{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T05:39:21Z","timestamp":1772429961417,"version":"3.50.1"},"reference-count":143,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.3892\/ijo.2017.3948","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T08:35:25Z","timestamp":1491294925000},"page":"1461-1476","source":"Crossref","is-referenced-by-count":31,"title":["MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review)"],"prefix":"10.3892","volume":"50","author":[{"given":"Carlos Palma","family":"Flores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Garc\u00eda-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores Gallardo","family":"Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Ruiz-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio Astudillo","family":"De La Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence A.","family":"Marchat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yarely M.","family":"Salinas Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"L\u00f3pez-Camarillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"key20180107175932_b1-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrc3144","article-title":"Rethinking ovarian cancer: Recommendations for improving outcomes","volume":"11","author":"Vaughan","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"key20180107175932_b2-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/IGC.0b013e31821b2669","article-title":"Role of molecular agents and targeted therapy in clinical trials for women with ovarian cancer","volume":"21","author":"Ledermann","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"key20180107175932_b3-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nrm1644","article-title":"MicroRNA biogenesis: Coordinated cropping and dicing","volume":"6","author":"Kim","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20180107175932_b4-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrc2622","article-title":"Metastasis: From dissemination to organ-specific colonization","volume":"9","author":"Nguyen","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"key20180107175932_b5-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3390\/ijms13021347","article-title":"MetastamiRs: Non-coding MicroRNAs driving cancer invasion and metastasis","volume":"13","author":"Lopez-Camarillo","year":"2012","journal-title":"Int J Mol Sci"},{"key":"key20180107175932_b6-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrclinonc.2010.173","article-title":"Metastamirs: A stepping stone towards improved cancer management","volume":"8","author":"White","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"key20180107175932_b7-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1261\/rna.7135204","article-title":"Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs","volume":"10","author":"Cai","year":"2004","journal-title":"RNA"},{"key":"key20180107175932_b8-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III Drosha initiates microRNA processing","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"key20180107175932_b9-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1126\/science.1149460","article-title":"Switching from repression to activation: microRNAs can up-regulate translation","volume":"318","author":"Vasudevan","year":"2007","journal-title":"Science"},{"key":"key20180107175932_b10-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm2080","article-title":"P bodies: At the crossroads of post-transcriptional pathways","volume":"8","author":"Eulalio","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20180107175932_b11-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/ncb1265","article-title":"Argonaute 2\/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies","volume":"7","author":"Sen","year":"2005","journal-title":"Nat Cell Biol"},{"key":"key20180107175932_b12-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs - microRNAs with a role in cancer","volume":"6","author":"Esquela-Kerscher","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"key20180107175932_b13-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","article-title":"microRNAs as oncogenes and tumor suppressors","volume":"302","author":"Zhang","year":"2007","journal-title":"Dev Biol"},{"key":"key20180107175932_b14-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1158\/2159-8290.CD-13-0159","article-title":"Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment","volume":"3","author":"Nishimura","year":"2013","journal-title":"Cancer Discov"},{"key":"key20180107175932_b15-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ygyno.2014.04.055","article-title":"Ectopic over-expression of miR-429 induces mesenchymal-to-epithelial transition (MET) and increased