{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:12:09Z","timestamp":1790766729010,"version":"4.1.0"},"reference-count":40,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.3892\/ijo.2016.3395","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T09:18:56Z","timestamp":1455700736000},"page":"1571-1580","source":"Crossref","is-referenced-by-count":13,"title":["Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinoma"],"prefix":"10.3892","volume":"48","author":[{"given":"YOSHIKAZU","family":"TOGO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHIE","family":"YOSHIKAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TORU","family":"SUZUKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHIRO","family":"NAKANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AKIHIRO","family":"KANEMATSU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASATAKA","family":"ZOZUMI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHIO","family":"NOJIMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEIICHI","family":"HIROTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHINGO","family":"YAMAMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOMOKO","family":"HASHIMOTO-TAMAOKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,2,17]]},"reference":[{"key":"key20180107185055_b1-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/bfgp\/elm007","article-title":"Molecular analysis of deletions in human chromosome 3p21 and the role of resident cancer genes in disease","volume":"6","author":"Angeloni","year":"2007","journal-title":"Brief Funct Genomics Proteomics"},{"key":"key20180107185055_b2-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0065-230X(08)60096-2","article-title":"Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes","volume":"71","author":"Kok","year":"1997","journal-title":"Adv Cancer Res"},{"key":"key20180107185055_b3-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/ng0594-85","article-title":"Mutations of the VHL tumour suppressor gene in renal carcinoma","volume":"7","author":"Gnarra","year":"1994","journal-title":"Nat Genet"},{"key":"key20180107185055_b4-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/(SICI)1098-2264(199807)22:3<200::AID-GCC5>3.0.CO;2-#","article-title":"Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis","volume":"22","author":"Clifford","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"key20180107185055_b5-ijo-48-04-1571","first-page":"455","article-title":"Deletion of chromosome 3p14.2-p25 involving the VHL and FHIT genes in conventional renal cell carcinoma","volume":"63","author":"S\u00fck\u00f6sd","year":"2003","journal-title":"Cancer Res"},{"key":"key20180107185055_b6-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.urolonc.2011.08.012","article-title":"Investigation of tumor suppressor genes apart from VHL on 3p by deletion mapping in sporadic clear cell renal cell carcinoma (cRCC)","volume":"31","author":"Singh","year":"2013","journal-title":"Urol Oncol"},{"key":"key20180107185055_b7-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nature09639","article-title":"Exome sequencing identifies frequent mutation of the SWI\/SNF complex gene PBRM1 in renal carcinoma","volume":"469","author":"Varela","year":"2011","journal-title":"Nature"},{"key":"key20180107185055_b8-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature08672","article-title":"Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes","volume":"463","author":"Dalgliesh","year":"2010","journal-title":"Nature"},{"key":"key20180107185055_b9-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/ng.2323","article-title":"BAP1 loss defines a new class of renal cell carcinoma","volume":"44","author":"Pe\u00f1a-Llopis","year":"2012","journal-title":"Nat Genet"},{"key":"key20180107185055_b10-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng.1014","article-title":"Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma","volume":"44","author":"Guo","year":"2011","journal-title":"Nat Genet"},{"key":"key20180107185055_b11-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/ng.2699","article-title":"Integrated molecular analysis of clear-cell renal cell carcinoma","volume":"45","author":"Sato","year":"2013","journal-title":"Nat Genet"},{"key":"key20180107185055_b12-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/ng.912","article-title":"Germline BAP1 mutations predispose to malignant mesothelioma","volume":"43","author":"Testa","year":"2011","journal-title":"Nat Genet"},{"key":"key20180107185055_b13-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/ng.910","article-title":"Germline mutations in BAP1 predispose to melanocytic tumors","volume":"43","author":"Wiesner","year":"2011","journal-title":"Nat Genet"},{"key":"key20180107185055_b14-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1136\/jmedgenet-2011-100156","article-title":"Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers","volume":"48","author":"Abdel-Rahman","year":"2011","journal-title":"J Med Genet"},{"key":"key20180107185055_b15-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/1479-5876-10-179","article-title":"BAP1 cancer syndrome: Malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs","volume":"10","author":"Carbone","year":"2012","journal-title":"J Transl Med"},{"key":"key20180107185055_b16-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.ajhg.2013.04.012","article-title":"Germline BAP1 mutations predispose to renal cell carcinomas","volume":"92","author":"Popova","year":"2013","journal-title":"Am J Hum Genet"},{"key":"key20180107185055_b17-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1158\/1541-7786.MCR-13-0111","article-title":"A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma","volume":"11","author":"Farley","year":"2013","journal-title":"Mol Cancer Res"},{"key":"key20180107185055_b18-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cancergen.2015.02.008","article-title":"The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer","volume":"208","author":"Liao","year":"2015","journal-title":"Cancer