{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:37:06Z","timestamp":1768693026166,"version":"3.49.0"},"reference-count":37,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.3892\/ijo.2016.3431","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T07:05:05Z","timestamp":1457507105000},"page":"1913-1920","source":"Crossref","is-referenced-by-count":22,"title":["Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion"],"prefix":"10.3892","volume":"48","author":[{"given":"SALEH","family":"AL-DIMASSI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GILBERT","family":"SALLOUM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BECHARA","family":"SAYKALI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OULA","family":"KHOURY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIHUI","family":"LIU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN H.","family":"LEPPLA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RALPH","family":"ABI-HABIB","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIRVAT","family":"EL-SIBAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"key20180107185313_b1-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.3171\/foc.2006.20.4.E1","article-title":"Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001","volume":"20","author":"Deorah","year":"2006","journal-title":"Neurosurg Focus"},{"key":"key20180107185313_b2-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1750-3639.1993.tb00721.x","article-title":"Subsets of glioblastoma multiforme defined by molecular genetic analysis","volume":"3","author":"von Deimling","year":"1993","journal-title":"Brain Pathol"},{"key":"key20180107185313_b3-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1056\/NEJM200101113440207","article-title":"Brain tumors","volume":"344","author":"DeAngelis","year":"2001","journal-title":"N Engl J Med"},{"key":"key20180107185313_b4-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0962-8924(02)00004-1","article-title":"Rho GTPase-activating proteins in cell regulation","volume":"13","author":"Moon","year":"2003","journal-title":"Trends Cell Biol"},{"key":"key20180107185313_b5-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1349-7006.2005.00062.x","article-title":"Regulation of cancer cell motility through actin reorganization","volume":"96","author":"Yamazaki","year":"2005","journal-title":"Cancer Sci"},{"key":"key20180107185313_b6-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.yexcr.2008.01.016","article-title":"RhoA\/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells","volume":"314","author":"El-Sibai","year":"2008","journal-title":"Exp Cell Res"},{"key":"key20180107185313_b7-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"303","DOI":"10.7150\/ijbs.3.303","article-title":"The forces behind cell movement","volume":"3","author":"Ananthakrishnan","year":"2007","journal-title":"Int J Biol Sci"},{"key":"key20180107185313_b8-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1083\/jcb.201011038","article-title":"RhoA and RhoC have distinct roles in migration and invasion by acting through different targets","volume":"193","author":"Vega","year":"2011","journal-title":"J Cell Biol"},{"key":"key20180107185313_b9-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/eji.200635875","article-title":"Phospholipase C \u03b3 negatively regulates Rac\/Cdc42 activation in antigen-stimulated mast cells","volume":"37","author":"El-Sibai","year":"2007","journal-title":"Eur J Immunol"},{"key":"key20180107185313_b10-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/sj.onc.1202262","article-title":"A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival","volume":"18","author":"Moorman","year":"1999","journal-title":"Oncogene"},{"key":"key20180107185313_b11-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/jmi.12025","article-title":"RhoA, RhoB and RhoC have different roles in cancer cell migration","volume":"251","author":"Ridley","year":"2013","journal-title":"J Microsc"},{"key":"key20180107185313_b12-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1242\/jcs.03428","article-title":"Rho activation at a glance","volume":"120","author":"Buchsbaum","year":"2007","journal-title":"J Cell Sci"},{"key":"key20180107185313_b13-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4161\/sgtp.25131","article-title":"Dynamic functions of RhoA in tumor cell migration and invasion","volume":"4","author":"O'Connor","year":"2013","journal-title":"Small GTPases"},{"key":"key20180107185313_b14-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cell.2011.06.010","article-title":"Life at the leading edge","volume":"145","author":"Ridley","year":"2011","journal-title":"Cell"},{"key":"key20180107185313_b15-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10585-007-9119-1","article-title":"Rho GTPases: Functions and association with cancer","volume":"24","author":"Ellenbroek","year":"2007","journal-title":"Clin Exp Metastasis"},{"key":"key20180107185313_b16-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/j.febslet.2008.04.039","article-title":"Rho GTPases in cancer cell biology","volume":"582","author":"Vega","year":"2008","journal-title":"FEBS Lett"},{"key":"key20180107185313_b17-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0378-1119(02)00426-2","article-title":"The role of Rho GTPases in disease development","volume":"286","author":"Boettner","year":"2002","journal-title":"Gene"},{"key":"key20180107185313_b18-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.yexcr.2013.11.023","article-title":"The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility","volume":"321","author":"Khalil","year":"2014","journal-title":"Exp Cell