{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:35:45Z","timestamp":1776432945230,"version":"3.51.2"},"reference-count":38,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2018.3762","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T12:13:39Z","timestamp":1530879219000},"source":"Crossref","is-referenced-by-count":4,"title":["BMS\u2011345541 inhibits airway inflammation and epithelial\u2011mesenchymal transition in airway remodeling of asthmatic mice"],"prefix":"10.3892","author":[{"given":"Xiaohua","family":"Zhu","sequence":"first","affiliation":[{"name":"Graduate School, Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiugen","family":"Li","sequence":"additional","affiliation":[{"name":"Respiratory Department, Jiangxi People's Hospital, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guozhu","family":"Hu","sequence":"additional","affiliation":[{"name":"Central Laboratory, Jiangxi People's Hospital, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Respiratory Department, Jiangxi People's Hospital, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Hu","sequence":"additional","affiliation":[{"name":"Central Laboratory, Jiangxi Children's Hospital, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Jiangxi Children's Hospital, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Graduate School, Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhong","sequence":"additional","affiliation":[{"name":"Graduate School, Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"key":"key20200713175656_b1-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cnur.2012.11.001","article-title":"Pathophysiology, diagnosis, and clinical assessment of asthma in the adult","volume":"48","author":"Killeen","year":"2013","journal-title":"Nurs Clin North Am"},{"key":"key20200713175656_b2-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1111\/j.1365-2222.2008.02971.x","article-title":"Pathogenesis of asthma","volume":"38","author":"Holgate","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"key20200713175656_b3-ijmm-42-04-1998","first-page":"687","article-title":"Bronchial asthma-many types, different therapies","volume":"141","author":"Bergmann","year":"2016","journal-title":"Dtsch Med Wochenschr"},{"key":"key20200713175656_b4-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1378\/chest.12-3073","article-title":"Mechanisms of airway remodeling","volume":"144","author":"Hirota","year":"2013","journal-title":"Chest"},{"key":"key20200713175656_b5-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1051\/medsci\/20112711011","article-title":"Airway remodeling in asthma: Clinical and functional correlates","volume":"27","author":"Gras","year":"2011","journal-title":"Med Sci (Paris)"},{"key":"key20200713175656_b6-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s12931-014-0146-6","article-title":"Vitamin D regulating TGF-\u03b2 induced epithelial-mesenchymal transition","volume":"15","author":"Fischer","year":"2014","journal-title":"Respir Res"},{"key":"key20200713175656_b7-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1080\/21645515.2017.1313366","article-title":"Bacillus Calmette-Guerin alleviates airway inflammation and remodeling by preventing TGF-\u03b21 induced epithelial-mesenchymal transition","volume":"13","author":"Tian","year":"2017","journal-title":"Hum Vaccin Immunother"},{"key":"key20200713175656_b8-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"505864","DOI":"10.1155\/2013\/505864","article-title":"Systems approaches to modeling chronic mucosal inflammation","volume":"2013","author":"Kalita","year":"2013","journal-title":"Biomed Res Int"},{"key":"key20200713175656_b9-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1939-4551-7-13","article-title":"Systems biology approaches to understanding Epithelial Mesenchymal transition (EMT) in mucosal remodeling and signaling in asthma","volume":"7","author":"Ijaz","year":"2014","journal-title":"World Allergy Organ J"},{"key":"key20200713175656_b10-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1111\/all.13222","article-title":"Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma","volume":"72","author":"Loffredo","year":"2017","journal-title":"Allergy"},{"key":"key20200713175656_b11-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1007\/s40265-014-0250-4","article-title":"Asthma therapy and its effect on airway remodelling","volume":"74","author":"Berair","year":"2014","journal-title":"Drugs"},{"key":"key20200713175656_b12-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jprot.2016.07.014","article-title":"Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition","volume":"148","author":"Zhao","year":"2016","journal-title":"J Proteom"},{"key":"key20200713175656_b13-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"635e1","DOI":"10.1016\/j.jaci.2011.03.045","article-title":"I\u03baB kinase-driven nuclear factor-\u03baB activation in patients with asthma and chronic obstructive pulmonary disease","volume":"128","author":"Gagliardo","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"key20200713175656_b14-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3109\/10799893.2014.980950","article-title":"The small-molecule inhibitor selectivity between IKK\u03b1 and IKK\u03b2 kinases in NF-\u03baB signaling pathway","volume":"35","author":"Tian","year":"2015","journal-title":"J Recept Signal Transduct Res"},{"key":"key20200713175656_b15-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1002\/art.11131","article-title":"A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice","volume":"48","author":"McIntyre","year":"2003","journal-title":"Arthritis Rheum"},{"key":"key20200713175656_b16-ijmm-42-04-1998","first-page":"1141","article-title":"Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD","volume":"5","author":"Caramori","year":"2004","journal-title":"Curr Opin Investig Drugs"},{"key":"key20200713175656_b17-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1124\/jpet.105.087569","article-title":"Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression","volume":"315","author":"Pattoli","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"key20200713175656_b18-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.3892\/or.2016.4915","article-title":"IKK