{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T17:46:48Z","timestamp":1649008008148},"reference-count":44,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2018.3566","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T09:52:33Z","timestamp":1521021153000},"source":"Crossref","is-referenced-by-count":4,"title":["hTERT peptide fragment GV1001 demonstrates radioprotective and antifibrotic effects through suppression of TGF\u2011\u03b2 signaling"],"prefix":"10.3892","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2011Hyuk","family":"Shin","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangjae","family":"Kim","sequence":"additional","affiliation":[{"name":"TELOID\u00ef\u00bf\u00bdInc, Los Angeles, CA 90024, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won\u2011Jun","family":"Shon","sequence":"additional","affiliation":[{"name":"School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reuben","family":"Kim","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u2011Hee","family":"Park","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Kang","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"key20200713175047_b1-ijmm-41-06-3211","first-page":"3079","article-title":"Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ","volume":"7","author":"Kim","year":"2001","journal-title":"Clin Cancer Res"},{"key":"key20200713175047_b2-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"key20200713175047_b3-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S1357-4310(00)01731-7","article-title":"Telomerase: The search for a universal cancer vaccine","volume":"6","author":"Greener","year":"2000","journal-title":"Mol Med Today"},{"key":"key20200713175047_b4-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1007\/s00262-006-0145-7","article-title":"Telomerase peptide vaccination: A phase I\/II study in patients with non-small cell lung cancer","volume":"55","author":"Brunsvig","year":"2006","journal-title":"Cancer Immunol Immunother"},{"key":"key20200713175047_b5-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/sj.bjc.6603437","article-title":"Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I\/II study","volume":"95","author":"Bernhardt","year":"2006","journal-title":"Br J Cancer"},{"key":"key20200713175047_b6-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.exphem.2006.10.006","article-title":"Telomerase (hTERT 611-626) serves as a tumor antigen in B-cell chronic lymphocytic leukemia and generates spontaneously antileukemic, cytotoxic T cells","volume":"35","author":"Kokhaei","year":"2007","journal-title":"Exp Hematol"},{"key":"key20200713175047_b7-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1007\/s13238-011-1093-3","article-title":"Molecular regulation of telomerase activity in aging","volume":"2","author":"Nicholls","year":"2011","journal-title":"Protein Cell"},{"key":"key20200713175047_b8-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1093\/ejcts\/ezw135","article-title":"Reduction of ischaemia-reperfusion injury in a rat lung transplantation model by low-concentration GV1001","volume":"50","author":"Chang","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"key20200713175047_b9-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"291","DOI":"10.4110\/in.2015.15.6.291","article-title":"The anti-inflammatory effect of GV1001 mediated by the downregulation of ENO1-induced pro-inflammatory cytokine production","volume":"15","author":"Choi","year":"2015","journal-title":"Immune Netw"},{"key":"key20200713175047_b10-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"385127","DOI":"10.1155\/2015\/385127","article-title":"The anti-inflammatory effect of human telomerase-derived peptide on P. gingivalis lipopolysaccharide-induced inflammatory cytokine production and its mechanism in human dental pulp cells","volume":"2015","author":"Ko","year":"2015","journal-title":"Mediators Inflamm"},{"key":"key20200713175047_b11-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1016\/j.biomaterials.2013.12.077","article-title":"Tumor-suppressive effect of a telomerase-derived peptide by inhibiting hypoxia-induced HIF-1\u03b1-VEGF signaling axis","volume":"35","author":"Kim","year":"2014","journal-title":"Biomaterials"},{"key":"key20200713175047_b12-ijmm-41-06-3211","doi-asserted-by":"crossref","first-page":"75081","DOI":"10.18632\/oncotarget.12057","article-title":"The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma","volume":"7","author":"Park","year":"2016","journal-title":"Oncotarget"},{"key":"key20200713175047_b13-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"28896","DOI":"10.1038\/srep28896","article-title":"Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner","volume":"6","author":"Kim","year":"2016","journal-title":"Sci