{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:12:03Z","timestamp":1770966723326,"version":"3.50.1"},"reference-count":170,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2020.4636","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T06:08:56Z","timestamp":1591769336000},"page":"489-508","source":"Crossref","is-referenced-by-count":34,"title":["A dissection of SARS\u2011CoV2 with clinical implications (Review)"],"prefix":"10.3892","volume":"46","author":[{"given":"Felician","family":"Stancioiu","sequence":"first","affiliation":[{"name":"Bio\u2011Forum Foundation, 030121 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Papadakis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical School, University of Crete, 71003 Heraklion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stelios","family":"Kteniadakis","sequence":"additional","affiliation":[{"name":"Emergency Department, Venizeleion General Hospital, 71409 Heraklion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Izotov","sequence":"additional","affiliation":[{"name":"Department of Analytical and Forensic Medical Toxicology, Sechenov University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Coleman","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences, Aston University, B4 7ET Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetrios","family":"Spandidos","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristidis","family":"Tsatsakis","sequence":"additional","affiliation":[{"name":"Department of Analytical and Forensic Medical Toxicology, Sechenov University, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"key20200713162805_b1-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA"},{"key":"key20200713162805_b2-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S2213-2600(20)30079-5","article-title":"Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study","volume":"8","author":"Yang","year":"2020","journal-title":"Lancet Respir Med"},{"key":"key20200713162805_b3-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.micinf.2020.02.002","article-title":"The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future","volume":"22","author":"Li","year":"2020","journal-title":"Microbes Infect"},{"key":"key20200713162805_b4-ijmm-46-02-0489","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0994","article-title":"Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China","author":"Wu","year":"2020","journal-title":"JAMA Intern Med"},{"key":"key20200713162805_b5-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1001\/jama.2020.4031","article-title":"Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: Early experience and forecast during an emergency response","volume":"323","author":"Grasselli","year":"2020","journal-title":"JAMA"},{"key":"key20200713162805_b6-ijmm-46-02-0489","first-page":"20","article-title":"COVID-19 in Northern Italy: An integrative overview of factors possibly influencing the sharp increase of the outbreak (Review)","volume":"22","author":"Goumenou","year":"2020","journal-title":"Mol Med Rep"},{"key":"key20200713162805_b7-ijmm-46-02-0489","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3892\/mmr.2020.11127","article-title":"Obesity - a risk factor for increased COVID-19 prevalence, severity and lethality (Review)","volume":"22","author":"Petrakis","year":"2020","journal-title":"Mol Med Rep"},{"key":"key20200713162805_b8-ijmm-46-02-0489","first-page":"1631","article-title":"A new threat from an old enemy: Re-emergence of coronavirus (Review)","volume":"45","author":"Docea","year":"2020","journal-title":"Int J Mol Med"},{"key":"key20200713162805_b9-ijmm-46-02-0489","doi-asserted-by":"publisher","DOI":"10.1007\/s00063-020-00689-w","article-title":"German recommendations for critically ill patients with COVID-19","author":"Kluge","year":"2020","journal-title":"Med Klin Intensivmed Notfmed"},{"key":"key20200713162805_b10-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1056\/NEJMoa2004500","article-title":"Covid-19 in critically ill patients in the Seattle region - case series","volume":"382","author":"Bhatraju","year":"2020","journal-title":"N Engl J Med"},{"key":"key20200713162805_b11-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.toxrep.2020.04.012","article-title":"Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system","volume":"7","author":"Farsalinos","year":"2020","journal-title":"Toxicol Rep"},{"key":"key20200713162805_b12-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S2213-2600(14)70097-9","article-title":"Subphenotypes in acute respiratory distress syndrome: Latent class analysis of data from two randomised controlled trials","volume":"2","author":"Calfee","year":"2014","journal-title":"Lancet Respir Med"},{"key":"key20200713162805_b13-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13054-020-2778-x","article-title":"ARDS subphenotypes: Understanding a heterogeneous syndrome","volume":"24","author":"Wilson","year":"2020","journal-title":"Crit Care"},{"key":"key20200713162805_b14-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1164\/rccm.201603-0645OC","article-title":"Acute respiratory distress syndrome subphenotypes respond differently to randomized fluid management strategy","volume":"195","author":"Famous","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713162805_b15-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S2213-2600(18)30177-2","article-title":"Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: Secondary analysis of a randomised controlled trial","volume":"6","author":"Calfee","year":"2018","journal-title":"Lancet Respir Med"},{"key":"key20200713162805_b16-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1007\/s00134-018-5378-3","article-title":"Latent class analysis of ARDS subphenotypes: A secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study","volume":"44","author":"Sinha","year":"2018","journal-title":"Intensive Care Med"},{"key":"key20200713162805_b17-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"4875","DOI":"10.1128\/AAC.03011-14","article-title":"Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture","volume":"58","author":"de Wilde","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key20200713162805_b18-ijmm-46-02-0489","unstructured":"CascellaMRajnikMCuomoADulebohnSCDi