{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:00:10Z","timestamp":1792598410549,"version":"4.5.0"},"reference-count":44,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2018.3412","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T03:52:46Z","timestamp":1516679566000},"source":"Crossref","is-referenced-by-count":19,"title":["Dexamethasone-induced production of reactive oxygen species promotes apoptosis via endoplasmic reticulum stress and autophagy in MC3T3-E1 cells"],"prefix":"10.3892","author":[{"given":"Wanlin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatric Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"key20200713174756_b1-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1517\/14740338.2015.1040387","article-title":"Management of glucocorticoid-induced osteoporosis: Clinical data in relation to disease demographics, bone mineral density and fracture risk","volume":"14","author":"Kenanidis","year":"2015","journal-title":"Expert Opin Drug Saf"},{"key":"key20200713174756_b2-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1517\/14656566.2013.761975","article-title":"Glucocorticoid-induced osteoporosis: An update on current pharmacotherapy and future directions","volume":"14","author":"Bultink","year":"2013","journal-title":"Exp Opinion Pharmacotherapy"},{"key":"key20200713174756_b3-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1056\/NEJMcp1012926","article-title":"Clinical practice. Glucocorticoid-induced bone disease","volume":"365","author":"Weinstein","year":"2011","journal-title":"N Engl J Med"},{"key":"key20200713174756_b4-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.ecl.2012.04.004","article-title":"Glucocorticoid-induced osteoporosis and osteonecrosis","volume":"41","author":"Weinstein","year":"2012","journal-title":"Endocrinol Metab Clin North Am"},{"key":"key20200713174756_b5-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jgr.2014.06.001","article-title":"Protective effect of Korean Red Ginseng against glucocorticoid-induced osteoporosis in vitro and in vivo","volume":"39","author":"Kim","year":"2015","journal-title":"J Ginseng Res"},{"key":"key20200713174756_b6-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s00774-008-0019-5","article-title":"Glucocorticoid induces apoptosis of osteoblast cells through the activation of glycogen synthase kinase 3beta","volume":"27","author":"Yun","year":"2009","journal-title":"J Bone Miner Metab"},{"key":"key20200713174756_b7-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s10495-005-1893-0","article-title":"Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis","volume":"10","author":"Gu","year":"2005","journal-title":"Apoptosis"},{"key":"key20200713174756_b8-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/15216540601156188","article-title":"Effects of reactive oxygen species (ROS) on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells","volume":"59","author":"Arai","year":"2007","journal-title":"IUBMB Life"},{"key":"key20200713174756_b9-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00018-014-1712-2","article-title":"NADPH oxidases in bone homeostasis and osteoporosis","volume":"72","author":"Schr\u00f6der","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"key20200713174756_b10-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jbspin.2012.03.007","article-title":"Reactive oxygen species and exercise on bone metabolism: Friend or enemy","volume":"79","author":"Filaire","year":"2012","journal-title":"Joint Bone Spine"},{"key":"key20200713174756_b11-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.molmed.2009.08.004","article-title":"Oxidative stress in bone remodelling and disease","volume":"15","author":"Wauquier","year":"2009","journal-title":"Trends Mol Med"},{"key":"key20200713174756_b12-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"key20200713174756_b13-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"key20200713174756_b14-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0167-4889(03)00100-9","article-title":"Dexamethasone induces caspase activation in murine osteoblastic MC3T3-E1 cells","volume":"1642","author":"Chu","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"key20200713174756_b15-ijmm-41-04-2028","first-page":"3","article-title":"Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles","volume":"66","author":"Biederbick","year":"1995","journal-title":"Eur J Cell Biol"},{"key":"key20200713174756_b16-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-1-60761-411-1_4","article-title":"Identification of ROS using oxidized DCFDA and flow-cytometry","volume":"594","author":"Eruslanov","year":"2010","journal-title":"Methods Mol Biol"},{"key":"key20200713174756_b17-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1476-5381.2012.02110.x","article-title":"The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes","volume":"168","author":"Heckmann","year":"2013","journal-title":"Br J Pharmacol"},{"key":"key20200713174756_b18-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrn.2016.155","article-title":"Stress, gluco-corticoids and memory: Implications for treating fear-related disorders","volume":"18","author":"de Quervain","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"key20200713174756_b19-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"44618","DOI":"10.1038\/srep44618","article-title":"Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis","volume":"7","author":"Fowler","year":"2017","journal-title":"Sci Rep"},{"key":"key20200713174756_b20-ijmm-41-04-2028","first-page":"370","article-title":"An update on glucocorticoid-induced osteoporosis","volume":"19","author":"Woolf","year":"2007","journal-title":"Curr Opin Rheumatol"},{"key":"key20200713174756_b21-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.tem.2013.12.006","article-title":"Glucocorticoids and bone: Local effects and systemic implications","volume":"25","author":"Henneicke","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"key20200713174756_b22-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"e37030","DOI":"10.1371\/journal.pone.0037030","article-title":"Glucocorticoid receptor and sequential P53 activation by dexamethasone mediates apoptosis and cell cycle arrest of osteoblastic MC3T3-E1 cells","volume":"7","author":"Qian","year":"2012","journal-title":"PLoS