{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:46:03Z","timestamp":1777380363574,"version":"3.51.4"},"reference-count":39,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2017.3330","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T07:18:06Z","timestamp":1513667886000},"source":"Crossref","is-referenced-by-count":15,"title":["Exogenous hydrogen sulfide protects human umbilical vein endothelial cells against high glucose\u2011induced injury by inhibiting the necroptosis pathway"],"prefix":"10.3892","author":[{"given":"Jiaqiong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiji","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Huangpu Division of the First Affiliated Hospital, Sun Yat\u2011sen University, Guangzhou, Guangdong 510700, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The First Affiliated Hospital, Sun Yat\u2011sen University, Guangzhou 510080, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Zhongshan School of Medicine, Sun Yat\u2011sen University, Guangzhou 510080, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiou","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximei","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqiang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Physiology, Zhongshan School of Medicine, Sun Yat\u2011sen University, Guangzhou 510080, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"key20200713174634_b1-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/jp.2014.49","article-title":"A prospective study on hyperglycemia and retinopathy of prematurity","volume":"34","author":"Mohsen","year":"2014","journal-title":"J Perinatol"},{"key":"key20200713174634_b2-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"e0141109","DOI":"10.1371\/journal.pone.0141109","article-title":"High fat high cholesterol diet (western diet) aggravates atherosclerosis, hyperglycemia and renal failure in nephrectomized LDL receptor knockout mice: role of intestine derived lipopolysaccharide","volume":"10","author":"Ghosh","year":"2015","journal-title":"PLoS One"},{"key":"key20200713174634_b3-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrendo.2014.29","article-title":"Insulin resistance and hyperglycaemia in cardiovascular disease development","volume":"10","author":"Laakso","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"key20200713174634_b4-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.2337\/diabetes.51.6.1938","article-title":"Hypergly cemia-induced apoptosis in mouse myocardium: Mitochondrial cytochrome C-mediated caspase-3 activation pathway","volume":"51","author":"Cal","year":"2002","journal-title":"Diabetes"},{"key":"key20200713174634_b5-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"13829","DOI":"10.1073\/pnas.1105121108","article-title":"Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function","volume":"108","author":"Suzuki","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713174634_b6-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat Chem Biol"},{"key":"key20200713174634_b7-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1038\/ni.2159","article-title":"Programmed necrosis: Backup to and competitor with apoptosis in the immune system","volume":"12","author":"Han","year":"2011","journal-title":"Nat Immunol"},{"key":"key20200713174634_b8-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1111\/j.1582-4934.2011.01341.x","article-title":"Necroptosis, necrostatins and tissue injury","volume":"15","author":"Smith","year":"2011","journal-title":"J Cell Mol Med"},{"key":"key20200713174634_b9-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exer.2014.04.009","article-title":"Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia-reperfusion-induced retinal damage","volume":"123","author":"Dvoriantchikova","year":"2014","journal-title":"Exp Eye Res"},{"key":"key20200713174634_b10-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s00395-012-0270-8","article-title":"Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo","volume":"107","author":"Oerlemans","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"key20200713174634_b11-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J"},{"key":"key20200713174634_b12-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gammalyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"key20200713174634_b13-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713174634_b14-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.109.920991","article-title":"Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice","volume":"122","author":"Calvert","year":"2010","journal-title":"Circulation"},{"key":"key20200713174634_b15-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1042\/BSR20100003","article-title":"Hydrogen sulfide attenuates cardiac dysfunction in a rat model of heart failure: A mechanism through cardiac mitochondrial protection","volume":"31","author":"Wang","year":"2011","journal-title":"Biosci Rep"},{"key":"key20200713174634_b16-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"917","DOI":"10.3892\/ijmm.2013.1462","article-title":"Exogenous hydrogen sulfide protects H9c2 cardiac cells against high glucose-induced injury by inhibiting the activities of the p38 MAPK and ERK1\/2 pathways","volume":"32","author":"Xu","year":"2013","journal-title":"Int J Mol Med"},{"key":"key20200713174634_b17-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s11010-011-1194-6","article-title":"Hydrogen sulfide protects H9c2 cells against doxorubicin-induced cardiotoxicity through inhibition of endoplasmic reticulum stress","volume":"363","author":"Wang","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"key20200713174634_b18-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3892\/ijmm.2014.2007","article-title":"Exogenous H2S protects H9c2 cardiac cells against high glucose-induced injury and inflammation