drug sensitivity in meta- stasizing ovarian cancer cells","volume":"134","author":"Wang","year":"2014","journal-title":"Gynecol Oncol"},{"key":"key20180107175932_b16-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10911-010-9178-9","article-title":"Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression","volume":"15","author":"Micalizzi","year":"2010","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"key20180107175932_b17-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fonc.2015.00045","article-title":"Epithelial-to-mesenchymal plasticity harnesses endocytic circuitries","volume":"5","author":"Corallino","year":"2015","journal-title":"Front Oncol"},{"key":"key20180107175932_b18-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.stem.2014.02.002","article-title":"Metastatic stem cells: Sources, niches, and vital pathways","volume":"14","author":"Oskarsson","year":"2014","journal-title":"Cell Stem Cell"},{"key":"key20180107175932_b19-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J Clin Invest"},{"key":"key20180107175932_b20-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1517\/14728222.2014.975794","article-title":"Targeting microRNAs in epithelial-to-mesenchymal transition-induced cancer stem cells: Therapeutic approaches in cancer","volume":"19","author":"Garg","year":"2015","journal-title":"Expert Opin Ther Targets"},{"key":"key20180107175932_b21-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/jcm5010008","article-title":"MicroRNA regulation of epithelial to mesenchymal transition","volume":"5","author":"Abba","year":"2016","journal-title":"J Clin Med"},{"key":"key20180107175932_b22-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ceb.2005.08.001","article-title":"Molecular requirements for epithelial-mesenchymal transition during tumor progression","volume":"17","author":"Huber","year":"2005","journal-title":"Curr Opin Cell Biol"},{"key":"key20180107175932_b23-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"a002915","DOI":"10.1101\/cshperspect.a002915","article-title":"Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling","volume":"2","author":"Heuberger","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"key20180107175932_b24-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ygyno.2013.09.034","article-title":"The Wnt\/\u03b2-catenin pathway in ovarian cancer: A review","volume":"131","author":"Arend","year":"2013","journal-title":"Gynecol Oncol"},{"key":"key20180107175932_b25-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s12032-014-0368-y","article-title":"Sonic hedgehog-Gli1 signals promote epithelial-mesenchymal transition in ovarian cancer by mediating PI3K\/AKT pathway","volume":"32","author":"Ke","year":"2015","journal-title":"Med Oncol"},{"key":"key20180107175932_b26-ijo-50-05-1461","first-page":"2016","article-title":"Epithelial-mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1\/2 and Src signaling pathways","volume":"12","author":"Fang","journal-title":"Oncogene Sep"},{"key":"key20180107175932_b27-ijo-50-05-1461","first-page":"117","article-title":"Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies","volume":"3","author":"Talbot","year":"2012","journal-title":"Int J Biochem Mol Biol"},{"key":"key20180107175932_b28-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.4161\/cc.9.12.12050","article-title":"Transcriptional crosstalk between TGF-\u03b2 and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes","volume":"9","author":"Fuxe","year":"2010","journal-title":"Cell Cycle"},{"key":"key20180107175932_b29-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1111\/j.1349-7006.2007.00550.x","article-title":"Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression","volume":"98","author":"Moustakas","year":"2007","journal-title":"Cancer Sci"},{"key":"key20180107175932_b30-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1101\/gad.1820209","article-title":"Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression","volume":"23","author":"Gibbons","year":"2009","journal-title":"Genes Dev"},{"key":"key20180107175932_b31-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ncb1722","article-title":"The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1","volume":"10","author":"Gregory","year":"2008","journal-title":"Nat Cell Biol"},{"key":"key20180107175932_b32-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"14910","DOI":"10.1074\/jbc.C800074200","article-title":"The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2","volume":"283","author":"Korpal","year":"2008","journal-title":"J Biol Chem"},{"key":"key20180107175932_b33-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1101\/gad.1640608","article-title":"The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2","volume":"22","author":"Park","year":"2008","journal-title":"Genes