{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:38:32Z","timestamp":1793122712982,"version":"4.5.0"},"reference-count":161,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Mol Med"],"DOI":"10.3892\/ijmm.2026.6011","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:37:48Z","timestamp":1791542268000},"page":"1-37","source":"Crossref","is-referenced-by-count":0,"title":["Gomisin A as a multi\u2011target therapeutic agent: Pharmacological mechanisms, pharmacokinetics and network pharmacology (Review)"],"prefix":"10.3892","volume":"58","author":[{"given":"Jiaqi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang 310012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengkai","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang 310012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sui","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang 310012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanhao","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang 310012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang 310012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang 310012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"key20261027193126_b1-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1163445","DOI":"10.3389\/fbinf.2023.1163445","article-title":"Network medicine: Facilitating a new view on complex diseases","volume":"3","author":"Cvijovic","year":"2023","journal-title":"Front Bioinform"},{"key":"key20261027193126_b2-ijmm-58-06-06011","unstructured":"World Health OrganizationNoncommunicable diseaseshttps:\/\/www.who.int\/news-room\/fact-sheets\/detail\/noncommunicable-diseasesAccessed September 11, 2026"},{"key":"key20261027193126_b3-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"107686","DOI":"10.1016\/j.pharmthera.2020.107686","article-title":"The strategies and techniques of drug discovery from natural products","volume":"216","author":"Zhang","year":"2020","journal-title":"Pharmacol Ther"},{"key":"key20261027193126_b4-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"8367","DOI":"10.3390\/molecules27238367","article-title":"Natural products as anticancer agents: Current status and future perspectives","volume":"27","author":"Naeem","year":"2022","journal-title":"Molecules"},{"key":"key20261027193126_b5-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1142\/S0192415X00000416","article-title":"Clinical and pharmacological studies on liver diseases treated with Kampo herbal medicine","volume":"28","author":"Cyong","year":"2000","journal-title":"Am J Chin Med"},{"key":"key20261027193126_b6-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12906-022-03829-1","article-title":"Anxiolytic-like effect of Suanzaoren-Wuweizi herb-pair and evidence for the involvement of the monoaminergic system in mice based on network pharmacology","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Complement Med Ther"},{"key":"key20261027193126_b7-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1248\/bpb.35.171","article-title":"The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury","volume":"35","author":"Teraoka","year":"2012","journal-title":"Biol Pharm Bull"},{"key":"key20261027193126_b8-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"986","DOI":"10.3389\/fphar.2018.00986","article-title":"Gomisin A suppresses colorectal lung metastasis by inducing AMPK\/p38-mediated apoptosis and decreasing metastatic abilities of colorectal cancer cells","volume":"9","author":"Kee","year":"2018","journal-title":"Front Pharmacol"},{"key":"key20261027193126_b9-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/hr.2012.50","article-title":"Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability","volume":"35","author":"Young Park","year":"2012","journal-title":"Hypertens Res"},{"key":"key20261027193126_b10-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.fct.2013.10.048","article-title":"Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-\u03baB\/MAPKs pathway","volume":"63","author":"Wang","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"key20261027193126_b11-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/toxsci\/kfu216","article-title":"Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration","volume":"143","author":"Jiang","year":"2015","journal-title":"Toxicol Sci"},{"key":"key20261027193126_b12-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/bph.13729","article-title":"Schisandrol B protects against cholestatic liver injury through pregnane X receptors","volume":"174","author":"Zeng","year":"2017","journal-title":"Br J Pharmacol"},{"key":"key20261027193126_b13-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3892\/or.2022.8417","article-title":"Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer","volume":"48","author":"Wang","year":"2022","journal-title":"Oncol Rep"},{"key":"key20261027193126_b14-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jep.2009.06.028","article-title":"Gomisin A induces Ca2+-dependent activation of eNOS in human coronary artery endothelial cells","volume":"125","author":"Park","year":"2009","journal-title":"J Ethnopharmacol"},{"key":"key20261027193126_b15-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ejphar.2006.06.015","article-title":"Gomisin A improves scopolamine-induced memory impairment in mice","volume":"542","author":"Kim","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"key20261027193126_b16-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3109\/08923973.2014.909848","article-title":"Gomisin A decreases the LPS-induced expression of iNOS and COX-2 and activation of RIP2\/NF-\u03baB in mouse peritoneal macrophages","volume":"36","author":"Jeong","year":"2014","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"key20261027193126_b17-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/aps.2015.120","article-title":"Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2\/ARE signaling pathway","volume":"37","author":"Jiang","year":"2016","journal-title":"Acta Pharmacol