{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:08:42Z","timestamp":1789168122517,"version":"build-2803163510"},"reference-count":54,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2020.4480","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T06:43:37Z","timestamp":1580193817000},"source":"Crossref","is-referenced-by-count":20,"title":["HIF\u20111\u03b1 attenuates neuronal apoptosis by upregulating EPO expression following cerebral ischemia\u2011reperfusion injury in a rat MCAO model"],"prefix":"10.3892","author":[{"given":"Jun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital Guizhou Medical University, Guiyang, Guizhou 550001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Affiliated Hospital Guizhou Medical University, Guiyang, Guizhou 550001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhehua","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of General Practice, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qijiang Hospital of The First Affiliated Hospital of Chongqing Medical University, Chongqing 404100, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"key20200713162453_b1-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"key20200713162453_b2-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/S0140-6736(17)32152-9","article-title":"Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"GBD 2016 Causes of Death Collaborators","year":"2017","journal-title":"Lancet"},{"key":"key20200713162453_b3-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1016\/S0140-6736(13)61097-1","article-title":"Rapid health transition in China, 1990-2010: Findings from the global burden of disease study 2010","volume":"381","author":"Yang","year":"2013","journal-title":"Lancet"},{"key":"key20200713162453_b4-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1161\/STROKEAHA.111.635755","article-title":"Stroke and stroke care in China: Huge burden, significant workload, and a national priority","volume":"42","author":"Liu","year":"2011","journal-title":"Stroke"},{"key":"key20200713162453_b5-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1161\/CIRCULATIONAHA.116.025250","article-title":"Prevalence, incidence, and mortality of stroke in China: Results from a nationwide population-based survey of 480 687 adults","volume":"135","author":"Wang","year":"2017","journal-title":"Circulation"},{"key":"key20200713162453_b6-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1755-5949.2011.00290.x","article-title":"Chinese guidelines for the secondary prevention of ischemic stroke and transient ischemic attack 2010","volume":"18","author":"Wang","year":"2012","journal-title":"CNS Neurosci Ther"},{"key":"key20200713162453_b7-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","article-title":"Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke","volume":"359","author":"Hacke","year":"2008","journal-title":"N Engl J Med"},{"key":"key20200713162453_b8-ijmm-45-04-1027","first-page":"77","article-title":"Thrombolysis for acute ischemic stroke: A new paradigm","volume":"7","author":"Xydas","year":"2012","journal-title":"Hosp Chron"},{"key":"key20200713162453_b9-ijmm-45-04-1027","first-page":"210","article-title":"Intravenous thrombolysis with urokinase for acute cerebral infarctions","volume":"35","author":"National 'Ninth Five-Year Plan' Research Group","year":"2002","journal-title":"Chin J Neurol"},{"key":"key20200713162453_b10-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"key20200713162453_b11-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S1471-4914(01)02090-1","article-title":"Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology","volume":"7","author":"Semenza","year":"2001","journal-title":"Trends Mol Med"},{"key":"key20200713162453_b12-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"key20200713162453_b13-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"884","DOI":"10.5551\/jat.RV17009","article-title":"The roles of hypoxia signaling in the pathogenesis of cardiovascular diseases","volume":"24","author":"Abe","year":"2017","journal-title":"J Atheroscler Thromb"},{"key":"key20200713162453_b14-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.ijdevneu.2015.04.010","article-title":"Corticosteroid responses following hypoxic preconditioning provide neuroprotection against subsequent hypoxic-ischemic brain injury in the newborn rats","volume":"44","author":"Feng","year":"2015","journal-title":"Int J Dev Neurosci"},{"key":"key20200713162453_b15-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s10571-016-0445-1","article-title":"Hypoxic preconditioning augments the therapeutic efficacy of bone marrow stromal cells in a rat ischemic stroke model","volume":"37","author":"Chen","year":"2017","journal-title":"Cell Mol Neurobiol"},{"key":"key20200713162453_b16-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/313806a0","article-title":"Isolation and characterization of genomic and cDNA clones of human erythropoietin","volume":"313","author":"Jacobs","year":"1985","journal-title":"Nature"},{"key":"key20200713162453_b17-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"E1242","DOI":"10.1152\/ajpendo.2000.279.6.E1242","article-title":"Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus","volume":"279","author":"Chikuma","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key20200713162453_b18-ijmm-45-04-1027","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1242\/dev.129.2.505","article-title":"Erythropoietin receptor signalling is required for normal