Dev"},{"key":"key20180107175932_b34-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ygyno.2009.08.009","article-title":"Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: Evidence supporting a mesothelial-to-epithelial transition","volume":"116","author":"Bendoraite","year":"2010","journal-title":"Gynecol Oncol"},{"key":"key20180107175932_b35-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ygyno.2010.12.339","article-title":"Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells","volume":"121","author":"Chen","year":"2011","journal-title":"Gynecol Oncol"},{"key":"key20180107175932_b36-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1757-2215-7-12","article-title":"Sequence variation among members of the miR-200 microRNA family is correlated with variation in the ability to induce hallmarks of mesenchymal-epithelial transition in ovarian cancer cells","volume":"7","author":"Jabbari","year":"2014","journal-title":"J Ovarian Res"},{"key":"key20180107175932_b37-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s12032-014-0134-1","article-title":"miR-200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E-box-binding homeobox 2 (ZEB2) expression","volume":"31","author":"Lu","year":"2014","journal-title":"Med Oncol"},{"key":"key20180107175932_b38-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1757-2215-6-50","article-title":"MicroRNA-200c overexpression inhibits tumorige-nicity and metastasis of CD117+CD44+ ovarian cancer stem cells by regulating epithelial-mesenchymal transition","volume":"6","author":"Chen","year":"2013","journal-title":"J Ovarian Res"},{"key":"key20180107175932_b39-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.3892\/or.2014.3046","article-title":"miR-1236-3p represses the cell migration and invasion abilities by targeting ZEB1 in high-grade serous ovarian carcinoma","volume":"31","author":"Wang","year":"2014","journal-title":"Oncol Rep"},{"key":"key20180107175932_b40-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ygyno.2011.03.026","article-title":"MicroRNA-200a inhibits CD133\/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2","volume":"122","author":"Wu","year":"2011","journal-title":"Gynecol Oncol"},{"key":"key20180107175932_b41-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"e58226","DOI":"10.1371\/journal.pone.0058226","article-title":"Identification of ovarian cancer metastatic miRNAs","volume":"8","author":"Vang","year":"2013","journal-title":"PloS One"},{"key":"key20180107175932_b42-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"e103965","DOI":"10.1371\/journal.pone.0103965","article-title":"MicroRNA-150 predicts a favorable prognosis in patients with epithelial ovarian cancer, and inhibits cell invasion and metastasis by suppressing transcriptional repressor ZEB1","volume":"9","author":"Jin","year":"2014","journal-title":"PloS One"},{"key":"key20180107175932_b43-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1007\/s10620-010-1481-1","article-title":"miR-373 negatively regulates methyl-CpG-binding domain protein 2 (MBD2) in hilar cholangiocarcinoma","volume":"56","author":"Chen","year":"2011","journal-title":"Dig Dis Sci"},{"key":"key20180107175932_b44-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/jbmr.2052","article-title":"Set7\/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation","volume":"29","author":"Oppenheimer","year":"2014","journal-title":"J Bone Miner Res"},{"key":"key20180107175932_b45-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3892\/or.2015.3952","article-title":"MicroRNA-153 functions as a tumor suppressor by targeting SET7 and ZEB2 in ovarian cancer cells","volume":"34","author":"Zhou","year":"2015","journal-title":"Oncol Rep"},{"key":"key20180107175932_b46-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1038\/emm.2014.44","article-title":"Role of the epithelial-mesenchymal transition and its effects on embryonic stem cells","volume":"46","author":"Kim","year":"2014","journal-title":"Exp Mol Med"},{"key":"key20180107175932_b47-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ccr.2012.12.020","article-title":"Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer","volume":"23","author":"Yang","year":"2013","journal-title":"Cancer Cell"},{"key":"key20180107175932_b48-ijo-50-05-1461","first-page":"e447","article-title":"MiR-506: A Multitasker in suppression of the epithelial-to-mesenchymal transition","volume":"1","author":"Sun","year":"2014","journal-title":"RNA Dis"},{"key":"key20180107175932_b49-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/path.4443","article-title":"MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer","volume":"235","author":"Sun","year":"2015","journal-title":"J