{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:32:08Z","timestamp":1790613128334,"version":"4.1.0"},"reference-count":308,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2026.5848","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:00:15Z","timestamp":1778220015000},"page":"1-28","source":"Crossref","is-referenced-by-count":2,"title":["Radiotherapy and cytokines: A systems view of immunotherapy and toxicity (Review)"],"prefix":"10.3892","volume":"58","author":[{"given":"Siyuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222000, P.R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"key20260609110341_b1-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.it.2018.06.001","article-title":"Immunological mechanisms responsible for radiation-induced abscopal effect","volume":"39","author":"Rodriguez-Ruiz","year":"2018","journal-title":"Trends Immunol"},{"key":"key20260609110341_b2-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"10","DOI":"10.5582\/bst.2018.01261","article-title":"Efficacy and safety of external-beam radiation therapy for hepatocellular carcinoma: An overview of current evidence according to the different target population","volume":"13","author":"Han","year":"2019","journal-title":"Biosci Trends"},{"key":"key20260609110341_b3-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/s41575-024-00900-9","article-title":"Future direction of total neoadjuvant therapy for locally advanced rectal cancer","volume":"21","author":"Kagawa","year":"2024","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"key20260609110341_b4-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/S1470-2045(24)00032-9","article-title":"Use of radiotherapy in patients with oesophageal, stomach, colon, rectal, liver, pancreatic, lung, and ovarian cancer: an International Cancer Benchmarking Partnership (ICBP) population-based study","volume":"25","author":"McPhail","year":"2024","journal-title":"Lancet Oncol"},{"key":"key20260609110341_b5-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"173sr2","DOI":"10.1126\/scitranslmed.3005148","article-title":"New paradigms and future challenges in radiation oncology: an update of biological targets and technology","volume":"5","author":"Liauw","year":"2013","journal-title":"Sci Transl Med"},{"key":"key20260609110341_b6-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nrc3007","article-title":"Strategies to improve radiotherapy with targeted drugs","volume":"11","author":"Begg","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"key20260609110341_b7-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1200\/JCO.2017.76.2229","article-title":"Safety and clinical activity of pembrolizumab and multisite stereotactic body radiotherapy in patients with advanced solid tumors","volume":"36","author":"Luke","year":"2018","journal-title":"J Clin Oncol"},{"key":"key20260609110341_b8-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.semradonc.2017.02.001","article-title":"Normal tissue constraints for abdominal and thoracic stereotactic body radiotherapy","volume":"27","author":"Pollom","year":"2017","journal-title":"Semin Radiat Oncol"},{"key":"key20260609110341_b9-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.radonc.2013.06.013","article-title":"Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up","volume":"108","author":"Vignard","year":"2013","journal-title":"Radiother Oncol"},{"key":"key20260609110341_b10-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1007\/s10495-017-1424-9","article-title":"Induction of reactive oxygen species: An emerging approach for cancer therapy","volume":"22","author":"Zou","year":"2017","journal-title":"Apoptosis"},{"key":"key20260609110341_b11-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.tips.2017.11.003","article-title":"Cancer radiosensitizers","volume":"39","author":"Wang","year":"2018","journal-title":"Trends Pharmacol Sci"},{"key":"key20260609110341_b12-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3390\/ijms17010102","article-title":"Cellular pathways in response to ionizing radiation and their targetability for tumor radiosensitization","volume":"17","author":"Maier","year":"2016","journal-title":"Int J Mol Sci"},{"key":"key20260609110341_b13-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cmet.2019.06.001","article-title":"Macrophages and metabolism in the tumor microenvironment","volume":"30","author":"Vitale","year":"2019","journal-title":"Cell Metab"},{"key":"key20260609110341_b14-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s12943-024-02183-9","article-title":"Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication","volume":"23","author":"Wang","year":"2024","journal-title":"Mol Cancer"},{"key":"key20260609110341_b15-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1182\/blood-2011-04-325225","article-title":"Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey","volume":"119","author":"Aggarwal","year":"2012","journal-title":"Blood"},{"key":"key20260609110341_b16-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.immuni.2019.03.025","article-title":"Shared and distinct functions of type I and III Interferons","volume":"50","author":"Lazear","year":"2019","journal-title":"Immunity"},{"key":"key20260609110341_b17-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"a028415","DOI":"10.1101\/cshperspect.a028415","article-title":"Interleukin-6 family cytokines","volume":"10","author":"Rose-John","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"key20260609110341_b18-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"a022145","DOI":"10.1101\/cshperspect.a022145","article-title":"TGF-beta family signaling in the control of cell proliferation and survival","volume":"9","author":"Zhang","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"key20260609110341_b19-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/s41568-021-00363-z","article-title":"Interleukins in cancer: from biology to therapy","volume":"21","author":"Briukhovetska","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"key20260609110341_b20-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.immuni.2019.03.022","article-title":"GM-CSF, IL-3, and IL-5 family of cytokines: Regulators of inflammation","volume":"50","author":"Dougan","year":"2019","journal-title":"Immunity"},{"key":"key20260609110341_b21-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth factor-\u03b2 signaling in immunity and cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"key":"key20260609110341_b22-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.immuni.2019.03.026","article-title":"Targeting interleukin-6 signaling in clinic","volume":"50","author":"Kang","year":"2019","journal-title":"Immunity"},{"key":"key20260609110341_b23-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.immuni.2019.03.028","article-title":"The \u04af(c) family of cytokines: Basic biology to therapeutic ramifications","volume":"50","author":"Leonard","year":"2019","journal-title":"Immunity"},{"key":"key20260609110341_b24-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.immuni.2019.03.012","article-title":"Interleukin-1 and related cytokines in the regulation of inflammation and immunity","volume":"50","author":"Mantovani","year":"2019","journal-title":"Immunity"},{"key":"key20260609110341_b25-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.immuni.2019.03.021","article-title":"The IL-17 family of cytokines in health and disease","volume":"50","author":"McGeachy","year":"2019","journal-title":"Immunity"},{"key":"key20260609110341_b26-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.immuni.2019.03.020","article-title":"IL-10 family cytokines IL-10 and IL-22: From basic science to clinical translation","volume":"50","author":"Ouyang","year":"2019","journal-title":"Immunity"},{"key":"key20260609110341_b27-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrc1252","article-title":"Cytokines in cancer pathogenesis and cancer therapy","volume":"4","author":"Dranoff","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"key20260609110341_b28-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.1073\/pnas.90.8.3539","article-title":"Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity","volume":"90","author":"Dranoff","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20260609110341_b29-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1089\/hum.1995.6.3-347","article-title":"Phase I study of non-replicating autologous tumor cell injections using cells prepared with or without GM-CSF gene transduction in patients with metastatic renal cell carcinoma","volume":"6","author":"Berns","year":"1995","journal-title":"Hum Gene Ther"},{"key":"key20260609110341_b30-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1073\/pnas.0712237105","article-title":"Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients","volume":"105","author":"Hodi","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20260609110341_b31-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"4712","DOI":"10.1073\/pnas.0830997100","article-title":"Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients","volume":"100","author":"Hodi","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20260609110341_b32-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1056\/NEJMoa1001294","article-title":"Sipuleucel-T immunotherapy for castration-resistant prostate cancer","volume":"363","author":"Kantoff","year":"2010","journal-title":"N Engl J Med"},{"key":"key20260609110341_b33-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1200\/JCO.2014.58.3377","article-title":"Talimogene laherparepvec improves durable response rate in patients with advanced melanoma","volume":"33","author":"Andtbacka","year":"2015","journal-title":"J Clin Oncol"},{"key":"key20260609110341_b34-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/s41584-020-0455-8","article-title":"Cell death in chronic inflammation: Breaking the cycle to treat rheumatic disease","volume":"16","author":"Anderton","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"key20260609110341_b35-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"115009","DOI":"10.1016\/j.intimp.2025.115009","article-title":"Tumor-associated macrophages inradiotherapy: Mechanisms of polarization, immune regulation and therapeutic strategies","volume":"161","author":"Xu","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"key20260609110341_b36-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"6049","DOI":"10.1038\/onc.2017.261","article-title":"Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas","volume":"36","author":"Yan","year":"2017","journal-title":"Oncogene"},{"key":"key20260609110341_b37-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1093\/neuonc\/nov272","article-title":"Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization","volume":"18","author":"Stafford","year":"2016","journal-title":"Neuro Oncol"},{"key":"key20260609110341_b38-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"11300","DOI":"10.1073\/pnas.1613187113","article-title":"Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF","volume":"113","author":"Takeshima","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20260609110341_b39-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e2504612","DOI":"10.1002\/adma.202504612","article-title":"Self-Powered \u03b1 radionuclide nanomedicine: Mitochondria-targeted multimodal energy recycling for amplified radioimmunotherapy","volume":"37","author":"Li","year":"2025","journal-title":"Adv Mater"},{"key":"key20260609110341_b40-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nrc3958","article-title":"The tumour microenvironment after radiotherapy: Mechanisms of resistance and recurrence","volume":"15","author":"Barker","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"key20260609110341_b41-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: New dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov"},{"key":"key20260609110341_b42-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"670464","DOI":"10.3389\/fonc.2021.670464","article-title":"Radiotherapy and cytokine storm: Risk and mechanism","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Oncol"},{"key":"key20260609110341_b43-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1177\/2051013617750561","article-title":"The influence of radiation in the context of developing combination immunotherapies in cancer","volume":"5","author":"Honeychurch","year":"2017","journal-title":"Ther Adv Vaccines Immunother"},{"key":"key20260609110341_b44-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nrclinonc.2016.211","article-title":"Radiotherapy and immunotherapy: A beneficial liaison?","volume":"14","author":"Weichselbaum","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"key20260609110341_b45-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/s13014-020-01678-1","article-title":"Reprogramming the tumour microenvironment by radiotherapy: Implications for radiotherapy and immunotherapy combinations","volume":"15","author":"Colton","year":"2020","journal-title":"Radiat Oncol"},{"key":"key20260609110341_b46-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"101474","DOI":"10.1016\/j.smim.2021.101474","article-title":"Radiotherapy: An immune response modifier for immuno-oncology","volume":"52","author":"De Martino","year":"2021","journal-title":"Semin Immunol"},{"key":"key20260609110341_b47-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e1523097","DOI":"10.1080\/2162402X.2018.1523097","article-title":"Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells","volume":"8","author":"Krombach","year":"2018","journal-title":"Oncoimmunology"},{"key":"key20260609110341_b48-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nrc3245","article-title":"The immune contexture in human tumours: impact on clinical outcome","volume":"12","author":"Fridman","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"key20260609110341_b49-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.21037\/tlcr-21-152","article-title":"Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition","volume":"10","author":"Liu","year":"2021","journal-title":"Transl Lung Cancer Res"},{"key":"key20260609110341_b50-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/j.ijrobp.2010.09.034","article-title":"Radiation enhances regulatory T cell representation","volume":"81","author":"Kachikwu","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b51-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"3959","DOI":"10.1038\/s41467-019-11906-2","article-title":"Tumor-reprogrammed resident T cells resist radiation to control tumors","volume":"10","author":"Arina","year":"2019","journal-title":"Nat Commun"},{"key":"key20260609110341_b52-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1158\/0008-5472.CAN-14-3511","article-title":"TGF\u03b2 is a master regulator of radiation therapy-induced antitumor immunity","volume":"75","author":"Vanpouille-Box","year":"2015","journal-title":"Cancer Res"},{"key":"key20260609110341_b53-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"5458","DOI":"10.1158\/0008-5472.CAN-14-1258","article-title":"Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade","volume":"74","author":"Dovedi","year":"2014","journal-title":"Cancer Res"},{"key":"key20260609110341_b54-ijmm-58-01-05848","first-page":"0450","article-title":"Targeting the cascade amplification of macrophage colony-stimulating factor to alleviate the immunosuppressive effects following radiotherapy","volume":"7","author":"Liao","year":"2024","journal-title":"Research (Wash D C)"},{"key":"key20260609110341_b55-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1056\/NEJMoa1809697","article-title":"Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC","volume":"379","author":"Antonia","year":"2018","journal-title":"N Engl J Med"},{"key":"key20260609110341_b56-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"key20260609110341_b57-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3390\/diagnostics12030656","article-title":"Cell signaling pathways that promote radioresistance of cancer cells","volume":"12","author":"Ouellette","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"key20260609110341_b58-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/nm1622","article-title":"Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy","volume":"13","author":"Apetoh","year":"2007","journal-title":"Nat Med"},{"key":"key20260609110341_b59-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1182\/blood-2009-02-206870","article-title":"Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: Changing strategies for cancer treatment","volume":"114","author":"Lee","year":"2009","journal-title":"Blood"},{"key":"key20260609110341_b60-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nrc.2018.6","article-title":"Using immunotherapy to boost the abscopal effect","volume":"18","author":"Ngwa","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"key20260609110341_b61-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41571-022-00709-y","article-title":"Predicting tumour radiosensitivity to deliver precision radiotherapy","volume":"20","author":"Price","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"key20260609110341_b62-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3390\/biom14070754","article-title":"FLASH radiotherapy: Mechanisms of biological effects and the therapeutic potential in cancer","volume":"14","author":"Yan","year":"2024","journal-title":"Biomolecules"},{"key":"key20260609110341_b63-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e01797","DOI":"10.1002\/advs.202501797","article-title":"FLASH irradiation modulates immune responses and accelerates lung recovery: A single-cell perspective","volume":"12","author":"Lu","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"key20260609110341_b64-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1186\/s12951-024-02855-0","article-title":"Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3","volume":"22","author":"Hu","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"key20260609110341_b65-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: A complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"key20260609110341_b66-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1158\/0008-5472.CAN-10-2820","article-title":"The efficacy of radiotherapy relies upon induction of type I interferon-dependent innate and adaptive immunity","volume":"71","author":"Burnette","year":"2011","journal-title":"Cancer Res"},{"key":"key20260609110341_b67-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.immuni.2014.10.019","article-title":"STING-Dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors","volume":"41","author":"Deng","year":"2014","journal-title":"Immunity"},{"key":"key20260609110341_b68-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"key20260609110341_b69-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature23470","article-title":"Mitotic progression following DNA damage enables pattern recognition within micronuclei","volume":"548","author":"Harding","year":"2017","journal-title":"Nature"},{"key":"key20260609110341_b70-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature23449","article-title":"cGAS surveillance of micronuclei links genome instability to innate immunity","volume":"548","author":"Mackenzie","year":"2017","journal-title":"Nature"},{"key":"key20260609110341_b71-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00262-013-1506-7","article-title":"Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8(+) T cells","volume":"63","author":"Lim","year":"2014","journal-title":"Cancer Immunol Immunother"},{"key":"key20260609110341_b72-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/s41590-020-0751-0","article-title":"Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy","volume":"21","author":"Yamazaki","year":"2020","journal-title":"Nat Immunol"},{"key":"key20260609110341_b73-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1158\/0008-5472.CAN-18-1003","article-title":"PARPi triggers the STING-Dependent immune response and enhances the therapeutic efficacy of immune checkpoint blockade independent of BRCAness","volume":"79","author":"Shen","year":"2019","journal-title":"Cancer Res"},{"key":"key20260609110341_b74-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1158\/2159-8290.CD-18-1218","article-title":"PARP inhibitor efficacy depends on CD8(+) T-cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer","volume":"9","author":"Pantelidou","year":"2019","journal-title":"Cancer Discov"},{"key":"key20260609110341_b75-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"5302","DOI":"10.1038\/onc.2014.457","article-title":"Diverse roles of STING-dependent signaling on the development of cancer","volume":"34","author":"Ahn","year":"2015","journal-title":"Oncogene"},{"key":"key20260609110341_b76-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.celrep.2017.04.031","article-title":"Interferon receptor signaling pathways regulating PD-L1 and PD-L2 expression","volume":"19","author":"Garcia-Diaz","year":"2017","journal-title":"Cell Rep"},{"key":"key20260609110341_b77-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13045-019-0721-x","article-title":"Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy","volume":"12","author":"Li","year":"2019","journal-title":"J Hematol Oncol"},{"key":"key20260609110341_b78-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.molcel.2009.09.032","article-title":"A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation","volume":"36","author":"Stilmann","year":"2009","journal-title":"Mol Cell"},{"key":"key20260609110341_b79-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"15408","DOI":"10.1073\/pnas.1512832112","article-title":"STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity","volume":"112","author":"Demaria","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20260609110341_b80-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/nature18268","article-title":"Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer","volume":"533","author":"Chen","year":"2016","journal-title":"Nature"},{"key":"key20260609110341_b81-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e181612","DOI":"10.1172\/JCI181612","article-title":"YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production","volume":"134","author":"Wen","year":"2024","journal-title":"J Clin Invest"},{"key":"key20260609110341_b82-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"102251","DOI":"10.1016\/j.xcrm.2025.102251","article-title":"Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer","volume":"6","author":"Huang","year":"2025","journal-title":"Cell