Sin"},{"key":"key20261027193126_b18-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"8862291","DOI":"10.1155\/2021\/8862291","article-title":"HPLC-MS\/MS-mediated analysis of the pharmacokinetics, bioavailability, and tissue distribution of schisandrol B in rats","volume":"2021","author":"Liang","year":"2021","journal-title":"Int J Anal Chem"},{"key":"key20261027193126_b19-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1248\/yakushi1947.101.11_1030","article-title":"Pharmacological studies on Schizandra fruit. I. General pharmacological effects of gomisin A and schizandrin (author's transl)","volume":"101","author":"Maeda","year":"1981","journal-title":"Yakugaku Zasshi"},{"key":"key20261027193126_b20-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1254\/jphs.FP0071738","article-title":"Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice","volume":"106","author":"Kim","year":"2008","journal-title":"J Pharmacol Sci"},{"key":"key20261027193126_b21-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"655531","DOI":"10.3389\/fphar.2021.655531","article-title":"The combination of schisandrol B and wedelolactone synergistically reverses hepatic fibrosis via modulating multiple signaling pathways in mice","volume":"12","author":"Ai","year":"2021","journal-title":"Front Pharmacol"},{"key":"key20261027193126_b22-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ejphar.2017.10.044","article-title":"Schisandrol B promotes liver regeneration after partial hepatectomy in mice","volume":"818","author":"Li","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"key20261027193126_b23-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"153147","DOI":"10.1016\/j.phymed.2019.153147","article-title":"Gomisin A ameliorates metastatic melanoma by inhibiting AMPK and ERK\/JNK-mediated cell survival and metastatic phenotypes","volume":"68","author":"Han","year":"2020","journal-title":"Phytomedicine"},{"key":"key20261027193126_b24-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1055\/s-2007-993757","article-title":"Gomisin A from Schisandra chinensis induces endothelium-dependent and direct relaxation in rat thoracic aorta","volume":"73","author":"Park","year":"2007","journal-title":"Planta Med"},{"key":"key20261027193126_b25-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00210-010-0571-0","article-title":"Effects of gomisin A on vascular contraction in rat aortic rings","volume":"383","author":"Seok","year":"2011","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"key20261027193126_b26-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3892\/ijmm.2013.1263","article-title":"Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury","volume":"31","author":"Hwang","year":"2013","journal-title":"Int J Mol Med"},{"key":"key20261027193126_b27-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1142\/S0192415X21500919","article-title":"Gomisin A alleviates obesity by regulating the phenotypic switch between white and brown adipocytes","volume":"49","author":"Han","year":"2021","journal-title":"Am J Chin Med"},{"key":"key20261027193126_b28-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"291","DOI":"10.4162\/nrp.2018.12.4.291","article-title":"Effects of Schisandra chinensis fruit extract and gomisin A on the contractility of penile corpus cavernosum smooth muscle: A potential mechanism through the nitric oxide-cyclic guanosine monophosphate pathway","volume":"12","author":"Choi","year":"2018","journal-title":"Nutr Res Pract"},{"key":"key20261027193126_b29-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"4836","DOI":"10.3390\/molecules16064836","article-title":"The immuno-regulatory effects of Schisandra chinensis and its constituents on human monocytic leukemia cells","volume":"16","author":"Lin","year":"2011","journal-title":"Molecules"},{"key":"key20261027193126_b30-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"117031","DOI":"10.1016\/j.jep.2023.117031","article-title":"Qingxin Kaiqiao Fang decreases Tau hyperphosphorylation in Alzheimer's disease via the PI3K\/Akt\/GSK3\u03b2 pathway in vitro and in vivo","volume":"318","author":"Liu","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"key20261027193126_b31-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"9102","DOI":"10.1039\/D5FO04217H","article-title":"Fucoxanthin suppresses amyloid-\u03b2 and pyroglutamate-3-A\u03b2 accumulation by modulating the PI3K\/Akt\/GSK-3\u03b2 signaling pathway","volume":"16","author":"Lee","year":"2025","journal-title":"Food Funct"},{"key":"key20261027193126_b32-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"e12023","DOI":"10.1002\/ccs3.12023","article-title":"Scutellarin alleviates microglia-mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K\/AKT\/GSK3\u03b2 signaling pathway","volume":"18","author":"Duan","year":"2024","journal-title":"J Cell Commun Signal"},{"key":"key20261027193126_b33-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"109635","DOI":"10.1016\/j.bioorg.2026.109635","article-title":"Eupalinolide B prevents cerebral ischemia-reperfusion injury via the PI3K\/Akt\/GSK3\u03b2(Ser9) signaling pathway","volume":"173","author":"Li","year":"2026","journal-title":"Bioorg Chem"},{"key":"key20261027193126_b34-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"issue":"W1","key":"key20261027193126_b35-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"W530","DOI":"10.1093\/nar\/gkab294","article-title":"PLIP 2021: Expanding the scope of the protein-ligand interaction profiler to DNA and RNA","volume":"49","author":"Adasme","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"key20261027193126_b36-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"e83922","DOI":"10.1371\/journal.pone.0083922","article-title":"Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology","volume":"8","author":"Hsin","year":"2013","journal-title":"PLoS One"},{"key":"key20261027193126_b37-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1347021","DOI":"10.3389\/fendo.2024.1347021","article-title":"Discussion on the mechanism of Danggui Sini decoction in treating diabetic foot based on network pharmacology and molecular docking and