{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:34:24Z","timestamp":1775028864036,"version":"3.50.1"},"reference-count":54,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2017.3235","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T12:24:50Z","timestamp":1509971090000},"source":"Crossref","is-referenced-by-count":10,"title":["Downregulation of microRNA\u2011124\u20113p suppresses the mTOR signaling pathway by targeting DDIT4 in males with major depressive disorder"],"prefix":"10.3892","author":[{"given":"Qiuling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Jining Psychiatric Hospital, Jining, Shandong 272051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaofeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jining Psychiatric Hospital, Jining, Shandong 272051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jining Psychiatric Hospital, Jining, Shandong 272051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jining Psychiatric Hospital, Jining, Shandong 272051, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing 100069, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"key20200713174407_b1-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1001\/archpsyc.64.5.543","article-title":"Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication","volume":"64","author":"Merikangas","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"key20200713174407_b2-ijmm-41-01-0493","unstructured":"World Health OrganizationGlobal burden of disease 2004 update: Disability weights for diseases and conditionsWHOGeneva, Switzerland2004Available at: http:\/\/www.who.int\/healthinfo\/global_burden_disease\/GBD2004_DisabilityWeights.pdf"},{"key":"key20200713174407_b3-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1001\/archgenpsychiatry.2009.36","article-title":"Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys","volume":"66","author":"Seedat","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"key20200713174407_b4-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"key20200713174407_b5-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nn.2294","article-title":"miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche","volume":"12","author":"Cheng","year":"2009","journal-title":"Nat Neurosci"},{"key":"key20200713174407_b6-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3389\/fnmol.2016.00144","article-title":"Integrative analysis of sex\u2011specific microRNA networks following stress in mouse nucleus accumbens","volume":"9","author":"Pfau","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"key20200713174407_b7-ijmm-41-01-0493","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"Krol","year":"2010","journal-title":"Nat Rev Genet"},{"key":"key20200713174407_b8-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: Small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat Rev Genet"},{"key":"key20200713174407_b9-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.conb.2009.05.015","article-title":"Fine-tuning neural gene expression with microRNAs","volume":"19","author":"Schratt","year":"2009","journal-title":"Curr Opin Neurobiol"},{"key":"key20200713174407_b10-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00441-012-1438-0","article-title":"Micro-RNAs (miRNAs): Genomic organisation, biogenesis and mode of action","volume":"349","author":"Ul Hussain","year":"2012","journal-title":"Cell Tissue Res"},{"key":"key20200713174407_b11-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1002\/humu.21344","article-title":"miRNA genes and the brain: Implications for psychiatric disorders","volume":"31","author":"Forero","year":"2010","journal-title":"Hum Mutat"},{"key":"key20200713174407_b12-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.brainres.2010.03.035","article-title":"MicroRNA dysregulation in psychiatric disease","volume":"1338","author":"Miller","year":"2010","journal-title":"Brain Res"},{"key":"key20200713174407_b13-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.biopsych.2010.09.039","article-title":"Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder","volume":"69","author":"Moreau","year":"2011","journal-title":"Biol Psychiatry"},{"key":"key20200713174407_b14-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fgene.2012.00082","article-title":"The Path to microRNA therapeutics in psychiatric and neurodegenerative disorders","volume":"3","author":"Chan","year":"2012","journal-title":"Front Genet"},{"key":"key20200713174407_b15-ijmm-41-01-0493","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature13976","article-title":"\u03b2-catenin mediates stress resilience through Dicer1\/microRNA regulation","volume":"516","author":"Dias","year":"2014","journal-title":"Nature"},{"key":"key20200713174407_b16-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"10106","DOI":"10.1038\/ncomms10106","article-title":"DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression","volume":"6","author":"Wingo","year":"2015","journal-title":"Nat Commun"},{"key":"key20200713174407_b17-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.pnpbp.2015.02.003","article-title":"Pathogenetic and therapeutic applications of microRNAs in major depressive disorder","volume":"64","author":"Dwivedi","year":"2016","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"key20200713174407_b18-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s11910-008-0031-0","article-title":"MicroRNAs in brain