Rep Med"},{"key":"key20260609110341_b83-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"18490","DOI":"10.1073\/pnas.0809242105","article-title":"An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer","volume":"105","author":"Weichselbaum","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20260609110341_b84-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.cell.2014.09.051","article-title":"Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways","volume":"159","author":"Boelens","year":"2014","journal-title":"Cell"},{"key":"key20260609110341_b85-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1101\/gad.289769.116","article-title":"A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1","volume":"31","author":"Erdal","year":"2017","journal-title":"Genes Dev"},{"key":"key20260609110341_b86-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1158\/1078-0432.CCR-17-2551","article-title":"Interferon-stimulated genes are involved in cross-resistance to radiotherapy in tamoxifen-resistant breast cancer","volume":"24","author":"Post","year":"2018","journal-title":"Clin Cancer Res"},{"key":"key20260609110341_b87-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1016\/j.cell.2016.11.022","article-title":"Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade","volume":"167","author":"Benci","year":"2016","journal-title":"Cell"},{"key":"key20260609110341_b88-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"4224","DOI":"10.1172\/JCI127458","article-title":"Type I IFN protects cancer cells from CD8+ T cell-mediated cytotoxicity after radiation","volume":"129","author":"Chen","year":"2019","journal-title":"J Clin Invest"},{"key":"key20260609110341_b89-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1111\/febs.14466","article-title":"A guide to chemokines and their receptors","volume":"285","author":"Hughes","year":"2018","journal-title":"FEBS J"},{"key":"key20260609110341_b90-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1080\/09553002.2017.1362504","article-title":"Cytokine profile of breast cell lines after different radiation doses","volume":"93","author":"Bravata","year":"2017","journal-title":"Int J Radiat Biol"},{"key":"key20260609110341_b91-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"19516","DOI":"10.3390\/ijms151119516","article-title":"X-ray-induced changes in the expression of inflammation-related genes in human peripheral blood","volume":"15","author":"Wang","year":"2014","journal-title":"Int J Mol Sci"},{"key":"key20260609110341_b92-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1667\/RR14503.1","article-title":"IL-6 mediates macrophage infiltration after irradiation via Up-regulation of CCL2\/CCL5 in Non-small cell lung cancer","volume":"187","author":"Wang","year":"2017","journal-title":"Radiat Res"},{"key":"key20260609110341_b93-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1038\/s41467-017-01566-5","article-title":"Host STING-dependent MDSC mobilization drives extrinsic radiation resistance","volume":"8","author":"Liang","year":"2017","journal-title":"Nat Commun"},{"key":"key20260609110341_b94-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1158\/2326-6066.CIR-18-0633","article-title":"CCR2-dependent recruitment of tregs and monocytes following radiotherapy is associated with TNF\u03b1-mediated resistance","volume":"7","author":"Mondini","year":"2019","journal-title":"Cancer Immunol Res"},{"key":"key20260609110341_b95-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1158\/1078-0432.CCR-16-0870","article-title":"Tumor-derived CCL2 mediates resistance to radiotherapy in pancreatic ductal adenocarcinoma","volume":"23","author":"Kalbasi","year":"2017","journal-title":"Clin Cancer Res"},{"key":"key20260609110341_b96-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1089\/ars.2017.7458","article-title":"Inhibition of radiation-induced Ccl2 signaling protects lungs from vascular dysfunction and endothelial cell loss","volume":"30","author":"Wiesemann","year":"2019","journal-title":"Antioxid Redox Signal"},{"key":"key20260609110341_b97-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bbi.2012.09.010","article-title":"Absence of CCL2 is sufficient to restore hippocampal neurogenesis following cranial irradiation","volume":"30","author":"Lee","year":"2013","journal-title":"Brain Behav Immun"},{"key":"key20260609110341_b98-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.2353\/ajpath.2010.090505","article-title":"Single-dose gamma-irradiation induces up-regulation of chemokine gene expression and recruitment of granulocytes into the portal area but not into other regions of rat hepatic tissue","volume":"176","author":"Malik","year":"2010","journal-title":"Am J Pathol"},{"key":"key20260609110341_b99-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.ijrobp.2020.06.022","article-title":"Intratumoral hydrogen peroxide with radiation therapy in locally advanced breast cancer: Results from a phase 1 clinical trial","volume":"108","author":"Nimalasena","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b100-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"7719","DOI":"10.2147\/OTT.S257852","article-title":"Radiotherapy increases 12-LOX and CCL5 levels in esophageal cancer cells and promotes cancer metastasis via THP-1-Derived macrophages","volume":"13","author":"Mi","year":"2020","journal-title":"Onco Targets Ther"},{"key":"key20260609110341_b101-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/s41419-020-2546-5","article-title":"Irradiation induces cancer lung metastasis through activation of the cGAS-STING-CCL5 pathway in mesenchymal stromal cells","volume":"11","author":"Zheng","year":"2020","journal-title":"Cell Death Dis"},{"key":"key20260609110341_b102-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"11934","DOI":"10.1038\/s41598-018-30417-6","article-title":"Inhibiting the CD8(+) T cell infiltration in the tumor microenvironment after radiotherapy is an important mechanism of radioresistance","volume":"8","author":"Chen","year":"2018","journal-title":"Sci Rep"},{"key":"key20260609110341_b103-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.canlet.2018.01.037","article-title":"Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment","volume":"418","author":"Yan","year":"2018","journal-title":"Cancer Lett"},{"key":"key20260609110341_b104-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"eaan0333","DOI":"10.1126\/scitranslmed.aan0333","article-title":"Eosinophil depletion suppresses radiation-induced small intestinal fibrosis","volume":"10","author":"Takemura","year":"2018","journal-title":"Sci Transl Med"},{"key":"key20260609110341_b105-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.bbrc.2015.05.081","article-title":"Single high-dose irradiation aggravates eosinophil-mediated fibrosis through IL-33 secreted from impaired vessels in the skin compared to fractionated irradiation","volume":"464","author":"Lee","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"key20260609110341_b106-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1080\/09553002.2018.1431699","article-title":"A role for endothelial cells in radiation-induced inflammation","volume":"94","author":"Bostrom","year":"2018","journal-title":"Int J Radiat Biol"},{"key":"key20260609110341_b107-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1667\/0033-7587(2002)157[0256:RIPFEO]2.0.CO;2","article-title":"Radiation-induced pulmonary fibrosis: Examination of chemokine and chemokine receptor families","volume":"157","author":"Johnston","year":"2002","journal-title":"Radiat Res"},{"key":"key20260609110341_b108-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1084\/jem.20170277","article-title":"CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes","volume":"216","author":"Rapp","year":"2019","journal-title":"J Exp Med"},{"key":"key20260609110341_b109-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.cell.2018.01.004","article-title":"NK Cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control","volume":"172","author":"Bottcher","year":"2018","journal-title":"Cell"},{"key":"key20260609110341_b110-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.4049\/jimmunol.181.5.3099","article-title":"Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells","volume":"181","author":"Matsumura","year":"2008","journal-title":"J Immunol"},{"key":"key20260609110341_b111-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1172\/JCI40283","article-title":"Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice","volume":"120","author":"Kioi","year":"2010","journal-title":"J Clin Invest"},{"key":"key20260609110341_b112-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1158\/0008-5472.CAN-12-2989","article-title":"CCR2 deficiency prevents neuronal dysfunction and cognitive impairments induced by cranial irradiation","volume":"73","author":"Belarbi","year":"2013","journal-title":"Cancer Res"},{"key":"key20260609110341_b113-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3389\/fimmu.2017.00517","article-title":"Ionizing radiation-induced immune and inflammatory reactions in the brain","volume":"8","author":"Lumniczky","year":"2017","journal-title":"Front Immunol"},{"key":"key20260609110341_b114-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13014-022-02038-x","article-title":"The roles of CC chemokines in response to radiation","volume":"17","author":"Wang","year":"2022","journal-title":"Radiat Oncol"},{"key":"key20260609110341_b115-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1007\/s00262-023-03379-6","article-title":"Radiotherapy enhances CXCR3(high)CD8(+) T cell activation through inducing IFNgamma-mediated CXCL10 and ICAM-1 expression in lung cancer cells","volume":"72","author":"Wang","year":"2023","journal-title":"Cancer Immunol Immunother"},{"key":"key20260609110341_b116-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.yexcr.2018.11.022","article-title":"NF\u0138B and TNF\u03b1 as individual key molecules associated with the cisplatin-resistance and radioresistance of lung cancer","volume":"374","author":"Zhu","year":"2019","journal-title":"Exp Cell Res"},{"key":"key20260609110341_b117-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3390\/diseases12030055","article-title":"Serum pro-inflammatory cytokines and leptin as potential biomarkers for treatment response and toxicity in locally advanced squamous cell carcinoma of the head and neck","volume":"12","author":"Alrehaili","year":"2024","journal-title":"Diseases"},{"key":"key20260609110341_b118-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"7145","DOI":"10.1038\/s41467-025-62558-4","article-title":"PROCR diminishes the efficacy of radiation by impairing T-cell-mediated antitumour immunity","volume":"16","author":"Chen","year":"2025","journal-title":"Nat Commun"},{"key":"key20260609110341_b119-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2238499","DOI":"10.1080\/2162402X.2023.2238499","article-title":"A mechanism of IL-34-induced resistance against cytotoxic anti-cancer therapies such as radiation by X-ray and chemotherapy by