verification of the curative effect by meta-analysis","volume":"15","author":"Ni","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"key20261027193126_b38-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: Fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J Comput Chem"},{"key":"key20261027193126_b39-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1002\/prot.22711","article-title":"Improved side-chain torsion potentials for the Amber ff99SB protein force field","volume":"78","author":"Lindorff-Larsen","year":"2010","journal-title":"Proteins"},{"key":"key20261027193126_b40-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J Chem Phys"},{"key":"key20261027193126_b41-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"5068","DOI":"10.33011\/livecoms.1.1.5068","article-title":"From proteins to perturbed hamiltonians: A suite of tutorials for the GROMACS-2018 molecular simulation package [article v1.0]","volume":"1","author":"Lemkul","year":"2018","journal-title":"Living J Comp Mol Sci"},{"key":"key20261027193126_b42-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","article-title":"gmx_MMPBSA: A new tool to perform end-state free energy calculations with GROMACS","volume":"17","author":"Vald\u00e9s-Tresanco","year":"2021","journal-title":"J Chem Theory Comput"},{"key":"key20261027193126_b43-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.compbiomed.2014.04.022","article-title":"An investigation of molecular dynamics simulation and molecular docking: Interaction of citrus flavonoids and bovine \u03b2-lactoglobulin in focus","volume":"51","author":"Sahihi","year":"2014","journal-title":"Comput Biol Med"},{"key":"key20261027193126_b44-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"107801","DOI":"10.1016\/j.foodhyd.2022.107801","article-title":"Molecular dynamics simulation of the interactions between sesamol and myosin combined with spectroscopy and molecular docking studies","volume":"131","author":"Han","year":"2022","journal-title":"Food Hydrocoll"},{"key":"key20261027193126_b45-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"460942","DOI":"10.1016\/j.chroma.2020.460942","article-title":"Effect directed analysis and TLC screening of Schisandra chinensis fruits","volume":"1618","author":"Sobstyl","year":"2020","journal-title":"J Chromatogr A"},{"key":"key20261027193126_b46-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1248\/cpb.27.1383","article-title":"The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin","volume":"27","author":"Ikeya","year":"1979","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"key20261027193126_b47-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1021\/jm901137j","article-title":"New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays","volume":"53","author":"Baell","year":"2010","journal-title":"J Med Chem"},{"key":"key20261027193126_b48-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1021\/acs.jcim.6b00465","article-title":"Phantom PAINS: Problems with the utility of alerts for pan-assay interference compounds","volume":"57","author":"Capuzzi","year":"2017","journal-title":"J Chem Inf Model"},{"key":"key20261027193126_b49-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.bcp.2006.06.036","article-title":"Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells","volume":"72","author":"Wan","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"key20261027193126_b50-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr Biol"},{"key":"key20261027193126_b51-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/hep.32583","article-title":"Organoids and regenerative hepatology","volume":"77","author":"Jalan-Sakrikar","year":"2023","journal-title":"Hepatology"},{"key":"key20261027193126_b52-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: Mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"key":"key20261027193126_b53-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jhep.2016.03.020","article-title":"A synthetic biology-based device prevents liver injury in mice","volume":"65","author":"Bai","year":"2016","journal-title":"J Hepatol"},{"key":"key20261027193126_b54-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"174442","DOI":"10.1016\/j.ejphar.2021.174442","article-title":"Study on the effect of active components of Schisandra chinensis on liver injury and its mechanisms in mice based on network pharmacology","volume":"910","author":"Xu","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"key20261027193126_b55-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.phytochem.2017.01.010","article-title":"Lignans from the fruits of Schisandra chinensis (Turcz.) Baill inhibit proprotein convertase subtilisin\/kexin type 9 expression","volume":"136","author":"Pel","year":"2017","journal-title":"Phytochemistry"},{"key":"key20261027193126_b56-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.intimp.2015.06.036","article-title":"Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2\/4 and MAPK\/NF-\u03baB pathway","volume":"28","author":"Ma","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"key20261027193126_b57-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"key20261027193126_b58-ijmm-58-06-06011","first-page":"3951","article-title":"A study of regulatory effects of TLR4 and NF-\u03baB on primary biliary cholangitis","volume":"23","author":"Yu","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"key20261027193126_b59-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"161","DOI":"10.5625\/lar.2011.27.2.161","article-title":"Transcriptome analysis of the effects of gomisin a on the recovery of carbon tetrachloride-induced damage in rat liver","volume":"27","author":"Choi","year":"2011","journal-title":"Lab Anim Res"},{"key":"key20261027193126_b60-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/cc1465","article-title":"Acetaminophen poisoning: An update for the intensivist","volume":"6","author":"Dargan","year":"2002","journal-title":"Crit Care"},{"key":"key20261027193126_b61-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1124\/dmd.107.014738","article-title":"Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: Comparison of wild-type and Cyp2e1(-\/-) mice","volume":"35","author":"Wolf","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"key20261027193126_b62-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.phymed.2009.12.005","article-title":"Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis","volume":"17","author":"Wan","year":"2010","journal-title":"Phytomedicine"},{"key":"key20261027193126_b63-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cbi.2015.02.022","article-title":"Hepato-protective effects of six Schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation","volume":"231","author":"Jiang","year":"2015","journal-title":"Chem Biol Interact"},{"key":"key20261027193126_b64-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.3892\/ijmm.2014.1730","article-title":"Nature and mechanisms of hepatocyte apoptosis induced by D-galactosamine\/lipopolysaccharide challenge in mice","volume":"33","author":"Wu","year":"2014","journal-title":"Int J Mol Med"},{"key":"key20261027193126_b65-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.taap.2012.01.015","article-title":"Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative\/nitrosative stress via Nrf2-NF\u03baB pathways","volume":"260","author":"Das","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"key20261027193126_b66-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.1039\/D0FO00087F","article-title":"Investigation of the active components and mechanisms of Schisandra chinensis in the treatment of asthma based on a network pharmacology approach and experimental validation","volume":"11","author":"Lv","year":"2020","journal-title":"Food Funct"},{"key":"key20261027193126_b67-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1007\/s10354-006-0312-7","article-title":"Molecular mechanisms of cholestasis","volume":"156","author":"Zollner","year":"2006","journal-title":"Wien Med Wochenschr"},{"key":"key20261027193126_b68-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1053\/j.gastro.2010.09.004","article-title":"Pathogenesis of cholestatic liver disease and therapeutic approaches","volume":"139","author":"Hirschfield","year":"2010","journal-title":"Gastroenterology"},{"key":"key20261027193126_b69-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"115222","DOI":"10.1016\/j.bcp.2022.115222","article-title":"Schisandrol B protects against cholestatic liver injury by inhibiting pyroptosis through pregnane X receptor","volume":"204","author":"Liang","year":"2022","journal-title":"Biochem Pharmacol"},{"key":"key20261027193126_b70-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"112103","DOI":"10.1016\/j.jep.2019.112103","article-title":"Lignans from Schisandra sphenanthera protect against lithocholic acid-induced cholestasis by pregnane X receptor activation in mice","volume":"245","author":"Fan","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"key20261027193126_b71-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s13020-026-01342-y","article-title":"Schisandrol B protects against lithocholic acid-induced cholestatic liver injury in mice through mitochondrial biogenesis","volume":"21","author":"Yang","year":"2026","journal-title":"Chin Med"},{"key":"key20261027193126_b72-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"117016","DOI":"10.1016\/j.bcp.2025.117016","article-title":"METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA","volume":"239","author":"Wang","year":"2025","journal-title":"Biochem Pharmacol"},{"key":"key20261027193126_b73-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1016\/j.cellsig.2013.06.001","article-title":"Transforming growth factor-\u03b2 signalling: Role and consequences of Smad linker region phosphorylation","volume":"25","author":"Kamato","year":"2013","journal-title":"Cell Signal"},{"key":"key20261027193126_b74-ijmm-58-06-06011","first-page":"0435","article-title":"Hepatic Surf4 deficiency impairs serum amyloid A1 secretion and attenuates liver fibrosis in mice","volume":"7","author":"Wang","year":"2024","journal-title":"Research (Wash D C)"},{"key":"key20261027193126_b75-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.cld.2018.06.002","article-title":"Hepatitis B and C","volume":"22","author":"Mysore","year":"2018","journal-title":"Clin Liver Dis"},{"key":"key20261027193126_b76-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1478-3231.2006.01408.x","article-title":"Natural products and chronic hepatitis C virus","volume":"27","author":"Azzam","year":"2007","journal-title":"Liver Int"},{"key":"key20261027193126_b77-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: Biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"key20261027193126_b78-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41392-023-01575-5","article-title":"MDIG-mediated H3K9me3 demethylation upregulates Myc by activating OTX2 and facilitates liver regeneration","volume":"8","author":"Du","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"key20261027193126_b79-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1006\/bbrc.1999.0752","article-title":"Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5'-upstream regulatory region","volume":"259","author":"Westlind","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"key20261027193126_b80-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1208\/s12248-015-9827-4","article-title":"Gomisin A is a novel isoform-specific probe for the selective sensing of human cytochrome P450 3A4 in liver microsomes and living cells","volume":"18","author":"Wu","year":"2016","journal-title":"AAPS J"},{"key":"key20261027193126_b81-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: A systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"key20261027193126_b82-ijmm-58-06-06011","first-page":"0577","article-title":"Fat-1 ameliorates metabolic dysfunction-associated fatty liver disease and atherosclerosis through promoting the nuclear localization of PPAR\u03b1 in hamsters","volume":"8","author":"Zhang","year":"2025","journal-title":"Research (Wash D