brain development","volume":"129","author":"Yu","year":"2002","journal-title":"Development"},{"key":"key20200713162453_b19-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1161\/STROKEAHA.109.570325","article-title":"Enhanced oligodendrogenesis and recovery of neurological function by erythropoietin after neonatal hypoxic\/ischemic brain injury","volume":"41","author":"Iwai","year":"2010","journal-title":"Stroke"},{"key":"key20200713162453_b20-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"e0190039","DOI":"10.1371\/journal.pone.0190039","article-title":"Erythropoietin attenuates motor neuron programmed cell death in a burn animal model","volume":"13","author":"Wu","year":"2018","journal-title":"PLoS One"},{"key":"key20200713162453_b21-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"146391","DOI":"10.1016\/j.brainres.2019.146391","article-title":"Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion","volume":"1723","author":"Wang","year":"2019","journal-title":"Brain Res"},{"key":"key20200713162453_b22-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1093\/brain\/awp309","article-title":"Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice","volume":"133","author":"Saadoun","year":"2010","journal-title":"Brain"},{"key":"key20200713162453_b23-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"433","DOI":"10.4103\/1673-5374.202947","article-title":"Neural stem cells over-expressing brain-derived neurotrophic factor promote neuronal survival and cytoskeletal protein expression in traumatic brain injury sites","volume":"12","author":"Chen","year":"2017","journal-title":"Neural Regen Res"},{"key":"key20200713162453_b24-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jocn.2009.03.039","article-title":"Transplantation of neural stem cells expressing hypoxia-inducible factor-1alpha (HIF-1alpha) improves behavioral recovery in a rat stroke model","volume":"17","author":"Wu","year":"2010","journal-title":"J Clin Neurosci"},{"key":"key20200713162453_b25-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.4103\/0366-6999.209909","article-title":"Antiapoptotic effect of gene therapy with recombinant adenovirus vector containing hypoxia-inducible factor-1\u03b1 after cerebral ischemia and reperfu-sion in rats","volume":"130","author":"Yang","year":"2017","journal-title":"Chin Med J (Engl)"},{"key":"key20200713162453_b26-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1142\/S0219635210002433","article-title":"Electroacupuncture at Baihui acupoint (GV20) reverses behavior deficit and long-term potentiation through N-methyl-d-aspartate and transient receptor potential vanilloid subtype 1 receptors in middle cerebral artery occlusion rats","volume":"9","author":"Lin","year":"2010","journal-title":"J Integr Neurosci"},{"key":"key20200713162453_b27-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713162453_b28-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s12264-012-1057-5","article-title":"Caspase-3 activation as a bifurcation point between plasticity and cell death","volume":"28","author":"Snigdha","year":"2012","journal-title":"Neurosci Bull"},{"key":"key20200713162453_b29-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"E2428","DOI":"10.3390\/ijms19082428","article-title":"Repression of the glucocorticoid receptor aggravates acute ischemic brain injuries in adult mice","volume":"19","author":"Li","year":"2018","journal-title":"Int J Mol Sci"},{"key":"key20200713162453_b30-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1159\/000210544","article-title":"The concept of ischemic penumbra in acute stroke and therapeutic opportunities","volume":"61","author":"Paciaroni","year":"2009","journal-title":"Eur Neurol"},{"key":"key20200713162453_b31-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/WCO.0000000000000047","article-title":"The ischemic penumbra: The location rather than the volume of recovery determines outcome","volume":"27","author":"Rosso","year":"2014","journal-title":"Curr Opin Neurol"},{"key":"key20200713162453_b32-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.wneu.2018.04.193","article-title":"Related research and recent progress of ischemic penumbra","volume":"116","author":"Ran","year":"2018","journal-title":"World Neurosurg"},{"key":"key20200713162453_b33-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrn2735","article-title":"Plasticity during stroke recovery: From synapse to behaviour","volume":"10","author":"Murphy","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"key20200713162453_b34-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"e84767","DOI":"10.1371\/journal.pone.0084767","article-title":"Inhibition of HIF prolyl-4-hydroxylases by FG-4497 reduces brain tissue injury and edema formation during ischemic stroke","volume":"9","author":"Reischl","year":"2014","journal-title":"PLoS One"},{"key":"key20200713162453_b35-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.nbd.2011.10.020","article-title":"Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1\u03b1","volume":"45","author":"Ogle","year":"2012","journal-title":"Neurobiol Dis"},{"key":"key20200713162453_b36-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"368","DOI":"10.2174\/1567202614666171128120558","article-title":"Post-stroke constraint-induced movement therapy increases functional recovery, angiogenesis, and neurogenesis with enhanced expression of HIF-1\u03b1 and VEGF","volume":"14","author":"Li","year":"2017","journal-title":"Curr Neurovasc