NapoliRFeatures, evaluation and treatment coronavirus (COVID-19)StatPearls [Internet]Treasure Island (FL)StatPearls Publishing2020JanPMID: 32150360https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554776"},{"key":"key20200713162805_b19-ijmm-46-02-0489","first-page":"113","article-title":"Protein microarray technology: Assisting personalized medicine in oncology (Review)","volume":"1","author":"Neagu","year":"2019","journal-title":"World Acad Sci J"},{"key":"key20200713162805_b20-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1586\/14789450.2016.1172481","article-title":"Proteomic study of acute respiratory distress syndrome: Current knowledge and implications for drug development","volume":"13","author":"Levitt","year":"2016","journal-title":"Expert Rev Proteomics"},{"key":"key20200713162805_b21-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/CCM.0000000000002749","article-title":"Mortality benefit of recombinant human interleukin-1 receptor antagonist for sepsis varies by initial interleukin-1 receptor antagonist plasma concentration","volume":"46","author":"Meyer","year":"2018","journal-title":"Crit Care Med"},{"key":"key20200713162805_b22-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cell.2013.06.013","article-title":"A systems analysis identifies a feed forward inflammatory circuit leading to lethal influenza infection","volume":"154","author":"Brandes","year":"2013","journal-title":"Cell"},{"key":"key20200713162805_b23-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.virusres.2016.01.005","article-title":"Systems biology: A tool for charting the antiviral landscape","volume":"218","author":"Bowen","year":"2016","journal-title":"Virus Res"},{"key":"key20200713162805_b24-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/bs.aivir.2016.08.006","article-title":"Interaction of SARS and MERS coronaviruses with the antiviral interferon response","volume":"96","author":"Kindler","year":"2016","journal-title":"Adv Virus Res"},{"key":"key20200713162805_b25-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.chom.2016.01.007","article-title":"Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice","volume":"19","author":"Channappanavar","year":"2016","journal-title":"Cell Host Microbe"},{"key":"key20200713162805_b26-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1164\/ajrccm.154.1.8680703","article-title":"Changes in the inflammatory response of the lung during acute respiratory distress syndrome: Prognostic indicators","volume":"154","author":"Baughman","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713162805_b27-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1080\/01902148.2020.1753266","article-title":"Dapsone as treatment adjunct in ARDS","volume":"46","author":"Kast","year":"2020","journal-title":"Exp Lung Res"},{"key":"key20200713162805_b28-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1365-2125.1992.tb04131.x","article-title":"The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients","volume":"34","author":"Coleman","year":"1992","journal-title":"Br J Clin Pharmacol"},{"key":"key20200713162805_b29-ijmm-46-02-0489","first-page":"2012","article-title":"Novel coronavirus 2019-nCoV: Prevalence, biological and clinical characteristics comparison with SARS-CoV and MERS-CoV","volume":"24","author":"Meo","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"key20200713162805_b30-ijmm-46-02-0489","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3892\/ijmm.2020.4608","article-title":"Comprehensive analysis of drugs to treat SARS-CoV-2 infection: Mechanistic insights into current COVID-19 therapies (Review)","volume":"46","author":"Nitulescu","year":"2020","journal-title":"Int J Mol Med"},{"key":"key20200713162805_b31-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"111418","DOI":"10.1016\/j.fct.2020.111418","article-title":"COVID-19, an opportunity to reevaluate the correlation between long-term effects of anthropogenic pollutants on viral epidemic\/pandemic events and prevalence","volume":"141","author":"Tsatsakis","year":"2020","journal-title":"Food Chem Toxicol"},{"key":"key20200713162805_b32-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"key20200713162805_b33-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.chom.2020.02.001","article-title":"Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China","volume":"27","author":"Wu","year":"2020","journal-title":"Cell Host Microbe"},{"key":"key20200713162805_b34-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1128\/MRA.00169-20","article-title":"Complete genome sequence of a 2019 novel coronavirus (SARS-CoV-2) strain isolated in Nepal","volume":"9","author":"Sah","year":"2020","journal-title":"Microbiol Resour Announc"},{"key":"key20200713162805_b35-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","article-title":"Origin and evolution of pathogenic coronaviruses","volume":"17","author":"Cui","year":"2019","journal-title":"Nat Rev Microbiol"},{"key":"key20200713162805_b36-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/v12020244","article-title":"Systematic comparison of two animal-to-human transmitted human coronaviruses: SARS-CoV-2 and SARS-CoV","volume":"12","author":"Xu","year":"2020","journal-title":"Viruses"},{"key":"key20200713162805_b37-ijmm-46-02-0489","doi-asserted-by":"crossref","unstructured":"LiuWLiHCOVID-19: Attacks the 1-beta chain of hemoglobin and captures the porphyrin to inhibit human heme metabolismChemRxiv2020Preprint. https:\/\/doi.org\/10.26434\/chemrxiv.11938173.v8","DOI":"10.26434\/chemrxiv.11938173.v8"},{"key":"key20200713162805_b38-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1128\/JVI.00718-19","article-title":"Human hemoglobin subunit beta functions as a pleiotropic regulator of RIG-I\/MDA5-mediated antiviral innate immune responses","volume":"93","author":"Yang","year":"2019","journal-title":"J Virol"},{"key":"key20200713162805_b39-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1080\/22221751.2020.1741327","article-title":"Clinical observation and management of COVID-19 patients","volume":"9","author":"Li","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"key20200713162805_b40-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1128\/JVI.00127-20","article-title":"Receptor