C)"},{"key":"key20261027193126_b83-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.18632\/oncotarget.23213","article-title":"Schisandrol B and schisandrin B inhibit TGF\u03b21-mediated NF-\u03baB activation via a Smad-independent mechanism","volume":"9","author":"Chun","year":"2017","journal-title":"Oncotarget"},{"key":"key20261027193126_b84-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1126\/science.274.5291.1379","article-title":"Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice","volume":"274","author":"Cressman","year":"1996","journal-title":"Science"},{"key":"key20261027193126_b85-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1055\/s-2006-960107","article-title":"Effect of gomisin A in the prevention of acute hepatic failure induction","volume":"57","author":"Mizoguchi","year":"1991","journal-title":"Planta Med"},{"key":"key20261027193126_b86-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"834729","DOI":"10.3389\/fonc.2022.834729","article-title":"Solasonine inhibits pancreatic cancer progression with involvement of ferroptosis induction","volume":"12","author":"Liang","year":"2022","journal-title":"Front Oncol"},{"key":"key20261027193126_b87-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"151","DOI":"10.4103\/cjp.cjp_6_22","article-title":"Action of the natural compound gomisin a on Ca2+ movement in human prostate cancer cells","volume":"65","author":"Hao","year":"2022","journal-title":"Chin J Physiol"},{"key":"key20261027193126_b88-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1080\/14737140.2018.1527689","article-title":"Mathematical models of tumor cell proliferation: A review of the literature","volume":"18","author":"Jarrett","year":"2018","journal-title":"Expert Rev Anticancer Ther"},{"key":"key20261027193126_b89-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"9408","DOI":"10.1200\/JCO.2005.01.5594","article-title":"Targeting the cell cycle: A new approach to cancer therapy","volume":"23","author":"Schwartz","year":"2005","journal-title":"J Clin Oncol"},{"key":"key20261027193126_b90-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"3512","DOI":"10.1158\/0008-5472.CAN-06-3914","article-title":"Novel action of paclitaxel against cancer cells: Bystander effect mediated by reactive oxygen species","volume":"67","author":"Alexandre","year":"2007","journal-title":"Cancer Res"},{"key":"key20261027193126_b91-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1248\/bpb.b12-00450","article-title":"Gomisin A enhances tumor necrosis factor-\u03b1-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein","volume":"35","author":"Waiwut","year":"2012","journal-title":"Biol Pharm Bull"},{"key":"key20261027193126_b92-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol Pathol"},{"key":"key20261027193126_b93-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"6054","DOI":"10.1016\/j.bmcl.2011.08.065","article-title":"A compound isolated from Schisandra chinensis induces apoptosis","volume":"21","author":"Hwang","year":"2011","journal-title":"Bioorg Med Chem Lett"},{"key":"key20261027193126_b94-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41416-020-01149-0","article-title":"Mutational drivers of cancer cell migration and invasion","volume":"124","author":"Novikov","year":"2021","journal-title":"Br J Cancer"},{"key":"key20261027193126_b95-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"110939","DOI":"10.1016\/j.biopha.2020.110939","article-title":"Interactions of the major effective components in Shengmai formula with breast cancer resistance protein at the cellular and vesicular levels","volume":"133","author":"Wu","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"key20261027193126_b96-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/bdd.705","article-title":"Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats","volume":"31","author":"Jin","year":"2010","journal-title":"Biopharm Drug Dispos"},{"key":"key20261027193126_b97-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1111\/bcp.14303","article-title":"Potential for pharmacokinetic interactions between Schisandra sphenanthera and bosutinib, but not imatinib: In vitro metabolism study combined with a physiologically-based pharmacokinetic modelling approach","volume":"86","author":"Adiwidjaja","year":"2020","journal-title":"Br J Clin Pharmacol"},{"key":"key20261027193126_b98-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"3430","DOI":"10.1002\/jssc.201700588","article-title":"A sensitive UHPLC-MS\/MS method for the simultaneous quantification of three lignans in human plasma and its application to a pharmacokinetic study","volume":"40","author":"Kim","year":"2017","journal-title":"J Sep Sci"},{"key":"key20261027193126_b99-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1002\/jssc.201400451","article-title":"Simultaneous determination of nine lignans from Schisandra chinensis extract using ultra-performance liquid chromatography with tandem mass spectrometry in rat plasma, urine, and gastrointestinal tract samples: Application to the pharmacokinetic study of Schisandra chinensis","volume":"37","author":"Kim","year":"2014","journal-title":"J Sep Sci"},{"key":"key20261027193126_b100-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1211\/jpp.60.3.0012","article-title":"Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers-an in-vitro model of intestinal transport","volume":"60","author":"Madgula","year":"2008","journal-title":"J Pharm Pharmacol"},{"key":"key20261027193126_b101-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1124\/dmd.113.053892","article-title":"In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A\/P-glycoprotein-mediated absorption and metabolism of tacrolimus","volume":"42","author":"Qin","year":"2014","journal-title":"Drug Metab Dispos"},{"key":"key20261027193126_b102-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"18756","DOI":"10.1074\/jbc.M110.206193","article-title":"Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein","volume":"286","author":"Aertgeerts","year":"2011","journal-title":"J Biol