{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:42:09Z","timestamp":1784126529922,"version":"3.55.0"},"reference-count":46,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.3892\/ijo.2015.3303","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T12:20:16Z","timestamp":1450441216000},"page":"747-755","source":"Crossref","is-referenced-by-count":12,"title":["Aminoacyl-tRNA synthetase interacting multi-functional protein 1 attenuates liver fibrosis by inhibiting TGF\u03b2 signaling"],"prefix":"10.3892","volume":"48","author":[{"given":"JONGCHAN","family":"AHN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MI KWON","family":"SON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KYUNG HEE","family":"JUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KWANGIL","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GI JIN","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SOO-HONG","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SOON-SUN","family":"HONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SANG GYU","family":"PARK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,12,18]]},"reference":[{"key":"key20180107185400_b1-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"key20180107185400_b2-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00535-008-2180-y","article-title":"Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies","volume":"43","author":"Li","year":"2008","journal-title":"J Gastroenterol"},{"key":"key20180107185400_b3-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1053\/j.gastro.2006.01.036","article-title":"The bone marrow functionally contributes to liver fibrosis","volume":"130","author":"Russo","year":"2006","journal-title":"Gastroenterology"},{"key":"key20180107185400_b4-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.dld.2004.01.003","article-title":"Liver fibrosis: From the bench to clinical targets","volume":"36","author":"Pinzani","year":"2004","journal-title":"Dig Liver Dis"},{"key":"key20180107185400_b5-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/hep.510240129","article-title":"Tissue inhibitor of metal-loproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis","volume":"24","author":"Iredale","year":"1996","journal-title":"Hepatology"},{"key":"key20180107185400_b6-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"G39","DOI":"10.1152\/ajpgi.00263.2007","article-title":"Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis","volume":"294","author":"Cheng","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key20180107185400_b7-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"G907","DOI":"10.1152\/ajpgi.00420.2004","article-title":"Imatinib mesylate (STI-571) attenuates liver fibrosis development in rats","volume":"288","author":"Yoshiji","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key20180107185400_b8-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1038\/srep03470","article-title":"HS-173, a novel PI3K inhibitor, attenuates the activation of hepatic stellate cells in liver fibrosis","volume":"3","author":"Son","year":"2013","journal-title":"Sci Rep"},{"key":"key20180107185400_b9-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/jgm.961","article-title":"Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF","volume":"8","author":"Bueno","year":"2006","journal-title":"J Gene Med"},{"key":"key20180107185400_b10-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jhep.2007.02.024","article-title":"Gliotoxin causes apoptosis and necrosis of rat Kupffer cells in vitro and in vivo in the absence of oxidative stress: Exacerbation by caspase and serine protease inhibition","volume":"47","author":"Anselmi","year":"2007","journal-title":"J Hepatol"},{"key":"key20180107185400_b11-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/hep.20551","article-title":"In pursuit of the \u2018Holy Grail\u2019 - stem cells, hepatic injury, fibrogenesis and repair","volume":"41","author":"Shackel","year":"2005","journal-title":"Hepatology"},{"key":"key20180107185400_b12-ijo-48-02-0747","first-page":"215","article-title":"Cytokines and human fibrosis","volume":"1","author":"LeRoy","year":"1990","journal-title":"Eur Cytokine Netw"},{"key":"key20180107185400_b13-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jcp.1041480119","article-title":"Direct evidence for spatial and temporal regulation of transforming growth factor beta 1 expression during cutaneous wound healing","volume":"148","author":"Kane","year":"1991","journal-title":"J Cell Physiol"},{"key":"key20180107185400_b14-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.1073\/pnas.84.16.5788","article-title":"Transforming growth factor type beta induces monocyte chemotaxis and growth factor production","volume":"84","author":"Wahl","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107185400_b15-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"41361","DOI":"10.1074\/jbc.M204597200","article-title":"Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase","volume":"277","author":"Funaba","year":"2002","journal-title":"J Biol Chem"},{"key":"key20180107185400_b16-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"12546","DOI":"10.1021\/bi050560g","article-title":"Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3","volume":"44","author":"Matsuura","year":"2005","journal-title":"Biochemistry"},{"key":"key20180107185400_b17-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1359-6101(99)00026-X","article-title":"Role of Ras and Mapks in TGFbeta signaling","volume":"11","author":"Mulder","year":"2000","journal-title":"Cytokine Growth Factor Rev"},{"key":"key20180107185400_b18-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1101\/gad.13.7.804","article-title":"A mechanism of repression of TGFbeta\/Smad signaling by oncogenic Ras","volume":"13","author":"Kretzschmar","year":"1999","journal-title":"Genes Dev"},{"key":"key20180107185400_b19-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ncb1117","article-title":"Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis","volume":"6","author":"Conery","year":"2004","journal-title":"Nat Cell Biol"},{"key":"key20180107185400_b20-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/sj.emboj.7600917","article-title":"Novel roles of Akt and mTOR in suppressing TGF-beta\/ALK5-mediated Smad3 activation","volume":"25","author":"Song","year":"2006","journal-title":"EMBO J"},{"key":"key20180107185400_b21-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/ncb1113","article-title":"PKB\/Akt modulates TGF-beta signalling through a direct interaction with Smad3","volume":"6","author":"Remy","year":"2004","journal-title":"Nat Cell Biol"},{"key":"key20180107185400_b22-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1600-0765.1997.tb00577.x","article-title":"Effects of basic fibroblast growth factor on human periodontal ligament cells","volume":"32","author":"Takayama","year":"1997","journal-title":"J