{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:24:21Z","timestamp":1789179861168,"version":"build-2803163510"},"reference-count":58,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.3892\/ijo.2012.1751","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T11:24:21Z","timestamp":1356348261000},"page":"657-666","source":"Crossref","is-referenced-by-count":12,"title":["NF1 deficiency causes Bcl-xL upregulation in Schwann cells derived from neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors"],"prefix":"10.3892","volume":"42","author":[{"given":"HO-JIN","family":"PARK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SU-JIN","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOUNG BAE","family":"SOHN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HYUN-SEOK","family":"JIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAE-HO","family":"HAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOUNG-BAE","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HYUNEE","family":"YIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEON-YONG","family":"JEONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2012,12,24]]},"reference":[{"key":"key20180107181112_b1-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2008.12.051","article-title":"Neurofibromatosis type 1","volume":"61","author":"Boyd","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"key20180107181112_b2-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/sj.ejhg.5201676","article-title":"Neurofibromatosis 1","volume":"15","author":"Ferner","year":"2007","journal-title":"Eur J Hum Genet"},{"key":"key20180107181112_b3-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0092-8674(90)90253-B","article-title":"A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations","volume":"62","author":"Cawthon","year":"1990","journal-title":"Cell"},{"key":"key20180107181112_b4-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/GIM.0b013e3181bf15e3","article-title":"Clinical and genetic aspects of neurofibromatosis 1","volume":"12","author":"Jett","year":"2010","journal-title":"Genet Med"},{"key":"key20180107181112_b5-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/jso.20971","article-title":"Malignant peripheral nerve sheath tumor: Molecular pathogenesis and current management considerations","volume":"97","author":"Grobmyer","year":"2008","journal-title":"J Surg Oncol"},{"key":"key20180107181112_b6-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1227\/01.NEU.0000190651.45384.8B","article-title":"Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications","volume":"58","author":"Gottfried","year":"2006","journal-title":"Neurosurgery"},{"key":"key20180107181112_b7-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jnen\/64.1.1","article-title":"Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors: II. The role of dysregulated growth factor signaling","volume":"64","author":"Carroll","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"key20180107181112_b8-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/(SICI)1098-2264(199903)24:3<283::AID-GCC15>3.0.CO;2-K","article-title":"Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma","volume":"24","author":"Kluwe","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"key20180107181112_b9-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/hmg\/9.7.1059","article-title":"Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1","volume":"9","author":"Rutkowski","year":"2000","journal-title":"Hum Mol Genet"},{"key":"key20180107181112_b10-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1093\/hmg\/9.20.3055","article-title":"Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations","volume":"9","author":"Serra","year":"2000","journal-title":"Hum Mol Genet"},{"key":"key20180107181112_b11-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.1068452","article-title":"Neurofibromas in NF1: Schwann cell origin and role of tumor environment","volume":"296","author":"Zhu","year":"2002","journal-title":"Science"},{"key":"key20180107181112_b12-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.ajpath.2010.12.056","article-title":"The pathoetiology of neurofibromatosis 1","volume":"178","author":"Jouhilahti","year":"2011","journal-title":"Am J Pathol"},{"key":"key20180107181112_b13-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1182\/blood-2009-09-242875","article-title":"Mast cells and the neurofibroma microenvironment","volume":"116","author":"Staser","year":"2010","journal-title":"Blood"},{"key":"key20180107181112_b14-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1017\/S1462399409001227","article-title":"Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways","volume":"11","author":"Katz","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"key20180107181112_b15-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1470-2045(09)70033-6","article-title":"Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1","volume":"10","author":"Brems","year":"2009","journal-title":"Lancet Oncol"},{"key":"key20180107181112_b16-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1007\/s00432-010-0846-3","article-title":"Molecular evolution of a neurofibroma to malignant peripheral nerve sheath tumor (MPNST) in an NF1 patient: correlation between histopathological, clinical and molecular findings","volume":"136","author":"Spurlock","year":"2010","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20180107181112_b17-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.39.5.311","article-title":"Malignant peripheral nerve sheath tumours in neurofibromatosis 1","volume":"39","author":"Evans","year":"2002","journal-title":"J Med Genet"},{"key":"key20180107181112_b18-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/jmg.2006.048140","article-title":"Further evidence of the increased risk for malignant peripheral nerve sheath tumour