inhibitor suppresses epithelial-mesenchymal transition and induces cell death in prostate cancer","volume":"36","author":"Ping","year":"2016","journal-title":"Oncol Rep"},{"key":"key20200713175656_b19-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"503213","DOI":"10.1155\/2013\/503213","article-title":"NF-\u03baB inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense","volume":"2013","author":"Li","year":"2013","journal-title":"Mediators Inflamm"},{"key":"key20200713175656_b20-ijmm-42-04-1998","first-page":"556","article-title":"Establishment and evaluation of a mouse model of bronchial asthma with Yin deficiency syndrome","volume":"31","author":"Wang","year":"2015","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"key20200713175656_b21-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.intimp.2016.01.005","article-title":"Chrysin alleviates allergic inflammation and airway remodeling in a murine model of chronic asthma","volume":"32","author":"Yao","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"key20200713175656_b22-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1089\/ars.2014.5887","article-title":"Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy","volume":"22","author":"Yao","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"key20200713175656_b23-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713175656_b24-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1164\/ajrccm.163.2.2004039","article-title":"Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression","volume":"163","author":"Ordo\u00f1ez","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713175656_b25-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1080\/02770903.2016.1225760","article-title":"Airway smooth muscle cells from ovalbumin-sensitized mice show increased proliferative response to TGF\u03b21 due to up-regulation of Smad3 and TGF\u03b2RII","volume":"54","author":"Shi","year":"2017","journal-title":"J Asthma"},{"key":"key20200713175656_b26-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s00408-008-9129-z","article-title":"Estrogen replacement therapy prevents airway dysfunction in a murine model of allergen-induced asthma","volume":"187","author":"Dimitropoulou","year":"2009","journal-title":"Lung"},{"key":"key20200713175656_b27-ijmm-42-04-1998","first-page":"1134","article-title":"Physiology of airway mucus secretion and pathophysiology of hypersecretion","volume":"52","author":"Rogers","year":"2007","journal-title":"Respir Care"},{"key":"key20200713175656_b28-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1165\/rcmb.2016-0307TR","article-title":"Transforming growth factor \u03b21 function in airway remodeling and hyperresponsiveness. The missing link?","volume":"56","author":"Ojiaku","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20200713175656_b29-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1111\/j.1398-9995.2012.02880.x","article-title":"Transforming growth factor-beta1 in inflammatory airway disease: A key for understanding inflammation and remodeling","volume":"67","author":"Yang","year":"2012","journal-title":"Allergy"},{"key":"key20200713175656_b30-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1177\/0022034512467352","article-title":"Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma","volume":"92","author":"Scanlon","year":"2013","journal-title":"J Dent Res"},{"key":"key20200713175656_b31-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1159\/000101320","article-title":"Vimentin and epithelial-mesenchymal transition in human breast cancer-observations in vitro and in vivo","volume":"185","author":"Kokkinos","year":"2007","journal-title":"Cells Tissues Organs"},{"key":"key20200713175656_b32-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"e0149180","DOI":"10.1371\/journal.pone.0149180","article-title":"Vitamin D supplementation reduces induction of epithelial-mesenchymal transition in allergen sensitized and challenged mice","volume":"11","author":"Fischer","year":"2016","journal-title":"Plos One"},{"key":"key20200713175656_b33-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1139\/Y08-004","article-title":"Altered expression of epithelial junctional proteins in atopic asthma: Possible role in inflammation","volume":"86","author":"de Boer","year":"2008","journal-title":"Can J Physiol Pharmacol"},{"key":"key20200713175656_b34-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.3390\/biom5031266","article-title":"NF-kappaB signaling in chronic inflammatory airway disease","volume":"5","author":"Schuliga","year":"2015","journal-title":"Biomolecules"},{"key":"key20200713175656_b35-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.intimp.2017.10.005","article-title":"Pinocembrin attenuates allergic airway inflammation via inhibition of NF-\u03baB pathway in mice","volume":"53","author":"Gu","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"key20200713175656_b36-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1074\/jbc.M209677200","article-title":"BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice","volume":"278","author":"Burke","year":"2003","journal-title":"J Biol Chem"},{"key":"key20200713175656_b37-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1007\/s00011-003-1206-4","article-title":"An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice","volume":"52","author":"MacMaster","year":"2003","journal-title":"Inflamm Res"},{"key":"key20200713175656_b38-ijmm-42-04-1998","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3389\/fphys.2017.00159","article-title":"Bosutinib therapy ameliorates lung inflammation and fibrosis in experimental silicosis","volume":"8","author":"Carneiro","year":"2017","journal-title":"Front Physiol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:51:31Z","timestamp":1594666291000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2018.3762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,6]]},"references-count":38,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2018.3762","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,6]]}}}