Pathol"},{"key":"key20180107175932_b50-ijo-50-05-1461","first-page":"34","article-title":"miR-203 functions as a tumor suppressor by inhibiting epithelial to mesenchymal transition in ovarian cancer","volume":"7","author":"Zhao","year":"2015","journal-title":"J Cancer Sci Ther"},{"key":"key20180107175932_b51-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1097\/IGC.0000000000000546","article-title":"miR-30d blocked transforming growth factor \u03b21-induced epithelial-mesenchymal transition by targeting Snail in ovarian cancer cells","volume":"25","author":"Ye","year":"2015","journal-title":"Int J Gynecol Cancer"},{"key":"key20180107175932_b52-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.4161\/cc.10.24.18552","article-title":"miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions","volume":"10","author":"Siemens","year":"2011","journal-title":"Cell Cycle"},{"key":"key20180107175932_b53-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1158\/0008-5472.CAN-09-4148","article-title":"Downregulation of microRNA miR-520h by E1A contributes to anticancer activity","volume":"70","author":"Su","year":"2010","journal-title":"Cancer Res"},{"key":"key20180107175932_b54-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00109-013-1055-8","article-title":"HMGA2 and high-grade serous ovarian carcinoma","volume":"91","author":"Wu","year":"2013","journal-title":"J Mol Med (Berl)"},{"key":"key20180107175932_b55-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1158\/0008-5472.CAN-10-2550","article-title":"HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes","volume":"71","author":"Wu","year":"2011","journal-title":"Cancer Res"},{"key":"key20180107175932_b56-ijo-50-05-1461","first-page":"1329","article-title":"Epigenetic silencing of microRNA-373 plays an important role in regulating cell proliferation in colon cancer","volume":"26","author":"Tanaka","year":"2011","journal-title":"Oncol Rep"},{"key":"key20180107175932_b57-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"12291","DOI":"10.18632\/oncotarget.2577","article-title":"MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer","volume":"5","author":"Zhang","year":"2014","journal-title":"Oncotarget"},{"key":"key20180107175932_b58-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"16943","DOI":"10.3390\/ijms140816943","article-title":"The association of IFI27 expression and fatigue intensification during localized radiation therapy: Implication of a para-inflammatory bystander response","volume":"14","author":"Hsiao","year":"2013","journal-title":"Int J Mol Sci"},{"key":"key20180107175932_b59-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jss.2014.06.055","article-title":"Interferon alpha-inducible protein 27 promotes epithelial-mesenchymal transition and induces ovarian tumorigenicity and stemness","volume":"193","author":"Li","year":"2015","journal-title":"J Surg Res"},{"key":"key20180107175932_b60-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4161\/mabs.19870","article-title":"Targeting malignant B cells with an immunotoxin against ROR1","volume":"4","author":"Baskar","year":"2012","journal-title":"MAbs"},{"key":"key20180107175932_b61-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3892\/ijo.2015.3241","article-title":"miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer","volume":"48","author":"Tan","year":"2016","journal-title":"Int J Oncol"},{"key":"key20180107175932_b62-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/ijc.28086","article-title":"MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1\u03b1","volume":"133","author":"Yeh","year":"2013","journal-title":"Int J Cancer"},{"key":"key20180107175932_b63-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1593\/neo.09942","article-title":"The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells","volume":"11","author":"Cowden Dahl","year":"2009","journal-title":"Neoplasia"},{"key":"key20180107175932_b64-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"e0131961","DOI":"10.1371\/journal.pone.0131961","article-title":"ARID3B directly regulates ovarian cancer promoting genes","volume":"10","author":"Bobbs","year":"2015","journal-title":"PloS One"},{"key":"key20180107175932_b65-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"e96718","DOI":"10.1371\/journal.pone.0096718","article-title":"MicroRNA-7 inhibits tumor metastasis and reverses epithelial-mesenchymal transition through AKT\/ERK1\/2 inactivation by targeting EGFR in epithelial ovarian cancer","volume":"9","author":"Zhou","year":"2014","journal-title":"PloS One"},{"key":"key20180107175932_b66-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1038\/sj.onc.1203598","article-title":"Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase\/Akt