{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:34:00Z","timestamp":1782398040309,"version":"3.54.5"},"reference-count":44,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2018.3841","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T11:56:23Z","timestamp":1535111783000},"source":"Crossref","is-referenced-by-count":9,"title":["Involvement of brain-derived neurotrophic factor in exercise\u2011induced cardioprotection of post-myocardial infarction rats"],"prefix":"10.3892","author":[{"given":"Bi\u2011Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department and Institute of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2011Qiong","family":"Han","sequence":"additional","affiliation":[{"name":"Department and Institute of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai\u2011Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department and Institute of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,8,24]]},"reference":[{"key":"key20200713175855_b1-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/0955-0674(95)80022-0","article-title":"Neurotrophic factors and their receptors","volume":"7","author":"Barbacid","year":"1995","journal-title":"Curr Opin Cell Biol"},{"key":"key20200713175855_b2-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nrn1078","article-title":"Neurotrophins and their receptors: A convergence point for many signalling pathways","volume":"4","author":"Chao","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"key20200713175855_b3-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"10827","DOI":"10.1073\/pnas.0402141101","article-title":"Essential role of brain-derived neurotrophic factor in adult hippocampal function","volume":"101","author":"Monteggia","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713175855_b4-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1161\/ATVBAHA.112.248930","article-title":"Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway","volume":"32","author":"Okada","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20200713175855_b5-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1172\/JCI200522655","article-title":"Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors","volume":"115","author":"Kermani","year":"2005","journal-title":"J Clin Invest"},{"key":"key20200713175855_b6-ijmm-42-05-2867","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1242\/dev.127.21.4531","article-title":"Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization","volume":"127","author":"Donovan","year":"2000","journal-title":"Development"},{"key":"key20200713175855_b7-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1111\/j.1582-4934.2012.01621.x","article-title":"BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing","volume":"16","author":"Cao","year":"2012","journal-title":"J Cell Mol Med"},{"key":"key20200713175855_b8-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jss.2006.04.034","article-title":"Application of bFGF and BDNF to improve angiogenesis and cardiac function","volume":"136","author":"Liu","year":"2006","journal-title":"J Surg Res"},{"key":"key20200713175855_b9-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1073\/pnas.1417949112","article-title":"Constitutive BDNF\/TrkB signaling is required for normal cardiac contraction and relaxation","volume":"112","author":"Feng","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713175855_b10-ijmm-42-05-2867","first-page":"1003","article-title":"BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB","volume":"210","author":"Fulgenzi","year":"2015","journal-title":"T1 receptor activation J Cell Biol"},{"key":"key20200713175855_b11-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"e142","DOI":"10.1016\/j.ijcard.2013.08.073","article-title":"Decreased serum brain-derived neurotrophic factor levels are correlated with exercise intolerance in patients with heart failure","volume":"168","author":"Fukushima","year":"2013","journal-title":"Int J Cardiol"},{"key":"key20200713175855_b12-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.bbi.2011.04.017","article-title":"Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease","volume":"25","author":"Swardfager","year":"2011","journal-title":"Brain Behav Immun"},{"key":"key20200713175855_b13-ijmm-42-05-2867","doi-asserted-by":"crossref","first-page":"e002098","DOI":"10.1161\/JAHA.116.002098","article-title":"Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community","volume":"5","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"key20200713175855_b14-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1161\/CIRCULATIONAHA.115.016442","article-title":"Coronary collateral growth induced by physical exercise: Results of the impact of intensive exercise training on coronary collateral circulation in patients with stable coronary artery disease (EXCITE) trial","volume":"133","author":"M\u00f6bius-Winkler","year":"2016","journal-title":"Circulation"},{"key":"key20200713175855_b15-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/cvr\/cvm109","article-title":"Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart","volume":"78","author":"Leosco","year":"2008","journal-title":"Cardiovasc Res"},{"key":"key20200713175855_b16-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/MCA.0b013e32834993d9","article-title":"Effects of exercise of different intensities on the angiogenesis, infarct healing, and function of the left ventricle in postmyocardial infarction rats","volume":"22","author":"Tang","year":"2011","journal-title":"Coron Artery Dis"},{"key":"key20200713175855_b17-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1161\/HYPERTENSIONAHA.109.146282","article-title":"Shear stress mediates endothelial adaptations to exercise training in humans","volume":"55","author":"Tinken","year":"2010","journal-title":"Hypertension"},{"key":"key20200713175855_b18-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1152\/physrev.00045.2006","article-title":"Regulation of coronary blood flow during exercise","volume":"88","author":"Duncker","year":"2008","journal-title":"Physiol Rev"},{"key":"key20200713175855_b19-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ijcard.2004.02.005","article-title":"Exercise and the endothelial cell","volume":"99","author":"Marsh","year":"2005","journal-title":"Int J Cardiol"},{"key":"key20200713175855_b20-ijmm-42-05-2867","first-page":"533","article-title":"The effect of physical activity on the brain derived neurotrophic factor: From animal to human studies","volume":"61","author":"Zoladz","year":"2010","journal-title":"J Physiol Pharmacol"},{"key":"key20200713175855_b21-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1113\/EP086049","article-title":"Effects of exercise training on brain-derived neurotrophic factor in skeletal muscle and heart of rats post myocardial infarction","volume":"102","author":"Lee","year":"2017","journal-title":"Exp Physiol"},{"key":"key20200713175855_b22-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1093\/cvr\/cvt219","article-title":"Physical