{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:02:27Z","timestamp":1791169347012,"version":"4.1.0"},"reference-count":33,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.3892\/ijo.2013.2214","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T09:30:15Z","timestamp":1386667815000},"page":"539-547","source":"Crossref","is-referenced-by-count":27,"title":["The small GTPase RhoA regulates the expression and function of the sodium channel Nav1.5 in breast cancer cells"],"prefix":"10.3892","volume":"44","author":[{"given":"C.","family":"DULONG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.J.","family":"FANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"GEST","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.","family":"ZHOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"PATTE-MENSAH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"MENSAH-NYAGAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"VANNIER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"LU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"SORIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"CAZIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.A.","family":"MEI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"VARIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2013,12,10]]},"reference":[{"key":"key20180107182534_b1-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1634\/theoncologist.2009-0078","article-title":"Metastatic breast cancer: therapeutic options according to molecular subtypes and prior adjuvant therapy","volume":"14","author":"Guarneri","year":"2009","journal-title":"Oncologist"},{"key":"key20180107182534_b2-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1158\/2159-8290.CD-11-0248","article-title":"Exemestane for breast cancer prevention: a critical shift?","volume":"2","author":"Decensi","year":"2012","journal-title":"Cancer Discov"},{"key":"key20180107182534_b3-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ymthe.2004.08.029","article-title":"Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo","volume":"11","author":"Pill\u00e9","year":"2005","journal-title":"Mol Ther"},{"key":"key20180107182534_b4-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1089\/hum.2006.17.1019","article-title":"Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer","volume":"17","author":"Pill\u00e9","year":"2006","journal-title":"Hum Gene Ther"},{"key":"key20180107182534_b5-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0092-8674(95)90370-4","article-title":"Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia","volume":"81","author":"Nobes","year":"1995","journal-title":"Cell"},{"key":"key20180107182534_b6-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/excr.2000.5049","article-title":"Rho GTPases: signaling, migration, and invasion","volume":"261","author":"Schmitz","year":"2000","journal-title":"Exp Cell Res"},{"key":"key20180107182534_b7-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"35622","DOI":"10.1074\/jbc.M804036200","article-title":"Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection","volume":"283","author":"Del Re","year":"2008","journal-title":"J Biol Chem"},{"key":"key20180107182534_b8-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1091\/mbc.E04-10-0945","article-title":"Protein kinase A gating of a pseudopodial-located RhoA\/ROCK\/p38\/NHE1 signal module regulates invasion in breast cancer cell lines","volume":"16","author":"Cardone","year":"2005","journal-title":"Mol Biol Cell"},{"key":"key20180107182534_b9-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.yexcr.2005.05.001","article-title":"Role of Rho, Rac, and Rho-kinase in phosphorylation of myosin light chain, development of polarity, and spontaneous migration of Walker 256 carcinosarcoma cells","volume":"308","author":"Gutjahr","year":"2005","journal-title":"Exp Cell Res"},{"key":"key20180107182534_b10-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00109-011-0753-3","article-title":"Proteomic identification of RhoA as a potential biomarker for proliferation and metastasis in hepatocellular carcinoma","volume":"89","author":"Gou","year":"2011","journal-title":"J Mol Med"},{"key":"key20180107182534_b11-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1002\/jcb.24153","article-title":"Rho GTPase signaling in the development of colorectal cancer","volume":"113","author":"Leve","year":"2012","journal-title":"J Cell Biochem"},{"key":"key20180107182534_b12-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1111\/j.1349-7006.2008.00977.x","article-title":"Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer","volume":"99","author":"Horiuchi","year":"2008","journal-title":"Cancer Sci"},{"key":"key20180107182534_b13-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.lungcan.2008.12.012","article-title":"Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer","volume":"63","author":"Liu","year":"2009","journal-title":"Lung Cancer"},{"key":"key20180107182534_b14-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"37021","DOI":"10.1074\/jbc.M112.382077","article-title":"The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry","volume":"287","author":"Balasuriya","year":"2012","journal-title":"J Biol Chem"},{"key":"key20180107182534_b15-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1074\/jbc.M806891200","article-title":"Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells","volume":"284","author":"Gillet","year":"2009","journal-title":"J Biol