Res"},{"key":"key20180107185313_b19-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0092-8674(00)81280-5","article-title":"Cell migration: A physically integrated molecular process","volume":"84","author":"Lauffenburger","year":"1996","journal-title":"Cell"},{"key":"key20180107185313_b20-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"C189","DOI":"10.1152\/ajpcell.00347.2009","article-title":"The dual-specificity MAP kinase phosphatases: Critical roles in development and cancer","volume":"299","author":"Bermudez","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"key20180107185313_b21-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1535-6108(03)00162-4","article-title":"ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility","volume":"4","author":"Vial","year":"2003","journal-title":"Cancer Cell"},{"key":"key20180107185313_b22-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/10533","article-title":"Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo","volume":"5","author":"Sebolt-Leopold","year":"1999","journal-title":"Nat Med"},{"key":"key20180107185313_b23-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1038\/sj.onc.1204541","article-title":"Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion","volume":"20","author":"Krueger","year":"2001","journal-title":"Oncogene"},{"key":"key20180107185313_b24-ijo-48-05-1913","first-page":"119","article-title":"Rho\/ROCK and MAPK signaling pathways are involved in glioblastoma cell migration and proliferation","volume":"29","author":"Zohrabian","year":"2009","journal-title":"Anticancer Res"},{"key":"key20180107185313_b25-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","article-title":"Identification of the cellular receptor for anthrax toxin","volume":"414","author":"Bradley","year":"2001","journal-title":"Nature"},{"key":"key20180107185313_b26-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1073\/pnas.0431098100","article-title":"Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor","volume":"100","author":"Scobie","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107185313_b27-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1158\/1535-7163.MCT-05-0145","article-title":"BRAF status and mitogen-activated protein\/extracellular signal-regulated kinase kinase 1\/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin","volume":"4","author":"Abi-Habib","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"key20180107185313_b28-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1083\/jcb.200211018","article-title":"Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process","volume":"160","author":"Abrami","year":"2003","journal-title":"J Cell Biol"},{"key":"key20180107185313_b29-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"9802","DOI":"10.1073\/pnas.0604000103","article-title":"A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation","volume":"103","author":"Melnyk","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107185313_b30-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1158\/0008-5472.CAN-07-5311","article-title":"Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo","volume":"68","author":"Huang","year":"2008","journal-title":"Cancer Res"},{"key":"key20180107185313_b31-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1086\/432516","article-title":"Anthrax lethal toxin paralyzes neutrophil actin-based motility","volume":"192","author":"During","year":"2005","journal-title":"J Infect Dis"},{"key":"key20180107185313_b32-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1073\/pnas.92.17.7686","article-title":"A synthetic inhibitor of the mitogen-activated protein kinase cascade","volume":"92","author":"Dudley","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107185313_b33-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.280.5364.734","article-title":"Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor","volume":"280","author":"Duesbery","year":"1998","journal-title":"Science"},{"key":"key20180107185313_b34-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1158\/1078-0432.CCR-06-2019","article-title":"Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice","volume":"12","author":"Abi-Habib","year":"2006","journal-title":"Clin Cancer Res"},{"key":"key20180107185313_b35-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"9402","DOI":"10.1074\/jbc.M211262200","article-title":"Anthrax lethal factor proteolysis and inactivation of MAPK kinase","volume":"278","author":"Chopra","year":"2003","journal-title":"J Biol Chem"},{"key":"key20180107185313_b36-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"36230","DOI":"10.1074\/jbc.M707622200","article-title":"Critical role of the phosphatidylinositol 3-kinase\/Akt\/glycogen synthase kinase-3 signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arrest and MEK cleavage in macrophages","volume":"282","author":"Ha","year":"2007","journal-title":"J Biol Chem"},{"key":"key20180107185313_b37-ijo-48-05-1913","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/j.cellsig.2013.04.009","article-title":"Signaling networks of Rho GTPases in cell motility","volume":"25","author":"Hanna","year":"2013","journal-title":"Cell Signal"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2016.3431\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T13:55:52Z","timestamp":1515333352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2016.3431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,9]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,3,9]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.3892\/ijo.2016.3431"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2016.3431","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,9]]}}}