{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:50:56Z","timestamp":1793901056184,"version":"4.8.0"},"reference-count":55,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.3892\/ijo.2014.2289","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T09:50:20Z","timestamp":1391507420000},"page":"1153-1162","source":"Crossref","is-referenced-by-count":50,"title":["Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence"],"prefix":"10.3892","volume":"44","author":[{"given":"SOUICHI","family":"YANAMOTO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHIN-ICHI","family":"YAMADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIDENORI","family":"TAKAHASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOMOFUMI","family":"NARUSE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUKI","family":"MATSUSHITA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HISAZUMI","family":"IKEDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKESHI","family":"SHIRAISHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SACHIKO","family":"SEKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHUICHI","family":"FUJITA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOHRU","family":"IKEDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IZUMI","family":"ASAHINA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASAHIRO","family":"UMEDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2014,2,4]]},"reference":[{"key":"key20180107182342_b1-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global Cancer Statistics 2011","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"key20180107182342_b2-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","article-title":"Global epidemiology of oral and oropharyngeal cancer","volume":"45","author":"Warnakulasuriya","year":"2009","journal-title":"Oral Oncol"},{"key":"key20180107182342_b3-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.oraloncology.2008.05.008","article-title":"Survival following primary surgery for oral cancer","volume":"45","author":"Rogers","year":"2009","journal-title":"Oral Oncol"},{"key":"key20180107182342_b4-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/01.pas.0000149687.90710.21","article-title":"Oral squamous cell carcinoma. Histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival","volume":"29","author":"Brandwein-Gensler","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"key20180107182342_b5-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1001\/archoto.2010.214","article-title":"Predicting the prognosis of oral squamous cell carcinoma after first recurrence","volume":"136","author":"Kernohan","year":"2010","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"key20180107182342_b6-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.ijom.2012.07.011","article-title":"Clinicopathological risk factors for local recurrence in oral squamous cell carcinoma","volume":"41","author":"Yanamoto","year":"2012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"key20180107182342_b7-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1245\/s10434-007-9761-5","article-title":"Analysis of risk factors of predictive local tumor control in oral cavity cancer","volume":"15","author":"Liao","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"key20180107182342_b8-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.joms.2006.05.026","article-title":"Surgical salvage for local and regional recurrence in oral cancer","volume":"64","author":"Ord","year":"2006","journal-title":"J Oral Maxillofac Surg"},{"key":"key20180107182342_b9-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.oraloncology.2010.01.019","article-title":"Molecular analysis of surgical margins in head and neck cancer: more than a marginal issue","volume":"46","author":"Braakhuis","year":"2010","journal-title":"Oral Oncol"},{"key":"key20180107182342_b10-ijo-44-04-1153","first-page":"2718","article-title":"Detection of minimal residual cancer to investigate why oral tumors recur despiteseemingly adequate treatment","volume":"6","author":"Partridge","year":"2000","journal-title":"Clin Cancer Res"},{"key":"key20180107182342_b11-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1158\/1078-0432.CCR-03-0631","article-title":"Molecular diagnosis of surgical margins and local recurrence in head and neck cancer patients: a prospective study","volume":"10","author":"van Houten","year":"2004","journal-title":"Clin Cancer Res"},{"key":"key20180107182342_b12-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0714.2008.00715.x","article-title":"Molecular markers in the surgical margin of oral carcinomas","volume":"38","author":"Bilde","year":"2009","journal-title":"J Oral Pathol Med"},{"key":"key20180107182342_b13-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s12253-013-9646-9","article-title":"Predictors of locoregional recurrence in T1-2N0 tongue cancer patients","volume":"19","author":"Yanamoto","year":"2013","journal-title":"Pathol Oncol Res"},{"key":"key20180107182342_b14-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nrc1650","article-title":"Repopulation of cancer cells during therapy: an important cause of treatment failure","volume":"5","author":"Kim","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"key20180107182342_b15-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1158\/0008-5472.CAN-12-3609-T","article-title":"xCT-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma","volume":"73","author":"Yoshikawa","year":"2013","journal-title":"Cancer Res"},{"key":"key20180107182342_b16-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0065-230X(08)60101-3","article-title":"CD44: structure, function, and association with the malignant process","volume":"71","author":"Naor","year":"1997","journal-title":"Adv Cancer Res"},{"key":"key20180107182342_b17-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1038\/onc.2012.638","article-title":"Redox