from a Scottish cohort of patients with neurofibromatosis type 1","volume":"44","author":"McCaughan","year":"2007","journal-title":"J Med Genet"},{"key":"key20180107181112_b19-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1212\/01.wnl.0000168830.79997.13","article-title":"Association between benign and malignant peripheral nerve sheath tumors in NF1","volume":"65","author":"Tucker","year":"2005","journal-title":"Neurology"},{"key":"key20180107181112_b20-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/01376517-200812000-00005","article-title":"Patient and physician attitudes regarding clinical trials in neurofibromatosis 1","volume":"40","author":"McQueen","year":"2008","journal-title":"J Neurosci Nurs"},{"key":"key20180107181112_b21-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/ng0996-110","article-title":"Identification of NF1 mutations in both alleles of a dermal neurofibroma","volume":"14","author":"Sawada","year":"1996","journal-title":"Nat Genet"},{"key":"key20180107181112_b22-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/humu.10272","article-title":"Somatic NF1 mutation spectra in a family with neurofibromatosis type 1: toward a theory of genetic modifiers","volume":"22","author":"Wiest","year":"2003","journal-title":"Hum Mutat"},{"key":"key20180107181112_b23-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0165-4608(99)00006-0","article-title":"Allelic loss of the NF1 gene in NF1-associated plexiform neurofibromas","volume":"113","author":"Kluwe","year":"1999","journal-title":"Cancer Genet Cytogenet"},{"key":"key20180107181112_b24-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/1098-2264(200008)28:4<425::AID-GCC8>3.0.CO;2-E","article-title":"Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1","volume":"28","author":"Rasmussen","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"key20180107181112_b25-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/humu.20601","article-title":"Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs)","volume":"29","author":"Upadhyaya","year":"2008","journal-title":"Hum Mutat"},{"key":"key20180107181112_b26-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/jcp.54.8.631","article-title":"Malignant peripheral nerve sheath tumour arising within neurofibroma. An immunohistochemical analysis in the comparison between benign and malignant components","volume":"54","author":"Watanabe","year":"2001","journal-title":"J Clin Pathol"},{"key":"key20180107181112_b27-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1158\/0008-5472.CAN-05-3330","article-title":"Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues","volume":"66","author":"Miller","year":"2006","journal-title":"Cancer Res"},{"key":"key20180107181112_b28-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1158\/1078-0432.CCR-07-1305","article-title":"High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization","volume":"14","author":"Mantripragada","year":"2008","journal-title":"Clin Cancer Res"},{"key":"key20180107181112_b29-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/humu.22044","article-title":"Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis","volume":"33","author":"Upadhyaya","year":"2012","journal-title":"Hum Mutat"},{"key":"key20180107181112_b30-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2741\/3727","article-title":"Genetic basis of tumorigenesis in NF1 malignant peripheral nerve sheath tumors","volume":"16","author":"Upadhyaya","year":"2011","journal-title":"Front Biosci"},{"key":"key20180107181112_b31-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00401-011-0928-6","article-title":"Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms","volume":"123","author":"Carroll","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key20180107181112_b32-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<23::AID-AJMG6>3.0.CO;2-#","article-title":"Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis","volume":"89","author":"Woodruff","year":"1999","journal-title":"Am J Med Genet"},{"key":"key20180107181112_b33-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3892\/ijmm.2012.1013","article-title":"Inhibition of Bcl-xL by ABT-737 enhances chemotherapy sensitivity in neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor cells","volume":"30","author":"Lee","year":"2012","journal-title":"Int J Mol Med"},{"key":"key20180107181112_b34-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/sj.emboj.7600225","article-title":"Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers","volume":"23","author":"Jeong","year":"2004","journal-title":"EMBO J"},{"key":"key20180107181112_b35-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/jmg.2006.045906","article-title":"Guidelines for the diagnosis and management of individuals with neurofibromatosis 1","volume":"44","author":"Ferner","year":"2007","journal-title":"J Med Genet"},{"key":"key20180107181112_b36-ijo-42-02-0657","first-page":"299","article-title":"Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors","volume":"49","author":"Weiss","year":"1983","journal-title":"Lab Invest"},{"key":"key20180107181112_b37-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1111\/j.1600-0625.2009.01017.x","article-title":"Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1","volume":"19","author":"Arima","year":"2010","journal-title":"Exp Dermatol"},{"key":"key20180107181112_b38-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.bbamcr.2006.10.001","article-title":"Roles of the Raf\/MEK\/ERK pathway in cell growth, malignant transformation and drug resistance","volume":"1773","author":"McCubrey","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"key20180107181112_b39-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/COC.0b013e3181e9c08a","article-title":"Early outcomes for malignant peripheral nerve sheath tumor treated with