{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:21:51Z","timestamp":1777317711771,"version":"3.51.4"},"reference-count":53,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2019.4114","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T10:48:57Z","timestamp":1551264537000},"source":"Crossref","is-referenced-by-count":5,"title":["Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation\u2011induced corneal neovascularization"],"prefix":"10.3892","author":[{"given":"Min","family":"He","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Han","sequence":"additional","affiliation":[{"name":"Clinical Medical College, Second Military Medical University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Bayi Children's Hospital Affiliated to PLA Army General Hospital, Beijing 100700, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao\u2011Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2011Shan","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling\u2011Zhen","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2011Qing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"key20200713170816_b1-ijmm-43-04-1888","first-page":"1540","article-title":"Protective effects of Dunaliella salina - a carotenoids-rich alga-against ultraviolet B-induced corneal oxidative damage in mice","volume":"18","author":"Tsai","year":"2012","journal-title":"Mol Vis"},{"key":"key20200713170816_b2-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.jpain.2015.06.002","article-title":"Topical tetrodotoxin attenuates photophobia induced by corneal injury in the rat","volume":"16","author":"Green","year":"2015","journal-title":"J Pain"},{"key":"key20200713170816_b3-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.biomaterials.2015.11.006","article-title":"The tissue-engineered human cornea as a model to study expression of matrix metalloproteinases during corneal wound healing","volume":"78","author":"Couture","year":"2016","journal-title":"Biomaterials"},{"key":"key20200713170816_b4-ijmm-43-04-1888","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3760\/cma.j.issn.0366-6999.20132571","article-title":"Anti-inflammatory effects of a synthetic peptide derived from pigment epithelium-derived factor on H2O2-induced corneal injury in vitro","volume":"127","author":"Lu","year":"2014","journal-title":"Chin Med J (Engl)"},{"key":"key20200713170816_b5-ijmm-43-04-1888","first-page":"455","article-title":"Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops","volume":"18","author":"Lennikov","year":"2012","journal-title":"Mol Vis"},{"key":"key20200713170816_b6-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.3390\/ijms14012175","article-title":"Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice","volume":"14","author":"Lennikov","year":"2013","journal-title":"Int J Mol Sci"},{"key":"key20200713170816_b7-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"8016","DOI":"10.1167\/iovs.12-10064","article-title":"Topical administration of peroxiredoxin-6 on the cornea suppresses inflammation and neovascularization induced by ultraviolet radiation","volume":"53","author":"Shi","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713170816_b8-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3892\/ijmm.2016.2594","article-title":"Involvement of NADPH oxidases in alkali burn-induced corneal injury","volume":"38","author":"Gu","year":"2016","journal-title":"Int J Mol Med"},{"key":"key20200713170816_b9-ijmm-43-04-1888","first-page":"153","article-title":"Epigallocatechin gallate eye drops protect against ultraviolet B-induced corneal oxidative damage in mice","volume":"20","author":"Chen","year":"2014","journal-title":"Mol Vis"},{"key":"key20200713170816_b10-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1097\/00004032-198905000-00012","article-title":"Ultraviolet-induced photochemical damage in ocular tissues","volume":"56","author":"Zuclich","year":"1989","journal-title":"Health Phys"},{"key":"key20200713170816_b11-ijmm-43-04-1888","first-page":"1115","article-title":"The effect of ultraviolet radiation on the cornea-experimental study","volume":"54","author":"Golu","year":"2013","journal-title":"Rom J Morphol Embryol"},{"key":"key20200713170816_b12-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12929-014-0104-0","article-title":"MicroRNA miR-466 inhibits Lymphangiogenesis by targeting prospero-related homeobox 1 in the alkali burn corneal injury model","volume":"22","author":"Seo","year":"2015","journal-title":"J Biomed Sci"},{"key":"key20200713170816_b13-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"5314","DOI":"10.1167\/iovs.08-2209","article-title":"Deletion of the FHL2 gene attenuating neovascularization after corneal injury","volume":"49","author":"Chu","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713170816_b14-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1006\/exer.1998.0603","article-title":"Expression of HGF, KGF, EGF and receptor messenger RNAs following corneal epithelial wounding","volume":"68","author":"Wilson","year":"1999","journal-title":"Exp Eye Res"},{"key":"key20200713170816_b15-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/biomedicines2040275","article-title":"HGF-Met pathway in regeneration and drug discovery","volume":"2","author":"Matsumoto","year":"2014","journal-title":"Biomedicines"},{"key":"key20200713170816_b16-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/34657","article-title":"Induction of epithelial tubules by growth factor HGF depends on the STAT