One"},{"key":"key20200713174756_b23-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"973","DOI":"10.2147\/DDDT.S65410","article-title":"Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway","volume":"8","author":"Lin","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"key20200713174756_b24-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.bbrc.2015.03.049","article-title":"Indole-3-carbinol as inhibitors of glucocorticoid-induced apoptosis in osteoblastic cells through blocking ROS-mediated Nrf2 pathway","volume":"460","author":"Lin","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"pii","key":"key20200713174756_b25-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"a008656","DOI":"10.1101\/cshperspect.a026716","article-title":"Caspase functions in cell death and disease","volume":"7","author":"Mcilwain","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"key20200713174756_b26-ijmm-41-04-2028","first-page":"13695","article-title":"Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production","volume":"8","author":"Li","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"key20200713174756_b27-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"3302","DOI":"10.4161\/15384101.2014.949111","article-title":"Cyclin A\/Cdk2 regulates Cdh1 and claspin during late S\/G2 phase of the cell cycle","volume":"13","author":"Oakes","year":"2014","journal-title":"Cell Cycle"},{"key":"key20200713174756_b28-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1111\/febs.13598","article-title":"Cell death induced by endoplasmic reticulum stress","volume":"283","author":"Iurlaro","year":"2016","journal-title":"FEBS J"},{"key":"key20200713174756_b29-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1196\/annals.1391.007","article-title":"Endoplasmic reticulum stress","volume":"1113","author":"B\u00e1nhegyi","year":"2007","journal-title":"Ann NY Acad Sci"},{"key":"key20200713174756_b30-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s00774-016-0778-3","article-title":"4-Phenyl butyric acid prevents glucocorticoid-induced osteoblast apoptosis by attenuating endoplasmic reticulum stress","volume":"35","author":"Yang","year":"2017","journal-title":"J Bone Miner Metab"},{"key":"key20200713174756_b31-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.bone.2014.12.012","article-title":"Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in Female Mice","volume":"73","author":"Sato","year":"2015","journal-title":"Bone"},{"key":"key20200713174756_b32-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: Cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J Pathol"},{"key":"key20200713174756_b33-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00109-016-1487-z","article-title":"Delicaflavone induces autophagic cell death in lung cancer via Akt\/mTOR\/70S6K signaling pathway","volume":"95","author":"Sui","year":"2017","journal-title":"J Mol Med"},{"key":"key20200713174756_b34-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"4638","DOI":"10.3892\/mmr.2016.5807","article-title":"Autophagy is involved in aldosterone-induced mesangial cell proliferation","volume":"14","author":"Yang","year":"2016","journal-title":"Mol Med Rep"},{"key":"key20200713174756_b35-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.biochi.2007.08.014","article-title":"Regulation of macroautophagy by mTOR and Beclin 1 complexes","volume":"90","author":"Pattingre","year":"2008","journal-title":"Biochimie"},{"key":"key20200713174756_b36-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"16649","DOI":"10.3390\/ijms150916649","article-title":"Dexamethasone and 1,25-dihy-droxyvitamin D3 reduce oxidative stress-related DNA damage in differentiating osteoblasts","volume":"15","author":"Pawlowska","year":"2014","journal-title":"Int J Mol Sci"},{"key":"key20200713174756_b37-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"351895","DOI":"10.1155\/2013\/351895","article-title":"Tanshinol attenuates the deleterious effects of oxidative stress on osteoblastic differentiation via Wnt\/FoxO3a signaling","volume":"2013","author":"Yang","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"key20200713174756_b38-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s12192-015-0585-0","article-title":"Plumbagin protects against glucocorticoid-induced osteoporosis through Nrf-2 pathway","volume":"20","author":"Zhang","year":"2015","journal-title":"Cell Stress Chaperones"},{"key":"key20200713174756_b39-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"502676","DOI":"10.1155\/2014\/502676","article-title":"The impact of autophagy on cell death modalities","volume":"2014","author":"Ryter","year":"2014","journal-title":"Int J Cell Biol"},{"key":"key20200713174756_b40-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrm3735","article-title":"Self-consumption: The interplay of autophagy and apoptosis","volume":"15","author":"Mari\u00f1o","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20200713174756_b41-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3390\/ijms17030332","article-title":"Crosstalk between autophagy and apoptosis: Potential and emerging therapeutic targets for cardiac diseases","volume":"17","author":"Li","year":"2016","journal-title":"Int J Mol Sci"},{"key":"key20200713174756_b42-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"803","DOI":"10.2131\/jts.39.803","article-title":"Grape seed proanthocyanidins inhibit H2O2-induced osteoblastic MC3T3-E1 cell apoptosis via ameliorating H2O2-induced mitochondrial dysfunction","volume":"39","author":"Zhang","year":"2014","journal-title":"J Toxicol Sci"},{"key":"key20200713174756_b43-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.fitote.2013.05.016","article-title":"Protective effect of albiflorin against oxidative-stress-mediated toxicity in osteo-blast-like MC3T3-E1 cells","volume":"89","author":"Suh","year":"2013","journal-title":"Fitoterapia"},{"key":"key20200713174756_b44-ijmm-41-04-2028","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s10571-015-0166-x","article-title":"ROS and Autophagy: Interactions and molecular regulatory mechanisms","volume":"35","author":"Li","year":"2015","journal-title":"Cell Mol Neurobiol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T14:23:13Z","timestamp":1594650193000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2018.3412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":44,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2018.3412","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]}}}