Chem"},{"key":"key20180107182534_b16-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1158\/0008-5472.CAN-10-1169","article-title":"Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion","volume":"70","author":"House","year":"2010","journal-title":"Cancer Res"},{"key":"key20180107182534_b17-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/ijc.26210","article-title":"Overexpression of NaV 1.6 channels is associated with the invasion capacity of human cervical cancer","volume":"130","author":"Hernandez-Plata","year":"2012","journal-title":"Int J Cancer"},{"key":"key20180107182534_b18-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00249-004-0389-0","article-title":"Voltage-gated Na+ channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects","volume":"33","author":"Diss","year":"2004","journal-title":"Eur Biophys J"},{"key":"key20180107182534_b19-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1158\/1078-0432.CCR-05-0327","article-title":"Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis","volume":"11","author":"Fraser","year":"2005","journal-title":"Clin Cancer Res"},{"key":"key20180107182534_b20-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10549-006-9281-1","article-title":"The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells","volume":"101","author":"Brackenbury","year":"2007","journal-title":"Breast Cancer Res Treat"},{"key":"key20180107182534_b21-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/onc.2010.574","article-title":"Na(V)1.5 enhances breast cancer cell invasiveness by increasing NHE1-dependent H(+) efflux in caveolae","volume":"30","author":"Brisson","year":"2011","journal-title":"Oncogene"},{"key":"key20180107182534_b22-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10549-012-2102-9","article-title":"Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer","volume":"134","author":"Yang","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"key20180107182534_b23-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.biocel.2009.11.021","article-title":"Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration","volume":"42","author":"Chioni","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"key20180107182534_b24-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/carcin\/22.8.1139","article-title":"Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study","volume":"22","author":"Denoyelle","year":"2001","journal-title":"Carcinogenesis"},{"key":"key20180107182534_b25-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0014-5793(01)02337-7","article-title":"Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect","volume":"495","author":"Vincent","year":"2001","journal-title":"FEBS Lett"},{"key":"key20180107182534_b26-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejphar.2009.08.040","article-title":"Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancer","volume":"625","author":"Onkal","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"key20180107182534_b27-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11596-009-0113-5","article-title":"Functional expression of voltage-gated sodium channels Nav1.5 in human breast cancer cell line MDA-MB-231","volume":"29","author":"Gao","year":"2009","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"key20180107182534_b28-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.tcb.2012.04.004","article-title":"Rho GTPase regulation by miRNAs and covalent modifications","volume":"22","author":"Liu","year":"2012","journal-title":"Trends Cell Biol"},{"key":"key20180107182534_b29-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.4161\/cc.21088","article-title":"Cell cycle regulation of Rho signaling pathways","volume":"11","author":"David","year":"2012","journal-title":"Cell Cycle"},{"key":"key20180107182534_b30-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/01.RES.0000170084.88780.ea","article-title":"Phosphorylation of serine 188 protects RhoA from ubiquitin\/proteasome-mediated degradation in vascular smooth muscle cells","volume":"96","author":"Rolli-Derkinderen","year":"2005","journal-title":"Circ Res"},{"key":"key20180107182534_b31-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1167\/iovs.10-6171","article-title":"Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells","volume":"52","author":"Von Zee","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180107182534_b32-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1152\/ajpcell.2001.280.4.C993","article-title":"Ca2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration","volume":"280","author":"Rao","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"key20180107182534_b33-ijo-44-02-0539","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1476-4598-6-76","article-title":"Epidermal growth factor potentiates in vitro metastatic behaviour of human prostate cancer PC-3M cells: involvement of voltage-gated sodium channel","volume":"6","author":"Uysal-Onganer","year":"2007","journal-title":"Mol Cancer"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2013.2214\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T18:29:26Z","timestamp":1515349766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2013.2214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,10]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,12,10]]},"published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.3892\/ijo.2013.2214"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2013.2214","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,10]]}}}