Periodontal Res"},{"key":"key20180107185400_b23-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cyto.2007.06.009","article-title":"Opposite effects of bFGF and TGF-beta on collagen metabolism by human periodontal ligament fibroblasts","volume":"39","author":"Silverio-Ruiz","year":"2007","journal-title":"Cytokine"},{"key":"key20180107185400_b24-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"32573","DOI":"10.1074\/jbc.272.51.32573","article-title":"The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine","volume":"272","author":"Quevillon","year":"1997","journal-title":"J Biol Chem"},{"key":"key20180107185400_b25-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0002-9440(10)63801-1","article-title":"Regulation of EMAP II by hypoxia","volume":"162","author":"Matschurat","year":"2003","journal-title":"Am J Pathol"},{"key":"key20180107185400_b26-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0002-9440(10)62262-6","article-title":"The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair","volume":"166","author":"Park","year":"2005","journal-title":"Am J Pathol"},{"key":"key20180107185400_b27-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"14913","DOI":"10.1073\/pnas.0602045103","article-title":"Hormonal activity of AIMP1\/p43 for glucose homeostasis","volume":"103","author":"Park","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107185400_b28-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"23028","DOI":"10.1074\/jbc.M101544200","article-title":"A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes","volume":"276","author":"Ko","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180107185400_b29-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"45243","DOI":"10.1074\/jbc.M207934200","article-title":"Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis","volume":"277","author":"Park","year":"2002","journal-title":"J Biol Chem"},{"key":"key20180107185400_b30-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1189\/jlb.71.2.223","article-title":"Monocyte cell adhesion induced by a human aminoacyl-tRNA synthetase-associated factor, p43: Identification of the related adhesion molecules and signal pathways","volume":"71","author":"Park","year":"2002","journal-title":"J Leukoc Biol"},{"key":"key20180107185400_b31-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4049\/jimmunol.176.1.256","article-title":"The novel cytokine p43 induces IL-12 production in macrophages via NF-kappaB activation, leading to enhanced IFN-gamma production in CD4+ T cells","volume":"176","author":"Kim","year":"2006","journal-title":"J Immunol"},{"key":"key20180107185400_b32-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.4049\/jimmunol.180.5.2894","article-title":"AIMP1\/p43 protein induces the maturation of bone marrow-derived dendritic cells with T helper type 1-polarizing ability","volume":"180","author":"Kim","year":"2008","journal-title":"J Immunol"},{"key":"key20180107185400_b33-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1089\/scd.2012.0714","article-title":"ARS-interacting multi-functional protein 1 induces proliferation of human bone marrow-derived mesenchymal stem cells by accumulation of \u03b2-catenin via fibroblast growth factor receptor 2-mediated activation of Akt","volume":"22","author":"Kim","year":"2013","journal-title":"Stem Cells Dev"},{"key":"key20180107185400_b34-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.biomaterials.2010.10.023","article-title":"The use of low molecular weight heparin-pluronic nanogels to impede liver fibrosis by inhibition the TGF-\u03b2\/Smad signaling pathway","volume":"32","author":"Lee","year":"2011","journal-title":"Biomaterials"},{"key":"key20180107185400_b35-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3350001","article-title":"Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation","volume":"335","author":"Coffer","year":"1998","journal-title":"Biochem J"},{"key":"key20180107185400_b36-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: New tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"key":"key20180107185400_b37-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/39348","article-title":"Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1","volume":"389","author":"Kretzschmar","year":"1997","journal-title":"Nature"},{"key":"key20180107185400_b38-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1523-1747.1999.00477.x","article-title":"Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: Involvement of Smad 3","volume":"112","author":"Chen","year":"1999","journal-title":"J Invest Dermatol"},{"key":"key20180107185400_b39-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1073\/pnas.96.5.2345","article-title":"Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat","volume":"96","author":"Qi","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107185400_b40-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"key20180107185400_b41-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1172\/JCI31487","article-title":"Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J Clin Invest"},{"key":"key20180107185400_b42-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbrc.2006.01.117","article-title":"Structural separation of different extracellular activities in aminoacyl-tRNA synthetase-interacting multi-functional protein, p43\/AIMP1","volume":"342","author":"Han","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107185400_b43-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J Biol Chem"},{"issue":"Suppl","key":"key20180107185400_b44-ijo-48-02-0747","first-page":"28","article-title":"Cytokines and cellular crosstalk involved in the activation of fat-storing cells","volume":"22","author":"Gressner","year":"1995","journal-title":"J Hepatol"},{"key":"key20180107185400_b45-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1172\/JCI118055","article-title":"Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation","volume":"96","author":"Bissell","year":"1995","journal-title":"J Clin Invest"},{"key":"key20180107185400_b46-ijo-48-02-0747","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1128\/MCB.20.8.2818-2826.2000","article-title":"The DNA binding protein BTEB mediates acetaldehyde-induced, jun N-terminal kinase-dependent alphaI(I) collagen gene expression in rat hepatic stellate cells","volume":"20","author":"Chen","year":"2000","journal-title":"Mol Cell Biol"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2015.3303\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T06:19:10Z","timestamp":1692166750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2015.3303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,18]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,12,18]]},"published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.3892\/ijo.2015.3303"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2015.3303","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,18]]}}}