{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:54:54Z","timestamp":1792007694851,"version":"4.4.0"},"reference-count":46,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2017.3349","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T13:58:05Z","timestamp":1513951085000},"source":"Crossref","is-referenced-by-count":12,"title":["Estrogen receptor\u2011\u03b2\u2011dependent effects of saikosaponin\u2011d on the suppression of oxidative stress\u2011induced rat hepatic stellate cell activation"],"prefix":"10.3892","author":[{"given":"Renye","family":"Que","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Scientific Research, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Second Military Medical University, Shanghai 200433, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"key20200713174615_b1-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"key20200713174615_b2-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: A review","volume":"19","author":"S\u00e1nchez-Valle","year":"2012","journal-title":"Curr Med Chem"},{"key":"key20200713174615_b3-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s00535-008-2180-y","article-title":"Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies","volume":"43","author":"Li","year":"2008","journal-title":"J Gastroenterol"},{"key":"key20200713174615_b4-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/fphar.2016.00033","article-title":"Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis","volume":"7","author":"Schon","year":"2016","journal-title":"Front Pharmacol"},{"key":"key20200713174615_b5-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.taap.2010.11.016","article-title":"Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice","volume":"251","author":"Ghatak","year":"2011","journal-title":"Toxicol Appl Pharmacol"},{"key":"key20200713174615_b6-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.cbi.2011.07.001","article-title":"Molecular pathogenesis of hepatic fibrosis and current therapeutic6 approaches","volume":"193","author":"Mormone","year":"2011","journal-title":"Chem Biol Interact"},{"key":"key20200713174615_b7-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1002\/hep.510290307","article-title":"Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats","volume":"29","author":"Yasuda","year":"1999","journal-title":"Hepatology"},{"key":"key20200713174615_b8-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"883","DOI":"10.3748\/wjg.v8.i5.883","article-title":"Estrogen reduces CCl4-induced liver fibrosis in rats","volume":"8","author":"Xu","year":"2002","journal-title":"World J Gastroenterol"},{"key":"key20200713174615_b9-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1136\/gut.44.1.127","article-title":"Inhibitory effect of oestradiol on activation of rat hepatic stellate cells in vivo and in vitro","volume":"44","author":"Shimizu","year":"1999","journal-title":"Gut"},{"key":"key20200713174615_b10-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1136\/gut.2004.053728","article-title":"Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells","volume":"54","author":"Itagaki","year":"2005","journal-title":"Gut"},{"key":"key20200713174615_b11-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1016\/j.ejca.2008.07.041","article-title":"Hormone replacement therapy and the risk of breast cancer","volume":"44","author":"Cuzick","year":"2008","journal-title":"Eur J Cancer"},{"key":"key20200713174615_b12-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.ejphar.2005.12.052","article-title":"Corticosteroids: The drugs to beat","volume":"533","author":"Barnes","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"key20200713174615_b13-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1111\/j.1872-034X.2011.00829.x","article-title":"Therapeutic effects of the oriental herbal medicine Sho-saiko-to on liver cirrhosis and carcinoma","volume":"41","author":"Lee","year":"2011","journal-title":"Hepatol Res"},{"key":"key20200713174615_b14-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jep.2011.04.008","article-title":"A single arm phase II study of a Far-Eastern traditional herbal formulation (sho-sai-ko-to or xiao-chai-hu-tang) in chronic hepatitis C patients","volume":"136","author":"Deng","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"key20200713174615_b15-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jep.2013.01.029","article-title":"Chaihu-Shugan-San, an oriental herbal preparation, for the treatment of chronic gastritis: A meta-analysis of randomized controlled trials","volume":"146","author":"Qin","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"key20200713174615_b16-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1139\/O07-010","article-title":"Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury","volume":"85","author":"Fan","year":"2007","journal-title":"Biochem Cell Biol"},{"key":"key20200713174615_b17-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3748\/wjg.v13.i4.557","article-title":"Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats","volume":"13","author":"Dang","year":"2007","journal-title":"World J Gastroenterol"},{"key":"key20200713174615_b18-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1089\/jmf.2013.2762","article-title":"Saikosaponin a and saikosaponin d inhibit proliferation and migratory activity of rat HSC-T6 cells","volume":"16","author":"Chen","year":"2013","journal-title":"J Med Food"},{"key":"key20200713174615_b19-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ejphar.2009.09.047","article-title":"Estrogen-like activities of saikosaponin-d in vitro: A pilot study","volume":"626","author":"Wang","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"key20200713174615_b20-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1080\/09513590802485020","article-title":"Effects of phytoestrogens genistein and daidzein on progesterone and estrogen (estradiol) production of human term trophoblast cells in vitro","volume":"25","author":"Richter","year":"2009","journal-title":"Gynecol Endocrinol"},{"key":"key20200713174615_b21-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/0921-8734(92)90043-O","article-title":"Cell culture models for oxidative stress: Superoxide and hydrogen peroxide versus normobaric hyperoxia","volume":"275","author":"Gille","year":"1992","journal-title":"Mutat Res"},{"key":"key20200713174615_b22-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.3892\/ijmm.2012.1102","article-title":"Oxidative stress caused by a low concentration of hydrogen peroxide induces senescence-like changes in mouse gingival fibroblasts","volume":"30","author":"Kiyoshima","year":"2012","journal-title":"Int J Mol Med"},{"key":"key20200713174615_b23-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/978-1-4939-6685-1_27","article-title":"Quantitative real-time gene profiling of human alveolar