Rep"},{"key":"key20200713175047_b14-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.bbrc.2016.01.160","article-title":"A telomerase-derived peptide regulates reactive oxygen species and hepatitis C virus RNA replication in HCV-infected cells via heat shock protein 90","volume":"471","author":"Lee","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713175047_b15-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/j.neurobiolaging.2013.12.015","article-title":"Novel vaccine peptide GV1001 effectively blocks \u03b2-amyloid toxicity by mimicking the extra-telomeric functions of human telomerase reverse transcriptase","volume":"35","author":"Park","year":"2014","journal-title":"Neurobiol Aging"},{"issue":"3 Suppl","key":"key20200713175047_b16-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"81S","DOI":"10.1378\/chest.99.3_Supplement.81S","article-title":"Fibroproliferative disorders","volume":"99","author":"Bitterman","year":"1991","journal-title":"Chest"},{"key":"key20200713175047_b17-ijmm-41-06-3211","doi-asserted-by":"crossref","first-page":"L879","DOI":"10.1152\/ajplung.00153.2015","article-title":"Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase","volume":"309","author":"Judge","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key20200713175047_b18-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"6043","DOI":"10.4049\/jimmunol.179.9.6043","article-title":"TGF-beta1 induces progressive pleural scarring and subpleural fibrosis","volume":"179","author":"Decologne","year":"2007","journal-title":"J Immunol"},{"key":"key20200713175047_b19-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"77","DOI":"10.2307\/3577586","article-title":"Jirtle, transforming growth factor-beta 1 expression in irradiated liver","volume":"122","author":"Anscher","year":"1990","journal-title":"Radiat Res"},{"key":"key20200713175047_b20-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"245","DOI":"10.2307\/3579426","article-title":"Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and 'non-fibrosing' mice during the latent period and early phase after irradiation","volume":"147","author":"Franko","year":"1997","journal-title":"Radiat Res"},{"key":"key20200713175047_b21-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1006\/excr.2000.4943","article-title":"In vitro replication and differentiation of normal human oral keratinocytes","volume":"258","author":"Kang","year":"2000","journal-title":"Exp Cell Res"},{"key":"key20200713175047_b22-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/jid.2011.11","article-title":"Radioprotective effects of Bmi-1 involve epigenetic silencing of oxidase genes and enhanced DNA repair in normal human keratinocytes","volume":"131","author":"Dong","year":"2011","journal-title":"J Invest Dermatol"},{"key":"key20200713175047_b23-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1471-2105-6-62","article-title":"A standard curve based method for relative real time PCR data processing","volume":"6","author":"Larionov","year":"2005","journal-title":"BMC Bioinformatics"},{"key":"key20200713175047_b24-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"e450","DOI":"10.1038\/cddis.2012.190","article-title":"Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism","volume":"3","author":"Chen","year":"2012","journal-title":"Cell Death Dis"},{"key":"key20200713175047_b25-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"40852","DOI":"10.1074\/jbc.M110.103812","article-title":"Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5\u2032-CpG island in normal human keratinocytes","volume":"285","author":"Chen","year":"2010","journal-title":"J Biol Chem"},{"key":"key20200713175047_b26-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1093\/carcin\/bgw027","article-title":"Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells","volume":"37","author":"Chen","year":"2016","journal-title":"Carcinogenesis"},{"key":"key20200713175047_b27-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"6299","DOI":"10.1158\/0008-5472.CAN-12-4082","article-title":"Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2","volume":"73","author":"Cieply","year":"2013","journal-title":"Cancer Res"},{"key":"key20200713175047_b28-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1159\/000443097","article-title":"MicroRNA-124 functions as a tumor suppressor by regulating CDH2 and epithelial-mesenchymal transition in non-small cell lung cancer","volume":"38","author":"Ma","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"key20200713175047_b29-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"e0154745","DOI":"10.1371\/journal.pone.0154745","article-title":"Dual Targeting of Akt and mTORC1 impairs repair of DNA double-strand breaks and increases