{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T01:52:50Z","timestamp":1760320370968},"reference-count":29,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2019.4364","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T06:42:14Z","timestamp":1570084934000},"source":"Crossref","is-referenced-by-count":17,"title":["The A3 adenosine receptor agonist, namodenoson, ameliorates non\u2011alcoholic steatohepatitis in mice"],"prefix":"10.3892","author":[{"given":"Pnina","family":"Fishman","sequence":"first","affiliation":[{"name":"Can\u2011Fite BioPharma Ltd., Petach\u2011Tikva 4951778, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shira","family":"Cohen","sequence":"additional","affiliation":[{"name":"Can\u2011Fite BioPharma Ltd., Petach\u2011Tikva 4951778, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inbal","family":"Itzhak","sequence":"additional","affiliation":[{"name":"Can\u2011Fite BioPharma Ltd., Petach\u2011Tikva 4951778, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Amer","sequence":"additional","affiliation":[{"name":"Liver Unit, Hadassah University Hospital, Jerusalem 54915, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Salhab","sequence":"additional","affiliation":[{"name":"Liver Unit, Hadassah University Hospital, Jerusalem 54915, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faina","family":"Barer","sequence":"additional","affiliation":[{"name":"Can\u2011Fite BioPharma Ltd., Petach\u2011Tikva 4951778, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rifaat","family":"Safadi","sequence":"additional","affiliation":[{"name":"Liver Unit, Hadassah University Hospital, Jerusalem 54915, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2019,10,3]]},"reference":[{"key":"key20200713171444_b1-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.jhep.2010.04.008","article-title":"A position statement on NAFLD\/NASH based on the EASL 2009, special conference","volume":"53","author":"Ratziu","year":"2010","journal-title":"J Hepatol"},{"key":"key20200713171444_b2-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1053\/j.gastro.2010.09.038","article-title":"Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study","volume":"140","author":"Williams","year":"2011","journal-title":"Gastroenterology"},{"key":"key20200713171444_b3-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1002\/hep.25762","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American association for the study of liver diseases, American college of gastroenterology, and the American gastro-enterological association","volume":"55","author":"Chalasani","year":"2012","journal-title":"Hepatology"},{"key":"key20200713171444_b4-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"9","DOI":"10.4103\/ijmr.IJMR_1456_17","article-title":"Non-alcoholic fatty liver disease associated with hepatocellular carcinoma: An increasing concern","volume":"149","author":"Dhamija","year":"2019","journal-title":"Indian J Med Res"},{"issue":"Suppl 1","key":"key20200713171444_b5-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1016\/j.jhep.2015.02.041","article-title":"Current efforts and trends in the treatment of NASH","volume":"62","author":"Ratziu","year":"2015","journal-title":"J Hepatol"},{"key":"key20200713171444_b6-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"3777","DOI":"10.3748\/wjg.v21.i13.3777","article-title":"Current pharmacological therapies for nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"21","author":"Takahashi","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"Suppl 2","key":"key20200713171444_b7-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1007\/s12072-013-9482-8","article-title":"Pharmacological agents for nonalcoholic steatohepatitis","volume":"7","author":"Guillaume","year":"2013","journal-title":"Hepatol Int"},{"key":"key20200713171444_b8-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.bbagrm.2016.03.002","article-title":"Nuclear receptors and nonalcoholic fatty liver disease","volume":"1859","author":"Cave","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"key20200713171444_b9-ijmm-44-06-2256","first-page":"287","article-title":"The A3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-kappaB signal transduction pathways","volume":"33","author":"Bar-Yehuda","year":"2008","journal-title":"Int J Oncol"},{"key":"key20200713171444_b10-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1002\/jcp.22593","article-title":"CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver","volume":"226","author":"Cohen","year":"2011","journal-title":"J Cell Physiol"},{"key":"key20200713171444_b11-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.3892\/mmr.2016.5746","article-title":"A3 adenosine receptor agonist, CF102, protects against hepatic ischemia\/reper-fusion injury following partial hepatectomy","volume":"14","author":"Ohana","year":"2016","journal-title":"Mol Med Rep"},{"key":"key20200713171444_b12-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1634\/theoncologist.2012-0211","article-title":"CF102 for the treatment of hepatocellular carcinoma: A phase