Genet"},{"key":"key20180107185055_b19-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"16538","DOI":"10.1073\/pnas.1414789111","article-title":"Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis","volume":"111","author":"Wang","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107185055_b20-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1158\/0008-5472.CAN-13-0360","article-title":"Cooperation and antagonism among cancer genes: The renal cancer paradigm","volume":"73","author":"Pe\u00f1a-Llopis","year":"2013","journal-title":"Cancer Res"},{"key":"key20180107185055_b21-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature08966","article-title":"Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB","volume":"465","author":"Scheuermann","year":"2010","journal-title":"Nature"},{"key":"key20180107185055_b22-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1126\/science.1194472","article-title":"Frequent mutation of BAP1 in metastasizing uveal melanomas","volume":"330","author":"Harbour","year":"2010","journal-title":"Science"},{"key":"key20180107185055_b23-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1167\/iovs.14-14550","article-title":"Chromosome 3 status combined with BAP1 and EIF1AX mutation profiles are associated with metastasis in uveal melanoma","volume":"55","author":"Ewens","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20180107185055_b24-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1349-7006.2012.02223.x","article-title":"Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesothelioma","volume":"103","author":"Yoshikawa","year":"2012","journal-title":"Cancer Sci"},{"key":"key20180107185055_b25-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/jhg.2015.91","article-title":"Frequent genomic rearrangements of BRCA1 associated protein-1 (BAP1) gene in Japanese malignant mesothelioma-characterization of deletions at exon level","volume":"60","author":"Emi","year":"2015","journal-title":"J Hum Genet"},{"key":"key20180107185055_b26-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ng.855","article-title":"The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma","volume":"43","author":"Bott","year":"2011","journal-title":"Nat Genet"},{"key":"key20180107185055_b27-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1097\/JTO.0b013e31829e7ef9","article-title":"Clinical characteristics of patients with malignant pleural mesothelioma harboring somatic BAP1 mutations","volume":"8","author":"Zauderer","year":"2013","journal-title":"J Thorac Oncol"},{"key":"key20180107185055_b28-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12253-013-9677-2","article-title":"BAP1 protein is a progression factor in malignant pleural mesothelioma","volume":"20","author":"Arzt","year":"2014","journal-title":"Pathol Oncol Res"},{"key":"key20180107185055_b29-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/JTO.0000000000000471","article-title":"High incidence of somatic BAP1 alterations in sporadic malignant mesothelioma","volume":"10","author":"Nasu","year":"2015","journal-title":"J Thorac Oncol"},{"key":"key20180107185055_b30-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/cas.12722","article-title":"Somatic alteration and depleted nuclear expression of BAP1 in human esophageal squamous cell carcinoma","volume":"106","author":"Mori","year":"2015","journal-title":"Cancer Sci"},{"key":"key20180107185055_b31-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1128\/MCB.00396-10","article-title":"The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression","volume":"30","author":"Yu","year":"2010","journal-title":"Mol Cell Biol"},{"key":"key20180107185055_b32-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.molcel.2014.03.002","article-title":"Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O","volume":"54","author":"Mashtalir","year":"2014","journal-title":"Mol Cell"},{"key":"key20180107185055_b33-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/genetics\/131.2.423","article-title":"A genetic map of the mouse suitable for typing intraspecific crosses","volume":"131","author":"Dietrich","year":"1992","journal-title":"Genetics"},{"key":"key20180107185055_b34-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly (Austin)"},{"key":"key20180107185055_b35-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"E2393","DOI":"10.1002\/humu.22376","article-title":"dbNSFP v2.0: A database of human non-synonymous SNVs and their functional predictions and annotations","volume":"34","author":"Liu","year":"2013","journal-title":"Hum Mutat"},{"key":"key20180107185055_b36-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands","volume":"93","author":"Herman","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107185055_b37-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.juro.2013.09.041","article-title":"BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinoma","volume":"191","author":"Kapur","year":"2014","journal-title":"J Urol"},{"key":"key20180107185055_b38-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ng.2891","article-title":"Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing","volume":"46","author":"Gerlinger","year":"2014","journal-title":"Nat Genet"},{"key":"key20180107185055_b39-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"486","DOI":"10.4161\/epi.24552","article-title":"Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC","volume":"8","author":"Ibragimova","year":"2013","journal-title":"Epigenetics"},{"key":"key20180107185055_b40-ijo-48-04-1571","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1158\/1078-0432.CCR-12-3886","article-title":"Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: A report by MSKCC and the KIRC TCGA research network","volume":"19","author":"Hakimi","year":"2013","journal-title":"Clin Cancer Res"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2016.3395\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T10:06:10Z","timestamp":1654337170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2016.3395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,17]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,2,17]]},"published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.3892\/ijo.2016.3395"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2016.3395","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,17]]}}}