{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:22:27Z","timestamp":1787030547094,"version":"build-2736575974"},"reference-count":38,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.3892\/ijo.2012.1703","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T06:50:15Z","timestamp":1353048615000},"page":"202-210","source":"Crossref","is-referenced-by-count":38,"title":["Ethyl acetate extraction from a Chinese herbal formula, Jiedu Xiaozheng Yin, inhibits the proliferation of hepatocellular carcinoma cells via induction of G0\/G1 phase arrest in vivo and in vitro"],"prefix":"10.3892","volume":"42","author":[{"given":"ZHIYUN","family":"CAO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WEI","family":"LIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHENGRONG","family":"HUANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XUZHENG","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JINYAN","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LIANGPU","family":"ZHENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HONGZHI","family":"YE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHIZHEN","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LIANMING","family":"LIAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIAN","family":"DU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2012,11,16]]},"reference":[{"key":"key20180107181213_b1-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(03)14964-1","article-title":"Hepatocellular carcinoma","volume":"362","author":"Llovet","year":"2003","journal-title":"Lancet"},{"key":"key20180107181213_b2-ijo-42-01-0202","first-page":"198","article-title":"Hepatocellular carcinoma (HCC): current and evolving therapies","volume":"11","author":"Gish","year":"2008","journal-title":"IDrugs"},{"key":"key20180107181213_b3-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jep.2007.12.009","article-title":"Evidence-based Chinese medicine for cancer therapy","volume":"116","author":"Konkimalla","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"key20180107181213_b4-ijo-42-01-0202","first-page":"38","article-title":"Chinese medicine and cancer care","volume":"9","author":"Beinfield","year":"2003","journal-title":"Altern Ther Health Med"},{"key":"key20180107181213_b5-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/cmi.2008.3","article-title":"The immunopharmaceutical effects and mechanisms of herb medicine","volume":"5","author":"Huang","year":"2008","journal-title":"Cell Mol Immunol"},{"key":"key20180107181213_b6-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3748\/wjg.v11.i3.439","article-title":"Effect of Fuzheng Yiliu decoction combined with chemotherapy on patients with intermediate and late stage gastrointestinal cancer","volume":"11","author":"Pan","year":"2005","journal-title":"World J Gastroenterol"},{"key":"key20180107181213_b7-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1593\/neo.07160","article-title":"Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A\/J mice","volume":"9","author":"Yan","year":"2007","journal-title":"Neoplasia"},{"key":"key20180107181213_b8-ijo-42-01-0202","first-page":"577","article-title":"The active component of Hedyotis diffusa Willd","volume":"26","author":"Fang","year":"2004","journal-title":"Chinese Trad Plant Med"},{"key":"key20180107181213_b9-ijo-42-01-0202","first-page":"530","article-title":"Shanghai Science and Technology Press","volume":"25","author":"Wu","year":"1998","journal-title":"Zhong hua ben cao (Chin)"},{"key":"key20180107181213_b10-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3892\/or.2012.1834","article-title":"Water extract of Hedyotis Diffusa Willd suppresses proliferation of human HepG2 cells and potentiates the anticancer efficacy of low-dose 5-fluorouracil by inhibiting the CDK2-E2F1 pathway","volume":"28","author":"Chen","year":"2012","journal-title":"Oncol Rep"},{"key":"key20180107181213_b11-ijo-42-01-0202","first-page":"1331","article-title":"Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells","volume":"37","author":"Lin","year":"2010","journal-title":"Int J Oncol"},{"key":"key20180107181213_b12-ijo-42-01-0202","first-page":"1283","article-title":"Effect of Hedyotis Diffusa Willd extract on tumor angiogenesis","volume":"4","author":"Lin","year":"2011","journal-title":"Mol Med Rep"},{"key":"key20180107181213_b13-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/ptr.1324","article-title":"Biological activities of Prunella vulgaris extract","volume":"17","author":"Jitka","year":"2003","journal-title":"Phytother Res"},{"key":"key20180107181213_b14-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jphotobiol.2006.02.012","article-title":"Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes","volume":"84","author":"Psotova","year":"2006","journal-title":"J Photochem Photobiol B"},{"key":"key20180107181213_b15-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0092-8674(94)90543-6","article-title":"Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age","volume":"79","author":"Hunter","year":"1994","journal-title":"Cell"},{"key":"key20180107181213_b16-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/374131a0","article-title":"Principles of CDK regulation","volume":"374","author":"Morgan","year":"1995","journal-title":"Nature"},{"key":"key20180107181213_b17-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1038\/sj.onc.1208619","article-title":"Pocket proteins and cell cycle control","volume":"24","author":"Cobrinik","year":"2005","journal-title":"Oncogene"},{"key":"key20180107181213_b18-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1126\/science.1096896","article-title":"The molecular requirements for cytokinesis","volume":"307","author":"Glotzer","year":"2005","journal-title":"Science"},{"key":"key20180107181213_b19-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/CAD.0b013e32834f6ea8","article-title":"Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes","volume":"23","author":"Tin","year":"2012","journal-title":"Anticancer