{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:49:35Z","timestamp":1789562975791,"version":"build-2803163510"},"reference-count":42,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2018.3674","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T10:12:51Z","timestamp":1526292771000},"source":"Crossref","is-referenced-by-count":15,"title":["Knockdown of TNF\u2011\u03b1 alleviates acute lung injury in rats with intestinal ischemia and reperfusion injury by upregulating IL\u201110 expression"],"prefix":"10.3892","author":[{"given":"Zhen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Respiration, First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2011Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sun Yat\u2011Sen Memorial Hospital, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510120, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Sun Yat\u2011Sen Memorial Hospital, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510120, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2011Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiration, First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu\u2011Lin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Respiration, First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2011Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2011Yuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Respiration, First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2011Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Kunming Medical University, Kunming, Yunnan 650500, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2011Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiration, First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"key20200713175420_b1-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1097\/00000658-200301000-00014","article-title":"Effects of interleukin-1alpha administration on intestinal ischemia and reperfusion injury, mucosal permeability, and bacterial translocation in burn and sepsis","volume":"237","author":"Tadros","year":"2003","journal-title":"Ann Surg"},{"key":"key20200713175420_b2-ijmm-42-02-0926","first-page":"66","article-title":"Acute intestinal ischemia and infarction","volume":"14","author":"Tendler","year":"2003","journal-title":"Semin Gastrointest Dis"},{"key":"key20200713175420_b3-ijmm-42-02-0926","first-page":"409","article-title":"Gut hyperpermiability after ischemia and reperfusion: attenuation with adrenomedullin and its binding protein treatment","volume":"1","author":"Higuchi","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"key":"key20200713175420_b4-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/0741-5214(93)90264-M","article-title":"Multiple organ dysfunction after mesenteric artery revascularization","volume":"18","author":"Harward","year":"1993","journal-title":"J Vasc Surg"},{"key":"key20200713175420_b5-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1164\/rccm.200804-625OC","article-title":"Milk fat globule epidermal growth factor 8 attenuates acute lung injury in mice after intestinal ischemia and reperfusion","volume":"181","author":"Cui","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713175420_b6-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1136\/thorax.57.6.540","article-title":"The pulmonary physician in critical care * 6: the pathogenesis of ALI\/ARDS","volume":"57","author":"Bellingan","year":"2002","journal-title":"Thorax"},{"key":"key20200713175420_b7-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.4049\/jimmunol.173.6.4137","article-title":"The essential role of the intestinal microbiota in facilitating acute inflammatory responses","volume":"173","author":"Souza","year":"2004","journal-title":"J Immunol"},{"key":"key20200713175420_b8-ijmm-42-02-0926","first-page":"G314","article-title":"Gut ischemia and mesenteric synthesis of inflammatory cytokines after hemorrhagic or endotoxic shock","volume":"273","author":"Tamion","year":"1997","journal-title":"Am J Physiol"},{"key":"key20200713175420_b9-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1164\/ajrccm\/143.3.590","article-title":"Plasma levels of tumor necrosis factor in the adult respiratory distress syndrome","volume":"143","author":"Roten","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"key20200713175420_b10-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.freeradbiomed.2004.10.029","article-title":"Edaravone protects against lung injury induced by intestinal ischemia\/reperfusion in rat","volume":"38","author":"Ito","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"key20200713175420_b11-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s10735-012-9396-0","article-title":"Anti-inflammatory and antioxidant effects of infliximab on acute lung injury in a rat model of intestinal ischemia\/reperfusion","volume":"43","author":"Guzel","year":"2012","journal-title":"J Mol Histol"},{"key":"key20200713175420_b12-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1007\/s00595-004-2847-9","article-title":"Lung injury after intestinal ischemia-reperfusion may be avoided by the reduced absorption of locally produced cytokines","volume":"34","author":"Narita","year":"2004","journal-title":"Surg Today"},{"key":"key20200713175420_b13-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1097\/00000658-199012000-00007","article-title":"Evidence for tumor necrosis factor-induced pulmonary micro-vascular injury after intestinal ischemia-reperfusion injury","volume":"212","author":"Caty","year":"1990","journal-title":"Ann Surg"},{"key":"key20200713175420_b14-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nrg2006","article-title":"Strategies for silencing human disease using RNA interference","volume":"8","author":"Kim","year":"2007","journal-title":"Nat Rev Genet"},{"key":"key20200713175420_b15-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"key20200713175420_b16-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/nrg1382","article-title":"Unravelling the general properties of siRNAs: strength in numbers and lessons from the past","volume":"5","author":"Hall","year":"2004","journal-title":"Nat Rev Genet"},{"key":"key20200713175420_b17-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1097\/00003246-199508000-00011","article-title":"Soluble tumor necrosis factor receptors reduce bowel ischemia-induced lung permeability and neutrophil sequestration","volume":"23","author":"Sorkine","year":"1995","journal-title":"Crit Care Med"},{"key":"key20200713175420_b18-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1164\/ajrccm.157.4.ats2-98","article-title":"The American-European Consensus Conference on ARDS, part 2: ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome","volume":"157","author":"Artigas","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713175420_b19-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"E31","DOI":"10.1038\/35000102","article-title":"RNA