pathway in human ovarian cancer","volume":"19","author":"Yuan","year":"2000","journal-title":"Oncogene"},{"key":"key20180107175932_b67-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/cpr.12038","article-title":"Enrichment of ovarian cancer stem-like cells is associated with epithelial to mesenchymal transition through an miRNA-activated AKT pathway","volume":"46","author":"Luo","year":"2013","journal-title":"Cell Prolif"},{"key":"key20180107175932_b68-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1038\/ncomms3977","article-title":"microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition","volume":"5","author":"Parikh","year":"2014","journal-title":"Nat Commun"},{"key":"key20180107175932_b69-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.18632\/oncotarget.1614","article-title":"MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression","volume":"5","author":"Fang","year":"2014","journal-title":"Oncotarget"},{"key":"key20180107175932_b70-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40709-015-0035-2","article-title":"MicroRNA-17-5p induces drug resistance and invasion of ovarian carcinoma cells by targeting PTEN signaling","volume":"22","author":"Fang","year":"2015","journal-title":"J Biol Res (Thessalon)"},{"key":"key20180107175932_b71-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.febslet.2013.03.023","article-title":"MicroRNA-155 is a novel suppressor of ovarian cancer-initiating cells that targets CLDN1","volume":"587","author":"Qin","year":"2013","journal-title":"FEBS Lett"},{"key":"key20180107175932_b72-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1158\/0008-5472.CAN-07-1936","article-title":"MicroRNA signatures in human ovarian cancer","volume":"67","author":"Iorio","year":"2007","journal-title":"Cancer Res"},{"key":"key20180107175932_b73-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.3892\/or.2015.3831","article-title":"BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR-29b and enhancing MMP2 expression","volume":"33","author":"Habata","year":"2015","journal-title":"Oncol Rep"},{"key":"key20180107175932_b74-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13046-016-0288-0","article-title":"MiR-548c impairs migration and invasion of endo-metrial and ovarian cancer cells via downregulation of Twist","volume":"35","author":"Sun","year":"2016","journal-title":"J Exp Clin Cancer Res"},{"key":"key20180107175932_b75-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.3892\/or.2013.2400","article-title":"miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma","volume":"29","author":"Su","year":"2013","journal-title":"Oncol Rep"},{"key":"key20180107175932_b76-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.humpath.2013.12.007","article-title":"The FOXO1-miR27 tandem regulates myometrial invasion in endometrioid endometrial adenocarcinoma","volume":"45","author":"Mozos","year":"2014","journal-title":"Hum Pathol"},{"key":"key20180107175932_b77-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"915","DOI":"10.12659\/MSM.893872","article-title":"MiR-191 modulates malignant transformation of endometriosis through regulating TIMP3","volume":"21","author":"Dong","year":"2015","journal-title":"Med Sci Monit"},{"key":"key20180107175932_b78-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.3892\/mmr.2014.2123","article-title":"miR-22 inhibits proliferation and invasion in estrogen receptor \u03b1-positive endometrial endometrioid carcinomas cells","volume":"9","author":"Li","year":"2014","journal-title":"Mol Med Rep"},{"key":"key20180107175932_b79-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.canlet.2011.09.014","article-title":"Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ER\u03b1-positive endometrioid adenocarcinoma","volume":"314","author":"Chen","year":"2012","journal-title":"Cancer Lett"},{"key":"key20180107175932_b80-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3892\/mmr.2014.2021","article-title":"microRNA-206 overexpression inhibits cellular proliferation and invasion of estrogen receptor \u03b1-positive ovarian cancer cells","volume":"9","author":"Li","year":"2014","journal-title":"Mol Med Rep"},{"key":"key20180107175932_b81-ijo-50-05-1461","first-page":"650","article-title":"Screening and identification of potential miRNA involved in ovarian cancer invasion and metastasis","volume":"32","author":"Liang","year":"2010","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"key20180107175932_b82-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ygyno.2010.08.034","article-title":"An inhibitory effect of miR-22 on cell migration and invasion in ovarian cancer","volume":"119","author":"Li","year":"2010","journal-title":"Gynecol