{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:10:28Z","timestamp":1790471428749,"version":"4.1.0"},"reference-count":52,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2018.3540","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T09:45:21Z","timestamp":1520415921000},"source":"Crossref","is-referenced-by-count":7,"title":["miR\u2011377 targets CUL4A and regulates metastatic capability in ovarian cancer"],"prefix":"10.3892","author":[{"given":"Rufen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325200, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325200, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingui","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325200, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangcui","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325200, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, The First Provincial Wenzhou Hospital of Zhejiang, Wenzhou, Zhejiang 325000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,3,7]]},"reference":[{"key":"key20200713175037_b1-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"key20200713175037_b2-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.1200\/JCO.2003.02.153","article-title":"Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: A Gynecologic Oncology Group study","volume":"21","author":"Ozols","year":"2003","journal-title":"J Clin Oncol"},{"key":"key20200713175037_b3-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.gore.2017.03.007","article-title":"Epigenetic therapy for the treatment of epithelial ovarian cancer: A clinical review","volume":"20","author":"Smith","year":"2017","journal-title":"Gynecol Oncol Rep"},{"key":"key20200713175037_b4-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1056\/NEJMoa052985","article-title":"Intraperitoneal cisplatin and paclitaxel in ovarian cancer","volume":"354","author":"Armstrong","year":"2006","journal-title":"N Engl J Med"},{"key":"key20200713175037_b5-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrc865","article-title":"Dissemination and growth of cancer cells in metastatic sites","volume":"2","author":"Chambers","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"key20200713175037_b6-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"e25114","DOI":"10.1371\/journal.pone.0025114","article-title":"Identification of microRNAs as potential prognostic markers in ependymoma","volume":"6","author":"Costa","year":"2011","journal-title":"PLoS One"},{"key":"key20200713175037_b7-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1038\/bjc.2011.388","article-title":"Expression of miR-487b and miR-410 encoded by 14q32.31 locus is a prognostic marker in neuroblastoma","volume":"105","author":"Gattolliat","year":"2011","journal-title":"Br J Cancer"},{"key":"key20200713175037_b8-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/path.2610","article-title":"Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31","volume":"220","author":"Haller","year":"2010","journal-title":"J Pathol"},{"key":"key20200713175037_b9-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1093\/neuonc\/nop061","article-title":"Gliomas display a microRNA expression profile reminiscent of neural precursor cells","volume":"12","author":"Lavon","year":"2010","journal-title":"Neuro Oncol"},{"key":"key20200713175037_b10-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.bone.2011.10.012","article-title":"Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma","volume":"50","author":"Thayanithy","year":"2012","journal-title":"Bone"},{"key":"key20200713175037_b11-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1126\/science.1149460","article-title":"Switching from repression to activation: microRNAs can up-regulate translation","volume":"318","author":"Vasudevan","year":"2007","journal-title":"Science"},{"key":"key20200713175037_b12-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1038\/onc.2012.318","article-title":"MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R","volume":"32","author":"Gong","year":"2013","journal-title":"Oncogene"},{"key":"key20200713175037_b13-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.1038\/emboj.2008.244","article-title":"microRNA-122 stimulates translation of hepatitis C virus RNA","volume":"27","author":"Henke","year":"2008","journal-title":"EMBO J"},{"key":"key20200713175037_b14-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"7639084","DOI":"10.1155\/2017\/7639084","article-title":"MicroRNA in glioblastoma: An overview","volume":"2017","author":"Banelli","year":"2017","journal-title":"Int J Genomics"},{"key":"key20200713175037_b15-ijmm-41-06-3147","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-017-2657-3","article-title":"Triangle of AKT2, miRNA, and tumorigenesis in different cancers","author":"Honardoost","year":"2017","journal-title":"Appl Biochem Biotechnol"},{"key":"key20200713175037_b16-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1042\/BCJ20170079","article-title":"Therapeutic targeting of