{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:25:12Z","timestamp":1792697112798,"version":"4.5.0"},"reference-count":35,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2020.4631","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T06:29:37Z","timestamp":1591252177000},"page":"663-674","source":"Crossref","is-referenced-by-count":18,"title":["TRAP1 attenuates H9C2 myocardial cell injury induced by\u00a0extracellular acidification via the inhibition of MPTP opening"],"prefix":"10.3892","volume":"46","author":[{"given":"Lingxiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The Sixth Affiliated Hospital, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510655, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lerong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Sixth Affiliated Hospital, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510655, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Sixth Affiliated Hospital, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510655, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510655, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangpei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Sixth Affiliated Hospital, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510655, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Sixth Affiliated Hospital, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510655, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangdong\u2011Hongkong\u2011Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, Guangdong 510632, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Sixth Affiliated Hospital, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510655, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"key20200713162829_b1-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/nrneph.2010.33","article-title":"Metabolic acidosis: Pathophysiology, diagnosis and management","volume":"6","author":"Kraut","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"key20200713162829_b2-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nrneph.2012.186","article-title":"Treatment of acute metabolic acidosis: A pathophysiologic approach","volume":"8","author":"Kraut","year":"2012","journal-title":"Nat Rev Nephrol"},{"key":"key20200713162829_b3-ijmm-46-02-0663","first-page":"H1193","article-title":"Effect of lactic acidosis on canine hemodynamics and left ventricular function","volume":"258","author":"Teplinsky","year":"1990","journal-title":"Am J Physiol"},{"key":"key20200713162829_b4-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"R22","DOI":"10.1186\/cc3987","article-title":"Lactate versus non-lactate metabolic acidosis: A retrospective outcome evaluation of critically ill patients","volume":"10","author":"Gunnerson","year":"2006","journal-title":"Crit Care"},{"key":"key20200713162829_b5-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/ki.1972.48","article-title":"The effects of acid-base disturbances on cardiovascular and pulmonary function","volume":"1","author":"Mitchell","year":"1972","journal-title":"Kidney Int"},{"key":"key20200713162829_b6-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.semnephrol.2019.04.004","article-title":"Molecular pathophysiology of acid-base disorders","volume":"39","author":"Wagner","year":"2019","journal-title":"Semin Nephrol"},{"key":"key20200713162829_b7-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.celrep.2016.12.056","article-title":"Absence of neurofibromin induces an oncogenic metabolic switch via mitochondrial ERK-mediated phosphorylation of the chaperone TRAP1","volume":"18","author":"Masgras","year":"2017","journal-title":"Cell Rep"},{"key":"key20200713162829_b8-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1038\/cdd.2016.67","article-title":"TRAP1 regulates stemness through Wnt\/\u03b2-catenin pathway in human colorectal carcinoma","volume":"23","author":"Lettini","year":"2016","journal-title":"Cell Death Differ"},{"key":"key20200713162829_b9-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1111\/j.1742-4658.2010.07615.x","article-title":"Mitochondrial chaperone tumour necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening","volume":"277","author":"Xiang","year":"2010","journal-title":"FEBS J"},{"key":"key20200713162829_b10-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"E1604","DOI":"10.1073\/pnas.1220659110","article-title":"Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis","volume":"110","author":"Yoshida","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713162829_b11-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"4503","DOI":"10.1096\/fj.201700283R","article-title":"TRAP1 ameliorates renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction by protecting renal tubular epithelial cell mitochondria","volume":"31","author":"Chen","year":"2017","journal-title":"FASEB J"},{"key":"key20200713162829_b12-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1042\/BJ20040224","article-title":"A proteome analysis of the arsenite response in cultured lung cells: Evidence for in vitro oxidative stress-induced apoptosis","volume":"382","author":"Lau","year":"2004","journal-title":"Biochem J"},{"key":"key20200713162829_b13-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1530\/ERC-16-0063","article-title":"TRAP1 regulates cell cycle and apoptosis in thyroid carcinoma cells","volume":"23","author":"Palladino","year":"2016","journal-title":"Endocr Relat Cancer"},{"key":"key20200713162829_b14-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.msec.2017.02.055","article-title":"Poly(l-lactic Acid) and polyurethane nanofibers fabri-cated by solution blow spinning as potential substrates for cardiac cell culture","volume":"75","author":"Tomecka","year":"2017","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"key20200713162829_b15-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/sms.12702","article-title":"An overview of technical considerations for Western blotting applications to physiological research","volume":"27","author":"Bass","year":"2017","journal-title":"Scand J Med Sci