recognition by the novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS coronavirus","volume":"94","author":"Wan","year":"2020","journal-title":"J Virol"},{"key":"key20200713162805_b41-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ijid.2020.03.071","article-title":"Insight into 2019 novel coronavirus - An updated interim review and lessons from SARS-CoV and MERS-CoV","volume":"94","author":"Xie","year":"2020","journal-title":"Int J Infect Dis"},{"key":"key20200713162805_b42-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1126\/science.aax0194","article-title":"mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence","volume":"367","author":"Hwang","year":"2020","journal-title":"Science"},{"key":"key20200713162805_b43-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"104742","DOI":"10.1016\/j.antiviral.2020.104742","article-title":"The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade","volume":"176","author":"Coutard","year":"2020","journal-title":"Antiviral Res"},{"key":"key20200713162805_b44-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"6537","DOI":"10.1128\/JVI.00094-12","article-title":"Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry","volume":"86","author":"Kawase","year":"2012","journal-title":"J Virol"},{"key":"key20200713162805_b45-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"key20200713162805_b46-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/s41422-020-0305-x","article-title":"Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion","volume":"30","author":"Xia","year":"2020","journal-title":"Cell Res"},{"key":"key20200713162805_b47-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.virol.2017.12.015","article-title":"Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells","volume":"517","author":"Millet","year":"2018","journal-title":"Virology"},{"key":"key20200713162805_b48-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/17460441.2019.1581171","article-title":"Broad-spectrum coronavirus antiviral drug discovery","volume":"14","author":"Totura","year":"2019","journal-title":"Expert Opin Drug Discov"},{"key":"key20200713162805_b49-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.4103\/0366-6999.230743","article-title":"Airway epithelial cell function and respiratory host defense in chronic obstructive pulmonary disease","volume":"131","author":"Amatngalim","year":"2018","journal-title":"Chin Med J (Engl)"},{"key":"key20200713162805_b50-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.cytogfr.2014.06.005","article-title":"Regulation of RIG-I-like receptor signaling by host and viral proteins","volume":"25","author":"Chiang","year":"2014","journal-title":"Cytokine Growth Factor Rev"},{"key":"key20200713162805_b51-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferonstimulated genes: A complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"key20200713162805_b52-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"key20200713162805_b53-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.cell.2010.04.018","article-title":"Peroxisomes are signaling platforms for antiviral innate immunity","volume":"141","author":"Dixit","year":"2010","journal-title":"Cell"},{"key":"key20200713162805_b54-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"e1006195","DOI":"10.1371\/journal.ppat.1006195","article-title":"Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication","volume":"13","author":"Kindler","year":"2017","journal-title":"PLoS Pathog"},{"key":"key20200713162805_b55-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1084\/jem.20071728","article-title":"Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling","volume":"205","author":"Cao","year":"2008","journal-title":"J Exp Med"},{"key":"key20200713162805_b56-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1002\/eji.201746959","article-title":"Post-translational regulation of antiviral innate signaling","volume":"47","author":"Zhou","year":"2017","journal-title":"Eur J Immunol"},{"key":"key20200713162805_b57-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/eji.201646484","article-title":"Negative regulators of the RIG-I-like receptor signaling pathway","volume":"47","author":"Quicke","year":"2017","journal-title":"Eur J Immunol"},{"key":"key20200713162805_b58-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1743-422X-2-69","article-title":"Chloroquine is a potent inhibitor of SARS coronavirus infection and spread","volume":"2","author":"Vincent","year":"2005","journal-title":"Virol J"},{"key":"key20200713162805_b59-ijmm-46-02-0489","doi-asserted-by":"crossref","unstructured":"SamarthSMcGregorKEnergetics based modeling of hydroxychloroquine and azithromycin binding to the SARS-CoV-2 spike (S)protein - ACE2 complexChemRxiv2020Preprint. https:\/\/doi.org\/10.26434\/chemrxiv.12015792.v2","DOI":"10.26434\/chemrxiv.12015792.v2"},{"key":"key20200713162805_b60-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1","DOI":"10.26434\/chemrxiv.11860011","article-title":"Potential inhibitors against papain-like protease of novel coronavirus (SARS-CoV-2) from FDA approved drugs","author":"Arya","year":"2020","journal-title":"ChemrxivOrg"},{"key":"key20200713162805_b61-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1007\/s40265-017-0830-1","article-title":"Middle East respiratory syndrome and severe acute respiratory syndrome: Current therapeutic options and potential targets for novel therapies","volume":"77","author":"Dyall","year":"2017","journal-title":"Drugs"},{"key":"key20200713162805_b62-ijmm-46-02-0489","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv.12005988","article-title":"Identification of SARS-CoV-2 cell entry inhibitors by drug repurposing using in silico structure-based virtual screening approach","author":"Choudhary","year":"2020","journal-title":"ChemRxiv"},{"key":"key20200713162805_b63-ijmm-46-02-0489","doi-asserted-by":"crossref","unstructured":"FaragAWangPBoysINEitsonJOhlsonMBFanWMcDougalMBAhmedMSchogginsJWIdentification of atovaquone, quabain and mebendazole as FDA approved drugs Tar-geting SARS-CoV-2 (Version 4)2020ChemRxivPreprint https:\/\/doi.org\/10.26434\/chemrxiv.12003930.v4","DOI":"10.26434\/chemrxiv.12003930.v4"},{"key":"key20200713162805_b64-ijmm-46-02-0489","doi-asserted-by":"crossref","unstructured":"NavanCPossible