{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:54:09Z","timestamp":1768589649124,"version":"3.49.0"},"reference-count":46,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2018.3861","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T06:22:45Z","timestamp":1536214965000},"source":"Crossref","is-referenced-by-count":8,"title":["Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd"],"prefix":"10.3892","author":[{"given":"Nuramina","family":"Mamat","sequence":"first","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, \ufffdr\ufffdmqi, Xinjiang 830011, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, \ufffdr\ufffdmqi, Xinjiang 830011, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maidina","family":"Kabas","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, \ufffdr\ufffdmqi, Xinjiang 830011, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haji","family":"Aisa","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, \ufffdr\ufffdmqi, Xinjiang 830011, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"key20200713175828_b1-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s12016-017-8622-7","article-title":"Vitiligo: Focus on clinical aspects, immunopathogenesis, and therapy","volume":"54","author":"Boniface","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"key20200713175828_b2-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1600-0625.2007.00666.x","article-title":"Vitiligo pathogenesis: Autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?","volume":"17","author":"Schallreuter","year":"2008","journal-title":"Exp Dermatol"},{"key":"key20200713175828_b3-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.jaad.2006.02.009","article-title":"The treatment of melasma: A review of clinical trials","volume":"55","author":"Gupta","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"key20200713175828_b4-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"a017046","DOI":"10.1101\/cshperspect.a017046","article-title":"Melanocytes and their diseases","volume":"4","author":"Yamaguchi","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"key20200713175828_b5-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cellsig.2017.09.004","article-title":"Recent development of signaling pathways inhibitors of melanogenesis","volume":"40","author":"Pillaiyar","year":"2017","journal-title":"Cell Signal"},{"key":"key20200713175828_b6-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.yexcr.2004.04.045","article-title":"Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells","volume":"298","author":"Rad","year":"2004","journal-title":"Exp Cell Res"},{"key":"key20200713175828_b7-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/s00018-005-5054-y","article-title":"Tyrosinase inhibitors from natural and synthetic sources: Structure, inhibition mechanism and perspective for the future","volume":"62","author":"Kim","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"key20200713175828_b8-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.molmed.2006.07.008","article-title":"MITF: Master regulator of melanocyte development and melanoma oncogene","volume":"12","author":"Levy","year":"2006","journal-title":"Trends Mol Med"},{"key":"key20200713175828_b9-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"E1303","DOI":"10.3390\/molecules22081303","article-title":"Upregulation of melanogenesis and tyrosinase activity: Potential agents for vitiligo","volume":"22","author":"Niu","year":"2017","journal-title":"Molecules"},{"key":"key20200713175828_b10-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"27557","DOI":"10.1074\/jbc.R700026200","article-title":"The regulation of skin pigmentation","volume":"282","author":"Yamaguchi","year":"2007","journal-title":"J Biol Chem"},{"key":"key20200713175828_b11-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00403-014-1461-y","article-title":"Additive effect of heat on the UVB-induced tyrosinase activation and melanogenesis via ERK\/p38\/MITF pathway in human epidermal melanocytes","volume":"306","author":"Gu","year":"2014","journal-title":"Arch Dermatol Res"},{"key":"key20200713175828_b12-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1034\/j.1600-0749.2000.130203.x","article-title":"Cyclic AMP a key messenger in the regulation of skin pigmentation","volume":"13","author":"Busc\u00e0","year":"2000","journal-title":"Pigment Cell Res"},{"key":"key20200713175828_b13-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"8914","DOI":"10.1128\/MCB.02299-05","article-title":"The microph-thalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression","volume":"26","author":"Schepsky","year":"2006","journal-title":"Mol Cell Biol"},{"key":"key20200713175828_b14-ijmm-42-05-2665","first-page":"5","article-title":"Compositae","volume-title":"Flora of China","author":"Lin","year":"1985"},{"key":"key20200713175828_b15-ijmm-42-05-2665","first-page":"755","article-title":"Evaluation