{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:15:19Z","timestamp":1792793719448,"version":"4.5.0"},"reference-count":36,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.3892\/ijo.2015.2917","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T14:49:29Z","timestamp":1425480569000},"page":"1978-1984","source":"Crossref","is-referenced-by-count":46,"title":["Interleukin-1 receptor antagonist (IL1RN) is associated with suppression of early carcinogenic events in human oral malignancies"],"prefix":"10.3892","volume":"46","author":[{"given":"MASASHI","family":"SHIIBA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KENGO","family":"SAITO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HITOMI","family":"YAMAGAMI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAI","family":"NAKASHIMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MORIHIRO","family":"HIGO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ATSUSHI","family":"KASAMATSU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSUKE","family":"SAKAMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATSUNORI","family":"OGAWARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATSUHIRO","family":"UZAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUICHI","family":"TAKIGUCHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIDEKI","family":"TANZAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"key20180107183909_b1-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.oraloncology.2003.09.013","article-title":"Trends in oral cancer mortality in Europe","volume":"40","author":"La Vecchia","year":"2004","journal-title":"Oral Oncol"},{"key":"key20180107183909_b2-ijo-46-05-1978","first-page":"59","article-title":"Identification of differentially expressed proteins in oral squamous cell carcinoma using a global proteomic approach","volume":"27","author":"Koike","year":"2005","journal-title":"Int J Oncol"},{"key":"key20180107183909_b3-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20100136","article-title":"Multifaceted link between cancer and inflammation","volume":"32","author":"Sethi","year":"2012","journal-title":"Biosci Rep"},{"key":"key20180107183909_b4-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.coph.2009.06.020","article-title":"Inflammation and cancer: How friendly is the relationship for cancer patients?","volume":"9","author":"Aggarwal","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"key20180107183909_b5-ijo-46-05-1978","first-page":"195","article-title":"Relationship of oral cancer with age, sex, site distribution and habits","volume":"47","author":"Patel","year":"2004","journal-title":"Indian J Pathol Microbiol"},{"key":"key20180107183909_b6-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/ijc.11114","article-title":"Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men","volume":"105","author":"Znaor","year":"2003","journal-title":"Int J Cancer"},{"key":"key20180107183909_b7-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jso.21245","article-title":"IL-1alpha secreted by colon cancer cells enhances angiogenesis: The relationship between IL-1alpha release and tumor cells\u2019 potential for liver metastasis","volume":"99","author":"Matsuo","year":"2009","journal-title":"J Surg Oncol"},{"key":"key20180107183909_b8-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jss.2008.04.040","article-title":"Interleukin-1alpha secreted by pancreatic cancer cells promotes angiogenesis and its therapeutic implications","volume":"153","author":"Matsuo","year":"2009","journal-title":"J Surg Res"},{"key":"key20180107183909_b9-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jss.2007.08.014","article-title":"Interleukin-1alpha enhances angiogenesis and is associated with liver metastatic potential in human gastric cancer cell lines","volume":"148","author":"Ma","year":"2008","journal-title":"J Surg Res"},{"key":"key20180107183909_b10-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0065-2776(08)60642-2","article-title":"Interleukin-1 and its biologically related cytokines","volume":"44","author":"Dinarello","year":"1989","journal-title":"Adv Immunol"},{"key":"key20180107183909_b11-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/08830189809043005","article-title":"Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist","volume":"16","author":"Dinarello","year":"1998","journal-title":"Int Rev Immunol"},{"key":"key20180107183909_b12-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1172\/JCI115453","article-title":"Interleukin 1 receptor antagonist. A new member of the interleukin 1 family","volume":"88","author":"Arend","year":"1991","journal-title":"J Clin Invest"},{"key":"key20180107183909_b13-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1359-6101(02)00020-5","article-title":"The balance between IL-1 and IL-1Ra in disease","volume":"13","author":"Arend","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"key20180107183909_b14-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1348-8643(06)80001-7","article-title":"Yamashiro M and and Ishikawa H: Oral leukoplakia related to malignant transformation","volume":"3","author":"Amagasa","year":"2006","journal-title":"Oral Sci Int"},{"key":"key20180107183909_b15-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/modpathol.3800174","article-title":"CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression","volume":"17","author":"Bilalovic","year":"2004","journal-title":"Mod Pathol"},{"issue":"Suppl 8","key":"key20180107183909_b16-ijo-46-05-1978","first-page":"S4244","article-title":"Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors","volume":"46","author":"McCarty","year":"1986","journal-title":"Cancer Res"},{"key":"key20180107183909_b17-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1186\/1471-2407-9-370","article-title":"Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse","volume":"9","author":"Lallemant","year":"2009","journal-title":"BMC Cancer"},{"key":"key20180107183909_b18-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S1368-8375(03)00079-4","article-title":"Allelic