regulation in stem-like cancer cells by CD44 variant isoforms","volume":"32","author":"Nagano","year":"2013","journal-title":"Oncogene"},{"key":"key20180107182342_b18-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"e24217","DOI":"10.1371\/journal.pone.0024217","article-title":"CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway","volume":"6","author":"Jijiwa","year":"2011","journal-title":"PLoS One"},{"key":"key20180107182342_b19-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/modpathol.2012.163","article-title":"Colorectal micropapillary carcinomas are associated with poor prognosis and enriched in markers of stem cells","volume":"26","author":"Lee","year":"2013","journal-title":"Mod Pathol"},{"key":"key20180107182342_b20-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/BSR20100018","article-title":"Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells","volume":"31","author":"Gaviraghi","year":"2011","journal-title":"Biosci Rep"},{"key":"key20180107182342_b21-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"e3360","DOI":"10.1371\/journal.pone.0003360","article-title":"CD44s and CD44v6 expression in head and neck epithelia","volume":"3","author":"Mack","year":"2008","journal-title":"PLoS One"},{"key":"key20180107182342_b22-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm0901-1028","article-title":"The ABC transporter Bcrp1\/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype","volume":"67","author":"Zhou","year":"2001","journal-title":"Nat Med"},{"key":"key20180107182342_b23-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.canlet.2008.12.015","article-title":"Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes","volume":"277","author":"Zhang","year":"2009","journal-title":"Cancer Lett"},{"key":"key20180107182342_b24-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.oraloncology.2011.06.501","article-title":"Isolation and characterization of cancer stem-like side population cells in human oral cancer cells","volume":"47","author":"Yanamoto","year":"2011","journal-title":"Oral Oncol"},{"key":"key20180107182342_b25-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/path.1711660409","article-title":"Malignancy grading of the deep invasive margins of oral squamous cell carcinoma has high prognostic value","volume":"166","author":"Bryne","year":"1992","journal-title":"J Pathol"},{"key":"key20180107182342_b26-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/(SICI)1097-0142(19980415)82:8<1443::AID-CNCR2>3.0.CO;2-A","article-title":"Tumor thickness predicts cervical metastasis in patients with stage I\/II carcinoma of the tongue","volume":"82","author":"Asakage","year":"1998","journal-title":"Cancer"},{"key":"key20180107182342_b27-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/hed.10130","article-title":"Risk factors for late cervical lymph node metastases in patients with stage I or II carcinoma of the tongue","volume":"24","author":"Kurokawa","year":"2002","journal-title":"Head Neck"},{"key":"key20180107182342_b28-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1158\/1078-0432.CCR-0533-3","article-title":"Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue","volume":"10","author":"Lim","year":"2004","journal-title":"Clin Cancer Res"},{"key":"key20180107182342_b29-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.otohns.2004.04.008","article-title":"Multivariate predictors of occult neck metastasis in early oral tongue cancer","volume":"131","author":"Sparano","year":"2004","journal-title":"Otolaryngol Head Neck Surg"},{"key":"key20180107182342_b30-ijo-44-04-1153","first-page":"1489","article-title":"Predictive value of tumor thickness for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity","volume":"115","author":"Huang","year":"2009","journal-title":"A meta-analysis of reported studies Cancer"},{"key":"key20180107182342_b31-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.ijrobp.2009.06.064","article-title":"Treatment results of postoperative radiotherapy on squamous cell carcinoma of the oral cavity: coexistence of multiple minor risk factors results in higher recurrence rates","volume":"77","author":"Fan","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180107182342_b32-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/01.sla.0000186170.38348.7b","article-title":"Histomorphologic tumor regression and lymph node metastases determine prognosis following neoadjuvant radiochemotherapy for esophageal cancer","volume":"242","author":"Schneider","year":"2005","journal-title":"Ann Surg"},{"key":"key20180107182342_b33-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1245\/s10434-010-1196-8","article-title":"Influence of neoadjuvant chemoradiation on the number and size of analyzed lymph nodes in esophageal cancer","volume":"17","author":"Bollschweiler","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"key20180107182342_b34-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.lungcan.2008.07.014","article-title":"Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy","volume":"64","author":"Ota","year":"2009","journal-title":"Lung Cancer"},{"key":"key20180107182342_b35-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1442-2050.2011.01298.x","article-title":"Prognostic value of the stem cell markers CD133 and ABCG2 expression in esophageal squamous cell carcinoma","volume":"25","author":"Hang","year":"2012","journal-title":"Dis Esophagus"},{"key":"key20180107182342_b36-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00432-008-0391-5","article-title":"Prognostic significance of surviving and CD44v6 in laryngeal cancer surgical margins","volume":"134","author":"Zhao","year":"2008","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20180107182342_b37-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.med.58.062105.204854","article-title":"Cancer stem