Chem"},{"key":"key20261027193126_b103-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1007\/s00018-008-7440-8","article-title":"The epidermal growth factor receptor family: Biology driving targeted therapeutics","volume":"65","author":"Wieduwilt","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"key20261027193126_b104-ijmm-58-06-06011","unstructured":"World Health OrganizationCardiovascular diseases (CVDs)July312025https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)Accessed September 11, 2026"},{"key":"key20261027193126_b105-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: A systematic analysis for the global burden of disease study 2017","volume":"392","author":"GBD 2017 Causes of Death Collaborators","year":"2018","journal-title":"Lancet"},{"key":"key20261027193126_b106-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"7839658","DOI":"10.1155\/2017\/7839658","article-title":"Schisandra chinensis and Morus alba synergistically inhibit in vivo thrombus formation and platelet aggregation by impairing the glycoprotein VI pathway","volume":"2017","author":"Kim","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20261027193126_b107-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"key20261027193126_b108-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"ra41","DOI":"10.1126\/scisignal.2000343","article-title":"The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo","volume":"2","author":"Schleicher","year":"2009","journal-title":"Sci Signal"},{"key":"key20261027193126_b109-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.febslet.2004.07.078","article-title":"Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt","volume":"573","author":"Thors","year":"2004","journal-title":"FEBS Lett"},{"key":"key20261027193126_b110-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"115925","DOI":"10.1016\/j.intimp.2025.115925","article-title":"CircUBE4B attenuates AngII-induced vascular smooth muscle cell proliferation and migration through upregulating GSK3B by sponging miR-199a-5p","volume":"168","author":"Wang","year":"2026","journal-title":"Int Immunopharmacol"},{"key":"key20261027193126_b111-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"xaag050","DOI":"10.1093\/reprod\/xaag050","article-title":"Lipid metabolism abnormalities induced by elevated PCSK9 in polycystic ovary syndrome mice lead to ovarian granulosa cell apoptosis via AMPK and GSK-3\u03b2","volume":"171","author":"Teng","year":"2026","journal-title":"Reproduction"},{"key":"key20261027193126_b112-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"e185","DOI":"10.1161\/ATVBAHA.117.309856","article-title":"Platelet-specific p38\u03b1 deficiency improved cardiac function after myocardial infarction in mice","volume":"37","author":"Shi","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20261027193126_b113-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"6451905","DOI":"10.1155\/2017\/6451905","article-title":"A molecular basis for the inhibition of transient receptor potential vanilloid type 1 by gomisin A","volume":"2017","author":"Lee","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20261027193126_b114-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jpba.2013.01.029","article-title":"Development of a UFLC-MS\/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. In rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats","volume":"77","author":"Wei","year":"2013","journal-title":"J Pharm Biomed Anal"},{"key":"key20261027193126_b115-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/jms.3176","article-title":"UFLC-MS\/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. In normal and insomniac rats brain microdialysates and homogenate samples: Towards an in-depth study for its sedative-hypnotic activity","volume":"48","author":"Wei","year":"2013","journal-title":"J Mass Spectrom"},{"key":"key20261027193126_b116-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1002\/cbin.10537","article-title":"Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells","volume":"39","author":"E","year":"2015","journal-title":"Cell Biol Int"},{"key":"key20261027193126_b117-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"673","DOI":"10.3389\/fphar.2017.00673","article-title":"Schisandra chinensis stem ameliorates 3-nitropropionic acid-induced striatal toxicity via activation of the Nrf2 pathway and inhibition of the MAPKs and NF-\u03baB pathways","volume":"8","author":"Kim","year":"2017","journal-title":"Front Pharmacol"},{"key":"key20261027193126_b118-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/BF02977628","article-title":"Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensis","volume":"30","author":"Hung","year":"2007","journal-title":"Arch Pharm Res"},{"key":"key20261027193126_b119-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"154273","DOI":"10.1016\/j.phymed.2022.154273","article-title":"A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties","volume":"106","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"key":"key20261027193126_b120-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1042\/BST0341028","article-title":"STAT3-mediated anti-inflammatory signalling","volume":"34","author":"Murray","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"key20261027193126_b121-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/1440-1681.12914","article-title":"Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells","volume":"45","author":"Kim","year":"2018","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"key20261027193126_b122-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"153107","DOI":"10.1016\/j.phymed.2019.153107","article-title":"Effect of gomisin A on osteoblast differentiation in high glucose-mediated oxidative stress","volume":"66","author":"Takanche","year":"2020","journal-title":"Phytomedicine"},{"key":"key20261027193126_b123-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"e1800030","DOI":"10.1002\/cbdv.201800030","article-title":"Characteristics and antioxidant activity of lignans in Schisandra chinensis and Schisandra sphenanthera from different