{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T21:38:36Z","timestamp":1785101916101,"version":"3.55.0"},"reference-count":47,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.3892\/ijo.2014.2682","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T09:17:50Z","timestamp":1412587070000},"page":"2522-2532","source":"Crossref","is-referenced-by-count":20,"title":["Chronic exposure to asbestos enhances TGF-\u03b21 production in the human adult T cell leukemia virus-immortalized T cell line MT-2"],"prefix":"10.3892","volume":"45","author":[{"given":"MEGUMI","family":"MAEDA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YING","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROAKI","family":"HAYASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NAOKO","family":"KUMAGAI-TAKEI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIDENORI","family":"MATSUZAKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUNI","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YASUMITSU","family":"NISHIMURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKEMI","family":"OTSUKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2014,9,29]]},"reference":[{"key":"key20180107182038_b1-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1164\/rccm.200412-1731OC","article-title":"Residential proximity to naturally occurring asbestos and mesothelioma risk in California","volume":"172","author":"Pan","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"key20180107182038_b2-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1164\/rccm.200801-063OC","article-title":"Mapping the risk of mesothelioma due to neighborhood asbestos exposure","volume":"178","author":"Kurumatani","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"key20180107182038_b3-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1165\/rcmb.2009-0206TR","article-title":"Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways","volume":"42","author":"Heintz","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20180107182038_b4-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1289\/ehp.1002285","article-title":"The case for a global ban on asbestos","volume":"118","author":"LaDou","year":"2010","journal-title":"Environ Health Perspect"},{"key":"key20180107182038_b5-ijo-45-06-2522","first-page":"332","article-title":"Polyclonal human T-cell activation by silicate in vitro","volume":"82","author":"Ueki","year":"1994","journal-title":"Immunology"},{"key":"key20180107182038_b6-ijo-45-06-2522","first-page":"1355","article-title":"Activation-induced cell death in human peripheral blood lymphocytes after stimulation with silicate in vitro","volume":"12","author":"Aikoh","year":"1998","journal-title":"Int J Oncol"},{"key":"key20180107182038_b7-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1177\/039463200902200304","article-title":"Impairment in cytotoxicity and expression of NK cell- activating receptors on human NK cells following exposure to asbestos fibers","volume":"22","author":"Nishimura","year":"2009","journal-title":"Int J Immunopathol Pharmacol"},{"key":"key20180107182038_b8-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1177\/039463200902200403","article-title":"Decrease in phosphorylation of ERK following decreased expression of NK cell-activating receptors in human NK cell line exposed to asbestos","volume":"22","author":"Nishimura","year":"2009","journal-title":"Int J Immunopathol Pharmacol"},{"key":"key20180107182038_b9-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1165\/rcmb.2012-0134OC","article-title":"Effect of asbestos exposure on differentiation of cytotoxic T lymphocytes in mixed lymphocyte reaction of human peripheral blood mononuclear cells","volume":"49","author":"Kumagai-Takei","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20180107182038_b10-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s12199-013-0333-y","article-title":"Altered functions of alveolar macrophages and NK cells involved in asbestos-related diseases","volume":"18","author":"Nishimura","year":"2013","journal-title":"Environ Health Prev Med"},{"key":"key20180107182038_b11-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/294770a0","article-title":"Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells","volume":"294","author":"Miyoshi","year":"1981","journal-title":"Nature"},{"key":"key20180107182038_b12-ijo-45-06-2522","first-page":"11","article-title":"Immunological changes in mesothelioma patients and their experimental detection","volume":"2","author":"Maeda","year":"2008","journal-title":"Clin Med Circ Respirat Pulm Med"},{"key":"key20180107182038_b13-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-3083.2005.01592.x","article-title":"Inhibitory effects of anti-oxidants on apoptosis of a human polyclonal T-cell line, MT-2, induced by an asbestos, chrysotile-A","volume":"61","author":"Hyodoh","year":"2005","journal-title":"Scand J Immunol"},{"key":"key20180107182038_b14-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s10495-006-9235-4","article-title":"Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells","volume":"11","author":"Miura","year":"2006","journal-title":"Apoptosis"},{"key":"key20180107182038_b15-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1177\/039463200601900409","article-title":"Expression of the T cell receptor Vbeta repertoire in a human T cell resistant to asbestos-induced apoptosis and peripheral blood T cells from patients with silica and asbestos-related diseases","volume":"19","author":"Nishimura","year":"2006","journal-title":"Int J Immunopathol Pharmacol"},{"key":"key20180107182038_b16-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.imbio.2013.04.007","article-title":"Alteration of cytoskeletal molecules in a human T cell line caused by continuous exposure to chrysotile asbestos","volume":"218","author":"Maeda","year":"2013","journal-title":"Immunobiology"},{"key":"key20180107182038_b17-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.scitotenv.2012.04.043","article-title":"Resistance to asbestos-induced apoptosis with continuous exposure to crocidolite on a human T cell","volume":"429","author":"Maeda","year":"2012","journal-title":"Sci Total Environ"},{"key":"key20180107182038_b18-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1165\/rcmb.2010-0213OC","article-title":"Reduction of CXC chemokine receptor 3 in an in vitro model of continuous exposure to asbestos in a human T-cell line, MT-2","volume":"45","author":"Maeda","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20180107182038_b19-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1165\/rcmb.2010-0435OC","article-title":"Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients","author":"Maeda","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20180107182038_b20-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/intimm\/dxh366","article-title":"Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells","volume":"18","author":"Chen","year":"2006","journal-title":"Int