osteoblasts","volume":"1537","author":"Coates","year":"2017","journal-title":"Methods Mol Biol"},{"key":"key20200713174615_b24-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"G974","DOI":"10.1152\/ajpgi.00264.2003","article-title":"TGF-beta1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k","volume":"287","author":"Lechuga","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key20200713174615_b25-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1055\/s-2001-17557","article-title":"Hepatic stellate cell behavior during resolution of liver injury","volume":"21","author":"Iredale","year":"2001","journal-title":"Semin Liver Dis"},{"key":"key20200713174615_b26-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1142\/S0192415X14500797","article-title":"Saikosaponin-D attenuates heat stress-induced oxidative damage in LLC-PK1 cells by increasing the expression of anti-oxidant enzymes and HSP72","volume":"42","author":"Zhang","year":"2014","journal-title":"Am J Chin Med"},{"key":"key20200713174615_b27-ijmm-41-03-1357","first-page":"6472","article-title":"Saikosaponin-d protects renal tubular epithelial cell against high glucose induced injury through modulation of SIRT3","volume":"8","author":"Zhao","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20200713174615_b28-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/pin.12094","article-title":"JNK1 and JNK2 regulate \u03b1-SMA in hepatic stellate cells during CCl4-induced fibrosis in the rat liver","volume":"63","author":"Hong","year":"2013","journal-title":"Pathol Int"},{"key":"key20200713174615_b29-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0014-5793(02)03276-3","article-title":"p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells(1)","volume":"528","author":"Varela-Rey","year":"2002","journal-title":"FEBS Lett"},{"issue":"Suppl 1","key":"key20200713174615_b30-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1016\/S0168-8278(02)00429-4","article-title":"Liver fibrosis - from bench to bedside","volume":"38","author":"Friedman","year":"2003","journal-title":"J Hepatol"},{"key":"key20200713174615_b31-ijmm-41-03-1357","first-page":"300","article-title":"Management of cirrhosis and ascites","volume":"351","author":"Bhaskar","journal-title":"N Engl J Med"},{"key":"key20200713174615_b32-ijmm-41-03-1357","first-page":"300","article-title":"Management of cirrhosis and ascites","volume":"351","author":"O'Beirne","journal-title":"N Engl J Med"},{"key":"key20200713174615_b33-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3748\/wjg.v10.i2.250","article-title":"Effects of estradiol on liver estrogen receptor-alpha and its mRNA expression in hepatic fibrosis in rats","volume":"10","author":"Xu","year":"2004","journal-title":"World J Gastroenterol"},{"key":"key20200713174615_b34-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3109\/00365521.2010.525662","article-title":"Soy isoflavone delays the progression of thioacetamide-induced liver fibrosis in rats","volume":"46","author":"Li","year":"2011","journal-title":"Scand J Gastroenterol"},{"key":"key20200713174615_b35-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s12272-010-0616-4","article-title":"Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats","volume":"33","author":"Lee","year":"2010","journal-title":"Arch Pharm Res"},{"key":"key20200713174615_b36-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.clinre.2013.08.014","article-title":"Protective effects of L-carnitine, N-acetylcysteine and genistein in an experimental model of liver fibrosis","volume":"38","author":"Demiroren","year":"2014","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"key20200713174615_b37-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.jhep.2010.09.022","article-title":"Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells","volume":"54","author":"Novo","year":"2011","journal-title":"J Hepatol"},{"key":"key20200713174615_b38-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1002\/hep.510300406","article-title":"Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat","volume":"30","author":"Marra","year":"1999","journal-title":"Hepatology"},{"key":"key20200713174615_b39-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1002\/hep.23189","article-title":"Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats","volume":"50","author":"Zhong","year":"2009","journal-title":"Hepatology"},{"key":"key20200713174615_b40-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1002\/hep.22730","article-title":"Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2","volume":"49","author":"Fr\u00e9min","year":"2009","journal-title":"Hepatology"},{"key":"key20200713174615_b41-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1053\/j.gastro.2009.09.015","article-title":"Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition","volume":"138","author":"Kluwe","year":"2010","journal-title":"Gastroenterology"},{"key":"key20200713174615_b42-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1006\/bbrc.2001.5479","article-title":"Hepatic stellate cells contain the functional estrogen receptor beta but not the estrogen receptor alpha in male and female rats","volume":"286","author":"Zhou","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713174615_b43-ijmm-41-03-1357","first-page":"58","article-title":"Regulation of saikosaponin-d on the level of of ER\u03b1 and ER\u03b2 protein in hepatic stellate cells","volume":"27","author":"Li","year":"2016","journal-title":"Trad Chin Drug Res Clin Pharmacol"},{"key":"key20200713174615_b44-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1016\/j.biocel.2013.07.002","article-title":"Genistein modulates oxidative stress in breast cancer cell lines according to ER\u03b1\/ER\u03b2 ratio: Effects on mitochondrial functionality, sirtuins, uncoupling protein 2 and antioxidant enzymes","volume":"45","author":"Nadal- Serrano","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"key20200713174615_b45-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.1167\/iovs.10-5316","article-title":"17-\u03b2 estradiol protects ARPE-19 cells from oxidative stress through estrogen receptor-\u03b2","volume":"51","author":"Giddabasappa","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174615_b46-ijmm-41-03-1357","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1210\/jc.2010-0943","article-title":"Estrogen receptor-a but not -\u03b2 or GPER inhibits high glucose-induced human VSMC proliferation: Potential role of ROS and ERK","volume":"96","author":"Ortmann","year":"2011","journal-title":"J Clin Endocrinol Metab"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:18:54Z","timestamp":1594664334000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2017.3349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,22]]},"references-count":46,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2017.3349","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,22]]}}}