pathway","volume":"391","author":"Boccaccio","year":"1998","journal-title":"Nature"},{"key":"key20200713170816_b17-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1126\/science.2475908","article-title":"Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth","volume":"245","author":"Finch","year":"1989","journal-title":"Science"},{"key":"key20200713170816_b18-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"4473","DOI":"10.1242\/jcs.054791","article-title":"The growth-promoting effect of KGF on limbal epithelial cells is mediated by upregulation of DeltaNp63alpha through the p38 pathway","volume":"122","author":"Cheng","year":"2009","journal-title":"J Cell Sci"},{"key":"key20200713170816_b19-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1167\/iovs.02-0570","article-title":"HGF, MAPK, and a small physiological electric field interact during corneal epithelial cell migration","volume":"44","author":"McBain","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713170816_b20-ijmm-43-04-1888","first-page":"24","article-title":"Differential effects of hepatocyte growth factor and keratinocyte growth factor on corneal epithelial cell cycle protein expression, cell survival, and growth","volume":"20","author":"Chandrasekher","year":"2014","journal-title":"Mol Vis"},{"key":"key20200713170816_b21-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1021\/mp300445a","article-title":"Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model","volume":"10","author":"Li","year":"2013","journal-title":"Mol Pharm"},{"key":"key20200713170816_b22-ijmm-43-04-1888","first-page":"97","article-title":"Vascular permeability factor\/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis","volume":"237","author":"Dvorak","year":"1999","journal-title":"Curr Top Microbiol Immunol"},{"key":"key20200713170816_b23-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1139\/bcb-2012-0082","article-title":"Phenotypic alteration of limbal niche-associated limbal epithelial stem cell deficiency by ultraviolet-B exposure-induced phototoxicity in mice","volume":"91","author":"Das","year":"2013","journal-title":"Biochem Cell Biol"},{"key":"key20200713170816_b24-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/00003226-200003000-00015","article-title":"Lactoferrin protects against UV-B irradiation-induced corneal epithelial damage in rats","volume":"19","author":"Fujihara","year":"2000","journal-title":"Cornea"},{"key":"key20200713170816_b25-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/00003226-199305000-00004","article-title":"Periocular FK-506 delays allograft rejection in rat penetrating keratoplasty","volume":"12","author":"Dickey","year":"1993","journal-title":"Cornea"},{"key":"key20200713170816_b26-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"5806832","DOI":"10.1155\/2017\/5806832","article-title":"Lycium barbarum polysaccharides protect rat corneal epithelial cells against ultraviolet B-induced apoptosis by attenuating the mitochondrial pathway and inhibiting JNK phosphorylation","volume":"2017","author":"Du","year":"2017","journal-title":"Biomed Res Int"},{"key":"key20200713170816_b27-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s00109-006-0097-6","article-title":"Quantitative real-time RT-PCR data analysis: Current concepts and the novel \u2018gene expression\u2019s CT difference\u2019 formula","volume":"84","author":"Schefe","year":"2006","journal-title":"J Mol Med (Berl)"},{"issue":"Unit 1","key":"key20200713170816_b28-ijmm-43-04-1888","first-page":"8","article-title":"Principles of gating","volume":"1","author":"Wood","year":"2001","journal-title":"Curr Protoc Cytom Chapter"},{"key":"key20200713170816_b29-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0014-4835(85)80011-7","article-title":"Wavelength dependency of cataracts in albino mice following chronic exposure","volume":"41","author":"Jose","year":"1985","journal-title":"Exp Eye Res"},{"key":"key20200713170816_b30-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1034\/j.1600-0420.2001.790611.x","article-title":"Repeated UVR exposures cause keratocyte resistance to apoptosis and hyaluronan accumulation in the rabbit cornea","volume":"79","author":"Podskochy","year":"2001","journal-title":"Acta Ophthalmol Scand"},{"key":"key20200713170816_b31-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1167\/iovs.11-6863","article-title":"Corneal and retinal effects of ultraviolet-B exposure in a soft contact lens mouse model","volume":"53","author":"Ibrahim","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713170816_b32-ijmm-43-04-1888","first-page":"577","article-title":"High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells","volume":"15","author":"Pauloin","year":"2009","journal-title":"Mol Vis"},{"key":"key20200713170816_b33-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3109\/02713683.2011.574332","article-title":"Hydration and transparency of the rabbit cornea irradiated with UVB-doses of 0.25 J\/cm(2) and 0.5 J\/cm(2) compared with equivalent UVB radiation exposure reaching the human cornea from sunlight","volume":"36","author":"Cejka","year":"2011","journal-title":"Curr Eye Res"},{"key":"key20200713170816_b34-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/jcp.1041440219","article-title":"Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: Differentiation response distinguishes KGF from EGF family","volume":"144","author":"Marchese","year":"1990","journal-title":"J Cell Physiol"},{"key":"key20200713170816_b35-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1083\/jcb.111.5.2097","article-title":"Scatter factor: Molecular characteristics and effect on the invasiveness of epithelial cells","volume":"111","author":"Weidner","year":"1990","journal-title":"J