{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T17:30:50Z","timestamp":1747762250646},"reference-count":41,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2019.4054","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T12:26:30Z","timestamp":1547036790000},"source":"Crossref","is-referenced-by-count":4,"title":["Characterization of the human mucin 5AC promoter and its regulation by the histone acetyltransferase P300"],"prefix":"10.3892","author":[{"given":"Shiyao","family":"Xu","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonology, Wuxi Children's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hui","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Wuxi Children's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Qian","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Wuxi Children's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, Wuxi Children's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2019,1,9]]},"reference":[{"key":"key20200713170656_b1-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","article-title":"The global burden of asthma: Executive summary of the GINA dissemination committee report","volume":"59","author":"Masoli","year":"2004","journal-title":"Allergy"},{"key":"key20200713170656_b2-ijmm-43-03-1263","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40413-015-0073-0","article-title":"Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the world allergy organization","volume":"8","author":"D'Amato","year":"2015","journal-title":"World Allergy Organ J"},{"key":"key20200713170656_b3-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/S0002-9343(03)00241-9","article-title":"Characterization of airway plugging in fatal asthma","volume":"115","author":"Kuyper","year":"2003","journal-title":"Am J Med"},{"key":"key20200713170656_b4-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/MCP.0b013e32831da8d3","article-title":"Mucus hypersecretion in asthma: Causes and effects","volume":"15","author":"Evans","year":"2009","journal-title":"Curr Opin Pulm Med"},{"key":"key20200713170656_b5-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1136\/thx.38.6.463","article-title":"Impaired tracheobronchial clearance in patients with mild stable asthma","volume":"38","author":"Bateman","year":"1983","journal-title":"Thorax"},{"key":"key20200713170656_b6-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1042\/cs0660525","article-title":"Radionuclide demonstration of ventilatory abnormalities in mild asthma","volume":"66","author":"Agnew","year":"1984","journal-title":"Clin Sci (Lond)"},{"key":"key20200713170656_b7-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1164\/ajrccm\/146.3.598","article-title":"Mucociliary clearance in adult asthma","volume":"146","author":"O'Riordan","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"key20200713170656_b8-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1164\/ajrccm\/143.5_Pt_1.993","article-title":"Changes in mucociliary clearance during acute exacerbations of asthma","volume":"143","author":"Messina","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"key20200713170656_b9-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1146\/annurev.physiol.70.113006.100702","article-title":"Structure and function of the polymeric mucins in airways mucus","volume":"70","author":"Thornton","year":"2008","journal-title":"Annu Rev Physiol"},{"key":"key20200713170656_b10-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00010.2005","article-title":"Respiratory tract mucin genes and mucin glycoproteins in health and disease","volume":"86","author":"Rose","year":"2006","journal-title":"Physiol Rev"},{"key":"key20200713170656_b11-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"E112","DOI":"10.3390\/jcm6120112","article-title":"Airway mucus and asthma: The role of MUC5AC and MUC5B","volume":"6","author":"Bonser","year":"2017","journal-title":"J Clin Med"},{"key":"key20200713170656_b12-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1183\/09031936.97.10071655","article-title":"Airway mucosa: Secretory cells, mucus and mucin genes","volume":"10","author":"Jeffery","year":"1997","journal-title":"Eur Respir J"},{"key":"key20200713170656_b13-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1164\/rccm.200903-0392OC","article-title":"T-helper type 2-driven inflammation defines major subphenotypes of asthma","volume":"180","author":"Woodruff","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713170656_b14-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1172\/JCI84910","article-title":"Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma","volume":"126","author":"Bonser","year":"2016","journal-title":"J Clin Invest"},{"key":"key20200713170656_b15-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jaci.2005.03.024","article-title":"Dissecting asthma using focused transgenic modeling and functional genomics","volume":"116","author":"Kuperman","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"key20200713170656_b16-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1165\/rcmb.2006-0180OC","article-title":"IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production","volume":"36","author":"Zhen","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20200713170656_b17-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1073\/pnas.96.6.3081","article-title":"Epidermal growth factor system regulates mucin production in airways","volume":"96","author":"Takeyama","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713170656_b18-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1183\/09031936.00103307","article-title":"Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma","volume":"31","author":"Kraft","year":"2008","journal-title":"Eur Respir J"},{"key":"key20200713170656_b19-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1165\/rcmb.2005-0176OC","article-title":"Dexamethasone-mediated repression of MUC5AC gene expression in human lung epithelial cells","volume":"34","author":"Chen","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20200713170656_b20-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/384641a0","article-title":"The CBP co-activator is a histone