Oxaliplatin","volume":"12","author":"Han","year":"2023","journal-title":"Oncoimmunology"},{"key":"key20260609110341_b120-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"EAAG1266","DOI":"10.1126\/sciimmunol.aag1266","article-title":"The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications","volume":"1","author":"Spiotto","year":"2016","journal-title":"Sci Immunol"},{"key":"key20260609110341_b121-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.2174\/1871520622666220404090049","article-title":"Repurposing of various current medicines as radioprotective agents","volume":"23","author":"Kaur","year":"2023","journal-title":"Anticancer Agents Med Chem"},{"key":"key20260609110341_b122-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/lsm.22349","article-title":"Effect of low-level laser therapy on chemoradiotherapy-induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients","volume":"47","author":"Oton-Leite","year":"2015","journal-title":"Lasers Surg Med"},{"key":"key20260609110341_b123-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s13014-015-0527-0","article-title":"Dexamethasone administration during definitive radiation and temozolomide renders a poor prognosis in a retrospective analysis of newly diagnosed glioblastoma patients","volume":"10","author":"Shields","year":"2015","journal-title":"Radiat Oncol"},{"key":"key20260609110341_b124-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1080\/09553002.2017.1325024","article-title":"Synergistic effect of Ebselen and gamma radiation on breast cancer cells","volume":"93","author":"Thabet","year":"2017","journal-title":"Int J Radiat Biol"},{"key":"key20260609110341_b125-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/cei.12344","article-title":"Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function","volume":"179","author":"Wunderlich","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"key20260609110341_b126-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"104690","DOI":"10.1016\/j.isci.2022.104690","article-title":"Irradiation combined with PD-L1(\u2212\/\u2212) and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation","volume":"25","author":"Zhao","year":"2022","journal-title":"iScience"},{"key":"key20260609110341_b127-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1007\/s00432-015-1974-6","article-title":"Radiation-induced fibrosis: Mechanisms and implications for therapy","volume":"141","author":"Straub","year":"2015","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20260609110341_b128-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1007\/s10753-017-0568-7","article-title":"The fatty acid amide hydrolase inhibitor URB937 ameliorates radiation-induced lung injury in a mouse model","volume":"40","author":"Li","year":"2017","journal-title":"Inflammation"},{"key":"key20260609110341_b129-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/s12185-015-1743-y","article-title":"Phase 1 study in Japan of siltuximab, an anti-IL-6 monoclonal antibody, in relapsed\/refractory multiple myeloma","volume":"101","author":"Suzuki","year":"2015","journal-title":"Int J Hematol"},{"key":"key20260609110341_b130-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"7415","DOI":"10.1016\/j.vaccine.2015.05.105","article-title":"In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment","volume":"33","author":"Vanpouille-Box","year":"2015","journal-title":"Vaccine"},{"key":"key20260609110341_b131-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3389\/fonc.2019.00367","article-title":"Radiotherapy in combination with cytokine treatment","volume":"9","author":"Palata","year":"2019","journal-title":"Front Oncol"},{"key":"key20260609110341_b132-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/s41577-019-0167-y","article-title":"How macrophages deal with death","volume":"19","author":"Lemke","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"key20260609110341_b133-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.neuron.2022.12.009","article-title":"Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8(+) T lymphocytes","volume":"111","author":"Shi","year":"2023","journal-title":"Neuron"},{"key":"key20260609110341_b134-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3109\/09553002.2012.689464","article-title":"Low dose ionising radiation leads to a NF-kappaB dependent decreased secretion of active IL-1beta by activated macrophages with a discontinuous dose-dependency","volume":"88","author":"Lodermann","year":"2012","journal-title":"Int J Radiat Biol"},{"key":"key20260609110341_b135-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1093\/carcin\/bgw007","article-title":"Low doses of gamma irradiation potentially modifies immunosuppressive tumor microenvironment by retuning tumor-associated macrophages: lesson from insulinoma","volume":"37","author":"Prakash","year":"2016","journal-title":"Carcinogenesis"},{"key":"key20260609110341_b136-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1038\/cdd.2017.91","article-title":"NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy","volume":"24","author":"Wu","year":"2017","journal-title":"Cell Death Differ"},{"key":"key20260609110341_b137-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"18765","DOI":"10.1038\/srep18765","article-title":"Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities","volume":"6","author":"Teresa Pinto","year":"2016","journal-title":"Sci Rep"},{"key":"key20260609110341_b138-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e000667","DOI":"10.1136\/jitc-2020-000667","article-title":"Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer","volume":"8","author":"Stary","year":"2020","journal-title":"J Immunother Cancer"},{"key":"key20260609110341_b139-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e39295","DOI":"10.1371\/journal.pone.0039295","article-title":"Expression of NF-kappaB p50 in tumor stroma limits the control of tumors by radiation therapy","volume":"7","author":"Crittenden","year":"2012","journal-title":"PLoS One"},{"key":"key20260609110341_b140-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41590-019-0561-4","article-title":"Immunological impact of cell death signaling driven by radiation on the tumor microenvironment","volume":"21","author":"Rodriguez-Ruiz","year":"2020","journal-title":"Nat Immunol"},{"key":"key20260609110341_b141-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1186\/s12967-024-05797-1","article-title":"miR-1226-5p is involved in radioresistance of colorectal cancer by activating M2 macrophages through suppressing IRF1","volume":"22","author":"Choi","year":"2024","journal-title":"J Transl Med"},{"key":"key20260609110341_b142-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ijrobp.2022.06.054","article-title":"Tumor-Derived C-C motif ligand 2 induces the recruitment and polarization of tumor-associated macrophages and increases the metastatic potential of bladder cancer cells in the postirradiated microenvironment","volume":"114","author":"Chiang","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b143-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.3390\/biomedicines11072081","article-title":"Tumor-Associated macrophages affect the tumor microenvironment and radioresistance via the upregulation of CXCL6\/CXCR2 in hepatocellular carcinoma","volume":"11","author":"Lee","year":"2023","journal-title":"Biomedicines"},{"key":"key20260609110341_b144-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e30808","DOI":"10.1016\/j.heliyon.2024.e30808","article-title":"Tumor cell-derived exosomal miR-193b-3p promotes tumor-associated macrophage activation to facilitate nasopharyngeal cancer cell invasion and radioresistances","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"key20260609110341_b145-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/s41419-021-04087-8","article-title":"Exosomal transfer of tumor-associated macrophage-derived hsa_ circ_0001610 reduces radiosensitivity in endometrial cancer","volume":"12","author":"Gu","year":"2021","journal-title":"Cell Death Dis"},{"key":"key20260609110341_b146-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.3390\/cancers15051620","article-title":"Cancer-associated fibroblasts exposed to high-dose ionizing radiation promote M2 polarization of macrophages, which induce radiosensitivity in cervical cancer","volume":"15","author":"Sheng","year":"2023","journal-title":"Cancers (Basel)"},{"key":"key20260609110341_b147-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1158\/0008-5472.CAN-09-2995","article-title":"Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy","volume":"70","author":"Meng","year":"2010","journal-title":"Cancer Res"},{"key":"key20260609110341_b148-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3892\/or.2020.7628","article-title":"M2 macrophages reduce the radiosensitivity of head and neck cancer by releasing HB-EGF","volume":"44","author":"Fu","year":"2020","journal-title":"Oncol Rep"},{"key":"key20260609110341_b149-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.ccr.2013.09.014","article-title":"Low-dose irradiation programs macrophage differentiation to an iNOS(+)\/M1 phenotype that orchestrates effective T cell immunotherapy","volume":"24","author":"Klug","year":"2013","journal-title":"Cancer Cell"},{"key":"key20260609110341_b150-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"926","DOI":"10.7150\/ijbs.57445","article-title":"Macrophage contributes to radiation-induced anti-tumor abscopal effect on transplanted breast cancer by HMGB1\/TNF-\u03b1 signaling factors","volume":"17","author":"Zhu","year":"2021","journal-title":"Int J Biol Sci"},{"key":"key20260609110341_b151-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1021\/acs.bioconjchem.4c00488","article-title":"Iron oxide nanoparticles induce macrophage secretion of ATP and HMGB1 to enhance irradiation-led immunogenic cell death","volume":"36","author":"Zhan","year":"2025","journal-title":"Bioconjug Chem"},{"key":"key20260609110341_b152-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"eaay9789","DOI":"10.1126\/sciadv.aay9789","article-title":"Irradiated tumor cell-derived microparticles mediate tumor eradication via cell killing and immune reprogramming","volume":"6","author":"Wan","year":"2020","journal-title":"Sci Adv"},{"key":"key20260609110341_b153-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"86522","DOI":"10.18632\/oncotarget.13287","article-title":"Increasing the efficacy of radiotherapy by modulating the CCR2\/CCR5 chemokine axes","volume":"7","author":"Connolly","year":"2016","journal-title":"Oncotarget"},{"key":"key20260609110341_b154-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1158\/0008-5472.CAN-12-3981","article-title":"CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer","volume":"73","author":"Xu","year":"2013","journal-title":"Cancer Res"},{"key":"key20260609110341_b155-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.ijrobp.2018.06.401","article-title":"VEGF-Grab enhances the efficacy of radiation therapy by blocking VEGF-A and treatment-induced PlGF","volume":"102","author":"Park","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b156-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.semcdb.2014.12.005","article-title":"Smac mimetics as IAP