Drugs"},{"key":"key20180107181213_b20-ijo-42-01-0202","first-page":"1181","article-title":"Acetylbritannilactone suppresses growth via upregulation of kr\u00fcppel-like transcription factor 4 expression in HT-29 colorectal cancer cells","volume":"26","author":"Fang","year":"2011","journal-title":"Oncol Rep"},{"key":"key20180107181213_b21-ijo-42-01-0202","first-page":"832","article-title":"Effect of Chinese herbal medicine on patients with primary hepatic carcinoma in III stage during perioperational period: a report of 42 cases","volume":"25","author":"Chen","year":"2005","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"key20180107181213_b22-ijo-42-01-0202","first-page":"324","article-title":"Study on antitumor mechanism of Qingre Xiaozheng drink by molecular docking method","volume":"12","author":"Chen","year":"2007","journal-title":"Clin Pharmacol Ther (Chin)"},{"key":"key20180107181213_b23-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3748\/wjg.v4.i4.360","article-title":"Traditional Chinese medicine for primary liver cancer","volume":"4","author":"Li","year":"1998","journal-title":"World J Gastroenterol"},{"key":"key20180107181213_b24-ijo-42-01-0202","first-page":"275","article-title":"Clinical observation and experimental research in treatment of liver cancer at advanced stage by traditional medication of strengthening the Spleen, replenishing Qi, clearing away heat and toxic material","volume":"7","author":"Qui","year":"1987","journal-title":"J Integrated Trad Chin West Med"},{"key":"key20180107181213_b25-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3736\/jcim20060509","article-title":"Evidence for Oldenlandia diffusa-evoked cancer cell apoptosis through superoxide burst and caspase activation","volume":"4","author":"Yadav","year":"2006","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"key20180107181213_b26-ijo-42-01-0202","first-page":"2499","article-title":"Induction of mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells by kuraridin and Nor-kurarinone isolated from Sophora flavescens","volume":"12","author":"Rasul","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"key20180107181213_b27-ijo-42-01-0202","first-page":"88","article-title":"Historical and herbological studies on the traditional Japanese and Chinese crude drugs. On the \u2018Sh\u0101n-c\u00ed-g\u016b\u2019","volume":"20","author":"Lin","year":"1985","journal-title":"Yakushigaku Zasshi"},{"key":"key20180107181213_b28-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/bies.950170603","article-title":"Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle","volume":"17","author":"Nigg","year":"1995","journal-title":"Bioessays"},{"key":"key20180107181213_b29-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature06955","article-title":"Global control of cell-cycle transcription by coupled CDK and network oscillators","volume":"453","author":"Orlando","year":"2008","journal-title":"Nature"},{"key":"key20180107181213_b30-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.3390\/molecules15085093","article-title":"Identification of two polysaccharides from Prunella vulgaris L and evaluation on their anti-lung adenocarcinoma activity","volume":"15","author":"Feng","year":"2010","journal-title":"Molecules"},{"key":"key20180107181213_b31-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/ptr.1987","article-title":"Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities","volume":"20","author":"Kang","year":"2006","journal-title":"Phytother Res"},{"key":"key20180107181213_b32-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/ptr.3657","article-title":"Effects of matrine on proliferation and apoptosis in gallbladder carcinoma cells (GBC-SD)","volume":"26","author":"Zhang","year":"2012","journal-title":"Phytother Res"},{"key":"key20180107181213_b33-ijo-42-01-0202","first-page":"783","article-title":"Matrine inhibits proliferation and induces apoptosis of the androgen-independent prostate cancer cell line PC-3","volume":"5","author":"Zhang","year":"2012","journal-title":"Mol Med Rep"},{"key":"key20180107181213_b34-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/13880200903104101","article-title":"Effects of matrine on HepG2 cell proliferation and expression of tumor relevant proteins in vitro","volume":"48","author":"Qin","year":"2010","journal-title":"Pharm Biol"},{"key":"key20180107181213_b35-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00417-011-1751-4","article-title":"Effects of matrine on proliferation and apoptosis of cultured retinoblastoma cells","volume":"250","author":"Zhao","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"key20180107181213_b36-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3835(01)00785-6","article-title":"Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle","volume":"177","author":"Agami","year":"2002","journal-title":"Cancer Lett"},{"key":"key20180107181213_b37-ijo-42-01-0202","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/ijc.21445","article-title":"Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells","volume":"118","author":"Brew","year":"2006","journal-title":"Int J Cancer"},{"key":"key20180107181213_b38-ijo-42-01-0202","first-page":"893","article-title":"p21WAF1\/CIP1\/SDI1 is elevated through a p53-independent pathway by mimosine","volume":"7","author":"Alpan","year":"1996","journal-title":"Cell Growth Differ"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2012.1703\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T13:14:47Z","timestamp":1515330887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2012.1703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,16]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,11,16]]},"published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.3892\/ijo.2012.1703"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2012.1703","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,16]]}}}