{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:08:28Z","timestamp":1790791708468,"version":"4.1.0"},"reference-count":37,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.3892\/ijo.2015.3045","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T08:29:41Z","timestamp":1434011381000},"page":"555-562","source":"Crossref","is-referenced-by-count":29,"title":["The antitumor effects of oncolytic adenovirus H101 against lung cancer"],"prefix":"10.3892","volume":"47","author":[{"given":"JIE","family":"LEI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QI-HUA","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JU-LUN","family":"YANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FENG","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LI","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WEN-MANG","family":"XU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WEN-XING","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,6,11]]},"reference":[{"key":"key20180107190930_b1-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0025-6196(11)60735-0","article-title":"Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship","volume":"83","author":"Molina","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"key20180107190930_b2-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3322\/caac.20102","article-title":"Lung cancer: New biological insights and recent therapeutic advances","volume":"61","author":"Ramalingam","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"key20180107190930_b3-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"964743","DOI":"10.1155\/2013\/964743","article-title":"Nonsmall cell lung cancer therapy: Insight into multitargeted small-molecule growth factor receptor inhibitors","volume":"2013","author":"Roy","year":"2013","journal-title":"BioMed Res Int"},{"key":"key20180107190930_b4-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1200\/JCO.2006.09.7717","article-title":"Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study","volume":"25","author":"Lorigan","year":"2007","journal-title":"J Clin Oncol"},{"key":"key20180107190930_b5-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1056\/NEJMra0802714","article-title":"Lung cancer","volume":"359","author":"Herbst","year":"2008","journal-title":"N Engl J Med"},{"key":"key20180107190930_b6-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12094-013-1143-9","article-title":"Epidermal growth factor receptor tyrosine-kinase inhibitor treatment resistance in non-small cell lung cancer: Biological basis and therapeutic strategies","volume":"16","author":"Carrera","year":"2014","journal-title":"Clin Transl Oncol"},{"key":"key20180107190930_b7-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1158\/1055-9965.EPI-10-0437","article-title":"Global patterns of cancer incidence and mortality rates and trends","volume":"19","author":"Jemal","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key20180107190930_b8-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3322\/CA.2007.0010","article-title":"Cancer statistics, 2008","volume":"58","author":"Jemal","year":"2008","journal-title":"CA Cancer J Clin"},{"key":"key20180107190930_b9-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1470-2045(10)70087-5","article-title":"New driver mutations in non-small-cell lung cancer","volume":"12","author":"Pao","year":"2011","journal-title":"Lancet Oncol"},{"key":"key20180107190930_b10-ijo-47-02-0555","first-page":"217","article-title":"Oncolytic virotherapy: Molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic viruses","volume":"1785","author":"Guo","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"key20180107190930_b11-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1038\/bjc.2014.177","article-title":"Potent antitumour activity of a novel conditionally replicating adenovirus for melanoma via inhibition of migration and invasion","volume":"110","author":"Jiang","year":"2014","journal-title":"Br J Cancer"},{"key":"key20180107190930_b12-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ymthe.2004.08.002","article-title":"AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: A randomised, controlled study","volume":"10","author":"Immonen","year":"2004","journal-title":"Mol Ther"},{"key":"key20180107190930_b13-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/78638","article-title":"A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer","volume":"6","author":"Khuri","year":"2000","journal-title":"Nat Med"},{"key":"key20180107190930_b14-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/18715206113139990309","article-title":"Adenoviral vectors for prodrug activation-based gene therapy for cancer","volume":"14","author":"Doloff","year":"2014","journal-title":"Anticancer Agents Med Chem"},{"key":"key20180107190930_b15-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1158\/1078-0432.CCR-1075-3","article-title":"Telomerase-specific replication-selective virotherapy for human cancer","volume":"10","author":"Kawashima","year":"2004","journal-title":"Clin Cancer Res"},{"key":"key20180107190930_b16-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/156800907780058826","article-title":"Oncolytic virus therapy - foreword","volume":"7","author":"Kasuya","year":"2007","journal-title":"Curr Cancer Drug Targets"},{"key":"key20180107190930_b17-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/mt.2008.236","article-title":"Enhanced therapeutic efficacy by simultaneously targeting two genetic defects in tumors","volume":"17","author":"Zhang","year":"2009","journal-title":"Mol Ther"},{"key":"key20180107190930_b18-ijo-47-02-0555","first-page":"21","article-title":"Establishment and biological characteristics of lung cancer cell line XWLC-05","volume":"26","author":"Yan","year":"2007","journal-title":"Ai Zheng"},{"key":"key20180107190930_b19-ijo-47-02-0555","first-page":"2088","article-title":"Inhibition