antagonists","volume":"39","author":"Fulda","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"key20260609110341_b157-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1038\/s41467-019-10354-2","article-title":"A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages","volume":"10","author":"Feng","year":"2019","journal-title":"Nat Commun"},{"key":"key20260609110341_b158-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s41551-018-0236-8","article-title":"TLR7\/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy","volume":"2","author":"Rodell","year":"2018","journal-title":"Nat Biomed Eng"},{"key":"key20260609110341_b159-ijmm-58-01-05848","first-page":"359","article-title":"Polarization of tumor-associated macrophages by TLR7\/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance","volume":"16","author":"Zhang","year":"2022","journal-title":"Bioact Mater"},{"key":"key20260609110341_b160-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1038\/nnano.2016.168","article-title":"Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues","volume":"11","author":"Zanganeh","year":"2016","journal-title":"Nat Nanotechnol"},{"key":"key20260609110341_b161-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.ymthe.2023.12.012","article-title":"Irradiated engineered tumor cell-derived microparticles remodel the tumor immune microenvironment and enhance antitumor immunity","volume":"32","author":"Hu","year":"2024","journal-title":"Mol Ther"},{"key":"key20260609110341_b162-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1530890","DOI":"10.3389\/fimmu.2025.1530890","article-title":"Insights into CSF-1\/CSF-1R signaling: the role of macrophage in radiotherapy","volume":"16","author":"Shang","year":"2025","journal-title":"Front Immunol"},{"key":"key20260609110341_b163-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41572-019-0064-5","article-title":"Radiotherapy toxicity","volume":"5","author":"De Ruysscher","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"key20260609110341_b164-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/nrneurol.2016.185","article-title":"Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours","volume":"13","author":"Makale","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"key20260609110341_b165-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates Abeta-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model","volume":"22","author":"Zhang","year":"2019","journal-title":"Nat Neurosci"},{"key":"key20260609110341_b166-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e2304609","DOI":"10.1002\/advs.202304609","article-title":"Radiotherapy-Induced astrocyte senescence promotes an immunosuppressive microenvironment in glioblastoma to facilitate tumor regrowth","volume":"11","author":"Ji","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"key20260609110341_b167-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1186\/s12974-020-02001-1","article-title":"Regulatory coupling between long noncoding RNAs and senescence in irradiated microglia","volume":"17","author":"Xu","year":"2020","journal-title":"J Neuroinflammation"},{"key":"key20260609110341_b168-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1093\/neuonc\/noae153","article-title":"Defective autophagy of pericytes enhances radiation-induced senescence promoting radiation brain injury","volume":"26","author":"Luo","year":"2024","journal-title":"Neuro Oncol"},{"key":"key20260609110341_b169-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1667\/RR1269.1","article-title":"Transient inflammation in neurogenic regions after irradiation of the developing brain","volume":"171","author":"Kalm","year":"2009","journal-title":"Radiat Res"},{"key":"key20260609110341_b170-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3109\/09553002.2014.942015","article-title":"Different reactions to irradiation in the juvenile and adult hippocampus","volume":"90","author":"Blomstrand","year":"2014","journal-title":"Int J Radiat Biol"},{"key":"key20260609110341_b171-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1093\/gerona\/glt057","article-title":"Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity","volume":"68","author":"Ungvari","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key20260609110341_b172-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nn.3954","article-title":"Frequency-specific hippocampal-prefrontal interactions during associative learning","volume":"18","author":"Brincat","year":"2015","journal-title":"Nat Neurosci"},{"key":"key20260609110341_b173-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3389\/fncel.2019.00241","article-title":"Selective neural deletion of the Atg7 gene reduces irradiation-induced cerebellar white matter injury in the juvenile mouse brain by ameliorating oligodendrocyte progenitor cell loss","volume":"13","author":"Wang","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"key20260609110341_b174-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1126\/science.aag3048","article-title":"Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging","volume":"359","author":"Leeman","year":"2018","journal-title":"Science"},{"key":"key20260609110341_b175-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1007\/s11033-018-4552-6","article-title":"Effects of minocycline and rapamycin in gamma-irradiated human embryonic stem cells-derived cerebral organoids","volume":"46","author":"Shakhbazau","year":"2019","journal-title":"Mol Biol Rep"},{"key":"key20260609110341_b176-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/s43587-022-00278-w","article-title":"Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy","volume":"2","author":"Juricic","year":"2022","journal-title":"Nat Aging"},{"key":"key20260609110341_b177-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"eaba8426","DOI":"10.1126\/sciimmunol.aba8426","article-title":"All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages","volume":"6","author":"Rao","year":"2021","journal-title":"Sci Immunol"},{"key":"key20260609110341_b178-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"111131","DOI":"10.1016\/j.mad.2019.111131","article-title":"Regulation of cellular senescence by retinoid X receptors and their partners","volume":"183","author":"Martin","year":"2019","journal-title":"Mech Ageing Dev"},{"key":"key20260609110341_b179-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s12974-022-02596-7","article-title":"Pregabalin mitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury","volume":"19","author":"Zhang","year":"2022","journal-title":"J Neuroinflammation"},{"key":"key20260609110341_b180-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1093\/neuonc\/noae077","article-title":"EDA2R reflects the acute brain response to cranial irradiation in liquid biopsies","volume":"26","author":"Lastra Romero","year":"2024","journal-title":"Neuro Oncol"},{"key":"key20260609110341_b181-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/s41586-023-06047-y","article-title":"EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia","volume":"617","author":"Bilgic","year":"2023","journal-title":"Nature"},{"key":"key20260609110341_b182-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"84","DOI":"10.15586\/aei.v50i5.670","article-title":"Knockdown of EDA2R alleviates hyperoxia-induced lung epithelial cell injury by inhibiting NF-\u0138B pathway","volume":"50","author":"Jia","year":"2022","journal-title":"Allergol Immunopathol (Madr)"},{"key":"key20260609110341_b183-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia function in the central nervous system during health and neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu Rev Immunol"},{"key":"key20260609110341_b184-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jneuroim.2008.11.002","article-title":"Irradiation-induced loss of microglia in the young brain","volume":"206","author":"Kalm","year":"2009","journal-title":"J Neuroimmunol"},{"key":"key20260609110341_b185-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"107699","DOI":"10.1016\/j.celrep.2020.107699","article-title":"Radiation triggers a dynamic sequence of transient microglial alterations in juvenile brain","volume":"31","author":"Osman","year":"2020","journal-title":"Cell Rep"},{"key":"key20260609110341_b186-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1126\/science.1088417","article-title":"Inflammatory blockade restores adult hippocampal neurogenesis","volume":"302","author":"Monje","year":"2003","journal-title":"Science"},{"key":"key20260609110341_b187-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.ijrobp.2003.09.045","article-title":"Target cells in radiation pneumopathy","volume":"58","author":"Trott","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b188-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/s00066-004-1265-7","article-title":"Irradiation induces a biphasic expression of pro-inflammatory cytokines in the lung","volume":"180","author":"Rube","year":"2004","journal-title":"Strahlenther Onkol"},{"key":"key20260609110341_b189-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0360-3016(03)01444-5","article-title":"Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: A double-blind randomized trial","volume":"58","author":"Ozturk","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b190-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s13014-020-01654-9","article-title":"Radiation-induced lung toxicity-cellular and molecular mechanisms of pathogenesis, management, and literature review","volume":"15","author":"Kasmann","year":"2020","journal-title":"Radiat Oncol"},{"key":"key20260609110341_b191-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.jacbts.2018.01.014","article-title":"Radiation-induced endothelial vascular injury: A review of possible mechanisms","volume":"3","author":"Venkatesulu","year":"2018","journal-title":"JACC Basic Transl Sci"},{"key":"key20260609110341_b192-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41577-021-00568-1","article-title":"Immunomodulation by radiotherapy in tumour control and normal tissue toxicity","volume":"22","author":"Cytlak","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"key20260609110341_b193-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/jrr\/rraa119","article-title":"\u03b2-Catenin\/Lin28\/let-7 regulatory network determines type II alveolar epithelial stem cell differentiation phenotypes following thoracic irradiation","volume":"62","author":"Liu","year":"2021","journal-title":"J Radiat Res"},{"key":"key20260609110341_b194-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1158\/1078-0432.CCR-19-1868","article-title":"Macrophage-derived CXCL9 and CXCL10 are required for antitumor immune responses following immune checkpoint blockade","volume":"26","author":"House","year":"2020","journal-title":"Clin Cancer Res"},{"key":"key20260609110341_b195-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1186\/s12967-023-04446-3","article-title":"STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury","volume":"21","author":"Ni","year":"2023","journal-title":"J Transl Med"},{"key":"key20260609110341_b196-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"678457","DOI":"10.3389\/fimmu.2021.678457","article-title":"Roles of macrophage polarization and macrophage-derived miRNAs in pulmonary fibrosis","volume":"12","author":"Kishore","year":"2021","journal-title":"Front