cells: models and concepts","volume":"58","author":"Dalerba","year":"2007","journal-title":"Annu Rev Med"},{"key":"key20180107182342_b38-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrc2499","article-title":"Cancer stem cells in solid tumours: accumulating evidence and unresolved questions","volume":"8","author":"Visvader","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"key20180107182342_b39-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/jcb.21436","article-title":"The stem cell hypothesis in head and neck cancer","volume":"103","author":"Graziano","year":"2008","journal-title":"J Cell Biochem"},{"key":"key20180107182342_b40-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1200\/JCO.2007.15.1613","article-title":"Cancer stem cells in head and neck squamous cell cancer","volume":"26","author":"Prince","year":"2008","journal-title":"J Clin Oncol"},{"key":"key20180107182342_b41-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.oraloncology.2013.06.010","article-title":"Relevance of cancer initiating\/stem cells in carcinogenesis and therapy resistance in oral cancer","volume":"49","author":"Sinha","year":"2013","journal-title":"Oral Oncol"},{"key":"key20180107182342_b42-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"12160","DOI":"10.1073\/pnas.89.24.12160","article-title":"Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons","volume":"89","author":"Screaton","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107182342_b43-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/mp.52.4.189","article-title":"CD44 cell adhesion molecules","volume":"52","author":"Goodison","year":"1999","journal-title":"Mol Pathol"},{"key":"key20180107182342_b44-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/lary.20506","article-title":"CD44 variant isoforms in head and neck squamous cell carcinoma progression","volume":"119","author":"Wang","year":"2009","journal-title":"Laryngoscope"},{"key":"key20180107182342_b45-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1080\/07357900801941845","article-title":"Bladder cancer initiating cells (BCICs) are among (initiating) cells","volume":"26","author":"Yang","year":"2008","journal-title":"Cancer Invest"},{"key":"key20180107182342_b46-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1471-2407-13-182","article-title":"Correlation of CD44v6 expression with ovarian cancer progression and recurrence","volume":"13","author":"Shi","year":"2013","journal-title":"BMC Cancer"},{"key":"key20180107182342_b47-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3892\/etm.2011.331","article-title":"Expression and function of ABCG2 in head and neck squamous cell carcinoma and cell lines","volume":"2","author":"Shen","year":"2011","journal-title":"Exp Ther Med"},{"key":"key20180107182342_b48-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0002-9610(99)80341-9","article-title":"Improved survival with preoperative chemotherapy followed by tumor response for advanced squamous cell carcinoma of the head and neck","volume":"170","author":"Lore","year":"1995","journal-title":"Am J Surg"},{"key":"key20180107182342_b49-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-4","article-title":"Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: three meta-analyses of updated individual data","volume":"355","author":"Pignon","year":"2000","journal-title":"Lancet"},{"key":"key20180107182342_b50-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1200\/JCO.2003.06.146","article-title":"Primary chemotherapy in resectable oral cavity squamous cell carcinoma: a randomized controlled trial","volume":"21","author":"Licitra","year":"2003","journal-title":"J Clin Oncol"},{"key":"key20180107182342_b51-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12253-009-9208-3","article-title":"Neoadjuvant chemotherapy: does it have benefits for surgeon in the treatment of advanced squamous cell cancer of the oral cavity?","volume":"16","author":"Olasz","year":"2010","journal-title":"Pathol Oncol Res"},{"key":"key20180107182342_b52-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/gyno.2000.6016","article-title":"CD44 isoform 6 (CD44v6) is a prognostic indicator of the response to neoadjuvant chemo-therapy in cervical carcinoma","volume":"80","author":"Costa","year":"2001","journal-title":"Gynecol Oncol"},{"key":"key20180107182342_b53-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.clon.2010.09.012","article-title":"Clinical significance of CD133 and hypoxia inducible factor-1\u03b1 gene expression in rectal cancer after preoperative chemotherapy","volume":"23","author":"Saigusa","year":"2011","journal-title":"Clin Oncol"},{"key":"key20180107182342_b54-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3892\/etm.2011.438","article-title":"Clinical significance of radiation-induced CD133 expression in residual rectal cancer cells after chemoradiotherapy","volume":"3","author":"Kawamoto","year":"2012","journal-title":"Exp Ther Med"},{"key":"key20180107182342_b55-ijo-44-04-1153","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/cncr.27703","article-title":"Enrichment of CD133-expressing cells in rectal cancers treated with preoperative radiochemotherapy is an independent marker for metastasis and survival","volume":"119","author":"Sprenger","year":"2013","journal-title":"Cancer"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2014.2289\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T18:27:35Z","timestamp":1515349655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2014.2289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,4]]},"references-count":55,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,2,4]]},"published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.3892\/ijo.2014.2289"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2014.2289","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,4]]}}}