Cell Biol"},{"key":"key20200713170816_b36-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4103\/1658-354X.109805","article-title":"Protocolized eye care prevents corneal complications in ventilated patients in a medical intensive care unit","volume":"7","author":"Azfar","year":"2013","journal-title":"Saudi J Anaesth"},{"key":"key20200713170816_b37-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"21989","DOI":"10.1074\/jbc.M302650200","article-title":"p38 and ERK1\/2 coordinate cellular migration and proliferation in epithelial wound healing: Evidence of cross-talk activation between MAP kinase cascades","volume":"278","author":"Sharma","year":"2003","journal-title":"J Biol Chem"},{"key":"key20200713170816_b38-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1167\/iovs.09-3494","article-title":"Effect of mitomycin C on IL-1R expression, IL-1-related hepatocyte growth factor secretion and corneal epithelial cell migration","volume":"51","author":"Chen","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713170816_b39-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00006324-198407000-00009","article-title":"Ultraviolet-B damages corneal endothelium","volume":"61","author":"Cullen","year":"1984","journal-title":"Am J Optom Physiol Opt"},{"key":"key20200713170816_b40-ijmm-43-04-1888","first-page":"579","article-title":"Phototoxicity and the cornea","volume":"84","author":"Schein","year":"1992","journal-title":"J Natl Med Assoc"},{"key":"key20200713170816_b41-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"226","DOI":"10.4274\/tjo.67625","article-title":"Four cases of pediatric photokeratitis present to the emergency department after watching the same theater show","volume":"45","author":"Mangan","year":"2015","journal-title":"Turk J Ophthalmol"},{"key":"key20200713170816_b42-ijmm-43-04-1888","first-page":"846","article-title":"UV-blocking spectacle lens protects against UV-induced decline of visual performance","volume":"21","author":"Liou","year":"2015","journal-title":"Mol Vis"},{"key":"key20200713170816_b43-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/nature05249","article-title":"Corneal avascularity is due to soluble VEGF receptor-1","volume":"443","author":"Ambati","year":"2006","journal-title":"Nature"},{"key":"key20200713170816_b44-ijmm-43-04-1888","first-page":"264","article-title":"Corneal angiogenic privilege: Angiogenic and anti-angiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis)","volume":"104","author":"Azar","year":"2006","journal-title":"Trans Am Ophthalmol Soc"},{"key":"key20200713170816_b45-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2006.09.002","article-title":"Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy","volume":"26","author":"Zhang","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"key20200713170816_b46-ijmm-43-04-1888","first-page":"1029","article-title":"Vascular permeability factor\/vascular endothelial growth factor, micro-vascular hyperpermeability, and angiogenesis","volume":"146","author":"Dvorak","year":"1995","journal-title":"Am J Pathol"},{"key":"key20200713170816_b47-ijmm-43-04-1888","first-page":"2514","article-title":"Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas","volume":"41","author":"Philipp","year":"2000","journal-title":"Invest Ophthalmol vis Sci"},{"key":"key20200713170816_b48-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3892\/ijo.2012.1728","article-title":"HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K\/Akt, MAPK and STAT3, in CT26 murine cells","volume":"42","author":"Matsumura","year":"2013","journal-title":"Int J Oncol"},{"key":"key20200713170816_b49-ijmm-43-04-1888","first-page":"355","article-title":"Keratinocyte growth factor induces vascular endothelial growth factor-A expression in colorectal cancer cells","volume":"34","author":"Narita","year":"2009","journal-title":"Int J Oncol"},{"key":"key20200713170816_b50-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"4959","DOI":"10.1167\/iovs.17-21531","article-title":"Alterations in corneal sensory nerves during homeostasis, aging, and after injury in mice lacking the heparan sulfate proteoglycan syndecan-1","volume":"58","author":"Pal-Ghosh","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713170816_b51-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1096\/fj.12-225185","article-title":"Vascular endothelial growth factor promotes anatomical and functional recovery of injured peripheral nerves in the avascular cornea","volume":"27","author":"Pan","year":"2013","journal-title":"FASEB J"},{"key":"key20200713170816_b52-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1006\/exer.2001.1026","article-title":"HGF- and KGF-induced activation of PI-3K\/p70 s6 kinase pathway in corneal epithelial cells: Its relevance in wound healing","volume":"73","author":"Chandrasekher","year":"2001","journal-title":"Exp Eye Res"},{"key":"key20200713170816_b53-ijmm-43-04-1888","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/00003226-199707000-00015","article-title":"IL-1 upregulates keratinocyte growth factor and hepatocyte growth factor mRNA and protein production by cultured stromal fibroblast cells: Interleukin-1 beta expression in the cornea","volume":"16","author":"Weng","year":"1997","journal-title":"Cornea"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T04:54:57Z","timestamp":1721019297000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2019.4114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":53,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2019.4114","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]}}}