Immunol"},{"key":"key20260609110341_b197-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s12964-024-01557-2","article-title":"The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: A review","volume":"22","author":"Zhou","year":"2024","journal-title":"Cell Commun Signal"},{"key":"key20260609110341_b198-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1183\/09031936.04.00110203","article-title":"CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis","volume":"24","author":"Inoue","year":"2004","journal-title":"Eur Respir J"},{"key":"key20260609110341_b199-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e173649","DOI":"10.1172\/JCI173649","article-title":"TRAIL agonists rescue mice from radiation-induced lung, skin, or esophageal injury","volume":"135","author":"Strandberg","year":"2025","journal-title":"J Clin Invest"},{"key":"key20260609110341_b200-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/s43018-021-00245-1","article-title":"Radiation-activated secretory proteins of Scgb1a1(+) club cells increase the efficacy of immune checkpoint blockade in lung cancer","volume":"2","author":"Ban","year":"2021","journal-title":"Nat Cancer"},{"key":"key20260609110341_b201-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.ijrobp.2013.07.029","article-title":"Predicting esophagitis after chemoradiation therapy for non-small cell lung cancer: An individual patient data meta-analysis","volume":"87","author":"Palma","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b202-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.ijrobp.2012.01.071","article-title":"Predictors of high-grade esophagitis after definitive three-dimensional conformal therapy, intensity-modulated radiation therapy, or proton beam therapy for non-small cell lung cancer","volume":"84","author":"Gomez","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b203-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1200\/JCO.2009.27.1205","article-title":"Primary analysis of the phase II component of a phase I\/II dose intensification study using three-dimensional conformal radiation therapy and concurrent chemotherapy for patients with inoperable non-small-cell lung cancer: RTOG 0117","volume":"28","author":"Bradley","year":"2010","journal-title":"J Clin Oncol"},{"key":"key20260609110341_b204-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"120215","DOI":"10.1016\/j.lfs.2021.120215","article-title":"Interferon-alpha exerts proinflammatory properties in experimental radiation-induced esophagitis: Possible involvement of plasmacytoid dendritic cells","volume":"289","author":"Kitamura","year":"2022","journal-title":"Life Sci"},{"key":"key20260609110341_b205-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00441-010-1030-4","article-title":"Mucosal dendritic cell diversity in the gastrointestinal tract","volume":"343","author":"Fries","year":"2011","journal-title":"Cell Tissue Res"},{"key":"key20260609110341_b206-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.cytogfr.2007.10.006","article-title":"Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history","volume":"19","author":"Fitzgerald-Bocarsly","year":"2008","journal-title":"Cytokine Growth Factor Rev"},{"key":"key20260609110341_b207-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.immuni.2018.12.027","article-title":"Plasmacytoid dendritic cells: Development, regulation, and function","volume":"50","author":"Reizis","year":"2019","journal-title":"Immunity"},{"key":"key20260609110341_b208-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1007\/s00384-015-2289-4","article-title":"Chronic radiation proctitis: Tricks to prevent and treat","volume":"30","author":"Vanneste","year":"2015","journal-title":"Int J Colorectal Dis"},{"key":"key20260609110341_b209-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"eabc2344","DOI":"10.1126\/scitranslmed.abc2344","article-title":"Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy","volume":"13","author":"Lu","year":"2021","journal-title":"Sci Transl Med"},{"key":"key20260609110341_b210-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e2306217","DOI":"10.1002\/advs.202306217","article-title":"Gut microbiota-derived 3-hydroxybutyrate blocks GPR43-Mediated IL6 signaling to ameliorate radiation proctopathy","volume":"11","author":"Ge","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"key20260609110341_b211-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.1080\/15384101.2019.1670508","article-title":"HIF-1\u03b1 promotes the keloid development through the activation of TGF-beta\/Smad and TLR4\/MyD88\/NF-\u0138B pathways","volume":"18","author":"Lei","year":"2019","journal-title":"Cell Cycle"},{"key":"key20260609110341_b212-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s11481-014-9531-7","article-title":"Vascular endothelial growth factor signaling in hypoxia and inflammation","volume":"9","author":"Ramakrishnan","year":"2014","journal-title":"J Neuroimmune Pharmacol"},{"key":"key20260609110341_b213-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"9128128","DOI":"10.1155\/2018\/9128128","article-title":"Evaluation of mediators associated with the inflammatory response in prostate cancer patients undergoing radiotherapy","volume":"2018","author":"Bedini","year":"2018","journal-title":"Dis Markers"},{"key":"key20260609110341_b214-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.3390\/cancers15061670","article-title":"Release of Interferon-\u03b2 (IFN-\u03b2) from probiotic limosilactobacillus reuteri-IFN-\u03b2 (LR-IFN-\u03b2) mitigates gastrointestinal acute radiation syndrome (GI-ARS) following whole abdominal irradiation","volume":"15","author":"Hamade","year":"2023","journal-title":"Cancers (Basel)"},{"key":"key20260609110341_b215-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2347722","DOI":"10.1080\/19490976.2024.2347722","article-title":"Microbiota-derived I3A protects the intestine against radiation injury by activating AhR\/IL-10\/Wnt signaling and enhancing the abundance of probiotics","volume":"16","author":"Xie","year":"2024","journal-title":"Gut Microbes"},{"key":"key20260609110341_b216-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.ijrobp.2016.02.036","article-title":"Proton beam reirradiation for recurrent head and neck cancer: Multi-institutional report on feasibility and early outcomes","volume":"95","author":"Romesser","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b217-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"20680","DOI":"10.18632\/oncotarget.8004","article-title":"The efficacy and toxicity of individualized intensity-modulated radiotherapy based on the tumor extension patterns of nasopharyngeal carcinoma","volume":"7","author":"Lin","year":"2016","journal-title":"Oncotarget"},{"key":"key20260609110341_b218-ijmm-58-01-05848","first-page":"57","article-title":"The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies","volume":"72","author":"Elad","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"key20260609110341_b219-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10103-023-03940-w","article-title":"Impact of photobiomodulation for prevention of oral mucositis on the quality of life of patients with head and neck cancer: A systematic review","volume":"39","author":"Potrich","year":"2023","journal-title":"Lasers Med Sci"},{"key":"key20260609110341_b220-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nrc1318","article-title":"The pathobiology of mucositis","volume":"4","author":"Sonis","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"key20260609110341_b221-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.4161\/cbt.7.7.6207","article-title":"Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs","volume":"7","author":"Logan","year":"2008","journal-title":"Cancer Biol Ther"},{"key":"key20260609110341_b222-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1177\/0022034516641890","article-title":"Host-Microbiome cross-talk in oral mucositis","volume":"95","author":"Vasconcelos","year":"2016","journal-title":"J Dent Res"},{"key":"key20260609110341_b223-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nature18847","article-title":"The microbiome and innate immunity","volume":"535","author":"Thaiss","year":"2016","journal-title":"Nature"},{"key":"key20260609110341_b224-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/j.1601-0825.2006.01254.x","article-title":"Histomorphometry and immunohistochemical features of grade I (WHO) oral radiomucositis","volume":"13","author":"Bonan","year":"2007","journal-title":"Oral Diseases"},{"key":"key20260609110341_b225-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.3389\/fimmu.2018.01212","article-title":"Effector T helper cell subsets in inflammatory bowel diseases","volume":"9","author":"Imam","year":"2018","journal-title":"Front Immunol"},{"key":"key20260609110341_b226-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nrneph.2017.112","article-title":"T helper type 17 cells in immune-mediated glomerular disease","volume":"13","author":"Krebs","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"key20260609110341_b227-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.tranon.2018.03.014","article-title":"A review of clinical radioprotection and chemoprotection for oral mucositis","volume":"11","author":"Oronsky","year":"2018","journal-title":"Transl Oncol"},{"key":"key20260609110341_b228-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1007\/s12094-021-02586-w","article-title":"Randomized placebo-controlled phase II trial of high-dose melatonin mucoadhesive oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing radiation therapy concurrent with systemic treatment","volume":"23","author":"Lozano","year":"2021","journal-title":"Clin Transl Oncol"},{"key":"key20260609110341_b229-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.ijrobp.2019.10.023","article-title":"Randomized phase 2 trial of a novel clonidine mucoadhesive buccal tablet for the amelioration of oral mucositis in patients treated with concomitant chemoradiation therapy for head and neck cancer","volume":"106","author":"Giralt","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b230-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/s13054-019-2690-4","article-title":"The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: A systematic review of animal and human studies","volume":"23","author":"Flanders","year":"2019","journal-title":"Crit Care"},{"key":"key20260609110341_b231-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1164\/ajrccm.159.2.9804085","article-title":"Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages","volume":"159","author":"Marques","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"key20260609110341_b232-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s12032-019-1334-5","article-title":"Pentoxifylline and vitamin E reduce the severity of radiotherapy-induced oral mucositis and dysphagia in head and neck cancer patients: A randomized, controlled study","volume":"37","author":"Sayed","year":"2019","journal-title":"Med Oncol"},{"key":"key20260609110341_b233-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1186\/s12903-022-02348-2","article-title":"A prospective interventional study of recombinant human interleukin-11 mouthwash in chemotherapy-induced oral