radiation sensitivity of human tumor cells","volume":"11","author":"Holler","year":"2016","journal-title":"PLoS One"},{"key":"key20200713175047_b30-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"481","DOI":"10.18632\/aging.100673","article-title":"Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells","volume":"6","author":"Borodkina","year":"2014","journal-title":"Aging (Albany NY)"},{"key":"key20200713175047_b31-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1667\/RR14109.1","article-title":"Radiation sensitivity of human CD34(+) cells versus peripheral blood T lymphocytes of newborns and adults: DNA Repair and Mutagenic Effects","volume":"185","author":"Vandevoorde","year":"2016","journal-title":"Radiat Res"},{"key":"key20200713175047_b32-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.18632\/aging.100989","article-title":"Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: The role of TGF-\u03b2","volume":"8","author":"Liakou","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"key20200713175047_b33-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1111\/jcmm.12219","article-title":"Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1","volume":"18","author":"Chang","year":"2014","journal-title":"J Cell Mol Med"},{"key":"key20200713175047_b34-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.ejcb.2015.08.003","article-title":"Role of AKT and ERK pathways in controlling sensitivity to ionizing radiation and adaptive response induced by low-dose radiation in human immune cells","volume":"94","author":"Park","year":"2015","journal-title":"Eur J Cell Biol"},{"key":"key20200713175047_b35-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.neuro.2016.05.022","article-title":"Neural stem cells injured by oxidative stress can be rejuvenated by GV1001, a novel peptide, through scavenging free radicals and enhancing survival signals","volume":"55","author":"Park","year":"2016","journal-title":"Neurotoxicology"},{"key":"key20200713175047_b36-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"19999","DOI":"10.1074\/jbc.M115.659144","article-title":"The p63 gene is regulated by grainyhead-like 2 (GRHL2) through reciprocal feedback and determines the epithelial phenotype in human keratinocytes","volume":"290","author":"Mehrazarin","year":"2015","journal-title":"J Biol Chem"},{"key":"key20200713175047_b37-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1158\/0008-5472.CAN-11-4038","article-title":"Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2","volume":"72","author":"Cieply","year":"2012","journal-title":"Cancer Res"},{"key":"key20200713175047_b38-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"17151","DOI":"10.1074\/jbc.M114.558130","article-title":"Prostaglandin E2 inhibits \u03b1-smooth muscle actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum response factor and myocardin-related transcription factor-A","volume":"289","author":"Penke","year":"2014","journal-title":"J Biol Chem"},{"key":"key20200713175047_b39-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.retram.2016.09.003","article-title":"The role of myofibroblasts in wound healing","volume":"64","author":"Hinz","year":"2016","journal-title":"Curr Res Transl Med"},{"key":"key20200713175047_b40-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1513\/pats.200601-004TK","article-title":"Epithelial origin of myofibroblasts during fibrosis in the lung","volume":"3","author":"Willis","year":"2006","journal-title":"Proc Am Thorac Soc"},{"key":"key20200713175047_b41-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"key":"key20200713175047_b42-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/emboj.2012.336","article-title":"Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition","volume":"32","author":"Balli","year":"2013","journal-title":"EMBO J"},{"key":"key20200713175047_b43-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.archoralbio.2014.10.004","article-title":"Salivary hypofunction: An update on aetiology, diagnosis and therapeutics","volume":"60","author":"Saleh","year":"2015","journal-title":"Arch Oral Biol"},{"key":"key20200713175047_b44-ijmm-41-06-3211","doi-asserted-by":"publisher","first-page":"737","DOI":"10.3109\/14397595.2014.1002968","article-title":"Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz's disease","volume":"25","author":"Fukui","year":"2015","journal-title":"Mod Rheumatol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:32:06Z","timestamp":1594665126000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2018.3566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,14]]},"references-count":44,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2018.3566","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,14]]}}}