of anti-inflammatory and anti-oxidant potential of seed extracts o Vernonia anthelmintica","volume":"30","author":"Jamil","year":"2017","journal-title":"Pak J Pharm Sci"},{"key":"key20200713175828_b16-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/1472-6882-14-166","article-title":"Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells","volume":"14","author":"Tuerxuntayi","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"key20200713175828_b17-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1124\/dmd.104.002154","article-title":"Metabolic profile of 1,5-dicaffeoylquinic acid in rats, an in vivo and in vitro study","volume":"33","author":"Yang","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"key20200713175828_b18-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1128\/AAC.42.1.140","article-title":"Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase","volume":"42","author":"McDougall","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"key20200713175828_b19-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.brainres.2010.05.072","article-title":"1-5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD\/reper-fusion-induced oxidative stress in astrocytes","volume":"1347","author":"Cao","year":"2010","journal-title":"Brain Res"},{"key":"key20200713175828_b20-ijmm-42-05-2665","first-page":"2628","article-title":"1-5-dicaffeoylquinic acid protects primary neurons from amyloid \u03b2 1-42-induced apoptosis via PI3K\/Akt signaling pathway","volume":"124","author":"Xiao","year":"2011","journal-title":"Chin Med J (Engl)"},{"key":"key20200713175828_b21-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"E429","DOI":"10.3390\/molecules23020429","article-title":"Semi-preparative separation of 10 caffeoylquinic acid derivatives using high speed counter-current chromatogaphy combined with semi-preparative HPLC from the roots of burdock (Arctium lappa L.)","volume":"23","author":"Zheng","year":"2018","journal-title":"Molecules"},{"key":"key20200713175828_b22-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00403-011-1155-7","article-title":"Aromatic-turmerone inhibits \u03b1-MSH and IBMX-induced melanogenesis by inactivating CREB and MITF signaling pathways","volume":"303","author":"Park","year":"2011","journal-title":"Arch Dermatol Res"},{"key":"key20200713175828_b23-ijmm-42-05-2665","doi-asserted-by":"crossref","first-page":"56868","DOI":"10.18632\/oncotarget.18097","article-title":"Oleoylethanolamide inhibits \u03b1-melanocyte stimulating hormone-stimulated melanogenesis via ERK, Akt and CREB signaling pathways in B16 melanoma cells","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"key":"key20200713175828_b24-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"E99","DOI":"10.3390\/cancers9080099","article-title":"Performance of a RT-PCR assay in comparison to fish and immunohistochemistry for the detection of ALK in non-small cell lung cancer","volume":"9","author":"Hout","year":"2017","journal-title":"Cancers (Basel)"},{"key":"key20200713175828_b25-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jdermsci.2015.03.013","article-title":"Andrographolide suppresses melanin synthesis through Akt\/GSK3\u03b2\/\u03b2-catenin signal pathway","volume":"79","author":"Zhu","year":"2015","journal-title":"J Dermatol Sci"},{"key":"key20200713175828_b26-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s00280-013-2281-z","article-title":"DCA increases the antitumor effects of capecitabine in a mouse B16 melanoma allograft and a human non-small cell lung cancer A549 xenograft","volume":"72","author":"Zheng","year":"2013","journal-title":"Cancer Chemother Pharmacol"},{"key":"key20200713175828_b27-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713175828_b28-ijmm-42-05-2665","first-page":"438","article-title":"Characterization and expression analysis of six chitinase genes from the desert beetle microdera punctipennis in response to low temperature","volume":"35","author":"Lu","year":"2014","journal-title":"Cryo Letters"},{"key":"key20200713175828_b29-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s004030050315","article-title":"Variations in melanin formation by cultured melanocytes from different skin types","volume":"290","author":"Smit","year":"1998","journal-title":"Arch Dermatol Res"},{"key":"key20200713175828_b30-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1016\/j.bmc.2014.02.048","article-title":"Tyrosinase: The four oxidation states of the active site and their relevance to enzymatic activation, oxidation and inactivation","volume":"22","author":"Ramsden","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"key20200713175828_b31-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.cbi.2012.06.004","article-title":"Involvement of the p38 MAPK and ERK signaling pathway in the anti-melanogenic effect of methyl 3,5-dicaffeoyl