{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:53:04Z","timestamp":1761706384644},"reference-count":37,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2018.3666","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T10:46:27Z","timestamp":1525862787000},"source":"Crossref","is-referenced-by-count":6,"title":["CTRP9 ameliorates cellular senescence via PGC\u20111\u03b1\/AMPK signaling in mesenchymal stem cells"],"prefix":"10.3892","author":[{"given":"Qun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangzhang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengde","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianglong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiadong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianbin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,5,9]]},"reference":[{"key":"key20200713175439_b1-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The neurovascular unit coming of age: A journey through neurovascular coupling in health and disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"key":"key20200713175439_b2-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/ana.23543","article-title":"Mesenchymal stem cells restore cortical rewiring after neonatal ischemia in mice","volume":"71","author":"van Velthoven","year":"2012","journal-title":"Ann Neurol"},{"key":"key20200713175439_b3-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/pr.2011.64","article-title":"Mesenchymal stem cells as a treatment for neonatal ischemic brain damage","volume":"71","author":"van Velthoven","year":"2012","journal-title":"Pediatr Res"},{"key":"key20200713175439_b4-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.molmed.2016.06.003","article-title":"Aging, clonality, and rejuvenation of hematopoietic stem cells","volume":"22","author":"Akunuru","year":"2016","journal-title":"Trends Mol Med"},{"key":"key20200713175439_b5-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1182\/blood-2014-05-526285","article-title":"Bone marrow failure and the telomeropathies","volume":"124","author":"Townsley","year":"2014","journal-title":"Blood"},{"key":"key20200713175439_b6-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1177\/0963689717721221","article-title":"Adipose-derived mesenchymal stem cells from the elderly exhibit decreased migration and differentiation abilities with senescent properties","volume":"26","author":"Liu","year":"2017","journal-title":"Cell Transplant"},{"key":"key20200713175439_b7-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1097\/01.WCB.0000071883.63724.A7","article-title":"Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery","volume":"23","author":"Badan","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20200713175439_b8-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/ncpcardio1398","article-title":"Protective vascular and myocardial effects of adiponectin","volume":"6","author":"Goldstein","year":"2009","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"key20200713175439_b9-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1093\/cvr\/cvn017","article-title":"Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide","volume":"78","author":"Gonon","year":"2008","journal-title":"Cardiovasc Res"},{"key":"key20200713175439_b10-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1530\/JME-16-0171","article-title":"Molecular identification and functional analysis of CTRP9 in Epinepheluscoioides","volume":"58","author":"Yang","year":"2017","journal-title":"J Mol Endocrinol"},{"key":"key20200713175439_b11-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"1902025","DOI":"10.1155\/2016\/1902025","article-title":"C1q\/TNF-related protein 9 protects diabetic rat heart against ischemia reperfusion injury: Role of endoplasmic reticulum stress","volume":"2016","author":"Bai","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"key20200713175439_b12-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"6437467","DOI":"10.1155\/2017\/6437467","article-title":"Insights for oxidative stress and mTOR signaling in myocardial ischemia\/reperfusion injury under diabetes","volume":"2017","author":"Zhao","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"key20200713175439_b13-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1161\/CIRCULATIONAHA.117.029557","article-title":"C1q\/tumor necrosis factor-related protein-9 regulates the fate of implanted mesenchymal stem cells and mobilizes their protective effects against ischemic heart injury via multiple novel signaling pathways","volume":"136","author":"Yan","year":"2017","journal-title":"Circulation"},{"key":"key20200713175439_b14-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.celrep.2017.09.026","article-title":"AMPK maintains cellular metabolic homeostasis through regulation of mitochondrial reactive oxygen species","volume":"21","author":"Rabinovitch","year":"2017","journal-title":"Cell Rep"},{"key":"key20200713175439_b15-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.tem.2011.12.006","article-title":"AMPK functions as an adenylate charge-regulated protein kinase","volume":"23","author":"Oakhill","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"key20200713175439_b16-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1056\/NEJMcibr1405701","article-title":"The promise and perils of antioxidants for cancer patients","volume":"371","author":"Chandel","year":"2014","journal-title":"N Engl J Med"},{"key":"key20200713175439_b17-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1146\/annurev-biochem-060815-014451","article-title":"Signaling networks determining life span","volume":"85","author":"Riera","year":"2016","journal-title":"Annu Rev Biochem"},{"key":"key20200713175439_b18-ijmm-42-02-1054","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12715","article-title":"The mitochondrial ATP synthase is a shared drug target for aging and dementia","volume":"17","author":"Goldberg","year":"2018","journal-title":"Aging