Drug Candidates for COVID-19ChemRxiv2020Preprint. https:\/\/doi.org\/10.26434\/chemrxiv.11985231.v1","DOI":"10.26434\/chemrxiv.11985231.v1"},{"key":"key20200713162805_b65-ijmm-46-02-0489","doi-asserted-by":"crossref","unstructured":"BagABagATreatment of COVID-19 patients: Justicia adhatoda leaves extract is a strong remedy for COVID-19- Case report analysis and docking based studyChemRxiv2020Preprint. https:\/\/doi.org\/10.26434\/chemrxiv.12038604.v1","DOI":"10.26434\/chemrxiv.12038604.v1"},{"key":"key20200713162805_b66-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"8924","DOI":"10.1128\/JVI.01429-16","article-title":"Abelson kinase inhibitors are potent inhibitors of severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus fusion","volume":"90","author":"Coleman","year":"2016","journal-title":"J Virol"},{"key":"key20200713162805_b67-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1099\/jgv.0.001047","article-title":"Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors","volume":"99","author":"Sisk","year":"2018","journal-title":"J Gen Virol"},{"key":"key20200713162805_b68-ijmm-46-02-0489","doi-asserted-by":"crossref","unstructured":"SalimBNoureddineMIdentification of compounds from Nigella sativa as new potential inhibitors of 2019 novel corona virus (Covid-19): Molecular docking studyChemRxiv2020Preprint. https:\/\/doi.org\/10.26434\/chemrxiv.12055716.v1","DOI":"10.26434\/chemrxiv.12055716.v1"},{"key":"key20200713162805_b69-ijmm-46-02-0489","doi-asserted-by":"crossref","unstructured":"PendyalaBPatrasAIn silico screening of food bioactive compounds to predict potential inhibitors of COVID-19 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)ChemRxiv Preprinthttps:\/\/doi.org\/10.26434\/chemrxiv.12051927.v2","DOI":"10.26434\/chemrxiv.12051927.v2"},{"key":"key20200713162805_b70-ijmm-46-02-0489","doi-asserted-by":"crossref","unstructured":"MohammadiNInhibitory effect of eight secondary metabolites from conventional medicinal plants on COVID-19 virus protease by molecular docking analysisChemRxiv2020Preprint. https:\/\/doi.org\/10.26434\/chemrxiv.11987475.v1","DOI":"10.26434\/chemrxiv.11987475.v1"},{"key":"key20200713162805_b71-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"8455","DOI":"10.1073\/pnas.0400576101","article-title":"Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides","volume":"101","author":"Bosch","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713162805_b72-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"5642","DOI":"10.1128\/JVI.78.11.5642-5650.2004","article-title":"pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN","volume":"78","author":"Yang","year":"2004","journal-title":"J Virol"},{"key":"key20200713162805_b73-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"11416","DOI":"10.1128\/JVI.01410-12","article-title":"Intranasal treatment with poly(I\u2022C) protects aged mice from lethal respiratory virus infections","volume":"86","author":"Zhao","year":"2012","journal-title":"J Virol"},{"key":"key20200713162805_b74-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1189\/jlb.0312125","article-title":"Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type","volume":"94","author":"Mian","year":"2013","journal-title":"J Leukoc Biol"},{"key":"key20200713162805_b75-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"36741","DOI":"10.1074\/jbc.M003848200","article-title":"Polyarginines are potent furin inhibitors","volume":"275","author":"Cameron","year":"2000","journal-title":"J Biol Chem"},{"key":"key20200713162805_b76-ijmm-46-02-0489","unstructured":"ChannappanavarRLuLXiaSDuLMeyerholzDKPerlmanSJiangSProtective effect of intranasal regimens containing peptidic Middle East respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection. - Abstract - Europe PMChttps:\/\/europepmc.org\/article\/med\/26164863"},{"key":"key20200713162805_b77-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.00219-10","article-title":"Autocrine interferon priming in macrophages but not dendritic cells results in enhanced cytokine and chemokine production after coronavirus infection","volume":"1","author":"Zhou","year":"2010","journal-title":"MBio"},{"key":"key20200713162805_b78-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1126\/science.1183021","article-title":"Regulation of adaptive immunity by the innate immune system","volume":"327","author":"Iwasaki","year":"2010","journal-title":"Science"},{"key":"key20200713162805_b79-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.virol.2004.08.011","article-title":"Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV)","volume":"329","author":"Sainz","year":"2004","journal-title":"Virology"},{"key":"key20200713162805_b80-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"15623","DOI":"10.1073\/pnas.95.26.15623","article-title":"Identification of genes differentially regulated by interferon \u03b1, \u03b2, or \u03b3 using oligonucleotide arrays","volume":"95","author":"Der","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713162805_b81-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"16764","DOI":"10.1073\/pnas.0909142106","article-title":"25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production","volume":"106","author":"Bauman","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713162805_b82-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J Pathol"},{"key":"key20200713162805_b83-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/path.4454","article-title":"Molecular pathology of emerging coronavirus infections","volume":"235","author":"Gralinski","year":"2015","journal-title":"J Pathol"},{"key":"key20200713162805_b84-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"8318","DOI":"10.1128\/JVI.01029-15","article-title":"A kinome-wide small interfering RNA screen identifies proviral and antiviral host factors in severe acute respiratory syndrome coronavirus replication, including double-stranded RNA-activated protein kinase and early secretory pathway proteins","volume":"89","author":"de Wilde","year":"2015","journal-title":"J Virol"},{"key":"key20200713162805_b85-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"5668","DOI":"10.1074\/jbc.M509314200","article-title":"Hemoglobin