Res"},{"key":"key20200713162453_b37-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s11011-019-00450-z","article-title":"Modulating effects of preconditioning exercise in the expression of ET-1 and BNP via HIF-1\u03b1 in ischemically injured brain","volume":"34","author":"Wang","year":"2019","journal-title":"Metab Brain Dis"},{"key":"key20200713162453_b38-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"116611","DOI":"10.1016\/j.lfs.2019.116611","article-title":"Dexmedetomidine protects hippocampal neurons against hypoxia\/reoxygenation-induced apoptosis through activation HIF-1\u03b1\/p53 signaling","volume":"232","author":"Gao","year":"2019","journal-title":"Life Sci"},{"key":"key20200713162453_b39-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"6320","DOI":"10.1523\/JNEUROSCI.0449-07.2007","article-title":"Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia","volume":"27","author":"Baranova","year":"2007","journal-title":"J Neurosci"},{"key":"key20200713162453_b40-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1177\/0271678X15624933","article-title":"Neuronal HIF-1\u03b1 and HIF-2\u03b1 deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke","volume":"37","author":"Barteczek","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20200713162453_b41-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1523\/JNEUROSCI.4555-04.2005","article-title":"Brain-specific knock-out of hypoxia-inducible factor-1 alpha reduces rather than increases hypoxic-ischemic damage","volume":"25","author":"Helton","year":"2005","journal-title":"J Neurosci"},{"key":"key20200713162453_b42-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"e27798","DOI":"10.1371\/journal.pone.0027798","article-title":"Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke","volume":"6","author":"Yan","year":"2011","journal-title":"PLoS One"},{"key":"key20200713162453_b43-ijmm-45-04-1027","first-page":"a008656","article-title":"Caspase functions in cell death and disease","volume":"5","author":"McIlwain","year":"2013","journal-title":"Cold Spring Harb Perspect Boil"},{"key":"key20200713162453_b44-ijmm-45-04-1027","first-page":"738","article-title":"Caspase 3 in breast cancer","volume":"9","author":"O'Donovan","year":"2003","journal-title":"Clin Cancer Res"},{"key":"key20200713162453_b45-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/35088074","article-title":"Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades","volume":"412","author":"Digicaylioglu","year":"2001","journal-title":"Nature"},{"key":"key20200713162453_b46-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1182\/blood-2002-07-2332","article-title":"Critical role for PI 3-kinase in the control of erythropoietininduced erythroid progenitor proliferation","volume":"101","author":"Bouscary","year":"2003","journal-title":"Blood"},{"key":"key20200713162453_b47-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"17359","DOI":"10.1074\/jbc.M201842200","article-title":"Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases","volume":"277","author":"Haq","year":"2002","journal-title":"J Biol Chem"},{"key":"key20200713162453_b48-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2047-9158-1-7","article-title":"Erythropoietin prevents PC12 cells from beta-amyloid-induced apoptosis via PI3K\u2044Akt pathway","volume":"1","author":"Zhi-Kun","year":"2012","journal-title":"Transl Neurodegener"},{"key":"key20200713162453_b49-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1203\/PDR.0b013e3181fcbef3","article-title":"Beneficial effect of erythropoietin on sensorimotor function and white matter after hypoxia-ischemia in neonatal mice","volume":"69","author":"Fan","year":"2011","journal-title":"Pediatr Res"},{"key":"key20200713162453_b50-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s12013-014-0259-z","article-title":"Erythropoietin (EPO) protects against high glucose-induced apoptosis in retinal ganglional cells","volume":"71","author":"Wang","year":"2015","journal-title":"Cell Biochem Biophys"},{"key":"key20200713162453_b51-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fncel.2017.00020","article-title":"Hypoxia-inducible factor-1\u03b1 target genes contribute to retinal neuroprotection","volume":"11","author":"Cheng","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"key20200713162453_b52-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"15762","DOI":"10.1038\/s41598-019-52265-8","article-title":"Targeting ER\u03b2 in macrophage reduces crown-like structures in adipose tissue by inhibiting osteopontin and HIF-1\u03b1","volume":"9","author":"Wang","year":"2019","journal-title":"Sci Rep"},{"key":"key20200713162453_b53-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4174\/astr.2015.89.1.1","article-title":"Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis","volume":"89","author":"Lee","year":"2015","journal-title":"Ann Surg Treat Res"},{"key":"key20200713162453_b54-ijmm-45-04-1027","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/00004647-199603000-00002","article-title":"Apoptosis and necrosis after reversible focal ischemia: An in situ DNA fragmentation analysis","volume":"16","author":"Charriaut-Marlangue","year":"1996","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:25:43Z","timestamp":1665620743000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2020.4480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,28]]},"references-count":54,"URL":"https:\/\/doi.org\/10.3892\/ijmm.2020.4480","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,28]]}}}