Oncol"},{"key":"key20180107175932_b83-ijo-50-05-1461","first-page":"1835","article-title":"Tiam1, negatively regulated by miR-22, miR-183 and miR-31, is involved in migration, invasion and viability of ovarian cancer cells","volume":"27","author":"Li","year":"2012","journal-title":"Oncol Rep"},{"key":"key20180107175932_b84-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.3892\/ijo.2015.2929","article-title":"miR-338-3p suppresses tumor growth of ovarian epithelial carcinoma by targeting Runx2","volume":"46","author":"Wen","year":"2015","journal-title":"Int J Oncol"},{"key":"key20180107175932_b85-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1038\/ncomms6917","article-title":"Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B","volume":"6","author":"Lin","year":"2015","journal-title":"Nat Commun"},{"key":"key20180107175932_b86-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1757-2215-6-84","article-title":"MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1","volume":"6","author":"Zhang","year":"2013","journal-title":"J Ovarian Res"},{"key":"key20180107175932_b87-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.3892\/mmr.2015.3827","article-title":"MicroRNA-148a inhibits migration and invasion of ovarian cancer cells via targeting sphingosine-1-phosphate receptor 1","volume":"12","author":"Wen","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180107175932_b88-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.3892\/or.2014.3461","article-title":"Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1\/cofilin signaling","volume":"32","author":"Chen","year":"2014","journal-title":"Oncol Rep"},{"key":"key20180107175932_b89-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bbrc.2014.05.053","article-title":"MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1","volume":"449","author":"Wang","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107175932_b90-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.18632\/oncotarget.6474","article-title":"MicroRNAs 125a and 125b inhibit ovarian cancer cells through post-transcriptional inactivation of EIF4EBP1","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"key20180107175932_b91-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/bjc.2015.340","article-title":"Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients","volume":"113","author":"Meng","year":"2015","journal-title":"Br J Cancer"},{"key":"key20180107175932_b92-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3892\/or.2013.2482","article-title":"miR-335 represents an invasion suppressor gene in ovarian cancer by targeting Bcl-w","volume":"30","author":"Cao","year":"2013","journal-title":"Oncol Rep"},{"key":"key20180107175932_b93-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"e52397","DOI":"10.1371\/journal.pone.0052397","article-title":"Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT\/mTOR\/Rac1 signaling and actin reorganization","volume":"7","author":"Imam","year":"2012","journal-title":"PloS One"},{"key":"key20180107175932_b94-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/ijc.26060","article-title":"Dysregulation of microRNA-204 mediates migration and invasion of endometrial cancer by regulating FOXC1","volume":"130","author":"Chung","year":"2012","journal-title":"Int J Cancer"},{"key":"key20180107175932_b95-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1155\/2013\/451248","article-title":"Regulation of breast cancer and bone metastasis by microRNAs","volume":"35","author":"Vimalraj","year":"2013","journal-title":"Dis Markers"},{"key":"key20180107175932_b96-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3892\/ijmm.2013.1400","article-title":"miR-9 functions as a tumor suppressor in ovarian serous carcinoma by targeting TLN1","volume":"32","author":"Tang","year":"2013","journal-title":"Int J Mol Med"},{"key":"key20180107175932_b97-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/j.ajpath.2013.01.039","article-title":"miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin \u03b15 expression","volume":"182","author":"Ohyagi-Hara","year":"2013","journal-title":"Am J Pathol"},{"key":"key20180107175932_b98-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.canlet.2014.08.020","article-title":"miR-21-3p is a positive regulator of L1CAM in several human carcinomas","volume":"354","author":"Doberstein","year":"2014","journal-title":"Cancer Lett"},{"key":"key20180107175932_b99-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.canlet.2015.03.029","article-title":"MicroRNA-490-3P targets CDK1 and inhibits ovarian epithelial carcinoma tumorigenesis and progression","volume":"362","author":"Chen","year":"2015","journal-title":"Cancer Lett"},{"key":"key20180107175932_b100-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12943-015-0304-6","article-title":"RhoC