non-coding RNAs in cancer","volume":"474","author":"Slaby","year":"2017","journal-title":"Biochem J"},{"key":"key20200713175037_b17-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"e16264","DOI":"10.1371\/journal.pone.0016264","article-title":"Role of microRNA-26b in glioma development and its mediated regulation on EphA2","volume":"6","author":"Wu","year":"2011","journal-title":"PLoS One"},{"key":"key20200713175037_b18-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fonc.2016.00003","article-title":"MicroRNA targeting to modulate tumor microenvironment","volume":"6","author":"Kuninty","year":"2016","journal-title":"Front Oncol"},{"key":"key20200713175037_b19-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/gb-2011-12-4-220","article-title":"The cullin protein family","volume":"12","author":"Sarikas","year":"2011","journal-title":"Genome Biol"},{"key":"key20200713175037_b20-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.tibs.2009.07.002","article-title":"CRL4s: The CUL4-RING E3 ubiquitin ligases","volume":"34","author":"Jackson","year":"2009","journal-title":"Trends Biochem Sci"},{"key":"key20200713175037_b21-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"48175","DOI":"10.1074\/jbc.M106808200","article-title":"UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation","volume":"276","author":"Chen","year":"2001","journal-title":"J Biol Chem"},{"key":"key20200713175037_b22-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S0360-3016(01)02739-0","article-title":"Study of the G2\/M cell cycle checkpoint in irradiated mammary epithelial cells overexpressing Cul-4A gene","volume":"52","author":"Gupta","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20200713175037_b23-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713175037_b24-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1136\/jclinpath-2011-200463","article-title":"Human homologue for Caenorhabditis elegans CUL-4 protein overexpression is associated with malignant potential of epithelial ovarian tumours and poor outcome in carcinoma","volume":"65","author":"Birner","year":"2012","journal-title":"J Clin Pathol"},{"key":"key20200713175037_b25-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.1074\/jbc.M110.148726","article-title":"Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217","volume":"286","author":"Beckman","year":"2011","journal-title":"J Biol Chem"},{"issue":"Suppl 7","key":"key20200713175037_b26-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"vii89","DOI":"10.1093\/annonc\/mdq292","article-title":"The epithelial-mesenchymal transition (EMT) phenomenon","volume":"21","author":"Savagner","year":"2010","journal-title":"Ann Oncol"},{"key":"key20200713175037_b27-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3892\/or.2011.1608","article-title":"Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer","volume":"27","author":"Brun","year":"2012","journal-title":"Oncol Rep"},{"key":"key20200713175037_b28-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.biopha.2017.09.025","article-title":"MTA1 expression in human cancers-Clinical and pharmacological significance","volume":"95","author":"Malisetty","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"key20200713175037_b29-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S1097-2765(00)80299-3","article-title":"NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities","volume":"2","author":"Xue","year":"1998","journal-title":"Mol Cell"},{"key":"key20200713175037_b30-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"5173","DOI":"10.1038\/onc.2013.451","article-title":"MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells","volume":"33","author":"Formosa","year":"2014","journal-title":"Oncogene"},{"key":"key20200713175037_b31-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12943-015-0338-9","article-title":"miR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma","volume":"14","author":"Zehavi","year":"2015","journal-title":"Mol Cancer"},{"key":"key20200713175037_b32-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1093\/jb\/mvr044","article-title":"Cancer early dissemination: Cancerous epithelial- mesenchymal transdifferentiation and transforming growth factor \u03b2 signalling","volume":"149","author":"Sabe","year":"2011","journal-title":"J Biochem"},{"key":"key20200713175037_b33-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10911-010-9178-9","article-title":"Epithelial- mesenchymal transition in cancer: Parallels between normal development and tumor progression","volume":"15","author":"Micalizzi","year":"2010","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"key20200713175037_b34-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10911-010-9181-1","article-title":"The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells","volume":"15","author":"Taylor","year":"2010","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"key20200713175037_b35-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial- mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"key20200713175037_b36-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev-physiol-012110-142225","article-title":"Epithelial-mesenchymal