochem"},{"key":"key20180107234905_b7-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"8398","DOI":"10.1021\/jf0710635","article-title":"Antihypertensive effect of angiotensin I converting enzyme-inhibitory peptide from hydrolysates of Bigeye tuna dark muscle, Thunnus obesus","volume":"55","author":"Qian","year":"2007","journal-title":"J Agric Food Chem"},{"key":"key20180107234905_b8-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.atherosclerosis.2005.04.016","article-title":"Cross-talk between dyslipidemia and renin-angiotensin system and the role of LOX-1 and MAPK in atherogenesis studies with the combined use of rosuvastatin and candesartan","volume":"184","author":"Chen","year":"2006","journal-title":"Atherosclerosis"},{"key":"key20180107234905_b9-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"12094","DOI":"10.1074\/jbc.M209793200","article-title":"Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit","volume":"278","author":"Li","year":"2003","journal-title":"J Biol Chem"},{"key":"key20180107234905_b10-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1152\/ajpregu.00664.2001","article-title":"Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II","volume":"283","author":"Alonso-Galicia","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"key20180107234905_b11-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/01.ATV.0000047868.93732.B7","article-title":"Estrogen reduces angiotensin II-induced nitric oxide synthase and NAD(P)H oxidase expression in endothelial cells","volume":"23","author":"Gragasin","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20180107234905_b12-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1091\/mbc.1.9.649","article-title":"Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function","volume":"1","author":"Hahn","year":"1990","journal-title":"Cell Regul"},{"key":"key20180107234905_b13-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1166\/jbmb.2013.1264","article-title":"Angiotensin I-converting enzyme (ACE) inhibitory peptide isolated from biodiesel byproducts of marine microalgae, Nannochloropsis oculata","volume":"7","author":"Qian","year":"2013","journal-title":"J Biobased Mater Bioenergy"},{"key":"key20180107234905_b14-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1021\/acs.jafc.5b00241","article-title":"Polar lipid profile of Nannochloropsis oculata determined using a variety of lipid extraction procedures","volume":"63","author":"Servaes","year":"2015","journal-title":"J Agric Food Chem"},{"key":"key20180107234905_b15-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.procbio.2015.05.007","article-title":"A novel peptide purified from the fermented microalga Pavlova lutheri attenuates oxidative stress and melanogenesis in B16F10 melanoma cells","volume":"50","author":"Oh","year":"2015","journal-title":"Process Biochem"},{"key":"key20180107234905_b16-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10126-001-0012-7","article-title":"Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis","volume":"3","author":"Suetsuna","year":"2001","journal-title":"Mar Biotechnol (NY)"},{"key":"key20180107234905_b17-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.jff.2013.05.001","article-title":"Purification of novel anti-inflammatory peptides from enzymatic hydrolysate of the edible microalgal Spirulina maxima","volume":"5","author":"Vo","year":"2013","journal-title":"J Funct Foods"},{"key":"key20180107234905_b18-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1089\/109662002760178177","article-title":"Hypocholesterolemic effect of Spirulina in patients with hyperlipidemic nephrotic syndrome","volume":"5","author":"Samuels","year":"2002","journal-title":"J Med Food"},{"key":"key20180107234905_b19-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1089\/jmf.2006.101","article-title":"Free radical scavenging activity of a novel anti-oxidative peptide isolated from in vitro gastrointestinal digests of Mytilus coruscus","volume":"10","author":"Jung","year":"2007","journal-title":"J Med Food"},{"key":"key20180107234905_b20-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0006-2952(71)90292-9","article-title":"Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung","volume":"20","author":"Cushman","year":"1971","journal-title":"Biochem Pharmacol"},{"key":"key20180107234905_b21-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"330","DOI":"10.7164\/antibiotics.37.330","article-title":"Muraceins - muramyl peptides produced by Nocardia orientalis as angiotensin-converting enzyme inhibitors. I. Taxonomy, fermentation and biological properties","volume":"37","author":"Bush","year":"1984","journal-title":"J Antibiot (Tokyo)"},{"key":"key20180107234905_b22-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1002\/prot.22716","article-title":"Sub-angstrom modeling of complexes between flexible peptides and globular proteins","volume":"78","author":"Raveh","year":"2010","journal-title":"Proteins"},{"key":"key20180107234905_b23-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J Chem Phys"},{"key":"key20180107234905_b24-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","article-title":"Scalable molecular dynamics with NAMD","volume":"26","author":"Phillips","year":"2005","journal-title":"J Comput Chem"},{"key":"key20180107234905_b25-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1021\/jp973084f","article-title":"All-atom empirical potential for molecular modeling and dynamics studies of proteins","volume":"102","author":"MacKerell","year":"1998","journal-title":"J Phys Chem B"},{"key":"key20180107234905_b26-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"10913","DOI":"10.1063\/1.1324708","article-title":"Efficient particle-mesh Ewald based approach to fixed and induced dipolar interactions","volume":"113","author":"Toukmaji","year":"2000","journal-title":"J Chem Phys"},{"key":"key20180107234905_b27-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.procbio.2011.10.005","article-title":"Purification and characterization of angiotensin I-converting enzyme inhibitory peptide