loss on chromosomes 2q, 3p and 21q: Possibly a poor prognostic factor in oral squamous cell carcinoma","volume":"39","author":"Yamamoto","year":"2003","journal-title":"Oral Oncol"},{"key":"key20180107183909_b19-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1161\/01.ATV.20.11.2394","article-title":"Interleukin-1 receptor antagonist expression in human endothelial cells and atherosclerosis","volume":"20","author":"Dewberry","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20180107183909_b20-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/sj.gene.6364393","article-title":"Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels","volume":"8","author":"Rafiq","year":"2007","journal-title":"Genes Immun"},{"key":"key20180107183909_b21-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0753-3322(01)00140-8","article-title":"Cytokine deregulation in cancer","volume":"55","author":"Kurzrock","year":"2001","journal-title":"Biomed Pharmacother"},{"key":"key20180107183909_b22-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1182\/blood.V87.4.1458.bloodjournal8741458","article-title":"Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome","volume":"87","author":"Gherardi","year":"1996","journal-title":"Blood"},{"key":"key20180107183909_b23-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3109\/00365529709025103","article-title":"Interleukin-1 receptor antagonists and other markers in colorectal cancer patients","volume":"32","author":"Iwagaki","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"key20180107183909_b24-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1158\/1055-9965.EPI-07-0302","article-title":"Assessment of 54 biomarkers for biopsy-detectable prostate cancer","volume":"16","author":"Parekh","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key20180107183909_b25-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/mc.1031","article-title":"Role of intracellular interleukin-1 receptor antagonist in skin carcinogenesis","volume":"30","author":"La","year":"2001","journal-title":"Mol Carcinog"},{"key":"key20180107183909_b26-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1158\/1078-0432.CCR-05-1603","article-title":"The role of interleukin 1 in growth and metastasis of human cancer xenografts","volume":"12","author":"Elaraj","year":"2006","journal-title":"Clin Cancer Res"},{"key":"key20180107183909_b27-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1158\/0008-5472.CAN-10-2289","article-title":"Tamoxifen, flaxseed, and the lignan enterolactone increase stroma- and cancer cell-derived IL-1Ra and decrease tumor angiogenesis in estrogen-dependent breast cancer","volume":"71","author":"Lindahl","year":"2011","journal-title":"Cancer Res"},{"key":"key20180107183909_b28-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0090-8258(02)00154-3","article-title":"Clinical significance of interleukin-1 receptor antagonist in patients with cervical carcinoma","volume":"89","author":"Fujiwaki","year":"2003","journal-title":"Gynecol Oncol"},{"key":"key20180107183909_b29-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0304-3835(99)00162-7","article-title":"Interleukin-1 receptor antagonist mRNA expression and the progression of gastric carcinoma","volume":"142","author":"Iizuka","year":"1999","journal-title":"Cancer Lett"},{"key":"key20180107183909_b30-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/(SICI)1097-0215(19970611)71:6<1066::AID-IJC25>3.0.CO;2-A","article-title":"Autocrine interleukin-1 receptor antagonist can support malignant growth of glioblastoma by blocking growth-inhibiting autocrine loop of interleukin-1","volume":"71","author":"Oelmann","year":"1997","journal-title":"Int J Cancer"},{"key":"key20180107183909_b31-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0304-3835(95)03876-X","article-title":"Growth modulation of human prostatic cancer cells by interleukin-1 and interleukin-1 receptor antagonist","volume":"95","author":"Hsieh","year":"1995","journal-title":"Cancer Lett"},{"key":"key20180107183909_b32-ijo-46-05-1978","first-page":"1059","article-title":"Expression of an IL-1 receptor antagonist during mouse hepato-carcinogenesis demonstrated by differential display analysis","volume":"79","author":"Yamada","year":"1999","journal-title":"Lab Invest"},{"key":"key20180107183909_b33-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1189\/jlb.0905509","article-title":"Immune phenomena involved in the in vivo regression of fibrosarcoma cells expressing cell-associated IL-1alpha","volume":"80","author":"Dvorkin","year":"2006","journal-title":"J Leukoc Biol"},{"key":"key20180107183909_b34-ijo-46-05-1978","first-page":"1029","article-title":"Antitumor and immunotherapeutic effects of activated invasive T lymphoma cells that display short-term interleukin 1alpha expression","volume":"59","author":"Voronov","year":"1999","journal-title":"Cancer Res"},{"key":"key20180107183909_b35-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.ebd.6400745","article-title":"Oral dysplasia and risk of progression to cancer","volume":"11","author":"Al-Dakkak","year":"2010","journal-title":"Evid Based Dent"},{"key":"key20180107183909_b36-ijo-46-05-1978","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-2559.2011.03938.x","article-title":"Malignant transformation of oral epithelial dysplasia: Clinicopathological risk factors and outcome analysis in a retrospective cohort of 138 cases","volume":"59","author":"Liu","year":"2011","journal-title":"Histopathology"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2015.2917\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T14:09:57Z","timestamp":1598796597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2015.2917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,3,4]]},"published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.3892\/ijo.2015.2917"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2015.2917","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,4]]}}}