acetyltransferase","volume":"384","author":"Bannister","year":"1996","journal-title":"Nature"},{"key":"key20200713170656_b21-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/S0092-8674(00)82001-2","article-title":"The transcriptional coactivators P300 and CBP are histone acetyltransferases","volume":"87","author":"Ogryzko","year":"1996","journal-title":"Cell"},{"key":"key20200713170656_b22-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1164\/rccm.2110060","article-title":"Expression and activity of histone deacetylases (HDAC) in human asthmatic airways","volume":"166","author":"Ito","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713170656_b23-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1021\/cr500452k","article-title":"Protein lysine acetylation by P300\/CBP","volume":"115","author":"Dancy","year":"2015","journal-title":"Chem Rev"},{"key":"key20200713170656_b24-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/25166","article-title":"Regulation of activity of the transcription factor GATA-1 by acetylation","volume":"396","author":"Boyes","year":"1998","journal-title":"Nature"},{"key":"key20200713170656_b25-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713170656_b26-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1007\/s40265-014-0235-3","article-title":"Targeting mucus hyper-secretion: New therapeutic opportunities for COPD?","volume":"74","author":"Martin","year":"2014","journal-title":"Drugs"},{"key":"key20200713170656_b27-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"a009720","DOI":"10.1101\/cshperspect.a009720","article-title":"Structure and function of the mucus clearance system of the lung","volume":"3","author":"Button","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"key20200713170656_b28-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1136\/jcp.13.1.27","article-title":"The pathology of asthma, with special reference to changes in the bronchial mucosa","volume":"13","author":"Dunnill","year":"1960","journal-title":"J Clin Pathol"},{"key":"key20200713170656_b29-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1080\/07853890600585795","article-title":"Treatment of airway mucus hypersecretion","volume":"38","author":"Rogers","year":"2006","journal-title":"Ann Med"},{"key":"key20200713170656_b30-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"L185","DOI":"10.1152\/ajplung.90367.2008","article-title":"New asthma biomarkers: Lessons from murine models of acute and chronic asthma","volume":"296","author":"Di Valentin","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key20200713170656_b31-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3109\/15419061.2010.551682","article-title":"Interlenkin-13 induces mucin 5AC production involving STAT6\/SPDEF in human airway epithelial cells","volume":"17","author":"Yu","year":"2010","journal-title":"Cell Commun Adhes"},{"key":"key20200713170656_b32-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1146\/annurev.physiol.70.113006.100659","article-title":"Structure and function of the cell surface (tethered) mucins","volume":"70","author":"Hattrup","year":"2008","journal-title":"Annu Rev Physiol"},{"key":"key20200713170656_b33-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"4472","DOI":"10.1021\/acs.jafc.7b00923","article-title":"Grape seed proanthocyanidin inhibits mucin synthesis and viral replication by suppression of AP-1 and NF-\u03baB via p38 MAPKs\/JNK signaling pathways in respiratory syncytial virus-infected A549 cells","volume":"65","author":"Lee","year":"2017","journal-title":"J Agric Food Chem"},{"key":"key20200713170656_b34-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"e0132559","DOI":"10.1371\/journal.pone.0132559","article-title":"Epinephrine activation of the \u03b22-adrenoceptor is required for IL-13-induced mucin production in human bronchial epithelial cells","volume":"10","author":"Al-Sawalha","year":"2015","journal-title":"PLoS One"},{"key":"key20200713170656_b35-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"49","DOI":"10.4014\/jmb.1610.10012","article-title":"Tilianin inhibits MUC5AC expression mediated via down-regulation of EGFR-MEK-ERK-Sp1 signaling pathway in NCI-H292 human airway cells","volume":"27","author":"Song","year":"2017","journal-title":"J Microbiol Biotechnol"},{"key":"key20200713170656_b36-ijmm-43-03-1263","article-title":"Respiratory carcinoma cell lines express MUC5\/5AC mRNA and secrete MUC5\/5AC mucins(C)","author":"Berger"},{"key":"key20200713170656_b37-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1177\/039463201302600210","article-title":"Histone modifications of Notch1 promoter affect lung CD4+T cell differentiation in asthmatic rats","volume":"26","author":"Cui","year":"2013","journal-title":"Int J Immunopathol Pharmacol"},{"key":"key20200713170656_b38-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.jmb.2004.09.059","article-title":"PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF\/TGF-alpha, Ras\/Raf, MEK, ERK and Sp1-dependent mechanisms","volume":"344","author":"Hewson","year":"2004","journal-title":"J Mol Biol"},{"key":"key20200713170656_b39-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"32258","DOI":"10.1074\/jbc.M204862200","article-title":"Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor\/Ras\/Raf\/extracellular signal-regulated kinase cascade and Sp1","volume":"277","author":"Perrais","year":"2002","journal-title":"J Biol Chem"},{"key":"key20200713170656_b40-ijmm-43-03-1263","doi-asserted-by":"publisher","first-page":"L797","DOI":"10.1152\/ajplung.00347.2013","article-title":"IL-1\u03b2 induction of MUC5AC gene expression is mediated by CREB and NF-\u03baB and repressed by dexamethasone","volume":"306","author":"Chen","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key20200713170656_b41-ijmm-43-03-1263","first-page":"657","article-title":"The versatile functions of the transcriptional coactivators P300 and CBP and their roles in disease","volume":"17","author":"Janknecht","year":"2002","journal-title":"Histol Histopathol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T17:21:34Z","timestamp":1594660894000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2019.4054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,9]]},"references-count":41,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2019.4054","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,9]]}}}