from enzymatic hydrolysates of Styela clava flesh tissue","volume":"47","author":"Ko","year":"2012","journal-title":"Process Biochem"},{"key":"key20180107234905_b28-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1016\/j.biortech.2007.08.018","article-title":"Protective effect of an antioxidative peptide purified from gastrointestinal digests of oyster, Crassostrea gigas against free radical induced DNA damage","volume":"99","author":"Qian","year":"2008","journal-title":"Bioresour Technol"},{"key":"key20180107234905_b29-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.foodchem.2011.12.020","article-title":"An active peptide purified from gastrointestinal enzyme hydrolysate of Pacific cod skin gelatin attenuates angiotensin-1 converting enzyme (ACE) activity and cellular oxidative stress","volume":"132","author":"Himaya","year":"2012","journal-title":"Food Chem"},{"key":"key20180107234905_b30-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.foodchem.2004.09.048","article-title":"Angiotensin I-converting enzyme inhibitory peptide from yellow sole (Limanda aspera) frame protein and its antihypertensive effect in spontaneously hypertensive rats","volume":"94","author":"Jung","year":"2006","journal-title":"Food Chem"},{"key":"key20180107234905_b31-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.foodchem.2013.03.038","article-title":"Matrix metalloproteinases (MMPs) inhibitory effects of an octameric oligopeptide isolated from abalone Haliotis discus hannai","volume":"141","author":"Nguyen","year":"2013","journal-title":"Food Chem"},{"key":"key20180107234905_b32-ijmm-39-05-1072","first-page":"690","article-title":"Inhibitory effects and molecular mechanism of an anti-inflammatory peptide isolated from intestine of abalone, Haliotis discus hannai on LPS-induced cytokine production via the p-38\/p-JNK pathways in RAW264.7 macrophages","volume":"4","author":"Qian","year":"2016","journal-title":"J Food Biochem"},{"key":"key20180107234905_b33-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.peptides.2014.07.026","article-title":"A novel angiotensin-I converting enzyme (ACE) inhibitory peptide from gastrointestinal protease hydrolysate of silkworm pupa (Bombyx mori) protein: biochemical characterization and molecular docking study","volume":"68","author":"Wu","year":"2015","journal-title":"Peptides"},{"key":"key20180107234905_b34-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.procbio.2008.02.019","article-title":"ACE-inhibitory peptides identified from the muscle protein hydrolysate of hard clam (Meretrix lusoria)","volume":"43","author":"Tsai","year":"2008","journal-title":"Process Biochem"},{"key":"key20180107234905_b35-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00217-011-1585-7","article-title":"Effect of angiotensin I-converting enzyme (ACE) inhibitory peptide purified from enzymatic hydrolysates of Styela plicata","volume":"233","author":"Ko","year":"2011","journal-title":"Eur Food Res Technol"},{"key":"key20180107234905_b36-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1161\/01.CIR.87.6.1816","article-title":"Molecular biology of the renin-angiotensin system","volume":"87","author":"Griendling","year":"1993","journal-title":"Circulation"},{"key":"key20180107234905_b37-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/01.CIR.0000030181.63741.56","article-title":"Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense","volume":"106","author":"Kagiyama","year":"2002","journal-title":"Circulation"},{"key":"key20180107234905_b38-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.RES.87.10.840","article-title":"Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress","volume":"87","author":"Cai","year":"2000","journal-title":"Circ Res"},{"key":"key20180107234905_b39-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-0115(99)00027-0","article-title":"Angiotensin II and nitric oxide: a question of balance","volume":"81","author":"Millatt","year":"1999","journal-title":"Regul Pept"},{"key":"key20180107234905_b40-ijmm-39-05-1072","first-page":"L315","article-title":"ANG II stimulates endothelial nitric oxide synthase expression in bovine pulmonary artery endothelium","volume":"273","author":"Olson","year":"1997","journal-title":"Am J Physiol"},{"key":"key20180107234905_b41-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1152\/japplphysiol.00419.2003","article-title":"iNOS activity is essential for endothelial stress gene expression protecting against oxidative damage","volume":"95","author":"Hemmrich","year":"2003","journal-title":"J Appl Physiol"},{"key":"key20180107234905_b42-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1172\/JCI116579","article-title":"Endothelin-1 is an autocrine\/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes","volume":"92","author":"Ito","year":"1993","journal-title":"J Clin Invest"},{"key":"key20180107234905_b43-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1016\/j.biocel.2008.05.005","article-title":"Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38\/ERK and NF-kappaB pathways","volume":"40","author":"Jung","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"key20180107234905_b44-ijmm-39-05-1072","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0006-2952(02)01349-7","article-title":"Antioxidants inhibit endothelin-1 (1\u201331)-induced proliferation of vascular smooth muscle cells via the inhibition of mitogen-activated protein (MAP) kinase and activator protein-1 (AP-1)","volume":"64","author":"Kyaw","year":"2002","journal-title":"Biochem Pharmacol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijmm.2017.2941\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T22:45:57Z","timestamp":1601851557000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2017.2941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,4]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,4,4]]},"published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.3892\/ijmm.2017.2941"],"URL":"https:\/\/doi.org\/10.3892\/ijmm.2017.2941","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,4]]}}}