Immunol"},{"key":"key20180107182038_b21-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"Sakaguchi","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"key20180107182038_b22-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nri2808","article-title":"The polarization of immune cells in the tumour environment by TGFbeta","author":"Flavell","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"key20180107182038_b23-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/(SICI)1097-0274(199611)30:5<515::AID-AJIM1>3.0.CO;2-S","article-title":"Mineral phases and some reexamined characteristics of the International Union Against Cancer standard asbestos samples","volume":"30","author":"Kohyama","year":"1996","journal-title":"Am J Ind Med"},{"key":"key20180107182038_b24-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1126\/science.1068999","article-title":"A system for stable expression of short interfering RNAs in mammalian cells","volume":"296","author":"Brummelkamp","year":"2002","journal-title":"Science"},{"key":"key20180107182038_b25-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/ng1173","article-title":"Induction of an interferon response by RNAi vectors in mammalian cells","volume":"34","author":"Bridge","year":"2003","journal-title":"Nat Genet"},{"key":"key20180107182038_b26-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1126\/science.272.5259.263","article-title":"In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector","volume":"272","author":"Naldini","year":"1996","journal-title":"Science"},{"key":"key20180107182038_b27-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nbt0997-871","article-title":"Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo","volume":"15","author":"Zufferey","year":"1997","journal-title":"Nat Biotechnol"},{"key":"key20180107182038_b28-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1182\/blood-2001-12-0372","article-title":"Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis","volume":"100","author":"Arnulf","year":"2002","journal-title":"Blood"},{"key":"key20180107182038_b29-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"key20180107182038_b30-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"Zhang","year":"2002","journal-title":"Cell Res"},{"key":"key20180107182038_b31-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1038\/sj.onc.1208922","article-title":"TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia","volume":"24","author":"Letterio","year":"2005","journal-title":"Oncogene"},{"key":"key20180107182038_b32-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/ni1398","article-title":"A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance","volume":"7","author":"Li","year":"2006","journal-title":"Nat Immunol"},{"key":"key20180107182038_b33-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/gene.2012.63","article-title":"The TGF-beta-Smad3 pathway inhibits CD28-dependenT cell growth and proliferation of CD4 T cells","volume":"14","author":"Delisle","year":"2013","journal-title":"Genes Immun"},{"key":"key20180107182038_b34-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/jb\/mvq043","article-title":"Cellular and molecular basis for the regulation of inflammation by TGF-beta","volume":"147","author":"Yoshimura","year":"2010","journal-title":"J Biochem"},{"key":"key20180107182038_b35-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/23293","article-title":"A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation","volume":"400","author":"Zhu","year":"1999","journal-title":"Nature"},{"key":"key20180107182038_b36-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.1158\/1078-0432.CCR-07-1157","article-title":"Transforming growth factor-beta and the immune response: implications for anticancer therapy","volume":"13","author":"Wrzesinski","year":"2007","journal-title":"Clin Cancer Res"},{"key":"key20180107182038_b37-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1158\/0008-5472.CAN-06-2389","article-title":"A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection","volume":"67","author":"Suzuki","year":"2007","journal-title":"Cancer Res"},{"key":"key20180107182038_b38-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri1806","article-title":"Regulatory T cells, tumour immunity and immunotherapy","volume":"6","author":"Zou","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"key20180107182038_b39-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1084\/jem.20111653","article-title":"TGF-beta synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth","volume":"209","author":"Fujii","year":"2012","journal-title":"J Exp Med"},{"key":"key20180107182038_b40-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12199-008-0063-8","article-title":"Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases","volume":"14","author":"Murakami","year":"2009","journal-title":"Environ Health Prev Med"},{"key":"key20180107182038_b41-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"key20180107182038_b42-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jcb.21255","article-title":"A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling","volume":"101","author":"Brown","year":"2007","journal-title":"J Cell Biochem"},{"key":"key20180107182038_b43-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nrc1208","article-title":"Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer","volume":"3","author":"Siegel","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"key20180107182038_b44-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cytogfr.2005.09.009","article-title":"Alterations in components of the TGF-beta superfamily signaling pathways in human cancer","volume":"17","author":"Levy","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"key":"key20180107182038_b45-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.4049\/jimmunol.181.5.3575","article-title":"Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells","volume":"181","author":"Xiao","year":"2008","journal-title":"J Immunol"},{"key":"key20180107182038_b46-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"e3302","DOI":"10.1371\/journal.pone.0003302","article-title":"P38 MAP kinase signaling is required for the conversion of CD4+CD25\u2212 T cells into iTreg","volume":"3","author":"Huber","year":"2008","journal-title":"PLoS One"},{"key":"key20180107182038_b47-ijo-45-06-2522","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/S1470-2045(13)70381-4","article-title":"Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: an open-label, single-arm, phase 2 trial","volume":"14","author":"Calabro","year":"2013","journal-title":"Lancet Oncol"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2014.2682\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T18:24:31Z","timestamp":1515349471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2014.2682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,29]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,9,29]]},"published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.3892\/ijo.2014.2682"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2014.2682","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,29]]}}}