quinate in B16F10 mouse melanoma cells","volume":"199","author":"Shen","year":"2012","journal-title":"Chem Biol Interact"},{"key":"key20200713175828_b32-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0960-9822(98)70226-X","article-title":"Downregulation of beta-catenin by human axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta","volume":"8","author":"Hart","year":"1998","journal-title":"Curr Biol"},{"key":"key20200713175828_b33-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1248\/bpb.b16-00690","article-title":"Scopoletin stimulates melanogenesis via cAMP\/PKA pathway and partially p38 activation","volume":"14","author":"Kim","year":"2017","journal-title":"Biol Pharm Bull"},{"key":"key20200713175828_b34-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0190-9622(79)70018-1","article-title":"Kligman, hotoprotection by melanin-a comparison of black and caucasian skin","volume":"1","author":"Kaidbey","year":"1979","journal-title":"J Am Acad Dermatol"},{"key":"key20200713175828_b35-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11010-016-2823-x","article-title":"2-Ethoxybenzamide stimulates melanin synthesis in B16F1 melanoma cells via the CREB signaling pathway","volume":"423","author":"Sato","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"key20200713175828_b36-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.1046\/j.1432-1327.2000.01402.x","article-title":"Activated phenoloxidase from Tenebrio molitor larvae enhances the synthesis of melanin by using a vitellogenin-like protein in the presence of dopamine","volume":"267","author":"Lee","year":"2000","journal-title":"Eur J Biochem"},{"key":"key20200713175828_b37-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1111\/jdv.13686","article-title":"Glabrous lesional stem cells differentiated into functional mela-nocytes: New hope for repigmentation","volume":"30","author":"Kumar","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"key20200713175828_b38-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1080\/10286020.2016.1269760","article-title":"Two new compounds from the seeds o Vernonia anthelmintica","volume":"19","author":"Maimaiti","year":"2017","journal-title":"J Asian Nat Prod Res"},{"key":"key20200713175828_b39-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1080\/10286020.2017.1343304","article-title":"Three new elemanolides from the seeds o Vernonia anthelmintica","volume":"20","author":"Turak","year":"2018","journal-title":"J Asian Nat Prod Res"},{"key":"key20200713175828_b40-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1093\/abbs\/gmv040","article-title":"Hyperpigmentation mechanism of methyl 3,5-dicaffeoylquinate through activation of p38 andMITF induction of tyrosinase","volume":"47","author":"Kim","year":"2015","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20200713175828_b41-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1093\/abbs\/gmx072","article-title":"Isochlorogenic acid A promotes melanin synthesis in B16 cell through the \u03b2-catenin signal pathway","volume":"49","author":"Mamat","year":"2017","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20200713175828_b42-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jep.2016.06.001","article-title":"Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula","volume":"190","author":"Pei","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"key20200713175828_b43-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00403-008-0863-0","article-title":"LPS induces melanogenesis through p38 MAPK activation in human melanocytes","volume":"300","author":"Ahn","year":"2008","journal-title":"Arch Dermatol Res"},{"key":"key20200713175828_b44-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1034\/j.1600-0749.2001.140205.x","article-title":"Possible involvement of ERK 1\/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes","volume":"14","author":"Yanase","year":"2001","journal-title":"Pigment Cell Res"},{"key":"key20200713175828_b45-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1093\/emboj\/19.12.2900","article-title":"Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes","volume":"19","author":"Busc\u00e0","year":"2000","journal-title":"EMBO J"},{"key":"key20200713175828_b46-ijmm-42-05-2665","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.sjbs.2015.03.009","article-title":"Quercetin -3-O-\u03b2-D-g lucopyranosyl-(1\u21926)-\u03b2-D-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells","volume":"22","author":"Jung","year":"2015","journal-title":"Saudi J Biol Sci"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T18:54:16Z","timestamp":1594666456000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2018.3861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,6]]},"references-count":46,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2018.3861","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,6]]}}}