{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:17:00Z","timestamp":1783570620308,"version":"3.55.0"},"reference-count":39,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.3892\/ijo.2013.1873","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T10:57:52Z","timestamp":1364468272000},"page":"1674-1681","source":"Crossref","is-referenced-by-count":46,"title":["Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and -9 and \u03b1v\u03b26 integrin"],"prefix":"10.3892","volume":"42","author":[{"given":"HAIXIA","family":"LI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAYONG","family":"HUANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHONGXIUZI","family":"GAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YAN","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LINA","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JINHUA","family":"ZHENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2013,3,28]]},"reference":[{"key":"key20180107181004_b1-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.oraloncology.2009.01.004","article-title":"Oral squamous cell carcinoma overview","volume":"45","author":"Scully","year":"2009","journal-title":"Oral Oncol"},{"key":"key20180107181004_b2-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","article-title":"Matrix metalloproteinases: regulators of the tumor microenvironment","volume":"141","author":"Kessenbrock","year":"2010","journal-title":"Cell"},{"key":"key20180107181004_b3-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/excr.2000.5042","article-title":"Insights into extracellular matrix functions from mutant mouse models","volume":"261","author":"Gustafsson","year":"2000","journal-title":"Exp Cell Res"},{"key":"key20180107181004_b4-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1368-8375(99)00004-4","article-title":"Matrix metalloproteinases and oral cancer","volume":"35","author":"Thomas","year":"1999","journal-title":"Oral Oncol"},{"key":"key20180107181004_b5-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s12291-010-0060-8","article-title":"Matrix metalloproteinases and their inhibitors: correlation with invasion and metastasis in oral cancer","volume":"25","author":"Singh","year":"2010","journal-title":"Indian J Clin Biochem"},{"key":"key20180107181004_b6-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1756-9966-31-90","article-title":"Changes in the expression of MMP2, MMP9, and ColIV in stromal cells in oral squamous tongue cell carcinoma: relationships and prognostic implications","volume":"31","author":"Fan","year":"2012","journal-title":"J Exp Clin Cancer Res"},{"key":"key20180107181004_b7-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.oraloncology.2004.08.013","article-title":"Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma","volume":"41","author":"De Vicente","year":"2005","journal-title":"Oral Oncol"},{"key":"key20180107181004_b8-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(92)90115-S","article-title":"Integrins: versatility, modulation, and signaling in cell adhesion","volume":"69","author":"Hynes","year":"1992","journal-title":"Cell"},{"key":"key20180107181004_b9-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1242\/jcs.108.6.2241","article-title":"Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling","volume":"108","author":"Breuss","year":"1995","journal-title":"J Cell Sci"},{"key":"key20180107181004_b10-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2174\/138945009788680374","article-title":"Defining the role of integrin alphavbeta6 in cancer","volume":"10","author":"Bandyopadhyay","year":"2009","journal-title":"Curr Drug Targets"},{"key":"key20180107181004_b11-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.0022-202x.2001.01379.x","article-title":"Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells","volume":"117","author":"Thomas","year":"2001","journal-title":"J Invest Dermatol"},{"key":"key20180107181004_b12-ijo-42-05-1674","first-page":"125","article-title":"The role of the integrin alpha v beta6 in regulating the epithelial to mesenchymal transition in oral cancer","volume":"29","author":"Ramos","year":"2009","journal-title":"Anticancer Res"},{"key":"key20180107181004_b13-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/1097-0215(20010601)92:5<641::AID-IJC1243>3.0.CO;2-P","article-title":"AlphaVbeta6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9","volume":"92","author":"Thomas","year":"2001","journal-title":"Int J Cancer"},{"key":"key20180107181004_b14-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1349-7006.2008.00762.x","article-title":"Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver","volume":"99","author":"Yang","year":"2008","journal-title":"Cancer Sci"},{"key":"key20180107181004_b15-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S1808-8694(15)31173-3","article-title":"Expression of basement membrane laminin in oral squamous cell carcinomas","volume":"73","author":"Souza","year":"2007","journal-title":"Braz J Otorhinolaryngol"},{"key":"key20180107181004_b16-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.mam.2010.02.001","article-title":"Targeting anoikis resistance in prostate cancer metastasis","volume":"31","author":"Sakamoto","year":"2010","journal-title":"Mol Aspects Med"},{"key":"key20180107181004_b17-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1600-0714.2005.00325.x","article-title":"Molecular pathogenesis of oral submucous fibrosis - a collagen metabolic disorder","volume":"34","author":"Rajalalitha","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"key20180107181004_b18-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.4161\/cc.6.21.4850","article-title":"Deciphering AP-1 function in tumorigenesis: fraternizing on target promoters","volume":"6","author":"Verde","year":"2007","journal-title":"Cell Cycle"},{"key":"key20180107181004_b19-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/1097-4636(20001215)52:4<725::AID-JBM18>3.0.CO;2-O","article-title":"Integrin-mediated signaling regulates AP-1 transcription factors and proliferation in