interactions in pulmonary fibrosis","volume":"73","author":"Chapman","year":"2011","journal-title":"Ann Rev Physiol"},{"key":"key20200713175037_b37-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.2174\/13816128113199990300","article-title":"Cullin-RING Ligases as attractive anti-cancer targets","volume":"19","author":"Zhao","year":"2013","journal-title":"Curr Pharm Des"},{"key":"key20200713175037_b38-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"347","DOI":"10.2174\/156800911794519734","article-title":"SCF E3 ubiquitin ligases as anticancer targets","volume":"11","author":"Jia","year":"2011","journal-title":"Curr Cancer Drug Targets"},{"key":"key20200713175037_b39-ijmm-41-06-3147","first-page":"3677","article-title":"The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers","volume":"58","author":"Chen","year":"1998","journal-title":"Cancer Res"},{"key":"key20200713175037_b40-ijmm-41-06-3147","first-page":"949","article-title":"Overexpression of the human homologue for Caenorhabditis elegans cul-4 gene is associated with poor outcome in node-negative breast cancer","volume":"27","author":"Schindl","year":"2007","journal-title":"Anticancer Res"},{"key":"key20200713175037_b41-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"e97421","DOI":"10.1371\/journal.pone.0097421","article-title":"Maternal separation enhances conditioned fear and decreases the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat amygdala","volume":"9","author":"Toda","year":"2014","journal-title":"PLoS One"},{"key":"key20200713175037_b42-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1126\/science.1071549","article-title":"The promise and perils of Wnt signaling through beta-catenin","volume":"296","author":"Moon","year":"2002","journal-title":"Science"},{"key":"key20200713175037_b43-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nrg1427","article-title":"WNT and beta-catenin signalling: Diseases and therapies","volume":"5","author":"Moon","year":"2004","journal-title":"Nat Rev Genet"},{"key":"key20200713175037_b44-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1460-9568.2010.7483.x","article-title":"The Wnt\/\u03b2-catenin signaling pathway in the adult neurogenesis","volume":"33","author":"Zhang","year":"2011","journal-title":"Eur J Neurosci"},{"key":"key20200713175037_b45-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1126\/science.1094291","article-title":"Convergence of Wnt, beta-catenin, and cadherin pathways","volume":"303","author":"Nelson","year":"2004","journal-title":"Science"},{"key":"key20200713175037_b46-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.pneurobio.2008.08.001","article-title":"Wnt signaling in neuroprotection and stem cell differentiation","volume":"86","author":"Toledo","year":"2008","journal-title":"Prog Neurobiol"},{"key":"key20200713175037_b47-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1177\/0022034510363373","article-title":"Wnt\/beta-catenin signaling in oral tissue development and disease","volume":"89","author":"Liu","year":"2010","journal-title":"J Dent Res"},{"key":"key20200713175037_b48-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00441-007-0476-5","article-title":"Wnt signaling and neural stem cells: Caught in the Wnt web","volume":"331","author":"Michaelidis","year":"2008","journal-title":"Cell Tissue Res"},{"key":"key20200713175037_b49-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00705-011-0943-x","article-title":"Hepatitis C virus core protein activates Wnt\/\u03b2-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line","volume":"156","author":"Liu","year":"2011","journal-title":"Arch Virol"},{"key":"key20200713175037_b50-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3389\/fphys.2017.00352","article-title":"Thermodynamics in gliomas: Interactions between the Canonical WNT\/Beta-catenin pathway and PPAR Gamma","volume":"8","author":"Vall\u00e9e","year":"2017","journal-title":"Front Physiol"},{"key":"key20200713175037_b51-ijmm-41-06-3147","first-page":"69","article-title":"The role of gelatinases in colorectal cancer progression and metastasis","volume":"1705","author":"Mook","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"key20200713175037_b52-ijmm-41-06-3147","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s10555-014-9526-0","article-title":"Post-transcriptional regulation of MTA family by microRNAs in the context of cancer","volume":"33","author":"Zhang","year":"2014","journal-title":"Cancer Metastasis Rev"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:31:42Z","timestamp":1594665102000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2018.3540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,7]]},"references-count":52,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2018.3540","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,7]]}}}