{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:22:22Z","timestamp":1770988942752,"version":"3.50.1"},"reference-count":56,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2018.3455","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T08:52:32Z","timestamp":1517820752000},"source":"Crossref","is-referenced-by-count":2,"title":["Protective effect of adenovirus-mediated erythropoietin expression on the spiral ganglion neurons in the rat inner ear"],"prefix":"10.3892","author":[{"given":"Cheng","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Southwest Hospital, The Third Military Medical University, Chongqing 400038, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhendong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Southwest Hospital, The Third Military Medical University, Chongqing 400038, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, The Third Military Medical University, Chongqing 400038, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Southwest Hospital, The Third Military Medical University, Chongqing 400038, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"key20200713174928_b1-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.neuro.2005.01.016","article-title":"Erythropoietin: a novel neuroprotective cytokine","volume":"26","author":"Bartesaghi","year":"2005","journal-title":"Neurotoxicology"},{"key":"key20200713174928_b2-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cell.2012.01.051","article-title":"The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO","volume":"149","author":"Rankin","year":"2012","journal-title":"Cell"},{"key":"key20200713174928_b3-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neulet.2012.10.004","article-title":"Neuroprotective effect of erythropoietin on nandrolone decanoate-induced brain injury in rats","volume":"533","author":"Tugyan","year":"2013","journal-title":"Neurosci Lett"},{"key":"key20200713174928_b4-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-62703-308-4_7","article-title":"Erythropoietin as a neuroprotectant for neonatal brain injury: animal models","volume":"982","author":"Traudt","year":"2013","journal-title":"Methods Mol Biol"},{"key":"key20200713174928_b5-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1089\/neu.2009.1149","article-title":"A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury","volume":"28","author":"Kwon","year":"2011","journal-title":"J Neurotrauma"},{"key":"key20200713174928_b6-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.neuroscience.2010.02.007","article-title":"Erythropoietin promotes spinal cord-derived neural progenitor cell proliferation by regulating cell cycle","volume":"167","author":"Wang","year":"2010","journal-title":"Neuroscience"},{"key":"key20200713174928_b7-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/978-1-62703-308-4_16","article-title":"Photoreceptor degeneration in mice: adeno-associated viral vector-mediated delivery of erythropoietin","volume":"982","author":"Colella","year":"2013","journal-title":"Methods Mol Biol"},{"key":"key20200713174928_b8-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"e55291","DOI":"10.1371\/journal.pone.0055291","article-title":"Erythropoietin protects adult retinal ganglion cells against NMDA-, trophic factor withdrawal-, and TNF-\u03b1-induced damage","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS One"},{"key":"key20200713174928_b9-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"6997","DOI":"10.1167\/iovs.12-9671","article-title":"Antiangiogenic shift in vitreous after vitrectomy in patients with proliferative diabetic retinopathy","volume":"53","author":"Yoshida","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713174928_b10-ijmm-41-05-2669","first-page":"305","article-title":"Studies on erythropoiesis. VII. The role of the kidney in the production of erythropoietin","volume":"70","author":"Jacobson","year":"1957","journal-title":"Trans Assoc Am Physicians"},{"key":"key20200713174928_b11-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1152\/physrev.1992.72.2.449","article-title":"Erythropoietin: structure, control of production, and function","volume":"72","author":"Jelkmann","year":"1992","journal-title":"Physiol Rev"},{"key":"key20200713174928_b12-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1152\/japplphysiol.01211.2007","article-title":"Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle","volume":"104","author":"Lundby","year":"2008","journal-title":"J Appl Physiol (1985)"},{"key":"key20200713174928_b13-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"3974","DOI":"10.1073\/pnas.91.9.3974","article-title":"Erythropoietin receptor mRNA expression in human endothelial cells","volume":"91","author":"Anagnostou","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713174928_b14-ijmm-41-05-2669","doi-asserted-by":"crossref","first-page":"9733","DOI":"10.1523\/JNEUROSCI.21-24-09733.2001","article-title":"Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells","volume":"21","author":"Shingo","year":"2001","journal-title":"J Neurosci"},{"key":"key20200713174928_b15-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1182\/blood-2005-06-2516","article-title":"Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase\/AKT signaling pathway","volume":"107","author":"Zhao","year":"2006","journal-title":"Blood"},{"key":"key20200713174928_b16-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1111\/febs.12172","article-title":"Protective action of erythropoietin on neuronal damage induced by activated microglia","volume":"280","author":"Wenker","year":"2013","journal-title":"FEBS J"},{"key":"key20200713174928_b17-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.ijporl.2013.01.029","article-title":"Otoprotective effect of recombinant erythro-poietin in a model of newborn hypoxic-ischemic