function and disease","volume":"8","author":"Kuss","year":"2008","journal-title":"Curr Neurol Neurosci Rep"},{"key":"key20200713174407_b19-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jchemneu.2011.04.002","article-title":"Evidence demonstrating role of microRNAs in the etiopathology of major depression","volume":"42","author":"Dwivedi","year":"2011","journal-title":"J Chem Neuroanat"},{"key":"key20200713174407_b20-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"227","DOI":"10.4110\/in.2011.11.5.227","article-title":"MicroRNAs in human diseases: From autoimmune diseases to skin, psychiatric and neurodegenerative diseases","volume":"11","author":"Ha","year":"2011","journal-title":"Immune Netw"},{"key":"key20200713174407_b21-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.nbd.2011.12.035","article-title":"MicroRNAs and depression","volume":"46","author":"Mouillet-Richard","year":"2012","journal-title":"Neurobiol Dis"},{"key":"key20200713174407_b22-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"e33201","DOI":"10.1371\/journal.pone.0033201","article-title":"MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects","volume":"7","author":"Smalheiser","year":"2012","journal-title":"PLoS One"},{"key":"key20200713174407_b23-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.neuron.2009.10.020","article-title":"MicroRNAs potentiate neural development","volume":"64","author":"Fineberg","year":"2009","journal-title":"Neuron"},{"key":"key20200713174407_b24-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S0960-9822(02)00809-6","article-title":"Identification of tissue\u2011specific microRNAs from mouse","volume":"12","author":"Lagos-Quintana","year":"2002","journal-title":"Curr Biol"},{"key":"key20200713174407_b25-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/nm.3582","article-title":"miR-1202 is a primate\u2011specific and brain\u2011enriched microRNA involved in major depression and antidepressant treatment","volume":"20","author":"Lopez","year":"2014","journal-title":"Nat Med"},{"key":"key20200713174407_b26-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jad.2010.05.019","article-title":"A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform","volume":"127","author":"Xu","year":"2010","journal-title":"J Affect Disord"},{"key":"key20200713174407_b27-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"4017","DOI":"10.1093\/hmg\/ddq316","article-title":"Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia","volume":"19","author":"Saus","year":"2010","journal-title":"Hum Mol Genet"},{"key":"key20200713174407_b28-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s12031-009-9252-1","article-title":"Changes in brain MicroRNAs contribute to cholinergic stress reactions","volume":"40","author":"Meerson","year":"2010","journal-title":"Journal of molecular neuroscience: MN"},{"key":"key20200713174407_b29-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1210\/en.2008-1335","article-title":"MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: Implications for glucocorticoid responsiveness in the brain","volume":"150","author":"Vreugdenhil","year":"2009","journal-title":"Endocrinology"},{"key":"key20200713174407_b30-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for functional genomics data sets\u2013update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"key20200713174407_b31-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","article-title":"miRWalk\u2013database: Prediction of possible miRNA binding sites by 'walking' the genes of three genomes","volume":"44","author":"Dweep","year":"2011","journal-title":"J Biomed Inform"},{"key":"key20200713174407_b32-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1038\/npp.2015.15","article-title":"Quantification of the serotonin 1A receptor using PET: Identification of a potential biomarker of major depression in males","volume":"40","author":"Kaufman","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"key20200713174407_b33-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"e955","DOI":"10.1038\/tp.2016.188","article-title":"Identification of sex-specific urinary biomarkers for major depressive disorder by combined application of NMR- and GC-MS-based metabonomics","volume":"6","author":"Zheng","year":"2016","journal-title":"Transl Psychiatry"},{"key":"key20200713174407_b34-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"e185","DOI":"10.1038\/tp.2012.112","article-title":"Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode","volume":"2","author":"Belzeaux","year":"2012","journal-title":"Transl Psychiatry"},{"key":"key20200713174407_b35-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nm.3513","article-title":"REDD1 is essential for stress-induced synaptic loss and depressive behavior","volume":"20","author":"Ota","year":"2014","journal-title":"Nat Med"},{"key":"key20200713174407_b36-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1007\/s00406-006-0674-2","article-title":"Decreased quality of life and depression as predictors for shorter survival among patients with low-grade gliomas: A follow-up from 1990 to 2003","volume":"256","author":"Mainio","year":"2006","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"key20200713174407_b37-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0006-3223(03)00566-3","article-title":"Depression and cancer: Mechanisms and disease progression","volume":"54","author":"Spiegel","year":"2003","journal-title":"Biol