{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:09:52Z","timestamp":1785931792225,"version":"3.56.0"},"reference-count":32,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2019.4296","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T12:41:34Z","timestamp":1564576894000},"source":"Crossref","is-referenced-by-count":7,"title":["Irradiation enhances the therapeutic effect of the oncolytic adenovirus XVir-N-31 in brain tumor initiating cells"],"prefix":"10.3892","author":[{"given":"Rebecca","family":"Czolk","sequence":"first","affiliation":[{"name":"Department of Vascular Neurology, Laboratory for Molecular Neuro\u2011Oncology, Hertie Institute for Clinical Brain Research, T\ufffdbingen NeuroCampus, University of T\ufffdbingen, D\u201172076 T\ufffdbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, T\ufffdbingen NeuroCampus, University of T\ufffdbingen, D\u201172076 T\ufffdbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henner","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, T\ufffdbingen NeuroCampus, University of T\ufffdbingen, D\u201172076 T\ufffdbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Sch\ufffdtterl","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology, Laboratory for Molecular Neuro\u2011Oncology, Hertie Institute for Clinical Brain Research, T\ufffdbingen NeuroCampus, University of T\ufffdbingen, D\u201172076 T\ufffdbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wuttke","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital T\ufffdbingen, D\u201172076 T\ufffdbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital \u2018Rechts der Isar\u2019, Technical University of Munich, D\u201181675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Hospital T\ufffdbingen, D\u201172076 T\ufffdbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Naumann","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology, Laboratory for Molecular Neuro\u2011Oncology, Hertie Institute for Clinical Brain Research, T\ufffdbingen NeuroCampus, University of T\ufffdbingen, D\u201172076 T\ufffdbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"key20200713171300_b1-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1001\/jama.2017.18718","article-title":"Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: A randomized clinical trial","volume":"318","author":"Stupp","year":"2017","journal-title":"JAMA"},{"key":"key20200713171300_b2-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1586\/14737175.2015.1051968","article-title":"The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence","volume":"15","author":"Auffinger","year":"2015","journal-title":"Expert Rev Neurother"},{"key":"key20200713171300_b3-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/cdd.2014.31","article-title":"Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy","volume":"21","author":"Auffinger","year":"2014","journal-title":"Cell Death Differ"},{"key":"key20200713171300_b4-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1593\/neo.10126","article-title":"Invasive glioblastoma cells acquire stemness and increased Akt activation","volume":"12","author":"Molina","year":"2010","journal-title":"Neoplasia"},{"key":"key20200713171300_b5-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1002\/stem.521","article-title":"Crosstalk between the PI3K\/mTOR and MEK\/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells","volume":"28","author":"Sunayama","year":"2010","journal-title":"Stem Cells"},{"key":"key20200713171300_b6-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"R28","DOI":"10.1186\/bcr2845","article-title":"Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation","volume":"13","author":"Toulany","year":"2011","journal-title":"Breast Cancer Res"},{"key":"key20200713171300_b7-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1600-0625.2012.01448.x","article-title":"MAPK and PI3K\/AKT mediated YB-1 activation promotes melanoma cell proliferation which is counteracted by an autoregulatory loop","volume":"21","author":"Sinnberg","year":"2012","journal-title":"Exp Dermatol"},{"key":"key20200713171300_b8-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"4872","DOI":"10.1158\/0008-5472.CAN-05-3561","article-title":"Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2","volume":"66","author":"Lee","year":"2006","journal-title":"Cancer Res"},{"key":"key20200713171300_b9-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ejcb.2013.11.007","article-title":"Y-box binding protein 1-a prognostic marker and target in tumour therapy","volume":"93","author":"Kosnopfel","year":"2014","journal-title":"Eur J Cell Biol"},{"key":"key20200713171300_b10-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1002\/ijc.22512","article-title":"The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance","volume":"120","author":"Schittek","year":"2007","journal-title":"Int J Cancer"},{"key":"key20200713171300_b11-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.biochi.2015.10.008","article-title":"Poly(ADP-ribosyl)ation as a new posttranslational modification of YB-1","volume":"119","author":"Alemasova","year":"2015","journal-title":"Biochimie"},{"key":"key20200713171300_b12-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"pii: E2441","DOI":"10.3390\/ijms19082441","article-title":"Stress-induced phosphorylation of nuclear YB-1 depends on nuclear trafficking of p90 ribosomal S6 kinase","volume":"19","author":"Tiwari","year":"2018","journal-title":"Int J Mol Sci"},{"key":"key20200713171300_b13-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.atherosclerosis.2018.09.020","article-title":"Cold shock Y-box binding protein-1 acetylation status in monocytes is associated with