training and hypertension have opposite effects on endo-thelial brain-derived neurotrophic factor expression","volume":"100","author":"Prigent-Tessier","year":"2013","journal-title":"Cardiovasc Res"},{"key":"key20200713175855_b23-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0014-5793(00)01302-8","article-title":"Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor","volume":"470","author":"Nakahashi","year":"2000","journal-title":"FEBS Lett"},{"key":"key20200713175855_b24-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1016\/S0735-1097(96)00372-5","article-title":"Nitric oxide and murine coxsackievirus B3 myocarditis: Aggravation of myocarditis by inhibition of nitric oxide synthase","volume":"28","author":"Hiraoka","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"key20200713175855_b25-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"e115177","DOI":"10.1371\/journal.pone.0115177","article-title":"Chronic exercise increases plasma brain-derived neurotrophic factor levels, pancreatic islet size, and insulin tolerance in a TrkB-dependent manner","volume":"9","author":"Jim\u00e9nez-Maldonado","year":"2014","journal-title":"PLoS One"},{"key":"key20200713175855_b26-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Method"},{"key":"key20200713175855_b27-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s10456-011-9251-z","article-title":"CD34 marks angiogenic tip cells in human vascular endothelial cell cultures","volume":"15","author":"Siemerink","year":"2012","journal-title":"Angiogenesis"},{"key":"key20200713175855_b28-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"4971","DOI":"10.1073\/pnas.90.11.4971","article-title":"Characterization of glial trkB receptors: Differential response to injury in the central and peripheral nervous systems","volume":"90","author":"Fris\u00e9n","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713175855_b29-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1007\/s10439-011-0313-6","article-title":"Hemodynamic changes quantified in abdominal aortic aneurysms with increasing exercise intensity using mr exercise imaging and image-based computational fluid dynamics","volume":"39","author":"Suh","year":"2011","journal-title":"Ann Biomed Eng"},{"key":"key20200713175855_b30-ijmm-42-05-2867","first-page":"209","article-title":"Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation","volume":"5","author":"Rodriguez","year":"2014","journal-title":"Front Pharmacol"},{"key":"key20200713175855_b31-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/micc.12119","article-title":"Shear stress regulated gene expression and angiogenesis in vascular endothelium","volume":"21","author":"Wragg","year":"2014","journal-title":"Microcirculation"},{"key":"key20200713175855_b32-ijmm-42-05-2867","first-page":"9","article-title":"Vascular wall shear stress: Basic principles and methods","volume":"46","author":"Papaioannou","year":"2005","journal-title":"Hellenic J Cardiol"},{"key":"key20200713175855_b33-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"e50973","DOI":"10.1371\/journal.pone.0050973","article-title":"Resistance to fluid shear stress is a conserved biophysical property of malignant cells","volume":"7","author":"Barnes","year":"2012","journal-title":"PLoS One"},{"key":"key20200713175855_b34-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"7968","DOI":"10.1073\/pnas.1310842111","article-title":"Fluid shear stress threshold regulates angiogenic sprouting","volume":"111","author":"Galie","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713175855_b35-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"H994","DOI":"10.1152\/ajpheart.00400.2003","article-title":"Effect of shear stress on microvessel network formation of endothelial cells with in vitro three-dimensional model","volume":"287","author":"Ueda","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20200713175855_b36-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1242\/jcs.139964","article-title":"Neuronal activity alters BDNF-TrkB signaling kinetics and downstream functions","volume":"127","author":"Guo","year":"2014","journal-title":"J Cell Sci"},{"key":"key20200713175855_b37-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nn.2505","article-title":"Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons","volume":"13","author":"Ji","year":"2010","journal-title":"Nat Neurosci"},{"key":"key20200713175855_b38-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/0006-291X(91)91698-C","article-title":"Effect of extracellular ATP level on flow-induced Ca++ response in cultured vascular endothelial cells","volume":"179","author":"Ando","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713175855_b39-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1161\/01.RES.87.5.385","article-title":"Fluid shear stress activates Ca(2+) influx into human endothelial cells via P2X4 purinoceptors","volume":"87","author":"Yamamoto","year":"2000","journal-title":"Circ Res"},{"key":"key20200713175855_b40-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12872-018-0762-z","article-title":"Association between brain-derived neurotrophic factor and von Willebrand factor levels in patients with stable coronary artery disease","volume":"18","author":"Jin","year":"2018","journal-title":"BMC Cardiovasc Disord"},{"key":"key20200713175855_b41-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/cvr\/cvq307","article-title":"Cardioprotective effects of nitrite during exercise","volume":"89","author":"Calvert","year":"2011","journal-title":"Cardiovasc Res"},{"key":"key20200713175855_b42-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"e80358","DOI":"10.1371\/journal.pone.0080358","article-title":"Endothelial nitric oxide synthase regulates white matter changes via the BDNF\/TrkB pathway after stroke in mice","volume":"8","author":"Cui","year":"2013","journal-title":"PLoS One"},{"key":"key20200713175855_b43-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/cns.12182","article-title":"Endothelial nitric oxide synthase protects neurons against ischemic injury through regulation of brain-derived neurotrophic factor expression","volume":"20","author":"Li","year":"2014","journal-title":"CNS Neurosci Ther"},{"key":"key20200713175855_b44-ijmm-42-05-2867","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.niox.2010.02.004","article-title":"Shear stress promotes nitric oxide production in endothelial cells by sub-cellular delocalization of eNOS: A basis for shear stress mediated angiogenesis","volume":"22","author":"Kolluru","year":"2010","journal-title":"Nitric Oxide"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T05:43:32Z","timestamp":1661838212000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2018.3841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,24]]},"references-count":44,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2018.3841","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,24]]}}}