{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T03:51:48Z","timestamp":1769313108560,"version":"3.49.0"},"reference-count":42,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.3892\/ijo.2016.3527","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T08:48:06Z","timestamp":1463474886000},"page":"123-132","source":"Crossref","is-referenced-by-count":12,"title":["VEGF-D-enhanced lymph node metastasis of ovarian cancer is reversed by vesicular stomatitis virus matrix protein"],"prefix":"10.3892","volume":"49","author":[{"given":"XIAORONG","family":"QI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LICHENG","family":"DU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIANCHENG","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LIJUAN","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAO","family":"YI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIANG","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YANJUN","family":"WEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUQUAN","family":"WEI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIA","family":"ZHAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"key20180107190251_b1-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/jnci\/dji289","article-title":"Annual report to the nation on the status of cancer, 1975\u20132002 featuring population-based trends in cancer treatment","volume":"97","author":"Edwards","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"key20180107190251_b2-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/caac.20138","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"key20180107190251_b3-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0090-8258(02)00147-6","article-title":"Biological markers in pT1 and pT2 ovarian cancer with lymph node metastases","volume":"89","author":"Concin","year":"2003","journal-title":"Gynecol Oncol"},{"key":"key20180107190251_b4-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1200\/JCO.2007.10.8167","article-title":"Intraperitoneal chemotherapy for ovarian cancer: Overview and perspective","volume":"25","author":"Rao","year":"2007","journal-title":"J Clin Oncol"},{"key":"key20180107190251_b5-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ygyno.2005.01.038","article-title":"Lymphatic metastasis in epithelial ovarian carcinoma with respect to clinicopathological variables","volume":"97","author":"Ayhan","year":"2005","journal-title":"Gynecol Oncol"},{"key":"key20180107190251_b6-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/gyno.1996.0249","article-title":"Systematic pelvic and paraaortic lymphadenectomy for advanced ovarian cancer: Prognostic significance of node metastases","volume":"62","author":"di Re","year":"1996","journal-title":"Gynecol Oncol"},{"key":"key20180107190251_b7-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(93)90573-9","article-title":"High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis","volume":"72","author":"Millauer","year":"1993","journal-title":"Cell"},{"key":"key20180107190251_b8-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1073\/pnas.92.8.3566","article-title":"Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development","volume":"92","author":"Kaipainen","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107190251_b9-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/84635","article-title":"VEGF-D promotes the metastatic spread of tumor cells via the lymphatics","volume":"7","author":"Stacker","year":"2001","journal-title":"Nat Med"},{"key":"key20180107190251_b10-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"11153","DOI":"10.1007\/s11033-012-2024-y","article-title":"Lymphatic microvessel density and vascular endothelial growth factor-C and -D as prognostic factors in breast cancer: A systematic review and meta-analysis of the literature","volume":"39","author":"Wang","year":"2012","journal-title":"Mol Biol Rep"},{"key":"key20180107190251_b11-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1128\/JVI.66.7.4058-4064.1992","article-title":"Vesicular stomatitis virus matrix protein inhibits host cell-directed transcription of target genes in vivo","volume":"66","author":"Black","year":"1992","journal-title":"J Virol"},{"key":"key20180107190251_b12-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1128\/MMBR.00007-11","article-title":"Interplay between innate immunity and negative-strand RNA viruses: Towards a rational model","volume":"75","author":"Gerlier","year":"2011","journal-title":"Microbiol Mol Biol Rev"},{"key":"key20180107190251_b13-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"8413","DOI":"10.1128\/JVI.72.10.8413-8419.1998","article-title":"Effect of vesicular stomatitis virus matrix protein on transcription directed by host RNA polymerases I, II, and III","volume":"72","author":"Ahmed","year":"1998","journal-title":"J Virol"},{"key":"key20180107190251_b14-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1128\/JVI.75.9.4453-4458.2001","article-title":"Inhibition of host transcription by vesicular stomatitis virus involves a novel mechanism that is independent of phosphorylation of TATA-binding protein (TBP) or association of TBP with TBP-associated factor subunits","volume":"75","author":"Yuan","year":"2001","journal-title":"J Virol"},{"key":"key20180107190251_b15-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1128\/JVI.77.8.4646-4657.2003","article-title":"Ability of the matrix protein of vesicular stomatitis virus to suppress beta interferon gene expression is genetically correlated with the inhibition of host RNA and protein synthesis","volume":"77","author":"Ahmed","year":"2003","journal-title":"J Virol"},{"key":"key20180107190251_b16-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"8590","DOI":"10.1128\/MCB.20.22.8590-8601.2000","article-title":"The matrix protein of vesicular stomatitis virus inhibits nucleocytoplasmic transport when it is in the nucleus and associated with nuclear pore complexes","volume":"20","author":"Petersen","year":"2000","journal-title":"Mol Cell Biol"},{"key":"key20180107190251_b17-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1128\/JVI.01671-10","article-title":"Dominant inhibition of Akt\/protein kinase B signaling by the matrix protein of a negative-strand RNA virus","volume":"85","author":"Dunn","year":"2011","journal-title":"J Virol"},{"key":"key20180107190251_b18-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1093\/annonc\/mdn167","article-title":"Efficient inhibition of cisplatin-resistant human ovarian cancer growth and prolonged survival by gene transferred vesicular stomatitis virus matrix protein in nude mice","volume":"19","author":"Zhong","year":"2008","journal-title":"Ann Oncol"},{"key":"key20180107190251_b19-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1021\/nn1005599","article-title":"Efficient inhibition of C-26 colon carcinoma by VSVMP gene delivered by biodegradable cationic nanogel derived from polyethyleneimine","volume":"4","author":"Gou","year":"2010","journal-title":"ACS Nano"},{"key":"key20180107190251_b20-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/cgt.2010.46","article-title":"Susceptibility