of the Raf\/MEK\/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells","volume":"63","author":"Anders","year":"2003","journal-title":"Cancer Res"},{"key":"key20180107190930_b20-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1167\/iovs.09-3516","article-title":"Inhibition of retinoblastoma in vitro and in vivo with conditionally replicating oncolytic adenovirus H101","volume":"51","author":"Song","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180107190930_b21-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"e58037","DOI":"10.1371\/journal.pone.0058037","article-title":"Superior antitumor activity of nanoparticle albumin-bound paclitaxel in experimental gastric cancer","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"key20180107190930_b22-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/gt.2008.72","article-title":"Gene therapy progress and prospects cancer: Oncolytic viruses","volume":"15","author":"Liu","year":"2008","journal-title":"Gene Ther"},{"key":"key20180107190930_b23-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.274.5286.373","article-title":"An adenovirus mutant that replicates selectively in p53-deficient human tumor cells","volume":"274","author":"Bischoff","year":"1996","journal-title":"Science"},{"key":"key20180107190930_b24-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1089\/104303403766682205","article-title":"Replicative oncolytic adenoviruses in multimodal cancer regimens","volume":"14","author":"Post","year":"2003","journal-title":"Hum Gene Ther"},{"key":"key20180107190930_b25-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/ijc.22627","article-title":"Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer","volume":"121","author":"Ranki","year":"2007","journal-title":"Int J Cancer"},{"key":"key20180107190930_b26-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1158\/1535-7163.MCT-06-0403","article-title":"Treatment of prostate cancer with Ad5\/3Delta24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo","volume":"6","author":"Rajecki","year":"2007","journal-title":"Mol Cancer Ther"},{"key":"key20180107190930_b27-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/mt.2009.262","article-title":"A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors","volume":"18","author":"Nemunaitis","year":"2010","journal-title":"Mol Ther"},{"key":"key20180107190930_b28-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/156800907780058817","article-title":"Clinical trials with oncolytic adenovirus in China","volume":"7","author":"Yu","year":"2007","journal-title":"Curr Cancer Drug Targets"},{"key":"key20180107190930_b29-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/mt.sj.6300120","article-title":"Phase I trial of replication-competent adenovirus-mediated suicide gene therapy combined with IMRT for prostate cancer","volume":"15","author":"Freytag","year":"2007","journal-title":"Mol Ther"},{"key":"key20180107190930_b30-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0016-5085(03)01196-X","article-title":"Infectivity enhanced, cyclooxy-genase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer","volume":"125","author":"Yamamoto","year":"2003","journal-title":"Gastroenterology"},{"key":"key20180107190930_b31-ijo-47-02-0555","first-page":"798","article-title":"A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer","volume":"6","author":"Ganly","year":"2000","journal-title":"Clin Cancer Res"},{"key":"key20180107190930_b32-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/cgt.2008.103","article-title":"Expression and function of the coxsackie and adenovirus receptor in Barrett\u2019s esophagus and associated neoplasia","volume":"16","author":"Anders","year":"2009","journal-title":"Cancer Gene Ther"},{"key":"key20180107190930_b33-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1158\/1078-0432.CCR-04-2370","article-title":"Coxsackie and adenovirus receptor promotes adenocarcinoma cell survival and is expressionally activated after transition from preneoplastic precursor lesions to invasive adenocarcinomas","volume":"11","author":"Br\u00fcning","year":"2005","journal-title":"Clin Cancer Res"},{"key":"key20180107190930_b34-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"6377","DOI":"10.1158\/0008-5472.CAN-04-1490","article-title":"A novel role for the coxsackie adenovirus receptor in mediating tumor formation by lung cancer cells","volume":"64","author":"Qin","year":"2004","journal-title":"Cancer Res"},{"key":"key20180107190930_b35-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/ijc.10891","article-title":"Expression of the coxsackie and adenovirus receptor in human astrocytic tumors and xenografts","volume":"103","author":"Fuxe","year":"2003","journal-title":"Int J Cancer"},{"key":"key20180107190930_b36-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/mt.2009.266","article-title":"Current issues and future directions of oncolytic adenoviruses","volume":"18","author":"Yamamoto","year":"2010","journal-title":"Mol Ther"},{"key":"key20180107190930_b37-ijo-47-02-0555","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/mp100219n","article-title":"Oncolytic adenoviruses for the treatment of human cancer: Focus on translational and clinical data","volume":"8","author":"Pesonen","year":"2011","journal-title":"Mol Pharm"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2015.3045\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T14:13:43Z","timestamp":1515334423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2015.3045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,11]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,6,11]]},"published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.3892\/ijo.2015.3045"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2015.3045","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,11]]}}}