is expressed by alveolar epithelial cells","volume":"281","author":"Newton","year":"2006","journal-title":"J Biol Chem"},{"key":"key20200713162805_b86-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"57606","DOI":"10.18632\/oncotarget.11586","article-title":"Expression and regulation of immunemodulatory enzyme indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation","volume":"7","author":"Aldajani","year":"2016","journal-title":"Oncotarget"},{"key":"key20200713162805_b87-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.immuni.2017.01.005","article-title":"A relay pathway between arginine and tryptophan metabolism confers immunosuppressive properties on dendritic cells","volume":"46","author":"Mondanelli","year":"2017","journal-title":"Immunity"},{"key":"key20200713162805_b88-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.biochi.2013.07.026","article-title":"Peroxisomal metabolism and oxidative stress","volume":"98","author":"Nordgren","year":"2014","journal-title":"Biochimie"},{"key":"key20200713162805_b89-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/j.1600-0854.2010.01144.x","article-title":"Peroxisome metabolism and cellular aging","volume":"12","author":"Titorenko","year":"2011","journal-title":"Traffic"},{"key":"key20200713162805_b90-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1128\/mBio.03395-19","article-title":"The HIV-1 accessory protein vpu downregulates peroxisome biogenesis","volume":"11","author":"Xu","year":"2020","journal-title":"MBio"},{"key":"key20200713162805_b91-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12985-017-0709-5","article-title":"Herpes simplex virus 1 infection dampens the immediate early antiviral innate immunity signaling from peroxisomes by tegument protein VP16","volume":"14","author":"Zheng","year":"2017","journal-title":"Virol J"},{"key":"key20200713162805_b92-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/ijms20153795","article-title":"Peroxisomes and innate immunity: Antiviral response and beyond","volume":"20","author":"Ferreira","year":"2019","journal-title":"Int J Mol Sci"},{"key":"key20200713162805_b93-ijmm-46-02-0489","first-page":"17","article-title":"Zinc and respiratory tract infections: Perspectives for COVID-19 (Review)","volume":"46","author":"Skalny","year":"2020","journal-title":"Int J Mol Med"},{"key":"key20200713162805_b94-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1073\/pnas.0912966107","article-title":"Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection","volume":"107","author":"Gastaminza","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713162805_b95-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"11876","DOI":"10.1073\/pnas.0505577102","article-title":"Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry","volume":"102","author":"Simmons","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713162805_b96-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"6964","DOI":"10.1128\/JVI.00024-06","article-title":"Hepatitis C virus entry depends on clathrin-mediated endocytosis","volume":"80","author":"Blanchard","year":"2006","journal-title":"J Virol"},{"key":"key20200713162805_b97-ijmm-46-02-0489","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.4049\/jimmunol.162.8.4849","article-title":"Extracellular acidification induces human neutrophil activation","volume":"162","author":"Trevani","year":"1999","journal-title":"J Immunol"},{"key":"key20200713162805_b98-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/0022-4804(88)90079-0","article-title":"The deleterious effect of reduced pH and hypoxia on neutrophil migration in vitro","volume":"45","author":"Rotstein","year":"1988","journal-title":"J Surg Res"},{"key":"key20200713162805_b99-ijmm-46-02-0489","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1189\/jlb.69.4.522","article-title":"The effects of extracellular pH on immune function","volume":"69","author":"Lardner","year":"2001","journal-title":"J Leukoc Biol"},{"key":"key20200713162805_b100-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1172\/JCI112061","article-title":"Intracellular pH modulates the generation of superoxide radicals by human neutrophils","volume":"76","author":"Simchowitz","year":"1985","journal-title":"J Clin Invest"},{"key":"key20200713162805_b101-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1159\/000217905","article-title":"pH-dependent LAK cell cytotoxicity","volume":"15","author":"Severin","year":"1994","journal-title":"Tumour Biol"},{"key":"key20200713162805_b102-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1186\/cc2900","article-title":"Science review: extracellular acidosis and the immune response: clinical and physiologic implications","volume":"8","author":"Kellum","year":"2004","journal-title":"Crit Care"},{"key":"key20200713162805_b103-ijmm-46-02-0489","doi-asserted-by":"crossref","unstructured":"HamdullahKSTanzilaAZainab SherMIqraAMohtasheemulHpH dependent differential binding behavior of protease inhibitor molecular drugs for SARS-COV-2ChemRxiv2020Preprint. https:\/\/doi.org\/10.26434\/chemrxiv.12009018.v1","DOI":"10.26434\/chemrxiv.12009018.v1"},{"key":"key20200713162805_b104-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.antiviral.2008.10.009","article-title":"Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol","volume":"81","author":"Leneva","year":"2009","journal-title":"Antiviral Res"},{"key":"key20200713162805_b105-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"e109713","DOI":"10.1371\/journal.pone.0109713","article-title":"Proteomic profiles in acute respiratory distress syndrome differentiates survivors from non-survivors","volume":"9","author":"Bhargava","year":"2014","journal-title":"PLoS One"},{"key":"key20200713162805_b106-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"e111953","DOI":"10.1371\/journal.pone.0111953","article-title":"Identification of novel single nucleotide polymorphisms associated with acute respiratory distress syndrome by exome-seq","volume":"9","author":"Shortt","year":"2014","journal-title":"PLoS One"},{"key":"key20200713162805_b107-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1136\/jmedgenet-2012-100972","article-title":"Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin","volume":"49","author":"Tejera","year":"2012","journal-title":"J