of breast cancer cells to an oncolytic matrix (M) protein mutant of vesicular stomatitis virus","volume":"17","author":"Ahmed","year":"2010","journal-title":"Cancer Gene Ther"},{"key":"key20180107190251_b21-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/cgt.2013.7","article-title":"Matrix protein of vesicular stomatitis virus: A potent inhibitor of vascular endothelial growth factor and malignant ascites formation","volume":"20","author":"Zhou","year":"2013","journal-title":"Cancer Gene Ther"},{"key":"key20180107190251_b22-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1002\/ijc.24244","article-title":"Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model","volume":"124","author":"Wen","year":"2009","journal-title":"Int J Cancer"},{"key":"key20180107190251_b23-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ygyno.2006.09.022","article-title":"Efficient inhibition of intraperitoneal human ovarian cancer growth and prolonged survival by gene transfer of vesicular stomatitis virus matrix protein in nude mice","volume":"104","author":"Lin","year":"2007","journal-title":"Gynecol Oncol"},{"key":"key20180107190251_b24-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jconrel.2010.03.007","article-title":"Improved tumor-targeting drug delivery and therapeutic efficacy by cationic liposome modified with truncated bFGF peptide","volume":"145","author":"Chen","year":"2010","journal-title":"J Control Release"},{"key":"key20180107190251_b25-ijo-49-01-0123","first-page":"941","article-title":"The antitumor and antimetastatic effects of N-trimethyl chitosan-encapsulated camptothecin on ovarian cancer with minimal side effects","volume":"24","author":"Zhou","year":"2010","journal-title":"Oncol Rep"},{"key":"key20180107190251_b26-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1152\/physrev.00005.2002","article-title":"Vascular growth factors and lymphangiogenesis","volume":"82","author":"Jussila","year":"2002","journal-title":"Physiol Rev"},{"key":"key20180107190251_b27-ijo-49-01-0123","first-page":"3581","article-title":"Clinicopathological features and overexpression of matrix metalloproteinases in intramucosal gastric carcinoma with lymph node metastasis","volume":"6","author":"Kabashima","year":"2000","journal-title":"Clin Cancer Res"},{"key":"key20180107190251_b28-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1615\/JEnvironPatholToxicolOncol.v25.i4.50","article-title":"Cell membrane-associated MT1-MMP dependent activation of MMP-2 in SiHa (human cervical cancer) cells","volume":"25","author":"Mitra","year":"2006","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"key20180107190251_b29-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1182\/blood-2009-01-198879","article-title":"Lymphangiogenesis factors: a target for therapy?","volume":"113","author":"Griffioen","year":"2009","journal-title":"Blood"},{"key":"key20180107190251_b30-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1182\/blood.V96.2.546","article-title":"Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis","volume":"96","author":"Kubo","year":"2000","journal-title":"Blood"},{"key":"key20180107190251_b31-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/jnci\/dji003","article-title":"Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody","volume":"97","author":"Pytowski","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"key20180107190251_b32-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"e35094","DOI":"10.1371\/journal.pone.0035094","article-title":"Co-expression of \u03b19\u03b21 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN","volume":"7","author":"Majumder","year":"2012","journal-title":"PLoS One"},{"key":"key20180107190251_b33-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1158\/1078-0432.CCR-05-1077","article-title":"Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer","volume":"11","author":"Renyi-Vamos","year":"2005","journal-title":"Clin Cancer Res"},{"key":"key20180107190251_b34-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1001\/archotol.129.7.716","article-title":"Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma","volume":"129","author":"Hall","year":"2003","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"key20180107190251_b35-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0002-9440(10)64328-3","article-title":"Tumor lymphangiogenesis: A novel prognostic indicator for cutaneous melanoma metastasis and survival","volume":"162","author":"Dadras","year":"2003","journal-title":"Am J Pathol"},{"key":"key20180107190251_b36-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"7144","DOI":"10.1158\/1078-0432.CCR-03-0826","article-title":"High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer","volume":"10","author":"Bono","year":"2004","journal-title":"Clin Cancer Res"},{"key":"key20180107190251_b37-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1365-2559.2007.02885.x","article-title":"Differential expression of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in non-melanoma skin cancer: Implications for tumour progression","volume":"51","author":"O'Grady","year":"2007","journal-title":"Histopathology"},{"key":"key20180107190251_b38-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1158\/0008-5472.CAN-06-4761","article-title":"Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice","volume":"67","author":"Taniwaki","year":"2007","journal-title":"Cancer Res"},{"key":"key20180107190251_b39-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","article-title":"New functions for the matrix metalloproteinases in cancer progression","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"key20180107190251_b40-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF02303800","article-title":"Sentinel lymph node metastasis in experimental melanoma: Relationships among primary tumor size, lymphatic vessel diameter and 99mTc-labeled human serum albumin clearance","volume":"4","author":"Nathanson","year":"1997","journal-title":"Ann Surg Oncol"},{"key":"key20180107190251_b41-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO;2-H","article-title":"Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases","volume":"63","author":"Carter","year":"1989","journal-title":"Cancer"},{"key":"key20180107190251_b42-ijo-49-01-0123","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1097\/00000478-198912000-00002","article-title":"Relationship of lymph node metastasis to primary tumor size and microscopic appearance of roentgenographically occult lung cancer","volume":"13","author":"Nagamoto","year":"1989","journal-title":"Am J Surg Pathol"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2016.3527\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T22:27:04Z","timestamp":1600554424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2016.3527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,5,17]]},"published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.3892\/ijo.2016.3527"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2016.3527","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]}}}