mucositis","volume":"22","author":"Wei","year":"2022","journal-title":"BMC Oral Health"},{"key":"key20260609110341_b234-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1186\/s12903-023-03118-4","article-title":"Efficacy of recombinant human interleukin-11 in preventing and treating oral mucositis after chemotherapy for patients with acute leukemia","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Oral Health"},{"key":"key20260609110341_b235-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1111\/bph.12131","article-title":"Curcumin: An orally bioavailable blocker of TNF and other pro-inflammatory biomarkers","volume":"169","author":"Aggarwal","year":"2013","journal-title":"Br J Pharmacol"},{"key":"key20260609110341_b236-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/NCC.0000000000001149","article-title":"Randomized control study of the effects of turmeric mouthwash on oral health status, treatment-induced mucositis, and associated oral dysfunctions among patients with head and neck cancer","volume":"46","author":"Thomas","year":"2023","journal-title":"Cancer Nurs"},{"key":"key20260609110341_b237-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1186\/s12885-023-10730-8","article-title":"Efficacy of curcumin for amelioration of radiotherapy-induced oral mucositis: A preliminary randomized controlled clinical trial","volume":"23","author":"Ramezani","year":"2023","journal-title":"BMC Cancer"},{"key":"key20260609110341_b238-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s10103-016-1904-0","article-title":"Photobiomodulation regulates cytokine release and new blood vessel formation during oral wound healing in rats","volume":"31","author":"Wagner","year":"2016","journal-title":"Lasers Med Sci"},{"key":"key20260609110341_b239-ijmm-58-01-05848","first-page":"3969","article-title":"Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines","volume":"27","author":"Zadik","year":"2019","journal-title":"Support Care Cancer"},{"key":"key20260609110341_b240-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"4423","DOI":"10.1002\/cncr.33100","article-title":"MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy","volume":"126","author":"Elad","year":"2020","journal-title":"Cancer"},{"key":"key20260609110341_b241-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"927685","DOI":"10.3389\/fonc.2022.927685","article-title":"Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022","volume":"12","author":"Robijns","year":"2022","journal-title":"Front Oncol"},{"key":"key20260609110341_b242-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1021\/acsmedchemlett.1c00662","article-title":"Contemporary computational applications and tools in drug discovery","volume":"13","author":"Cox","year":"2022","journal-title":"ACS Med Chem Lett"},{"key":"key20260609110341_b243-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"key20260609110341_b244-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e359","DOI":"10.1038\/emm.2017.85","article-title":"Radiation-induced liver disease: Current understanding and future perspectives","volume":"49","author":"Kim","year":"2017","journal-title":"Exp Mol Med"},{"key":"key20260609110341_b245-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.semradonc.2011.05.003","article-title":"Hepatic radiation toxicity: Avoidance and amelioration","volume":"21","author":"Guha","year":"2011","journal-title":"Semin Radiat Oncol"},{"key":"key20260609110341_b246-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"594789","DOI":"10.3389\/fpubh.2020.594789","article-title":"Low radiation environment switches the overgrowth-induced cell apoptosis toward autophagy","volume":"8","author":"Fischietti","year":"2021","journal-title":"Front Public Health"},{"key":"key20260609110341_b247-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.jhep.2017.11.040","article-title":"Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice","volume":"68","author":"Xu","year":"2018","journal-title":"J Hepatol"},{"key":"key20260609110341_b248-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1002\/hep4.1973","article-title":"Gasdermin D-mediated pyroptosis suppresses liver regeneration after 70% partial hepatectomy","volume":"6","author":"Lv","year":"2022","journal-title":"Hepatol Commun"},{"key":"key20260609110341_b249-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41419-020-2437-9","article-title":"Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia-reperfusion injury","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"key":"key20260609110341_b250-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.ijrobp.2021.05.115","article-title":"ALKBH5-Modified HMGB1-STING activation contributes to radiation induced liver disease via innate immune response","volume":"111","author":"Chen","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b251-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"6064","DOI":"10.1038\/s41467-025-61397-7","article-title":"Gasdermin D aggravates a mouse model of radiation-induced liver disease by promoting chemokine secretion and neutrophil recruitment","volume":"16","author":"Dong","year":"2025","journal-title":"Nat Commun"},{"key":"key20260609110341_b252-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.freeradbiomed.2020.03.007","article-title":"Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation","volume":"152","author":"Deng","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"key20260609110341_b253-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1186\/s12931-022-02279-0","article-title":"Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs","volume":"23","author":"Hu","year":"2022","journal-title":"Respir Res"},{"key":"key20260609110341_b254-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"780142","DOI":"10.3389\/fcell.2021.780142","article-title":"Treatment of severe acute pancreatitis and related lung injury by targeting gasdermin D-Mediated pyroptosis","volume":"9","author":"Wu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"key20260609110341_b255-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e255","DOI":"10.1002\/mco2.255","article-title":"Caffeic acid, but not ferulic acid, inhibits macrophage pyroptosis by directly blocking gasdermin D activation","volume":"4","author":"Liu","year":"2023","journal-title":"MedComm (2020)"},{"key":"key20260609110341_b256-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3390\/cancers12040799","article-title":"Ionizing radiation and complex DNA damage: Quantifying the radiobiological damage using monte carlo simulations","volume":"12","author":"Chatzipapas","year":"2020","journal-title":"Cancers (Basel)"},{"key":"key20260609110341_b257-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"178","DOI":"10.2174\/1389557518666181015151350","article-title":"Radicals, oxidative\/nitrosative stress and preeclampsia","volume":"19","author":"Taysi","year":"2019","journal-title":"Mini Rev Med Chem"},{"key":"key20260609110341_b258-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.2174\/1389557522666220104151225","article-title":"Thymoquinone: A review on its pharmacological importance, and its association with oxidative stress, COVID-19, and radiotherapy","volume":"22","author":"Taysi","year":"2022","journal-title":"Mini Rev Med Chem"},{"key":"key20260609110341_b259-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"5885","DOI":"10.1038\/sj.onc.1206701","article-title":"MAPK pathways in radiation responses","volume":"22","author":"Dent","year":"2003","journal-title":"Oncogene"},{"key":"key20260609110341_b260-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/j.ijrobp.2009.09.063","article-title":"Inactivation of kupffer cells by gadolinium chloride protects murine liver from radiation-induced apoptosis","volume":"76","author":"Du","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b261-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1002\/hep.28682","article-title":"Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury","volume":"64","author":"Mossanen","year":"2016","journal-title":"Hepatology"},{"key":"key20260609110341_b262-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"344","DOI":"10.4049\/jimmunol.1400574","article-title":"Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury","volume":"193","author":"Zigmond","year":"2014","journal-title":"J Immunol"},{"key":"key20260609110341_b263-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.ccell.2017.05.006","article-title":"Kupffer cell-derived tnf triggers cholangiocellular tumorigenesis through JNK due to chronic mitochondrial dysfunction and ROS","volume":"31","author":"Yuan","year":"2017","journal-title":"Cancer Cell"},{"key":"key20260609110341_b264-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41419-018-0377-4","article-title":"Kupffer cell-derived TNF-alpha promotes hepatocytes to produce CXCL1 and mobilize neutrophils in response to necrotic cells","volume":"9","author":"Su","year":"2018","journal-title":"Cell Death Dis"},{"key":"key20260609110341_b265-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"4097205","DOI":"10.1155\/2017\/4097205","article-title":"SECs (Sinusoidal Endothelial Cells), liver microenvironment, and fibrosis","volume":"2017","author":"Natarajan","year":"2017","journal-title":"Biomed Res Int"},{"key":"key20260609110341_b266-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1093\/jrr\/rrv026","article-title":"Mesenchymal stem cell-conditioned medium prevents radiation-induced liver injury by inhibiting inflammation and protecting sinusoidal endothelial cells","volume":"56","author":"Chen","year":"2015","journal-title":"J Radiat Res"},{"key":"key20260609110341_b267-ijmm-58-01-05848","first-page":"508","article-title":"Proteomic profiling of human hepatic stellate cell line LX2 responses to irradiation and TGF-\u03b21","volume":"18","author":"Yuan","year":"2019","journal-title":"J Proteome Res"},{"key":"key20260609110341_b268-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/S0360-3016(99)00401-0","article-title":"Early alteration in TGF-beta mRNA expression in irradiated rat liver","volume":"46","author":"Seong","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b269-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: The master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"key20260609110341_b270-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3389\/fphar.2018.00877","article-title":"Rapamycin upregulates connective tissue growth factor expression in hepatic progenitor cells through TGF-\u03b2-Smad2 dependent signaling","volume":"9","author":"Wu","year":"2018","journal-title":"Front Pharmacol"},{"key":"key20260609110341_b271-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.ijrobp.2010.06.046","article-title":"Radiation-induced liver fibrosis is mitigated by gene therapy inhibiting transforming growth factor-\u03b2 signaling in the rat","volume":"78","author":"Du","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b272-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41420-021-00634-6","article-title":"Radiation-induced liver injury and hepatocyte senescence","volume":"7","author":"Zhu","year":"2021","journal-title":"Cell Death Discov"},{"key":"key20260609110341_b273-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s40618-015-0381-9","article-title":"Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK\/SirT1 