interference: genetic wand and genetic watchdog","volume":"2","author":"Bosher","year":"2000","journal-title":"Nat Cell Biol"},{"key":"key20200713175420_b20-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.7150\/ijbs.10452","article-title":"RNA interference (RNAi) induced gene silencing: a promising approach of Hi-Tech plant breeding","volume":"10","author":"Younis","year":"2014","journal-title":"Int J Biol Sci"},{"key":"key20200713175420_b21-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s12035-014-8681-1","article-title":"Endoplasmic reticulum protein 29 protects cortical neurons from apoptosis and promoting corticospinal tract regeneration to improve neural behavior via caspase and Erk signal in rats with spinal cord transection","volume":"50","author":"Liu","year":"2014","journal-title":"Mol Neurobiol"},{"key":"key20200713175420_b22-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/mt.2008.220","article-title":"Chitosan\/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-infla mmatory treatment in a murine arthritis model","volume":"17","author":"Howard","year":"2009","journal-title":"Mol Ther"},{"key":"key20200713175420_b23-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3109\/08958378.2014.970784","article-title":"The role of p38 MAPK in acute paraquat-induced lung injury in rats","volume":"26","author":"Pei","year":"2014","journal-title":"Inhal Toxicol"},{"key":"key20200713175420_b24-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.resuscitation.2011.07.029","article-title":"Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion","volume":"83","author":"Kim","year":"2012","journal-title":"Resuscitation"},{"key":"key20200713175420_b25-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713175420_b26-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.lfs.2008.12.025","article-title":"Pharmacological preconditioning with erythropoietin reduces ischemia-reperfusion injury in the small intestine of rats","volume":"84","author":"Sayan","year":"2009","journal-title":"Life Sci"},{"key":"key20200713175420_b27-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.jpedsurg.2010.09.051","article-title":"Parenteral omega-3 fatty acids (Omegaven) modulate intestinal recovery after intestinal ischemia-reperfusion in a rat model","volume":"46","author":"Sukhotnik","year":"2011","journal-title":"J Pediatr Surg"},{"key":"key20200713175420_b28-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Mol Med"},{"key":"key20200713175420_b29-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1007\/s10753-013-9770-4","article-title":"1,8-Cineol attenuates LPS-induced acute pulmonary inflammation in mice","volume":"37","author":"Zhao","year":"2014","journal-title":"Inflammation"},{"key":"key20200713175420_b30-ijmm-42-02-0926","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0022-3565(25)21635-4","article-title":"Production and antagonism of cutaneous vascular permeability in the guinea pig in response to histamine, leukotrienes and A23187","volume":"230","author":"Rinkema","year":"1984","journal-title":"J Pharmacol Exp Ther"},{"key":"key20200713175420_b31-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/j.addr.2006.07.020","article-title":"Ocular delivery of nucleic acids: antisense oligonucleotides, aptamers and siRNA","volume":"58","author":"Fattal","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"key":"key20200713175420_b32-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.exer.2005.01.006","article-title":"siRNA strategy against overexpression of extracellular matrix in diabetic retinopathy","volume":"81","author":"Oshitari","year":"2005","journal-title":"Exp Eye Res"},{"key":"key20200713175420_b33-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1002\/eji.1830270722","article-title":"Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice","volume":"27","author":"Neurath","year":"1997","journal-title":"Eur J Immunol"},{"key":"key20200713175420_b34-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1124\/jpet.102.040329","article-title":"Antisense oligonucleotide blockade of tumor necrosis factor-\u03b1 in two murine models of colitis","volume":"304","author":"Myers","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"key20200713175420_b35-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/1074-7613(94)90045-0","article-title":"Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells","volume":"1","author":"Powrie","year":"1994","journal-title":"Immunity"},{"key":"key20200713175420_b36-ijmm-42-02-0926","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0022-3565(24)35257-7","article-title":"Specific type IV phosphodiesterase inhibitor rolipram mitigates experimental colitis in mice","volume":"292","author":"Hartmann","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"key20200713175420_b37-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1038\/mt.2009.141","article-title":"Amelioration of psoriasis by anti-TNF-alpha RNAi in the xenograft transplantation model","volume":"17","author":"Jakobsen","year":"2009","journal-title":"Mol Ther"},{"key":"key20200713175420_b38-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"5757","DOI":"10.1002\/anie.201209991","article-title":"Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-\u03b1 siRNA against systemic inflammation","volume":"52","author":"Yin","year":"2013","journal-title":"Angew Chem Int Ed Engl"},{"key":"key20200713175420_b39-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s10753-014-0047-3","article-title":"Protective effect of intestinal ischemic preconditioning on ischemia reperfusion-caused lung injury in rats","volume":"38","author":"Wang","year":"2015","journal-title":"Inflammation"},{"key":"key20200713175420_b40-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbrc.2009.02.105","article-title":"Hydrogen-rich saline reduces lung injury induced by intestinal ischemia\/reperfusion in rats","volume":"381","author":"Mao","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713175420_b41-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.jss.2009.04.047","article-title":"A novel ELR-CXC chemokine antagonist reduces intestinal ischemia reperfusion-induced mortality, and local and remote organ injury","volume":"162","author":"Zhao","year":"2010","journal-title":"J Surg Res"},{"key":"key20200713175420_b42-ijmm-42-02-0926","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jss.2010.03.062","article-title":"HB-EGF protects the lungs after intestinal ischemia\/reperfusion injury","volume":"163","author":"James","year":"2010","journal-title":"J Surg Res"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T13:51:32Z","timestamp":1751637092000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2018.3674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":42,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2018.3674","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,14]]}}}