locations","volume":"15","author":"Wang","year":"2018","journal-title":"Chem Biodivers"},{"key":"key20261027193126_b124-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.chroma.2019.01.050","article-title":"The in-capillary-2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)-sweeping micellar electrokinetic chromatography-Diode array detector method for screening and quantifying trace natural antioxidants from Schisandra chinensis","volume":"1593","author":"Ma","year":"2019","journal-title":"J Chromatogr A"},{"key":"key20261027193126_b125-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1128\/MCB.01204-10","article-title":"SCF\/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner","volume":"31","author":"Rada","year":"2011","journal-title":"Mol Cell Biol"},{"key":"key20261027193126_b126-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1101\/gad.13.1.76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain","volume":"13","author":"Itoh","year":"1999","journal-title":"Genes Dev"},{"key":"key20261027193126_b127-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","article-title":"NF-kappaB\/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"key20261027193126_b128-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1080\/00498254.2020.1737760","article-title":"Effects of 27 natural products on drug metabolism genes in channel catfish (Ictalurus punctatus) cell line","volume":"50","author":"Wang","year":"2020","journal-title":"Xenobiotica"},{"key":"key20261027193126_b129-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.3390\/molecules28052268","article-title":"Optimized extraction, identification and anti-biofilm action of Wu Wei Zi (Fructus Schisandrae Chinensis) extracts against Vibrio parahaemolyticus","volume":"28","author":"Zhang","year":"2023","journal-title":"Molecules"},{"key":"key20261027193126_b130-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1002\/ptr.3486","article-title":"The role of the lignan constituents in the effect of Schisandra chinensis fruit extract on penile erection","volume":"25","author":"Kim","year":"2011","journal-title":"Phytother Res"},{"key":"key20261027193126_b131-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"8816","DOI":"10.3390\/ijms21228816","article-title":"Inhibitory Effectiveness of Gomisin A, a Dibenzocyclooctadiene Lignan Isolated from Schizandra chinensis, on the amplitude and gating of voltage-gated Na+ current","volume":"21","author":"Chang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"key20261027193126_b132-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1007\/s11010-026-05497-y","article-title":"Gomisin A and metformin co-treatment attenuates diabetic nephropathy and cardiovascular dysfunction by modulating the AGE\/RAGE pathway in a diabetic rat model","volume":"481","author":"Nayak","year":"2026","journal-title":"Mol Cell Biochem"},{"key":"key20261027193126_b133-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jep.2015.03.024","article-title":"Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe","volume":"166","author":"Yang","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"key20261027193126_b134-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/jssc.201200887","article-title":"Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS","volume":"36","author":"Sun","year":"2013","journal-title":"J Sep Sci"},{"key":"key20261027193126_b135-ijmm-58-06-06011","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-014-0376-7","article-title":"Tissue distribution and excretion of herbal components after intravenous administration of a Chinese medicine (Shengmai injection) in rat","author":"Zhan","year":"2014","journal-title":"Arch Pharm Res"},{"key":"key20261027193126_b136-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.jep.2013.03.008","article-title":"Gender-dependent pharmacokinetics of lignans in rats after single and multiple oral administration of Schisandra chinensis extract","volume":"147","author":"Xu","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"key20261027193126_b137-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"224","DOI":"10.2174\/1389200222666210203182232","article-title":"Simultaneous determination of saponins and lignans in rat plasma by UPLC-MS\/MS and its application to a pharmacokinetic study of Shenqi jiangtang granule","volume":"22","author":"Zhang","year":"2021","journal-title":"Curr Drug Metab"},{"key":"key20261027193126_b138-ijmm-58-06-06011","first-page":"1891","article-title":"Determination of hepatic and small intestinal distribution of lignans of Wuzhi tablet in rats by liquid chromatography tandem mass spectrometry method","volume":"51","author":"Qin","year":"2016","journal-title":"Yao Xue Xue Bao"},{"key":"key20261027193126_b139-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.fitote.2018.02.024","article-title":"The influence of natural deep eutectic solvents on bioactive natural products: Studying interactions between a hydrogel model and Schisandra chinensis metabolites","volume":"127","author":"Liu","year":"2018","journal-title":"Fitoterapia"},{"key":"key20261027193126_b140-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.3390\/molecules22081298","article-title":"Time- and NADPH-dependent inhibition on CYP3A by gomisin A and the pharmacokinetic interactions between gomisin A and cyclophosphamide in rats","volume":"22","author":"Zhai","year":"2017","journal-title":"Molecules"},{"key":"key20261027193126_b141-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3390\/pharmaceutics13030371","article-title":"Inhibitory effects of Schisandra lignans on cytochrome P450s and uridine 5'-diphospho-glucuronosyl transferases in human liver microsomes","volume":"13","author":"Seo","year":"2021","journal-title":"Pharmaceutics"},{"key":"key20261027193126_b142-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/aor.13551","article-title":"Tacrolimus: 20 years of use in adult kidney transplantation. What we should know about its nephrotoxicity","volume":"44","author":"Bentata","year":"2020","journal-title":"Artif