Spor"},{"key":"key20200713162829_b16-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.ebiom.2019.04.050","article-title":"Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K\/Akt pathway in hepatic sinusoidal endothelial cells","volume":"43","author":"Wang","year":"2019","journal-title":"EbioMedicine"},{"key":"key20200713162829_b17-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1038\/jid.2012.455","article-title":"Immunofluorescence techniques","volume":"133","author":"Odell","year":"2013","journal-title":"J Invest Dermatol"},{"key":"key20200713162829_b18-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"34394","DOI":"10.1074\/jbc.M113.514372","article-title":"MicroRNA-27 (miR-27) targets prohibitin and impairs adipocyte differentiation and mitochondrial function in human adipose-derived stem cells","volume":"288","author":"Kang","year":"2013","journal-title":"J Biol Chem"},{"key":"key20200713162829_b19-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"e2716","DOI":"10.1038\/cddis.2017.133","article-title":"Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells","volume":"8","author":"Basit","year":"2017","journal-title":"Cell Death Dis"},{"key":"key20200713162829_b20-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.1007\/s12035-017-0576-5","article-title":"Exogenous BDNF increases mitochondrial pCREB and alleviates neuronal metabolic defects following mechanical injury in a MPTP-dependent way","volume":"55","author":"Xu","year":"2018","journal-title":"Mol Neurobiol"},{"key":"key20200713162829_b21-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"20553","DOI":"10.1074\/jbc.M703196200","article-title":"Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme m-mediated apoptosis","volume":"282","author":"Hua","year":"2007","journal-title":"J Biol Chem"},{"key":"key20200713162829_b22-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/jcbfm.2008.125","article-title":"Overexpression of mitochondrial Hsp70\/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia","volume":"29","author":"Xu","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20200713162829_b23-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1159\/000430174","article-title":"TRAP1 provides protection against myocardial ischemia-reperfusion injury by ameliorating mitochondrial dysfunction","volume":"36","author":"Zhang","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"key20200713162829_b24-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.canlet.2009.01.018","article-title":"TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells","volume":"279","author":"Costantino","year":"2009","journal-title":"Cancer Lett"},{"key":"key20200713162829_b25-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1111\/febs.12822","article-title":"Suppression of tumor necrosis factor receptor-associated protein 1 expression induces inhibition of cell proliferation and tumor growth in human esophageal cancer cells","volume":"281","author":"Tian","year":"2014","journal-title":"FEBS J"},{"key":"key20200713162829_b26-ijmm-46-02-0663","first-page":"2681","article-title":"Downregulation of TRAP1 aggravates injury of H9c2 cardiomyocytes in a hyperglycemic state","volume":"18","author":"Zhang","year":"2019","journal-title":"Exp Ther Med"},{"key":"key20200713162829_b27-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.redox.2017.12.018","article-title":"Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells","volume":"15","author":"Teixeira","year":"2018","journal-title":"Redox Biol"},{"key":"key20200713162829_b28-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"e05682","DOI":"10.7554\/eLife.05682","article-title":"Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction","volume":"4","author":"Wang","year":"2015","journal-title":"Elife"},{"key":"key20200713162829_b29-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.cmet.2014.12.001","article-title":"Physiological and pathological roles of the mitochondrial permeability transition pore in the heart","volume":"21","author":"Kwong","year":"2015","journal-title":"Cell Metab"},{"key":"key20200713162829_b30-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1152\/physrev.00001.2015","article-title":"The mitochondrial permeability transition pore: Channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology","volume":"95","author":"Bernardi","year":"2015","journal-title":"Physiol Rev"},{"key":"key20200713162829_b31-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1111\/acel.12650","article-title":"The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore","volume":"16","author":"Rottenberg","year":"2017","journal-title":"Aging Cell"},{"key":"key20200713162829_b32-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.2147\/DDDT.S194753","article-title":"Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening","volume":"13","author":"Li","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"key20200713162829_b33-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1002\/cmdc.201900376","article-title":"Second-generation inhibitors of the mitochondrial permeability transition pore with improved plasma stability","volume":"14","author":"\u0160ileikyt\u0117","year":"2019","journal-title":"ChemMedChem"},{"key":"key20200713162829_b34-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1053\/j.gastro.2019.07.026","article-title":"Small-molecule inhibitors of cyclophilins block opening of the mitochondrial permeability transition pore and protect mice from hepatic ischemia\/reperfusion injury","volume":"157","author":"Panel","year":"2019","journal-title":"Gastroenterology"},{"key":"key20200713162829_b35-ijmm-46-02-0663","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.devcel.2011.08.008","article-title":"The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation","volume":"21","author":"Hom","year":"2011","journal-title":"Dev Cell"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T11:53:32Z","timestamp":1597665212000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2020.4631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,4]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6,4]]}},"URL":"https:\/\/doi.org\/10.3892\/ijmm.2020.4631","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,4]]}}}