Med Genet"},{"key":"key20200713162805_b108-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1089\/ars.2018.7701","article-title":"Genomic and genetic approaches to deciphering acute respiratory distress syndrome risk and mortality","volume":"31","author":"Lynn","year":"2019","journal-title":"Antioxid Redox Signal"},{"key":"key20200713162805_b109-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1164\/rccm.2108086","article-title":"Angiotensin converting enzyme insertion\/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome","volume":"166","author":"Marshall","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"key20200713162805_b110-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.bbrc.2004.08.208","article-title":"ACE1 polymorphism and progression of SARS","volume":"323","author":"Itoyama","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713162805_b111-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2334-5-26","article-title":"Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: A case control study","volume":"5","author":"Chan","year":"2005","journal-title":"BMC Infect Dis"},{"key":"key20200713162805_b112-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1378\/chest.83.4.593","article-title":"Angiotensin-converting enzyme in human adult respiratory distress syndrome","volume":"83","author":"Fourrier","year":"1983","journal-title":"Chest"},{"key":"key20200713162805_b113-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nature03712","article-title":"Angiotensin-converting enzyme 2 protects from severe acute lung failure","volume":"436","author":"Imai","year":"2005","journal-title":"Nature"},{"key":"key20200713162805_b114-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"7233","DOI":"10.4049\/jimmunol.177.10.7233","article-title":"Systemic inhibition of the angiotensin-converting enzyme limits lipopolysaccharide-induced lung neutrophil recruitment through both bradykinin and angiotensin II-regulated pathways","volume":"177","author":"Arndt","year":"2006","journal-title":"J Immunol"},{"key":"key20200713162805_b115-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"154","DOI":"10.4266\/kjccm.2016.00976","article-title":"Effect of renin-angiotensin system blockage in patients with acute respiratory distress syndrome: A retrospective case control study","volume":"32","author":"Kim","year":"2017","journal-title":"Korean J Crit Care Med"},{"key":"key20200713162805_b116-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2217\/fvl.10.4","article-title":"Renin-angiotensin system in human coronavirus pathogenesis","volume":"5","author":"Wevers","year":"2010","journal-title":"Future Virol"},{"key":"key20200713162805_b117-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"134","DOI":"10.4172\/2576-1471.1000134","article-title":"Angiotensin-(17) and the regulation of anti-fibrotic signaling pathways","volume":"2","author":"Chappell","year":"2017","journal-title":"J Cell Signal"},{"key":"key20200713162805_b118-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1111\/j.1476-5381.2012.01905.x","article-title":"Angiotensin-(17) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1\/2- and NF-\u03baB-dependent pathways","volume":"166","author":"El-Hashim","year":"2012","journal-title":"Br J Pharmacol"},{"key":"key20200713162805_b119-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/hr.2010.82","article-title":"Cardioprotective properties of bradykinin: Role of the B(2) receptor","volume":"33","author":"Manolis","year":"2010","journal-title":"Hypertens Res"},{"key":"key20200713162805_b120-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1016\/S0140-6736(02)08914-6","article-title":"Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors","volume":"359","author":"Adam","year":"2002","journal-title":"Lancet"},{"key":"key20200713162805_b121-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/357420a0","article-title":"Human aminopeptidase N is a receptor for human coronavirus 229E","volume":"357","author":"Yeager","year":"1992","journal-title":"Nature"},{"key":"key20200713162805_b122-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"pe27","DOI":"10.1126\/scisignal.3135pe27","article-title":"Arginine: Master and commander in innate immune responses","volume":"3","author":"Morris","year":"2010","journal-title":"Sci Signal"},{"key":"key20200713162805_b123-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ijid.2004.04.012","article-title":"Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N- acetylpenicillamine, a nitric oxide donor compound","volume":"8","author":"Keyaerts","year":"2004","journal-title":"International Journal of Infectious Diseases Int J Infect Dis"},{"key":"key20200713162805_b124-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1128\/JVI.79.3.1966-1969.2005","article-title":"Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus","volume":"79","author":"Akerstr\u00f6m","year":"2005","journal-title":"J Virol"},{"key":"key20200713162805_b125-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(03)13973-6","article-title":"Treatment of SARS with human interferons","volume":"362","author":"Cinatl","year":"2003","journal-title":"Lancet"},{"key":"key20200713162805_b126-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1126\/science.7690156","article-title":"Inhibition of viral replication by interferon-\u03b3-induced nitric oxide synthase","volume":"261","author":"Karupiah","year":"1993","journal-title":"Science"},{"key":"key20200713162805_b127-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3389\/fimmu.2014.00428","article-title":"The role of myeloid cell activation and arginine metabolism in the pathogenesis of virus-induced diseases","volume":"5","author":"Burrack","year":"2014","journal-title":"Front Immunol"},{"key":"key20200713162805_b128-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1182\/blood-2006-11-010389","article-title":"Suppression of T-cell functions by human granulocyte arginase","volume":"108","author":"Munder","year":"2006","journal-title":"Blood"},{"key":"key20200713162805_b129-ijmm-46-02-0489","unstructured":"Racke\u0301KWarnkenML-Arginine metabolic pathwaysThe Open Nitric Oxide