{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:01:36Z","timestamp":1770508896378,"version":"3.49.0"},"reference-count":50,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2017.3207","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T16:20:46Z","timestamp":1508775646000},"source":"Crossref","is-referenced-by-count":13,"title":["YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells"],"prefix":"10.3892","author":[{"given":"Jie","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailian","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Organ Transplantation, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Medical School of the University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoping","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Organ Transplantation, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Medical School of the University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"key":"key20200713174317_b1-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010\u20132020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"key20200713174317_b2-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"key20200713174317_b3-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.exer.2005.10.011","article-title":"'What controls aqueous humour outflow resistance?'","volume":"82","author":"Johnson","year":"2006","journal-title":"Exp Eye Res"},{"key":"key20200713174317_b4-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/00061198-199704000-00009","article-title":"Severity of optic nerve damage in eyes with POAG is correlated with changes in the trabecular meshwork","volume":"6","author":"Gottanka","year":"1997","journal-title":"J Glaucoma"},{"key":"key20200713174317_b5-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1167\/iovs.10-6342","article-title":"Elastic modulus determination of normal and glaucomatous human trabecular meshwork","volume":"52","author":"Last","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b6-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/sj.eye.6701895","article-title":"Corticosteroid-induced glaucoma: a review of the literature","volume":"20","author":"Kersey","year":"2006","journal-title":"Eye (Lond)"},{"key":"key20200713174317_b7-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"5163","DOI":"10.1167\/iovs.02-1318","article-title":"Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma","volume":"44","author":"Stokes","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b8-ijmm-41-01-0164","first-page":"61","article-title":"Dexamethasone disrupts intercellular junction formation and cytoskeleton organization in human trabecular meshwork cells","volume":"16","author":"Zhuo","year":"2010","journal-title":"Mol Vis"},{"key":"key20200713174317_b9-ijmm-41-01-0164","first-page":"1093","article-title":"Effects of dexamethasone, progesterone, and testosterone on IOP and GAGs in the rabbit eye","volume":"26","author":"Knepper","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b10-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/cm.20049","article-title":"Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue","volume":"60","author":"Clark","year":"2005","journal-title":"Cell Motil Cytoskeleton"},{"key":"key20200713174317_b11-ijmm-41-01-0164","first-page":"281","article-title":"Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells","volume":"35","author":"Clark","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b12-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1002\/dvdy.21996","article-title":"Regulation of organ size: insights from the Drosophila Hippo signaling pathway","volume":"238","author":"Kango-Singh","year":"2009","journal-title":"Dev Dyn"},{"key":"key20200713174317_b13-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/nrm2221","article-title":"Filling out the Hippo pathway","volume":"8","author":"Saucedo","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20200713174317_b14-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/ncb1107-1225","article-title":"How size is controlled: from Hippos to Yorkies","volume":"9","author":"Buttitta","year":"2007","journal-title":"Nat Cell Biol"},{"key":"key20200713174317_b15-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1101\/gad.1536007","article-title":"Hippo signaling in organ size control","volume":"21","author":"Pan","year":"2007","journal-title":"Genes Dev"},{"key":"key20200713174317_b16-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.ceb.2008.10.001","article-title":"The Hippo-YAP pathway: new connections between regulation of organ size and cancer","volume":"20","author":"Zhao","year":"2008","journal-title":"Curr Opin Cell Biol"},{"key":"key20200713174317_b17-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1101\/gad.210773.112","article-title":"The Hippo pathway: regulators and regulations","volume":"27","author":"Yu","year":"2013","journal-title":"Genes Dev"},{"key":"key20200713174317_b18-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1139\/O08-114","article-title":"YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease","volume":"87","author":"Wang","year":"2009","journal-title":"Biochem Cell Biol"},{"key":"key20200713174317_b19-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1167\/iovs.12-11007","article-title":"Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ","volume":"54","author":"Raghunathan","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b20-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"key20200713174317_b21-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"e101526","DOI":"10.1371\/journal.pone.0101526","article-title":"Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"key20200713174317_b22-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3892\/ijmm.2016.2713","article-title":"Notoginsenoside R1 ameliorates podocyte injury in rats with diabetic nephropathy by activating the I3K\/Akt signaling pathway","volume":"38","author":"Huang","year":"2016","journal-title":"Int J Mol Med"},{"key":"key20200713174317_b23-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1258\/ebm.2011.011251","article-title":"Agaricus bisporus lectins mediates islet \u03b2-cell proliferation through regulation of cell cycle proteins","volume":"237","author":"Wang","year":"2012","journal-title":"Exp Biol Med (Maywood)"},{"key":"key20200713174317_b24-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1055\/s-0031-1295416","article-title":"Antihyperglycemic effect of ginsenoside Rh2 by inducing islet \u03b2-cell regeneration in mice","volume":"44","author":"Wang","year":"2012","journal-title":"Horm Metab Res"},{"key":"key20200713174317_b25-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"key20200713174317_b26-ijmm-41-01-0164","first-page":"1836","article-title":"Trabecular meshwork cells grown on filters. Conductivity and cytochalasin