encephalopathy","volume":"77","author":"Olgun","year":"2013","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"key20200713174928_b18-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3109\/08039488.2012.747176","article-title":"Structure and innervation of the cochlea and organ of corti","volume":"35","author":"Stephenson","year":"2012","journal-title":"J Vis Commun Med"},{"key":"key20200713174928_b19-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0361-9230(03)00047-9","article-title":"Structure and innervation of the cochlea","volume":"60","author":"Raphael","year":"2003","journal-title":"Brain Res Bull"},{"key":"key20200713174928_b20-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3389\/fncel.2013.00242","article-title":"A role for the canonical nuclear factor-\u03baB pathway in coupling neurotrophin-induced differential survival of developing spiral ganglion neurons","volume":"7","author":"Vandenbosch","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"key20200713174928_b21-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/cne.20564","article-title":"Chronic depolarization enhances the trophic effects of brain-derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss","volume":"486","author":"Shepherd","year":"2005","journal-title":"J Comp Neurol"},{"key":"key20200713174928_b22-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1159\/000077264","article-title":"Adenovirus-mediated expression of brain-derived neurotrophic factor protects spiral ganglion neurons from ototoxic damage","volume":"9","author":"Nakaizumi","year":"2004","journal-title":"Audiol Neurootol"},{"key":"key20200713174928_b23-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/srep00838","article-title":"BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice","volume":"2","author":"Fukui","year":"2012","journal-title":"Sci Rep"},{"key":"key20200713174928_b24-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.heares.2004.11.017","article-title":"Erythropoietin and erythropoietin receptor expression in the guinea pig inner ear","volume":"203","author":"Cay\u00e9-Thomasen","year":"2005","journal-title":"Hear Res"},{"key":"key20200713174928_b25-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/0006-8993(91)90809-A","article-title":"Growth factor interactions in cultures of dissociated adult acoustic ganglia: neuronotrophic effects","volume":"567","author":"Lefebvre","year":"1991","journal-title":"Brain Res"},{"key":"key20200713174928_b26-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1097\/00001756-200512190-00008","article-title":"Brain-derived neurotrophic factor\/glial cell line-derived neurotrophic factor survival effects on auditory neurons are not limited by dexamethasone","volume":"16","author":"Wefstaedt","year":"2005","journal-title":"Neuroreport"},{"key":"key20200713174928_b27-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3892\/mmr.2012.1237","article-title":"Construction of human BMP2-IRES-hIF1\u03b1mu adenovirus expression vector and its expression in mesenchymal stem cells","volume":"7","author":"Liu","year":"2013","journal-title":"Mol Med Rep"},{"key":"key20200713174928_b28-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.jbiotec.2011.11.016","article-title":"Hyperosmotic pressure on HEK 293 cells during the growth phase, but not the production phase, improves adenovirus production","volume":"157","author":"Shen","year":"2012","journal-title":"J Biotechnol"},{"key":"key20200713174928_b29-ijmm-41-05-2669","first-page":"109","article-title":"Manipulation of adenovirus vectors","volume":"7","author":"Graham","year":"1991","journal-title":"Methods Mol Biol"},{"key":"key20200713174928_b30-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.joca.2005.07.018","article-title":"Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments","volume":"14","author":"Struglics","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"key20200713174928_b31-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.heares.2008.07.003","article-title":"Neurite outgrowth on cultured spiral ganglion neurons induced by erythropoietin","volume":"243","author":"Berkingali","year":"2008","journal-title":"Hear Res"},{"issue":"Suppl 3","key":"key20200713174928_b32-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1177\/0194599812436449","article-title":"Clinical practice guideline: sudden hearing loss","volume":"146","author":"Stachler","year":"2012","journal-title":"Otolaryngol head Neck Surg"},{"key":"key20200713174928_b33-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1177\/000348947708600406","article-title":"Natural history of sudden sensori-neural hearing loss","volume":"86","author":"Mattox","year":"1977","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"key20200713174928_b34-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0378-5955(02)00553-1","article-title":"Functional and morphological response of the stria vascularis following a sensorineural hearing loss","volume":"172","author":"Hellier","year":"2002","journal-title":"Hear Res"},{"key":"key20200713174928_b35-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1007\/s11064-011-0455-9","article-title":"Salicylate initiates apoptosis in the spiral ganglion neuron of guinea pig cochlea by activating caspase-3","volume":"36","author":"Feng","year":"2011","journal-title":"Neurochem Res"},{"key":"key20200713174928_b36-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.bbrc.2012.09.111","article-title":"Hearing restoration in a deaf animal model with intravenous transplantation of mesenchymal stem cells derived from human umbilical cord blood","volume":"427","author":"Choi","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713174928_b37-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2012.07.002","article-title":"Combined application of brain-derived neurotrophic factor and neurotrophin-3 and its impact on spiral ganglion neuron firing properties and hyperpolarization-activated currents","volume":"291","author":"Needham","year":"2012","journal-title":"Hear