axis","volume":"39","author":"Marampon","year":"2016","journal-title":"J Endocrinol Invest"},{"key":"key20260609110341_b274-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1667\/RR13869.1","article-title":"Radioprotective effect of kupffer cell depletion on hepatic sinusoidal endothelial cells","volume":"183","author":"Chen","year":"2015","journal-title":"Radiat Res"},{"key":"key20260609110341_b275-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ejphar.2018.01.027","article-title":"Pirfenidone prevents radiation-induced intestinal fibrosis in rats by inhibiting fibroblast proliferation and differentiation and suppressing the TGF-\u03b21\/Smad\/CTGF signaling pathway","volume":"822","author":"Sun","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"key20260609110341_b276-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1269\/jrr.11062","article-title":"SirT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells","volume":"53","author":"Xie","year":"2012","journal-title":"J Radiat Res"},{"key":"key20260609110341_b277-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"20587384211016194","DOI":"10.1177\/20587384211016194","article-title":"Piceatannol promotes hepatic and renal AMPK\/SIRT1\/PGC-1alpha mitochondrial pathway in rats exposed to reserpine or gamma-radiation","volume":"35","author":"Mahmoud Moustafa","year":"2021","journal-title":"Int J Immunopathol Pharmacol"},{"key":"key20260609110341_b278-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbi.2008.03.006","article-title":"Effect of curcumin analog on gamma-radiation-induced cellular changes in primary culture of isolated rat hepatocytes in vitro","volume":"176","author":"Srinivasan","year":"2008","journal-title":"Chem Biol Interact"},{"key":"key20260609110341_b279-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12906-020-03182-1","article-title":"Curcumin protects radiation-induced liver damage in rats through the NF-\u0138B signaling pathway","volume":"21","author":"Li","year":"2021","journal-title":"BMC Complement Med Ther"},{"key":"key20260609110341_b280-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e114670","DOI":"10.1371\/journal.pone.0114670","article-title":"Hepatocyte growth factor gene-modified adipose-derived mesenchymal stem cells ameliorate radiation induced liver damage in a rat model","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"key20260609110341_b281-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"568759","DOI":"10.3389\/fimmu.2020.568759","article-title":"Combinational immunotherapy for hepatocellular carcinoma: Radiotherapy, immune checkpoint blockade and beyond","volume":"11","author":"Lee","year":"2020","journal-title":"Front Immunol"},{"key":"key20260609110341_b282-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s12943-023-01885-w","article-title":"Exploiting innate immunity for cancer immunotherapy","volume":"22","author":"Yi","year":"2023","journal-title":"Mol Cancer"},{"key":"key20260609110341_b283-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.ijrobp.2008.03.014","article-title":"IFN-gamma+ CD8+ T lymphocytes: possible link between immune and radiation responses in tumor-relevant hypoxia","volume":"71","author":"De Ridder","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20260609110341_b284-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s13046-024-03165-x","article-title":"Novel engineered IL-2 Nemvaleukin alfa combined with PD1 checkpoint blockade enhances the systemic anti-tumor responses of radiation therapy","volume":"43","author":"He","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"key20260609110341_b285-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"15618","DOI":"10.1038\/ncomms15618","article-title":"DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity","volume":"8","author":"Vanpouille-Box","year":"2017","journal-title":"Nat Commun"},{"key":"key20260609110341_b286-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"115445","DOI":"10.1016\/j.celrep.2025.115445","article-title":"AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8(+) T cell immunity","volume":"44","author":"Wang","year":"2025","journal-title":"Cell Rep"},{"key":"key20260609110341_b287-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/s12094-015-1473-x","article-title":"Stereotactic body radiation therapy and intensity modulated radiation therapy induce different plasmatic cytokine changes in non-small cell lung cancer patients: A pilot study","volume":"18","author":"Trovo","year":"2016","journal-title":"Clin Transl Oncol"},{"key":"key20260609110341_b288-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.celrep.2019.08.095","article-title":"Stereotactic body radiation and interleukin-12 combination therapy eradicates pancreatic tumors by repolarizing the immune microenvironment","volume":"29","author":"Mills","year":"2019","journal-title":"Cell Rep"},{"key":"key20260609110341_b289-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"102626","DOI":"10.1016\/j.redox.2023.102626","article-title":"STC2 activates PRMT5 to induce radioresistance through DNA damage repair and ferroptosis pathways in esophageal squamous cell carcinoma","volume":"60","author":"Jiang","year":"2023","journal-title":"Redox Biol"},{"key":"key20260609110341_b290-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.canlet.2012.02.001","article-title":"Pathways for repairing and tolerating the spectrum of oxidative DNA lesions","volume":"327","author":"Berquist","year":"2012","journal-title":"Cancer Lett"},{"key":"key20260609110341_b291-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.semcancer.2016.03.003","article-title":"DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation","volume":"37-38","author":"Mladenov","year":"2016","journal-title":"Semin Cancer Biol"},{"key":"key20260609110341_b292-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1002\/ijc.33918","article-title":"PARP mediated DNA damage response, genomic stability and immune responses","volume":"150","author":"Zong","year":"2022","journal-title":"Int J Cancer"},{"key":"key20260609110341_b293-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"19049","DOI":"10.1038\/srep19049","article-title":"Antitumor activity of cGAMP via stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"key20260609110341_b294-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"216440","DOI":"10.1016\/j.canlet.2023.216440","article-title":"The AEG-1-USP10-PARP1 axis confers radioresistance in esophageal squamous cell carcinoma via facilitating homologous recombination-dependent DNA damage repair","volume":"577","author":"Zhao","year":"2023","journal-title":"Cancer Lett"},{"key":"key20260609110341_b295-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/s41392-021-00735-9","article-title":"VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance","volume":"6","author":"Liu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"key20260609110341_b296-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e2579","DOI":"10.1038\/cddis.2016.460","article-title":"NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis"},{"key":"key20260609110341_b297-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/jpi.12191","article-title":"Melatonin blunts the mitochondrial\/NLRP3 connection and protects against radiation-induced oral mucositis","volume":"58","author":"Ortiz","year":"2015","journal-title":"J Pineal Res"},{"key":"key20260609110341_b298-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.cub.2007.05.074","article-title":"The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes","volume":"17","author":"Feldmeyer","year":"2007","journal-title":"Curr Biol"},{"key":"key20260609110341_b299-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3389\/fmicb.2011.00012","article-title":"Role of the nlrp3 inflammasome in microbial infection","volume":"2","author":"Anand","year":"2011","journal-title":"Front Microbiol"},{"key":"key20260609110341_b300-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"123241","DOI":"10.1155\/2013\/123241","article-title":"Inflammation and immunity in radiation damage to the gut mucosa","volume":"2013","author":"Francois","year":"2013","journal-title":"Biomed Res Int"},{"key":"key20260609110341_b301-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1667\/RR14357.1","article-title":"Late effects of total-body gamma irradiation on cardiac structure and function in male rhesus macaques","volume":"186","author":"DeBo","year":"2016","journal-title":"Radiat Res"},{"key":"key20260609110341_b302-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.ccr.2013.10.019","article-title":"A new twist on radiation oncology: Low-dose irradiation elicits immunostimulatory macrophages that unlock barriers to tumor immunotherapy","volume":"24","author":"De Palma","year":"2013","journal-title":"Cancer Cell"},{"key":"key20260609110341_b303-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.canlet.2015.03.031","article-title":"Radiation takes its toll","volume":"368","author":"Ratikan","year":"2015","journal-title":"Cancer Lett"},{"key":"key20260609110341_b304-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"e000773","DOI":"10.1136\/jitc-2020-000773","article-title":"Randomized phase II study of stereotactic body radiotherapy and interleukin-2 versus interleukin-2 in patients with metastatic melanoma","volume":"8","author":"Curti","year":"2020","journal-title":"J Immunother Cancer"},{"key":"key20260609110341_b305-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41698-020-0124-z","article-title":"Association of pro-inflammatory soluble cytokine receptors early during hepatocellular carcinoma stereotactic radiotherapy with liver toxicity","volume":"4","author":"Ng","year":"2020","journal-title":"NPJ Precis Oncol"},{"key":"key20260609110341_b306-ijmm-58-01-05848","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-94-007-4694-7_6","article-title":"In situ tumor ablation with radiation therapy: Its effect on the tumor microenvironment and anti-tumor immunity","volume-title":"Tumor ablation: Effects on systemic and local anti-tumor immunity and on other tumor-microenvironment interactions","author":"McBride","year":"2013"},{"key":"key20260609110341_b307-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"137ra74","DOI":"10.1126\/scitranslmed.3003649","article-title":"Phase 1 study of stereotactic body radiotherapy and interleukin-2-tumor and immunological responses","volume":"4","author":"Seung","year":"2012","journal-title":"Sci Transl Med"},{"key":"key20260609110341_b308-ijmm-58-01-05848","doi-asserted-by":"publisher","first-page":"102350","DOI":"10.1016\/j.omtn.2024.102350","article-title":"Integrating IL-12 mRNA nanotechnology with SBRT eliminates T cell exhaustion in preclinical models of pancreatic cancer","volume":"35","author":"Hughson","year":"2024","journal-title":"Mol Ther Nucleic Acids"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:04:01Z","timestamp":1780992241000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2026.5848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":308,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,5,8]]}},"URL":"https:\/\/doi.org\/10.3892\/ijmm.2026.5848","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]}}}