I\/II, open-label, dose-escalation study","volume":"18","author":"Stemmer","year":"2013","journal-title":"The Oncologist"},{"key":"key20200713171444_b13-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.bcp.2008.05.032","article-title":"The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB\/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats","volume":"76","author":"Ochaion","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"key20200713171444_b14-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"R33","DOI":"10.1186\/ar1887","article-title":"The PI3K-NF-\u03baB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant induced arthritis","volume":"8","author":"Fishman","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"key20200713171444_b15-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1016\/j.biochi.2013.09.003","article-title":"Wnt signaling in liver fibrosis: Progress challenges and potential directions","volume":"95","author":"Miao","year":"2013","journal-title":"Biochimie"},{"key":"key20200713171444_b16-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.intimp.2018.08.005","article-title":"Octreotide attenuates hepatic fibrosis and hepatic stellate cells proliferation and activation by inhibiting Wnt\/\u03b2-catenin signaling pathway, c-Myc and cyclin D1","volume":"63","author":"Zhang","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"key20200713171444_b17-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"472432","DOI":"10.1155\/2013\/472432","article-title":"Roles for PI3K\/akt\/PTEN pathway in cell signaling of nonalcoholic fatty liver disease","volume":"2013","author":"Matsuda","year":"2013","journal-title":"ISRN Endocrinol"},{"key":"key20200713171444_b18-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"e82571","DOI":"10.1371\/journal.pone.0082571","article-title":"Natural killer cell-dependent anti-fibrotic pathway in liver injury via toll-like receptor-9","volume":"8","author":"Abu-Tair","year":"2013","journal-title":"PLoS One"},{"key":"key20200713171444_b19-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"key20200713171444_b20-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713171444_b21-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"4472","DOI":"10.1182\/blood-2002-11-3624","article-title":"Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo","volume":"102","author":"Gomez","year":"2003","journal-title":"Blood"},{"key":"key20200713171444_b22-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1006\/bbrc.2001.5134","article-title":"Change in expression of GBP28\/adiponectin in carbon tetrachloride-administrated mouse liver","volume":"285","author":"Yoda-Murakami","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713171444_b23-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"42121","DOI":"10.1074\/jbc.M301243200","article-title":"A3 adenosine receptor activation in melanoma cells: Association between receptor fate and tumor growth inhibition","volume":"278","author":"Madi","year":"2003","journal-title":"J Biol Chem"},{"key":"key20200713171444_b24-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.3892\/mmr.2014.2099","article-title":"\u03b2-catenin is overexpressed in hepatic fibrosis and blockage of Wnt\/\u03b2-catenin signaling inhibits hepatic stellate cell activation","volume":"9","author":"Ge","year":"2014","journal-title":"Mol Med Rep"},{"key":"key20200713171444_b25-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.gene.2018.06.053","article-title":"Emerging role and therapeutic implication of Wnt signaling pathway in liver fibrosis","volume":"674","author":"Wang","year":"2018","journal-title":"Gene"},{"key":"key20200713171444_b26-ijmm-44-06-2256","first-page":"56","article-title":"Cyclin D1 in the liver: Role of noncanonical signaling in liver steatosis and hormone regulation","volume":"17","author":"N\u00fa\u00f1ez","year":"2017","journal-title":"Ochsner J"},{"key":"key20200713171444_b27-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"708","DOI":"10.4254\/wjh.v10.i10.708","article-title":"Adiponectin as a novel biomarker for liver fibrosis","volume":"10","author":"Udomsinprasert","year":"2018","journal-title":"World J Hepatol"},{"key":"key20200713171444_b28-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1002\/jnr.21071","article-title":"Activation of adenosine A3 receptors reduces ischemic brain injury in rodents","volume":"84","author":"Chen","year":"2006","journal-title":"J Neurosci Res"},{"key":"key20200713171444_b29-ijmm-44-06-2256","doi-asserted-by":"publisher","first-page":"H1562","DOI":"10.1152\/ajpheart.00335.2002","article-title":"Overexpression of A(3) adenosine receptors decreases heart rate, preserves energetics, and protects ischemic hearts","volume":"283","author":"Cross","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T17:58:19Z","timestamp":1594663099000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2019.4364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,3]]},"references-count":29,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2019.4364","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,3]]}}}