Journal29192010https:\/\/benthamopen.com\/contents\/pdf\/TONOJ\/TONOJ-2-9.pdf10.2174\/1875042701002020009"},{"key":"key20200713162805_b130-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1039\/b719777b","article-title":"The nucleobaseascorbate transporter (NAT) family: Genomics, evolution, structure-function relationships and physiological role","volume":"4","author":"Gournas","year":"2008","journal-title":"Mol Biosyst"},{"key":"key20200713162805_b131-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/nu9111211","article-title":"Vitamin C and immune function","volume":"9","author":"Carr","year":"2017","journal-title":"Nutrients"},{"key":"key20200713162805_b132-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/1743-7075-9-102","article-title":"Association between circulating ascorbic acid, \u03b1-tocopherol, 25-hydroxyvitamin D, and plasma cytokine concentrations in young adults: A cross-sectional study","volume":"9","author":"Garc\u00eda-Bailo","year":"2012","journal-title":"Nutr Metab (Lond)"},{"key":"key20200713162805_b133-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj3360001","article-title":"Arginine metabolism: Nitric oxide and beyond","volume":"336","author":"Wu","year":"1998","journal-title":"Biochem J"},{"key":"key20200713162805_b134-ijmm-46-02-0489","first-page":"5337","article-title":"Synergistic effects between catalase inhibitors and modulators of nitric oxide metabolism on tumor cell apoptosis","volume":"34","author":"Scheit","year":"2014","journal-title":"Anticancer Res"},{"key":"key20200713162805_b135-ijmm-46-02-0489","doi-asserted-by":"crossref","first-page":"14457","DOI":"10.1016\/S0021-9258(17)36645-0","article-title":"Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes","volume":"269","author":"Thomas","year":"1994","journal-title":"J Biol Chem"},{"key":"key20200713162805_b136-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1067\/msy.2000.107372","article-title":"Supplemental dietary arginine enhances wound healing in normal but not inducible nitric oxide synthase knockout mice","volume":"128","author":"Shi","year":"2000","journal-title":"Surgery"},{"key":"key20200713162805_b137-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1182\/blood-2006-06-031856","article-title":"L-arginine availability regulates T-lymphocyte cell-cycle progression","volume":"109","author":"Rodriguez","year":"2007","journal-title":"Blood"},{"key":"key20200713162805_b138-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1177\/014860710102500123","article-title":"Effects of L-arginine on the proliferation of T lymphocyte subpopulations","volume":"25","author":"Ochoa","year":"2001","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"key20200713162805_b139-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1172\/JCI0216143","article-title":"Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice","volume":"110","author":"de Jonge","year":"2002","journal-title":"J Clin Invest"},{"key":"key20200713162805_b140-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1089\/ars.2012.4988","article-title":"Vitamin C promotes maturation of T-cells","volume":"19","author":"Manning","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"key20200713162805_b141-ijmm-46-02-0489","first-page":"B280","article-title":"The effect of ascorbic acid on production of human interferon and the antiviral activity in vitro","volume":"84B","author":"Dahl","year":"1976","journal-title":"Acta Pathol Microbiol Scand B"},{"key":"key20200713162805_b142-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.jcyt.2015.01.004","article-title":"Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy","volume":"17","author":"Huijskens","year":"2015","journal-title":"Cytotherapy"},{"key":"key20200713162805_b143-ijmm-46-02-0489","first-page":"180","article-title":"Assessment of oral ascorbate in three children with chronic granulomatous disease and defective neutrophil motility over a 2-year period","volume":"43","author":"Anderson","year":"1981","journal-title":"Clin Exp Immunol"},{"key":"key20200713162805_b144-ijmm-46-02-0489","first-page":"163","article-title":"Effects of ascorbic acid on neutrophil function. Studies on normal and chronic granulomatous disease neutrophils","volume":"4","author":"Patrone","year":"1982","journal-title":"Acta Vitaminol Enzymol"},{"key":"key20200713162805_b145-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"7124","DOI":"10.1128\/JVI.02775-06","article-title":"Enhanced antiviral activity against foot-and-mouth disease virus by a combination of type I and II porcine interferons","volume":"81","author":"Moraes","year":"2007","journal-title":"J Virol"},{"key":"key20200713162805_b146-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1128\/JVI.01649-07","article-title":"Independent and cooperative antiviral actions of beta interferon and gamma interferon against herpes simplex virus replication in primary human fibroblasts","volume":"82","author":"Peng","year":"2008","journal-title":"J Virol"},{"key":"key20200713162805_b147-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1128\/JVI.01376-08","article-title":"The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts","volume":"83","author":"Bartee","year":"2009","journal-title":"J Virol"},{"key":"key20200713162805_b148-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"13334","DOI":"10.1128\/JVI.01689-12","article-title":"Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection","volume":"86","author":"Page","year":"2012","journal-title":"J Virol"},{"key":"key20200713162805_b149-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.freeradbiomed.2008.09.030","article-title":"Vitamin C treatment reduces elevated C-reactive protein","volume":"46","author":"Block","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"key20200713162805_b150-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/nu11122976","article-title":"Subphenotypes in patients with septic shock receiving vitamin C, hydrocortisone, and thiamine: A retrospective cohort analysis","volume":"11","author":"Kim","year":"2019","journal-title":"Nutrients"},{"key":"key20200713162805_b151-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.apsb.2015.06.002","article-title":"Regulation of AMP-activated protein kinase by natural and