by inhibiting the activation of the NF-\u03baB and IL-1\u03b2 pathways","volume":"35","author":"Xu","year":"2015","journal-title":"Int J Mol Med"},{"key":"key20200713174634_b19-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3892\/ijmm.2016.2467","article-title":"ATP-sensitive K+ channels contribute to the protective effects of exogenous hydrogen sulfide against high glucose-induced injury in H9c2 cardiac cells","volume":"37","author":"Liang","year":"2016","journal-title":"Int J Mol Med"},{"key":"key20200713174634_b20-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"key20200713174634_b21-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"e41147","DOI":"10.1371\/journal.pone.0041147","article-title":"Hydrogen sulfide inhibits the development of atherosclerosis with suppressing CX3CR1 and CX3CL1 expression","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"key20200713174634_b22-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1089\/ars.2009.2956","article-title":"Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation?","volume":"12","author":"Jain","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"key20200713174634_b23-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.jphs.2014.12.007","article-title":"Sitagliptin alleviated myocardial remodeling of the left ventricle and improved cardiac diastolic dysfunction in diabetic rats","volume":"127","author":"Liu","year":"2015","journal-title":"J Pharmacol Sci"},{"key":"key20200713174634_b24-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.celrep.2012.12.012","article-title":"A role of RIP3-mediated macrophage necrosis in atherosclerosis development","volume":"3","author":"Lin","year":"2013","journal-title":"Cell Reports"},{"key":"key20200713174634_b25-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1007\/s10495-009-0334-x","article-title":"Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis","volume":"14","author":"Han","year":"2009","journal-title":"Apoptosis"},{"key":"key20200713174634_b26-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1096\/fasebj.6.11.1644256","article-title":"Glucose and diabetic vascular disease","volume":"6","author":"Ruderman","year":"1992","journal-title":"FASEB J"},{"issue":"Suppl 1","key":"key20200713174634_b27-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1097\/01.hjr.0000368191.86614.5a","article-title":"The global burden of diabetes and its complications: An emerging pandemic","volume":"17","author":"van Dieren","year":"2010","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"key20200713174634_b28-ijmm-41-03-1477","first-page":"3972","article-title":"Response of capillary cell death to aminoguanidine predicts the development of retinopathy: Comparison of diabetes and galactosemia","volume":"41","author":"Kern","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174634_b29-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s10495-016-1234-5","article-title":"Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase\/Akt-dependent mechanism","volume":"21","author":"Zhang","year":"2016","journal-title":"Apoptosis"},{"key":"key20200713174634_b30-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1161\/01.RES.87.12.1123","article-title":"Myocardial cell death in human diabetes","volume":"87","author":"Frustaci","year":"2000","journal-title":"Circ Res"},{"key":"key20200713174634_b31-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1161\/CIRCRESAHA.110.225730","article-title":"Programmed necrosis, not apoptosis, in the heart","volume":"108","author":"Kung","year":"2011","journal-title":"Circ Res"},{"key":"key20200713174634_b32-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","article-title":"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha","volume":"137","author":"He","year":"2009","journal-title":"Cell"},{"key":"key20200713174634_b33-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"key":"key20200713174634_b34-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.cell.2009.07.006","article-title":"RIP kinases at the crossroads of cell death and survival","volume":"138","author":"Declercq","year":"2009","journal-title":"Cell"},{"key":"key20200713174634_b35-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s10557-007-6035-1","article-title":"Necrostatin: A potentially novel cardioprotective agent","volume":"21","author":"Smith","year":"2007","journal-title":"Cardiovasc Drugs Ther"},{"key":"key20200713174634_b36-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/82732","article-title":"Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule","volume":"1","author":"Holler","year":"2000","journal-title":"Nat Immunol"},{"key":"key20200713174634_b37-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"598","DOI":"10.4161\/auto.7.6.15103","article-title":"PARP and RIP 1 are required for autophagy induced by 11\u2032-deoxyverticillin A, which precedes caspase-dependent apoptosis","volume":"7","author":"Zhang","year":"2011","journal-title":"Autophagy"},{"key":"key20200713174634_b38-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ijcard.2014.01.068","article-title":"Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis","volume":"172","author":"Xu","year":"2014","journal-title":"Int J Cardiol"},{"key":"key20200713174634_b39-ijmm-41-03-1477","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1089\/ars.2013.5324","article-title":"Hydrogen sulfide and the pathogenesis of atherosclerosis","volume":"20","author":"Mani","year":"2014","journal-title":"Antioxid Redox Signal"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:20:02Z","timestamp":1594664402000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2017.3330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,19]]},"references-count":39,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2017.3330","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,19]]}}}