osteoblasts","volume":"52","author":"Cowles","year":"2000","journal-title":"J Biomed Mater Res"},{"key":"key20180107181004_b20-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cellsig.2010.08.012","article-title":"Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin alpha(5)beta(1)\/alpha(v)beta(3)-dependent Akt, ERK and JNK signaling pathways in human umbilical vein endothelial cells","volume":"23","author":"Jin","year":"2011","journal-title":"Cell Signal"},{"key":"key20180107181004_b21-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"16830","DOI":"10.1074\/jbc.M110.106187","article-title":"AP-1 (Fra-1\/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosate traenoic acid-induced angiogenesis","volume":"285","author":"Singh","year":"2010","journal-title":"J Biol Chem"},{"key":"key20180107181004_b22-ijo-42-05-1674","first-page":"1153","article-title":"Scutellarin inhibits cell migration by regulating production of alphavbeta6 integrin and E-cadherin in human tongue cancer cells","volume":"24","author":"Li","year":"2010","journal-title":"Oncol Rep"},{"key":"key20180107181004_b23-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/019262301317226311","article-title":"Collagen matrix in development and progression of experimentally induced respiratory neoplasms in the hamster","volume":"29","author":"Laitakari","year":"2001","journal-title":"Toxicol Pathol"},{"key":"key20180107181004_b24-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ptr.2010","article-title":"Chemoprevention of Scutellaria bardata on human cancer cells and tumorigenesis in skin cancer","volume":"21","author":"Suh","year":"2007","journal-title":"Phytother Res"},{"key":"key20180107181004_b25-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"8197","DOI":"10.1021\/jf051506+","article-title":"Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo","volume":"53","author":"Goh","year":"2005","journal-title":"J Agric Food Chem"},{"key":"key20180107181004_b26-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.phymed.2009.07.003","article-title":"Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells","volume":"17","author":"Wang","year":"2010","journal-title":"Phytomedicine"},{"key":"key20180107181004_b27-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.3109\/10428194.2012.693177","article-title":"Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells","volume":"53","author":"Feng","year":"2012","journal-title":"Leuk Lymphoma"},{"key":"key20180107181004_b28-ijo-42-05-1674","first-page":"301","article-title":"Effects of scutellarin on apoptosis induced by cobalt chloride in PC12 cells","volume":"50","author":"Wang","year":"2007","journal-title":"Chin J Physiol"},{"key":"key20180107181004_b29-ijo-42-05-1674","first-page":"3043","article-title":"Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation","volume":"29","author":"Chan","year":"2009","journal-title":"Anticancer Res"},{"key":"key20180107181004_b30-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0945-053X(02)00002-1","article-title":"Expression of integrin beta 6 enhances invasive behavior in oral squamous cell carcinoma","volume":"21","author":"Ramos","year":"2002","journal-title":"Matrix Biol"},{"key":"key20180107181004_b31-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1152\/physrev.1993.73.1.161","article-title":"Biology and biochemistry of proteinases in tumor invasion","volume":"73","author":"Mignatti","year":"1993","journal-title":"Physiol Rev"},{"key":"key20180107181004_b32-ijo-42-05-1674","first-page":"1","article-title":"Matrix metalloproteinases","volume":"103","author":"Vargova","year":"2012","journal-title":"EXS"},{"key":"key20180107181004_b33-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/bse0380021","article-title":"Matrix metalloproteinases in cancer","volume":"38","author":"Itoh","year":"2002","journal-title":"Essays Biochem"},{"key":"key20180107181004_b34-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/hed.20561","article-title":"Clinical significance of MMP-2 and MMP-9 in patients with oral cancer","volume":"29","author":"Patel","year":"2007","journal-title":"Head Neck"},{"key":"key20180107181004_b35-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1124\/jpet.110.177337","article-title":"Regulation of transforming growth factor-beta1-dependent integrin beta6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cells","volume":"337","author":"Sullivan","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"key20180107181004_b36-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/emm.2005.31","article-title":"Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells","volume":"37","author":"Hong","year":"2005","journal-title":"Exp Mol Med"},{"key":"key20180107181004_b37-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1023\/A:1026028303196","article-title":"Regulation of matrix metalloproteinases: an overview","volume":"253","author":"Chakraborti","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"key20180107181004_b38-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0014-5793(00)01591-X","article-title":"The alpha2 and alpha5 integrin genes: identification of transcription factors that regulate promoter activity in epidermal keratinocytes","volume":"474","author":"Corbi","year":"2000","journal-title":"FEBS Lett"},{"key":"key20180107181004_b39-ijo-42-05-1674","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbrc.2010.08.034","article-title":"Scutellarin promotes in vitro angiogenesis in human umbilical vein endothelial cells","volume":"400","author":"Gao","year":"2010","journal-title":"Biochem Biophys Res Commun"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2013.1873\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T16:10:49Z","timestamp":1644682249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2013.1873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,28]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,3,28]]},"published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.3892\/ijo.2013.1873"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2013.1873","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,28]]}}}