{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:01:58Z","timestamp":1775203318347,"version":"3.50.1"},"reference-count":33,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2017.3218","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T12:15:43Z","timestamp":1509106543000},"source":"Crossref","is-referenced-by-count":9,"title":["Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice"],"prefix":"10.3892","author":[{"given":"T\u00ef\u00bf\u00bdng","family":"Nguy\u1ec5n-Thanh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dal","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sik","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"key":"key20200713174307_b1-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/S0140-6736(13)60439-0","article-title":"Evolving importance of kidney disease: From subspecialty to global health burden","volume":"382","author":"Eckardt","year":"2013","journal-title":"Lancet"},{"key":"key20200713174307_b2-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/ckj\/sfv111","article-title":"The global nephrology workforce: Emerging threats and potential solutions","volume":"9","author":"Sharif","year":"2016","journal-title":"Clin Kidney J"},{"key":"key20200713174307_b3-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1038\/ki.2011.368","article-title":"The contribution of chronic kidney disease to the global burden of major noncommunicable diseases","volume":"80","author":"Couser","year":"2011","journal-title":"Kidney Int"},{"key":"key20200713174307_b4-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0140-6736(13)61545-7","article-title":"The global issue of kidney disease","volume":"382","year":"2013","journal-title":"Lancet"},{"key":"key20200713174307_b5-ijmm-41-01-0095","first-page":"151","article-title":"High burden and unmet patient needs in chronic kidney disease","volume":"5","author":"Braun","year":"2012","journal-title":"Int J Nephrol Renovasc Dis"},{"key":"key20200713174307_b6-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"key20200713174307_b7-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s40139-015-0077-z","article-title":"Key Fibrogenic Signaling","volume":"3","author":"He","year":"2015","journal-title":"Curr Pathobiol Rep"},{"key":"key20200713174307_b8-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S2095-4964(16)60256-X","article-title":"Interventional mechanisms of herbs or herbal extracts on renal interstitial fibrosis","volume":"14","author":"Xia","year":"2016","journal-title":"J Integr Med"},{"key":"key20200713174307_b9-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"a021873","DOI":"10.1101\/cshperspect.a021873","article-title":"TGF-\u03b2 and the TGF-\u03b2 family: Context-dependent roles in cell and tissue physiology","volume":"8","author":"Morikawa","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"key20200713174307_b10-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1093\/ndt\/gfu240","article-title":"Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor \u03b1-mediated transforming growth factor-\u03b21\/Smad signaling pathway","volume":"29","author":"Kim","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"key20200713174307_b11-ijmm-41-01-0095","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/479364","article-title":"Molecular and therapeutic potential and toxicity of valproic acid","volume":"479364","author":"Chateauvieux","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"key20200713174307_b12-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/med.20027","article-title":"Evolving anticancer drug valproic acid: Insights into the mechanism and clinical studies","volume":"25","author":"Blaheta","year":"2005","journal-title":"Med Res Rev"},{"key":"key20200713174307_b13-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"G\u00f6ttlicher","year":"2001","journal-title":"EMBO J"},{"key":"key20200713174307_b14-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3389\/fphys.2015.00121","article-title":"Treatment of chronic kidney diseases with histone deacetylase inhibitors","volume":"6","author":"Liu","year":"2015","journal-title":"Front Physiol"},{"key":"key20200713174307_b15-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.yexmp.2015.01.003","article-title":"Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat","volume":"98","author":"Khan","year":"2015","journal-title":"Exp Mol Pathol"},{"key":"key20200713174307_b16-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1681\/ASN.2010111196","article-title":"Valproic acid attenuates proteinuria and kidney injury","volume":"22","author":"Van Beneden","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"key20200713174307_b17-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jss.2014.05.030","article-title":"Valproic acid protects septic mice from renal injury by reducing the inflammatory response","volume":"192","author":"Zheng","year":"2014","journal-title":"J Surg Res"},{"key":"key20200713174307_b18-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/ki.2009.86","article-title":"Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy","volume":"75","author":"Chevalier","year":"2009","journal-title":"Kidney Int"},{"key":"key20200713174307_b19-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nrneph.2014.114","article-title":"Inflammatory processes in renal fibrosis","volume":"10","author":"Meng","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"key20200713174307_b20-ijmm-41-01-0095","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1096\/fasebj.8.11.7520879","article-title":"Fibrogenic cytokines and connective tissue production","volume":"8","author":"Kovacs","year":"1994","journal-title":"FASEB J"},{"key":"key20200713174307_b21-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: The master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"key20200713174307_b22-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0065-2776(05)89006-6","article-title":"Regulation of fibrosis by the immune system","volume":"89","author":"Lupher","year":"2006","journal-title":"Adv Immunol"},{"key":"key20200713174307_b23-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: Therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat Med"},{"key":"key20200713174307_b24-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nrneph.2009.74","article-title":"Fibroblast activation and myofibroblast generation in obstructive nephropathy","volume":"5","author":"Grande","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"key20200713174307_b25-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/nep.12014","article-title":"Mononuclear phagocyte system in kidney disease and repair","volume":"18","author":"Alikhan","year":"2013","journal-title":"Nephrology (Carlton)"},{"key":"key20200713174307_b26-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nrneph.2010.120","article-title":"Renal fibrosis: Novel insights into mechanisms and therapeutic targets","volume":"6","author":"Boor","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"key20200713174307_b27-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1755-1536-7-4","article-title":"The extracellular matrix in the kidney: A source of novel non-invasive biomarkers of kidney fibrosis","volume":"7","author":"Genovese","year":"2014","journal-title":"Fibrogenesis Tissue Repair"},{"key":"key20200713174307_b28-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00109-015-1358-z","article-title":"Valproic acid suppresses collagen by selective regulation of Smads in conjunctival fibrosis","volume":"94","author":"Seet","year":"2016","journal-title":"J Mol Med (Berl)"},{"key":"key20200713174307_b29-ijmm-41-01-0095","first-page":"44247","article-title":"The role of TIMPs in regulation of extracellular matrix proteolysis","author":"Arpino","year":"2015","journal-title":"Matrix Biol"},{"key":"key20200713174307_b30-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2165\/00002018-199005010-00006","article-title":"Acute valproic acid overdose. Clinical course and pharmacokinetic disposition of valproic acid and metabolites","volume":"5","author":"Dupuis","year":"1990","journal-title":"Drug Saf"},{"key":"key20200713174307_b31-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/YIC.0b013e3281c61b28","article-title":"Valproate-induced hyperammonaemic encephalopathy: Review of 14 cases in the psychiatric setting","volume":"22","author":"Dealberto","year":"2007","journal-title":"Int Clin Psychopharmacol"},{"key":"key20200713174307_b32-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1212\/WNL.46.2.465","article-title":"Valproic acid hepatic fatalities. III. U.S. experience since 1986","volume":"46","author":"Bryant","year":"1996","journal-title":"Neurology"},{"key":"key20200713174307_b33-ijmm-41-01-0095","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S0887-8994(02)00447-2","article-title":"Renal injury from valproic acid: Case report and literature review","volume":"27","author":"Zaki","year":"2002","journal-title":"Pediatr Neurol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:07:00Z","timestamp":1594663620000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2017.3218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,27]]},"references-count":33,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2017.3218","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,27]]}}}