synthetic activators","volume":"6","author":"Grahame Hardie","year":"2016","journal-title":"Acta Pharm Sin B"},{"key":"key20200713162805_b152-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1091\/mbc.e07-06-0612","article-title":"Hypoxia-inducible factor-1\u03b1 stabilization in nonhypoxic conditions: Role of oxidation and intracellular ascorbate depletion","volume":"19","author":"Page\u0301","year":"2008","journal-title":"Mol Biol Cell"},{"key":"key20200713162805_b153-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1046\/j.1524-475X.2003.11605.x","article-title":"Arginine physiology and its implication for wound healing","volume":"11","author":"Witte","year":"2003","journal-title":"Wound Repair Regen"},{"key":"key20200713162805_b154-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"533","DOI":"10.7326\/0003-4819-140-7-200404060-00010","article-title":"Vitamin C pharmacokinetics: Implications for oral and intravenous use","volume":"140","author":"Padayatty","year":"2004","journal-title":"Ann Intern Med"},{"key":"key20200713162805_b155-ijmm-46-02-0489","first-page":"13","article-title":"Antiviral activity of L-arginine and extended-release Vitamin C","volume":"3","author":"Stancioiu","year":"2016","journal-title":"AASCIT J Health"},{"key":"key20200713162805_b156-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1007\/s00134-003-1711-5","article-title":"Early enteral immunonutrition in patients with severe sepsis: Results of an interim analysis of a randomized multicentre clinical trial","volume":"29","author":"Bertolini","year":"2003","journal-title":"Intensive Care Med"},{"key":"key20200713162805_b157-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1001\/jama.286.8.944","article-title":"Should immunonutrition become routine in critically ill patients? A systematic review of the evidence","volume":"286","author":"Heyland","year":"2001","journal-title":"JAMA"},{"key":"key20200713162805_b158-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"017","DOI":"10.23937\/2474-3674\/1510017","article-title":"Arginine in the critically ill: Can we finally push past the controversy?","volume":"2","author":"Rosenthal","year":"2016","journal-title":"Int J Crit Care Emerg Med"},{"key":"key20200713162805_b159-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1097\/00003246-200003000-00007","article-title":"An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients","volume":"28","author":"Galb\u00e1n","year":"2000","journal-title":"Crit Care Med"},{"key":"key20200713162805_b160-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1042\/CS20140343","article-title":"Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability","volume":"128","author":"Luiking","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"key20200713162805_b161-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1097\/CCM.0b013e318212097c","article-title":"The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis","volume":"39","author":"Gough","year":"2011","journal-title":"Crit Care Med"},{"key":"key20200713162805_b162-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.3945\/ajcn.113.075473","article-title":"Nutrition before, during, and after surgery increases the arginine:asymmetric dimethylarginine ratio and relates to improved myocardial glucose metabolism: a randomized controlled trial","volume":"99","author":"Visser","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"key20200713162805_b163-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1017\/S0007114511004648","article-title":"Imbalance of arginine and asymmetric dimethylarginine is associated with markers of circulatory failure, organ failure and mortality in shock patients","volume":"107","author":"Visser","year":"2012","journal-title":"Br J Nutr"},{"key":"key20200713162805_b164-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1097\/TA.0b013e3181d039fd","article-title":"L-arginine infusion during resuscitation for hemorrhagic shock: Impact and mechanism","volume":"72","author":"Arora","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"key20200713162805_b165-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.freeradbiomed.2004.06.025","article-title":"Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression","volume":"37","author":"Wu","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"key20200713162805_b166-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13613-019-0532-9","article-title":"Effects of different ascorbic acid doses on the mortality of critically ill patients: a meta-analysis","volume":"9","author":"Wang","year":"2019","journal-title":"Ann Intensive Care"},{"key":"key20200713162805_b167-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1001\/jama.2019.11825","article-title":"Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI Randomized Clinical Trial","volume":"322","author":"Fowler","year":"2019","journal-title":"JAMA"},{"key":"key20200713162805_b168-ijmm-46-02-0489","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/ijmm.2020.4596","article-title":"Towards effective COVID-19 vaccines: Updates, perspectives and challenges (Review)","volume":"46","author":"Calina","year":"2020","journal-title":"Int J Mol Med"},{"key":"key20200713162805_b169-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/j.1365-2796.2004.01323.x","article-title":"Serum LD1 isoenzyme and blood lymphocyte subsets as prognostic indicators for severe acute respiratory syndrome","volume":"255","author":"Chan","year":"2004","journal-title":"J Intern Med"},{"key":"key20200713162805_b170-ijmm-46-02-0489","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1093\/clinchem\/hvaa051","article-title":"Associations of cardiac, kidney, and diabetes biomarkers with peripheral neuropathy among older adults in the atherosclerosis risk in communities (ARIC) study","volume":"66","author":"Hicks","year":"2020","journal-title":"Clin Chem"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:17:10Z","timestamp":1696227430000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2020.4636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":170,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6,10]]}},"URL":"https:\/\/doi.org\/10.3892\/ijmm.2020.4636","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,10]]}}}