systemic inflammation and vascular damage","volume":"278","author":"Ewert","year":"2018","journal-title":"Atherosclerosis"},{"key":"key20200713171300_b14-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"6193","DOI":"10.18632\/oncotarget.14051","article-title":"The tumor-associated YB-1 protein: New player in the circadian control of cell proliferation","volume":"8","author":"Pagano","year":"2017","journal-title":"Oncotarget"},{"issue":"Suppl 2","key":"key20200713171300_b15-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"S187","DOI":"10.1007\/s00292-008-1030-2","article-title":"YB-1 as a potential target in cancer therapy","volume":"2","author":"Lage","year":"2008","journal-title":"Pathologe"},{"key":"key20200713171300_b16-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"10427","DOI":"10.1074\/jbc.M106955200","article-title":"YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter","volume":"277","author":"Holm","year":"2002","journal-title":"J Biol Chem"},{"key":"key20200713171300_b17-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1158\/0008-5472.CAN-0482-2","article-title":"Multidrug-resistant cancer cells facilitate E1-independent adenoviral replication: Impact for cancer gene therapy","volume":"64","author":"Holm","year":"2004","journal-title":"Cancer Res"},{"key":"key20200713171300_b18-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/1479-5876-11-216","article-title":"YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells","volume":"11","author":"Mantwill","year":"2013","journal-title":"J Transl Med"},{"key":"key20200713171300_b19-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.radonc.2007.10.009","article-title":"Impact of radiation therapy on the oncolytic adenovirus dl520: Implications on the treatment of glioblastoma","volume":"86","author":"Bieler","year":"2008","journal-title":"Radiother Oncol"},{"key":"key20200713171300_b20-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"4010","DOI":"10.1158\/0008-5472.CAN-06-4180","article-title":"CD133(+) and CD133(\u2212) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles","volume":"67","author":"Beier","year":"2007","journal-title":"Cancer Res"},{"key":"key20200713171300_b21-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"17197","DOI":"10.1523\/JNEUROSCI.3158-13.2013","article-title":"Mechanisms underlying the rules for associative plasticity at adult human neocortical synapses","volume":"33","author":"Verhoog","year":"2013","journal-title":"J Neurosci"},{"key":"key20200713171300_b22-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"12249","DOI":"10.1038\/s41598-017-12527-9","article-title":"Human Cerebrospinal fluid promotes long-term neuronal viability and network function in human neocortical organotypic brain slice cultures","volume":"7","author":"Schwarz","year":"2017","journal-title":"Sci Rep"},{"key":"key20200713171300_b23-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"key20200713171300_b24-ijmm-44-04-1484","volume-title":"An\u00e4sthesie und Analgesie beim klein-und heimtier","author":"Erhardt","year":"2004"},{"key":"key20200713171300_b25-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"12423","DOI":"10.1038\/s41598-017-12403-6","article-title":"Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells","volume":"7","author":"Mutschelknaus","year":"2017","journal-title":"Sci Rep"},{"key":"key20200713171300_b26-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1093\/abbs\/gmw012","article-title":"YB-1, a new biomarker of glioma progression, is associated with the prognosis of glioma patients","volume":"48","author":"Zheng","year":"2016","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20200713171300_b27-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"317","DOI":"10.2147\/DDDT.S185514","article-title":"YB-1 modulates the drug resistance of glioma cells by activation of MDM2\/p53 pathway","volume":"13","author":"Tong","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"key20200713171300_b28-ijmm-44-04-1484","first-page":"49","article-title":"YB-1 is a transcription\/translation factor that orchestrates the oncogenome by hardwiring signal transduction to gene expression","volume":"2","author":"Wu","year":"2007","journal-title":"transl Oncogenomics"},{"key":"key20200713171300_b29-ijmm-44-04-1484","first-page":"2744","article-title":"Sublethal irradiation promotes migration and invasiveness of glioma cells: Implications for radiotherapy of human glioblastoma","volume":"61","author":"Wild-Bode","year":"2001","journal-title":"Cancer Res"},{"key":"key20200713171300_b30-ijmm-44-04-1484","first-page":"CD011475","article-title":"External beam radiation dose escalation for high grade glioma","volume":"19","author":"Khan","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"key20200713171300_b31-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1038\/mt.2015.115","article-title":"Viral infection of tumors overcomes resistance to PD-1-immunotherapy by broadening neoantigenome-directed T-cell responses","volume":"23","author":"Woller","year":"2015","journal-title":"Mol Ther"},{"key":"key20200713171300_b32-ijmm-44-04-1484","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s11060-017-2413-0","article-title":"Immunotherapy and radiation in glioblastoma","volume":"134","author":"Sahebjam","year":"2017","journal-title":"J Neurooncol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T17:50:25Z","timestamp":1594662625000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2019.4296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,31]]},"references-count":32,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2019.4296","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,31]]}}}