effects","volume":"29","author":"Perkins","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b27-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.exer.2013.05.014","article-title":"Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells","volume":"113","author":"Thomasy","year":"2013","journal-title":"Exp Eye Res"},{"key":"key20200713174317_b28-ijmm-41-01-0164","first-page":"125","article-title":"Gene expression profile of human trabecular meshwork cells in response to long-term dexamethasone exposure","volume":"12","author":"Rozsa","year":"2006","journal-title":"Mol Vis"},{"key":"key20200713174317_b29-ijmm-41-01-0164","first-page":"2242","article-title":"The effects of dexamethasone on fibronectin expression in cultured human trabecular meshwork cells","volume":"33","author":"Steely","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b30-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.yexcr.2014.07.035","article-title":"A syndecan-4 binding peptide derived from laminin 5 uses a novel PKC\u03b5 pathway to induce cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells","volume":"327","author":"Filla","year":"2014","journal-title":"Exp Cell Res"},{"key":"key20200713174317_b31-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/00061198-199506000-00007","article-title":"Cytoskeletal changes in cultured human glaucoma trabecular meshwork cells","volume":"4","author":"Clark","year":"1995","journal-title":"J Glaucoma"},{"key":"key20200713174317_b32-ijmm-41-01-0164","first-page":"339","article-title":"Glucocorticoid effects on extracellular matrix proteins and integrins in bovine trabecular meshwork cells in relation to glaucoma","volume":"1","author":"Zhou","year":"1998","journal-title":"Int J Mol Med"},{"key":"key20200713174317_b33-ijmm-41-01-0164","first-page":"1376","article-title":"Effects of dexamethasone and HA1077 on actin cytoskeleton and \u03b2-catenin in cultured human trabecular meshwork cells","volume":"9","author":"Peng","year":"2016","journal-title":"Int J Ophthalmol"},{"key":"key20200713174317_b34-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1093\/jmcb\/mju046","article-title":"Hippo\/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung","volume":"7","author":"Lange","year":"2015","journal-title":"J Mol Cell Biol"},{"key":"key20200713174317_b35-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exer.2013.06.012","article-title":"What do mechanotransduction, Hippo, Wnt, and TGF\u03b2 have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease","volume":"115","author":"Morgan","year":"2013","journal-title":"Exp Eye Res"},{"key":"key20200713174317_b36-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"5723","DOI":"10.1167\/iovs.08-3215","article-title":"Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathways","volume":"50","author":"Filla","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b37-ijmm-41-01-0164","first-page":"1029","article-title":"Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632","volume":"42","author":"Rao","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b38-ijmm-41-01-0164","first-page":"57","article-title":"Pathophysiology of glaucoma and continuous measurements of intraocular pressure","volume":"6","author":"Sit","year":"2009","journal-title":"Mol Cell Biomech"},{"key":"key20200713174317_b39-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1016\/j.biomaterials.2010.11.071","article-title":"The effect of biophysical attributes of the ocular trabecular meshwork associated with glaucoma on the cell response to therapeutic agents","volume":"32","author":"McKee","year":"2011","journal-title":"Biomaterials"},{"key":"key20200713174317_b40-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"9298","DOI":"10.1167\/iovs.11-7857","article-title":"Substratum compliance regulates human trabecular meshwork cell behaviors and response to latrunculin B","volume":"52","author":"Wood","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b41-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"5056","DOI":"10.1016\/j.biomaterials.2011.03.054","article-title":"The role of substratum compliance of hydrogels on vascular endothelial cell behavior","volume":"32","author":"Wood","year":"2011","journal-title":"Biomaterials"},{"key":"key20200713174317_b42-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/jbm.a.33064","article-title":"Scaffold-based approach to direct stem cell neural and cardiovascular differentiation: an analysis of physical and biochemical effects","volume":"97","author":"Chew","year":"2011","journal-title":"J Biomed Mater Res A"},{"key":"key20200713174317_b43-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1167\/iovs.10-6640","article-title":"Elasticity-dependent modulation of TGF-\u03b2 responses in human trabecular meshwork cells","volume":"52","author":"Han","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b44-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1101\/gad.1909210","article-title":"The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev"},{"key":"key20200713174317_b45-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S1350-9462(98)00035-4","article-title":"Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma","volume":"18","author":"Wordinger","year":"1999","journal-title":"Prog Retin Eye Res"},{"key":"key20200713174317_b46-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.tcb.2008.10.003","article-title":"The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development","volume":"19","author":"Morrison","year":"2009","journal-title":"Trends Cell Biol"},{"key":"key20200713174317_b47-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1016\/j.ajpath.2012.02.030","article-title":"Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork","volume":"180","author":"Junglas","year":"2012","journal-title":"Am J Pathol"},{"key":"key20200713174317_b48-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1167\/iovs.07-0835","article-title":"Tissue transglutaminase expression and activity in normal and glaucomatous human trabecular meshwork cells and tissues","volume":"49","author":"Tovar-Vidales","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b49-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"7043","DOI":"10.1167\/iovs.12-9664","article-title":"Existence of the canonical Wnt signaling pathway in the human trabecular meshwork","volume":"53","author":"Mao","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174317_b50-ijmm-41-01-0164","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.devcel.2010.03.007","article-title":"The Hippo pathway regulates Wnt\/beta-catenin signaling","volume":"18","author":"Varelas","year":"2010","journal-title":"Dev Cell"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:07:48Z","timestamp":1594663668000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2017.3207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":50,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2017.3207","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}