Organs"},{"key":"key20261027193126_b143-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1021\/acschembio.7b00903","article-title":"Seven year itch: Pan-assay interference compounds (PAINS) in 2017-utility and limitations","volume":"13","author":"Baell","year":"2018","journal-title":"ACS Chem Biol"},{"key":"key20261027193126_b144-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"4265","DOI":"10.1021\/jm030266r","article-title":"A specific mechanism of nonspecific inhibition","volume":"46","author":"McGovern","year":"2003","journal-title":"J Med Chem"},{"key":"key20261027193126_b145-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.pharmthera.2015.10.004","article-title":"Targeting transcription factor STAT3 for cancer prevention and therapy","volume":"162","author":"Chai","year":"2016","journal-title":"Pharmacol Ther"},{"issue":"Suppl 10","key":"key20261027193126_b146-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"x12","DOI":"10.1093\/annonc\/mdz381","article-title":"Efficacy of PI3K inhibitors in advanced breast cancer","volume":"30","author":"Verret","year":"2019","journal-title":"Ann Oncol"},{"key":"key20261027193126_b147-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12929-020-00679-2","article-title":"Amino acid-dependent control of mTORC1 signaling: A variety of regulatory modes","volume":"27","author":"Takahara","year":"2020","journal-title":"J Biomed Sci"},{"key":"key20261027193126_b148-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1096\/fj.201600669R","article-title":"Selective p38\u03b1 MAP kinase\/MAPK14 inhibition in enzymatically modified LDL-stimulated human monocytes: Implications for atherosclerosis","volume":"31","author":"Cheng","year":"2017","journal-title":"FASEB J"},{"key":"key20261027193126_b149-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1186\/s12967-024-05822-3","article-title":"EBV-induced upregulation of CD55 reduces the efficacy of cetuximab treatment in nasopharyngeal carcinoma","volume":"22","author":"Zhu","year":"2024","journal-title":"J Transl Med"},{"key":"key20261027193126_b150-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"117140","DOI":"10.1016\/j.ejmech.2024.117140","article-title":"Catalytic Lysine745 targeting strategy in fourth-generation EGFR tyrosine kinase inhibitors to address C797S mutation resistance","volume":"283","author":"Patil","year":"2025","journal-title":"Eur J Med Chem"},{"key":"key20261027193126_b151-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1080\/15548627.2019.1586250","article-title":"TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1\/\u03b2-catenin degradation and is targeted for GSK3B\/GSK3\u03b2-mediated phosphorylation and degradation","volume":"15","author":"Wu","year":"2019","journal-title":"Autophagy"},{"key":"key20261027193126_b152-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1016\/j.celrep.2018.04.045","article-title":"GSK3\u03b2 regulates brain energy metabolism","volume":"23","author":"Martin","year":"2018","journal-title":"Cell Rep"},{"key":"key20261027193126_b153-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"e14818","DOI":"10.1111\/cns.14818","article-title":"GSK3: A potential target and pending issues for treatment of Alzheimer's disease","volume":"30","author":"Zhao","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"key20261027193126_b154-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12964-020-0527-z","article-title":"Role of STAT3 signaling pathway in breast cancer","volume":"18","author":"Ma","year":"2020","journal-title":"Cell Commun Signal"},{"key":"key20261027193126_b155-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13046-024-02949-5","article-title":"Unraveling the complexity of STAT3 in cancer: Molecular understanding and drug discovery","volume":"43","author":"Hu","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"key20261027193126_b156-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1515\/med-2021-0254","article-title":"Propofol postpones colorectal cancer development through circ_0026344\/miR-645\/Akt\/mTOR signal pathway","volume":"16","author":"Cui","year":"2021","journal-title":"Open Med (Wars)"},{"key":"key20261027193126_b157-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41571-024-00924-9","article-title":"HER2-targeted therapies beyond breast cancer-an update","volume":"21","author":"Yoon","year":"2024","journal-title":"Nat Rev Clin Oncol"},{"key":"key20261027193126_b158-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"103575","DOI":"10.1016\/j.drudis.2023.103575","article-title":"Small-molecule modulators of tumor necrosis factor signaling","volume":"28","author":"Ch\u00e9dotal","year":"2023","journal-title":"Drug Discov Today"},{"key":"key20261027193126_b159-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1126\/science.1233606","article-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","volume":"341","author":"Martinez Molina","year":"2013","journal-title":"Science"},{"key":"key20261027193126_b160-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"21984","DOI":"10.1073\/pnas.0910040106","article-title":"Target identification using drug affinity responsive target stability (DARTS)","volume":"106","author":"Lomenick","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20261027193126_b161-ijmm-58-06-06011","doi-asserted-by":"publisher","first-page":"771459","DOI":"10.3389\/fphar.2021.771459","article-title":"The potential application of Chinese medicine in liver diseases: A new opportunity","volume":"12","author":"Fu","year":"2021","journal-title":"Front Pharmacol"}],"container-title":["International Journal of Molecular Medicine"],"original-title":[],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:31:37Z","timestamp":1793122297000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijmm.2026.6011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":161,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,10,9]]}},"URL":"https:\/\/doi.org\/10.3892\/ijmm.2026.6011","relation":{},"ISSN":["1107-3756","1791-244X"],"issn-type":[{"value":"1107-3756","type":"print"},{"value":"1791-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]}}}