Psychiatry"},{"key":"key20200713174407_b38-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1054\/plef.1999.0037","article-title":"Depression and bipolar disorder: Relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis. Possible candidate genes","volume":"60","author":"Horrobin","year":"1999","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"key20200713174407_b39-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s11060-010-0266-x","article-title":"Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma","volume":"101","author":"Seznec","year":"2011","journal-title":"J Neurooncol"},{"key":"key20200713174407_b40-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"8077","DOI":"10.1158\/0008-5472.CAN-10-1313","article-title":"hsa-miR-191 is a candidate oncogene target for hepatocellular carcinoma therapy","volume":"70","author":"Elyakim","year":"2010","journal-title":"Cancer Res"},{"key":"key20200713174407_b41-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"23847","DOI":"10.1074\/jbc.R400004200","article-title":"Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer","volume":"279","author":"Nebert","year":"2004","journal-title":"J Biol Chem"},{"key":"key20200713174407_b42-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jad.2015.02.022","article-title":"CSF miR-16 is decreased in major depression patients and its neutralization in rats induces depression-like behaviors via a serotonin transmitter system","volume":"178","author":"Song","year":"2015","journal-title":"J Affect Disord"},{"key":"key20200713174407_b43-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.molcel.2007.07.015","article-title":"The MicroRNA miR-124 promotes neuronal differentiation by triggering brain\u2011specific alternative pre\u2011mRNA splicing","volume":"27","author":"Makeyev","year":"2007","journal-title":"Mol Cell"},{"key":"key20200713174407_b44-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/npp.2016.175","article-title":"Identification of MicroRNA-124-3p as a putative epigenetic signature of major depressive disorder","volume":"42","author":"Roy","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"key20200713174407_b45-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"977","DOI":"10.7150\/ijms.16642","article-title":"Genetic analysis of BDNF, GNB3, MTHFR, ACE and APOE variants in major and recurrent depressive disorders in Russia","volume":"13","author":"Bondarenko","year":"2016","journal-title":"Int J Med Sci"},{"key":"key20200713174407_b46-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jpsychires.2016.03.015","article-title":"Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder","volume":"78","author":"He","year":"2016","journal-title":"J Psychiatr Res"},{"key":"key20200713174407_b47-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.psyneuen.2014.04.009","article-title":"Selective lentiviral-mediated suppression of microRNA124a in the hippocampus evokes antidepressants-like effects in rats","volume":"46","author":"Bahi","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"key20200713174407_b48-ijmm-41-01-0493","first-page":"1585","article-title":"Screening of specific microRNA in hippocampus of depression model rats and intervention effect of Chaihu Shugan San","volume":"38","author":"Cao","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"key20200713174407_b49-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/ng.556","article-title":"Subtle variations in Pten dose determine cancer susceptibility","volume":"42","author":"Alimonti","year":"2010","journal-title":"Nat Genet"},{"key":"key20200713174407_b50-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/mp.2010.38","article-title":"Poor replication of candidate genes for major depressive disorder using genome-wide association data","volume":"16","author":"Bosker","year":"2011","journal-title":"Mol Psychiatry"},{"key":"key20200713174407_b51-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"e69637","DOI":"10.1371\/journal.pone.0069637","article-title":"The epidemiological modelling of major depressive disorder: Application for the Global Burden of Disease Study 2010","volume":"8","author":"Ferrari","year":"2013","journal-title":"PLoS One"},{"key":"key20200713174407_b52-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.euroneuro.2012.06.013","article-title":"Blood microRNA changes in depressed patients during antidepressant treatment","volume":"23","author":"Bocchio\u2011Chiavetto","year":"2013","journal-title":"Eur Neuropsychopharmacol"},{"key":"key20200713174407_b53-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1001\/archgenpsychiatry.2011.60","article-title":"Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder","volume":"68","author":"Kempton","year":"2011","journal-title":"Arch Gen Psychiatry"},{"key":"key20200713174407_b54-ijmm-41-01-0493","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jpsychires.2014.08.007","article-title":"Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients","volume":"59","author":"Fan","year":"2014","journal-title":"J Psychiatr Res"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:11:37Z","timestamp":1594663897000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2017.3235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,6]]},"references-count":54,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2017.3235","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,6]]}}}