Res"},{"key":"key20200713174928_b38-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.heares.2011.04.019","article-title":"Nerve maintenance and regeneration in the damaged cochlea","volume":"281","author":"Shibata","year":"2011","journal-title":"Hear Res"},{"key":"key20200713174928_b39-ijmm-41-05-2669","first-page":"923","article-title":"Cell- and gene- therapy approaches to inner ear repair","volume":"26","author":"Conde de Felipe","year":"2011","journal-title":"Histol Histopathol"},{"key":"key20200713174928_b40-ijmm-41-05-2669","first-page":"F474","article-title":"Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia","volume":"263","author":"Tan","year":"1992","journal-title":"Am J Physiol"},{"key":"key20200713174928_b41-ijmm-41-05-2669","doi-asserted-by":"crossref","first-page":"19488","DOI":"10.1016\/S0021-9258(17)32195-6","article-title":"A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes","volume":"269","author":"Masuda","year":"1994","journal-title":"J Biol Chem"},{"key":"key20200713174928_b42-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"32395","DOI":"10.1074\/jbc.272.51.32395","article-title":"Regulated human eryth-ropoietin receptor expression in mouse brain","volume":"272","author":"Liu","year":"1997","journal-title":"J Biol Chem"},{"key":"key20200713174928_b43-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1271\/bbb.64.1775","article-title":"Erythropoietin: multiple physiological functions and regulation of biosynthesis","volume":"64","author":"Sasaki","year":"2000","journal-title":"Biosci Biotechnol Biochem"},{"key":"key20200713174928_b44-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.neuroscience.2013.01.067","article-title":"Erythropoietin neuroprotection is enhanced by direct cortical application following subdural blood evacuation in a rat model of acute subdural hematoma","volume":"238","author":"Rahimi Nedjat","year":"2013","journal-title":"Neuroscience"},{"key":"key20200713174928_b45-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1471-2202-14-27","article-title":"Post-ischemic continuous infusion of erythropoeitin enhances recovery of lost memory function after global cerebral ischemia in the rat","volume":"14","author":"Und\u00e9n","year":"2013","journal-title":"BMC Neurosci"},{"key":"key20200713174928_b46-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1097\/01.mlg.0000199400.08550.3f","article-title":"The effect of erythropoietin on gentamicin-induced auditory hair cell loss","volume":"116","author":"Monge","year":"2006","journal-title":"Laryngoscope"},{"key":"key20200713174928_b47-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.neulet.2005.11.013","article-title":"Recombinant human erythropoietin prevents ischemia-induced apoptosis and necrosis in explant cultures of the rat organ of Corti","volume":"396","author":"Andreeva","year":"2006","journal-title":"Neurosci Lett"},{"key":"key20200713174928_b48-ijmm-41-05-2669","first-page":"310","article-title":"Expression of erythropoietin and angiogenic growth factors following inner ear injury of newborn rats","volume":"110","author":"Gross","year":"2009","journal-title":"Prague Med Rep"},{"key":"key20200713174928_b49-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1007\/s00018-009-0144-x","article-title":"Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear","volume":"66","author":"Monge Naldi","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"key20200713174928_b50-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.neuropharm.2013.08.008","article-title":"TGF-beta superfamily member activin A acts with BDNF and erythropoietin to improve survival of spiral ganglion neurons in vitro","volume":"75","author":"Kaiser","year":"2013","journal-title":"Neuropharmacology"},{"key":"key20200713174928_b51-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2013.01.052","article-title":"Otoprotective effects of erythropoietin on Cdh23erl\/erl mice","volume":"237","author":"Han","year":"2013","journal-title":"Neuroscience"},{"key":"key20200713174928_b52-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.heares.2006.11.002","article-title":"Does erythropoietin augment noise induced hearing loss","volume":"223","author":"Frederiksen","year":"2007","journal-title":"Hear Res"},{"key":"key20200713174928_b53-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1093\/jnen\/62.3.228","article-title":"The pleiotropic effects of erythropoietin in the central nervous system","volume":"62","author":"Buemi","year":"2003","journal-title":"J Neuropathol Exp Neurol"},{"key":"key20200713174928_b54-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.neuroscience.2007.01.036","article-title":"Culture conditions determine the prevalence of bipolar and monopolar neurons in cultures of dissociated spiral ganglion","volume":"146","author":"Whitlon","year":"2007","journal-title":"Neuroscience"},{"key":"key20200713174928_b55-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1038\/bmt.2013.33","article-title":"Adenoviral infections in adult allogeneic hematopoietic SCT recipients: a single center experience","volume":"48","author":"Yilmaz","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"key20200713174928_b56-ijmm-41-05-2669","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.transproceed.2012.04.042","article-title":"Adenovirus-mediated anti-sense extracellular signal-regulated kinase 2 gene therapy inhibits activation of vascular smooth muscle cells and angio-genesis, and ameliorates transplant arteriosclerosis","volume":"45","author":"Zhao","year":"2013","journal-title":"Transplant Proc"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T22:28:32Z","timestamp":1660429712000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2018.3455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":56,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2018.3455","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,5]]}}}