Cell"},{"key":"key20200713175439_b19-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.3390\/ijms18061097","article-title":"C1q\/TNF-related protein-9 ameliorates Ox-LDL-induced endothelial dysfunction via PGC-1\u03b1\/AMPK-mediated antioxidant enzyme induction","volume":"18","author":"Sun","year":"2017","journal-title":"Int J Mol Sci"},{"key":"key20200713175439_b20-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1002\/stem.1709","article-title":"Inhibition of Akt\/mTOR attenuates age-related changes in mesenchymal stem cells","volume":"32","author":"Gharibi","year":"2014","journal-title":"Stem Cells"},{"key":"key20200713175439_b21-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"4197","DOI":"10.1182\/blood-2008-09-176198","article-title":"Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells","volume":"113","author":"Otsu","year":"2009","journal-title":"Blood"},{"key":"key20200713175439_b22-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11010-015-2361-y","article-title":"Improved survival of mesenchymal stem cells by macrophage migration inhibitory factor","volume":"404","author":"Xia","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"key20200713175439_b23-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"7039","DOI":"10.3892\/mmr.2017.7430","article-title":"Long noncoding RNA-p21 modulates cellular senescence via the Wnt\/\u03b2-catenin signaling pathway in mesenchymal stem cells","volume":"16","author":"Xia","year":"2017","journal-title":"Mol Med Rep"},{"key":"key20200713175439_b24-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713175439_b25-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1111\/ajt.13092","article-title":"ATG-induced accelerated immune senescence: Clinical implications in renal transplant recipients","volume":"15","author":"Crepin","year":"2015","journal-title":"Am J Transplant"},{"key":"key20200713175439_b26-ijmm-42-02-1054","first-page":"2695","article-title":"Long intergenic noncoding RNA-p21 mediates cardiac senescence via the Wnt\/\u03b2-catenin signaling pathway in doxorubicin-induced cardiotoxicity","volume":"17","author":"Xie","year":"2018","journal-title":"Mol Med Rep"},{"key":"key20200713175439_b27-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1200\/JCO.2008.20.8983","article-title":"Future of cancer incidence in the United States: Burdens upon an aging, changing nation","volume":"27","author":"Smith","year":"2009","journal-title":"J Clin Oncol"},{"key":"key20200713175439_b28-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"7682960","DOI":"10.1155\/2016\/7682960","article-title":"Therapy effects of bone marrow stromal cells on ischemic stroke","volume":"2016","author":"Ye","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"key20200713175439_b29-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1002\/med.21400","article-title":"Stem cell-based therapies for ischemic stroke: Preclinical results and the potential of imaging-assisted evaluation of donor cell fate and mechanisms of brain regeneration","volume":"36","author":"Gervois","year":"2016","journal-title":"Med Res Rev"},{"key":"key20200713175439_b30-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1172\/JCI89511","article-title":"FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging","volume":"127","author":"Li","year":"2017","journal-title":"J Clin Invest"},{"key":"key20200713175439_b31-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13287-015-0076-3","article-title":"Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells","volume":"6","author":"Xia","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"key20200713175439_b32-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1002\/stem.2580","article-title":"Brief report: Proteasomal indoleamine 2,3-dioxygenase degradation reduces the immunosuppressive potential of clinical grade-mesenchymal stromal cells undergoing replicative senescence","volume":"35","author":"Loisel","year":"2017","journal-title":"Stem Cells"},{"key":"key20200713175439_b33-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1111\/jcmm.13196","article-title":"C1q\/TNF-related protein 9 inhibits the cholesterol-induced Vascular smooth muscle cell phenotype switch and cell dysfunction by activating AMP-dependent kinase","volume":"21","author":"Liu","year":"2017","journal-title":"J Cell Mol Med"},{"key":"key20200713175439_b34-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.tem.2011.09.007","article-title":"PGC-1 coactivators in the cardiovascular system","volume":"23","author":"Patten","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"key20200713175439_b35-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nature09787","article-title":"Telomere dysfunction induces metabolic and mitochondrial compromise","volume":"470","author":"Sahin","year":"2011","journal-title":"Nature"},{"key":"key20200713175439_b36-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1002\/stem.2404","article-title":"Hyaluronan upregulates mitochondrial biogenesis and reduces adenoside triphosphate production for efficient mitochondrial function in slow-proliferating human mesenchymal stem cells","volume":"34","author":"Solis","year":"2016","journal-title":"Stem Cells"},{"key":"key20200713175439_b37-ijmm-42-02-1054","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.mce.2015.10.023","article-title":"C1q\/TNF-related protein-9 inhibits cytokine-induced vascular inflammation and leukocyte adhesiveness via AMP-activated protein kinase activation in endothelial cells","volume":"419","author":"Jung","year":"2015","journal-title":"Mol Cell Endocrinol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:46:13Z","timestamp":1594665973000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2018.3666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,9]]},"references-count":37,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2018.3666","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,9]]}}}