chemotherapy","volume":"34","author":"Moretti","year":"2011","journal-title":"Am J Clin Oncol"},{"key":"key20180107181112_b40-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1074\/jbc.M009202200","article-title":"Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1\u2212\/\u2212 cells","volume":"276","author":"Hiatt","year":"2001","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"key20180107181112_b41-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1038\/onc.2009.52","article-title":"Mimicking the BH3 domain to kill cancer cells","volume":"27","author":"Ni Chonghaile","year":"2008","journal-title":"Oncogene"},{"key":"key20180107181112_b42-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainresbull.2011.08.005","article-title":"Genetically engineered mouse models shed new light on the pathogenesis of neurofibromatosis type I-related neoplasms of the peripheral nervous system","volume":"88","author":"Brossier","year":"2012","journal-title":"Brain Res Bull"},{"key":"key20180107181112_b43-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1111\/j.1349-7006.2010.01616.x","article-title":"MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1","volume":"101","author":"Chai","year":"2010","journal-title":"Cancer Sci"},{"key":"key20180107181112_b44-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/path.2633","article-title":"Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours","volume":"220","author":"Subramanian","year":"2010","journal-title":"J Pathol"},{"key":"key20180107181112_b45-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1158\/1078-0432.CCR-08-0144","article-title":"Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy","volume":"15","author":"Kang","year":"2009","journal-title":"Clin Cancer Res"},{"key":"key20180107181112_b46-ijo-42-02-0657","first-page":"441","article-title":"Anti-apoptotic proteins-targets for chemosensitization of tumor cells and cancer treatment","volume":"52","author":"Kostanova-Poliakova","year":"2005","journal-title":"Neoplasma"},{"key":"key20180107181112_b47-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2174\/138945010791170888","article-title":"Chemosensitization of prostate cancer by modulating Bcl-2 family proteins","volume":"11","author":"Karnak","year":"2010","journal-title":"Curr Drug Targets"},{"key":"key20180107181112_b48-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1038\/sj.onc.1210261","article-title":"Tumor microenvironment and neurofibromatosis type I: connecting the GAPs","volume":"26","author":"Le","year":"2007","journal-title":"Oncogene"},{"key":"key20180107181112_b49-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1172\/JCI62727","article-title":"Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis","volume":"122","author":"Dai","year":"2012","journal-title":"J Clin Invest"},{"key":"key20180107181112_b50-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1242\/jcs.115.12.2591","article-title":"Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways","volume":"115","author":"Edme","year":"2002","journal-title":"J Cell Sci"},{"key":"key20180107181112_b51-ijo-42-02-0657","first-page":"595","article-title":"Transcriptional regulation of the bcl-x gene encoding the anti-apoptotic Bcl-xL protein by Ets, Rel\/NFkappaB, STAT and AP1 transcription factor families","volume":"16","author":"Sevilla","year":"2001","journal-title":"Histol Histopathol"},{"key":"key20180107181112_b52-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1096\/fj.08-121046","article-title":"Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis","volume":"23","author":"Lee","year":"2009","journal-title":"FASEB J"},{"key":"key20180107181112_b53-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00001622-200011000-00006","article-title":"Regulation of Bcl-xL: a little bit of this and a little bit of STAT","volume":"12","author":"Grad","year":"2000","journal-title":"Curr Opin Oncol"},{"key":"key20180107181112_b54-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.advenzreg.2006.01.004","article-title":"Roles of the RAF\/MEK\/ERK and PI3K\/PTEN\/AKT pathways in malignant transformation and drug resistance","volume":"46","author":"McCubrey","year":"2006","journal-title":"Adv Enzyme Regul"},{"key":"key20180107181112_b55-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"30740","DOI":"10.1074\/jbc.M001702200","article-title":"Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts","volume":"275","author":"Sherman","year":"2000","journal-title":"J Biol Chem"},{"key":"key20180107181112_b56-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1093\/annonc\/mdr512","article-title":"Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance","volume":"23","author":"van Oosterwijk","year":"2012","journal-title":"Ann Oncol"},{"key":"key20180107181112_b57-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/pbc.22740","article-title":"Inhibition of Bcl-2 and Bcl-X enhances chemotherapy sensitivity in hepatoblastoma cells","volume":"55","author":"Lieber","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"key20180107181112_b58-ijo-42-02-0657","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.3171\/2009.11.FOCUS09221","article-title":"Neurofibromatosis type 1 and tumorigenesis: molecular mechanisms and therapeutic implications","volume":"28","author":"Gottfried","year":"2010","journal-title":"Neurosurg Focus"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2012.1751\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T15:42:56Z","timestamp":1643989376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2012.1751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,24]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,12,24]]},"published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.3892\/ijo.2012.1751"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2012.1751","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,24]]}}}