is a major target of microRNA-93-5P in epithelial ovarian carcinoma tumorigenesis and progression","volume":"14","author":"Chen","year":"2015","journal-title":"Mol Cancer"},{"key":"key20180107175932_b101-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s13277-014-2790-3","article-title":"MicroRNA-17 promotes normal ovarian cancer cells to cancer stem cells development via suppression of the LKB1-p53-p21\/WAF1 pathway","volume":"36","author":"Liu","year":"2015","journal-title":"Tumour Biol"},{"key":"key20180107175932_b102-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1158\/1078-0432.CCR-09-2642","article-title":"Frequent downregulation of miR-34 family in human ovarian cancers","volume":"16","author":"Corney","year":"2010","journal-title":"Clin Cancer Res"},{"key":"key20180107175932_b103-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.4161\/cc.10.22.18294","article-title":"MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF","volume":"10","author":"Hwang","year":"2011","journal-title":"Cell Cycle"},{"key":"key20180107175932_b104-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"14240","DOI":"10.1073\/pnas.1017536108","article-title":"Wild-type p53 controls cell motility and invasion by dual regulation of MET expression","volume":"108","author":"Hwang","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107175932_b105-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"7277","DOI":"10.1007\/s13277-015-3445-8","article-title":"MiR-34a suppresses ovarian cancer proliferation and motility by targeting AXL","volume":"36","author":"Li","year":"2015","journal-title":"Tumour Biol"},{"key":"key20180107175932_b106-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bbrc.2013.10.053","article-title":"MiR-145 is downreg-ulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1","volume":"441","author":"Wu","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107175932_b107-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/path.2696","article-title":"Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary","volume":"221","author":"Ahmed","year":"2010","journal-title":"J Pathol"},{"key":"key20180107175932_b108-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"10816","DOI":"10.18632\/oncotarget.2522","article-title":"miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma","volume":"5","author":"Dong","year":"2014","journal-title":"Oncotarget"},{"key":"key20180107175932_b109-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ygyno.2015.10.008","article-title":"MicroRNA-145 targets TRIM2 and exerts tumor-suppressing functions in epithelial ovarian cancer","volume":"139","author":"Chen","year":"2015","journal-title":"Gynecol Oncol"},{"key":"key20180107175932_b110-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.canlet.2014.11.011","article-title":"miR-145, targeting high-mobility group A2, is a powerful predictor of patient outcome in ovarian carcinoma","volume":"356B","author":"Kim","year":"2015","journal-title":"Cancer Lett"},{"key":"key20180107175932_b111-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1038\/onc.2014.236","article-title":"Regulation of tumor cell migration and invasion by the H19\/let-7 axis is antagonized by metformin-induced DNA methylation","volume":"34","author":"Yan","year":"2015","journal-title":"Oncogene"},{"key":"key20180107175932_b112-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/hmg\/ddu502","article-title":"LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b","volume":"24","author":"Gao","year":"2015","journal-title":"Hum Mol Genet"},{"key":"key20180107175932_b113-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s11095-013-1219-9","article-title":"Silencing the double-stranded RNA binding protein DGCR8 inhibits ovarian cancer cell proliferation, migration, and invasion","volume":"32","author":"Guo","year":"2015","journal-title":"Pharm Res"},{"key":"key20180107175932_b114-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1038\/onc.2015.492","article-title":"Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression","volume":"35","author":"Rupaimoole","year":"2016","journal-title":"Oncogene"},{"key":"key20180107175932_b115-ijo-50-05-1461","first-page":"846","article-title":"MicroRNA-16 regulates the proliferation, invasion and apoptosis of ovarian epithelial carcinoma cells in vitro","volume":"47","author":"Tang","year":"2012","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"key20180107175932_b116-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"12427","DOI":"10.1007\/s13277-014-2560-2","article-title":"MiR-212 exerts suppressive effect on SKOV3 ovarian cancer cells through targeting HBEGF","volume":"35","author":"Wei","year":"2014","journal-title":"Tumour Biol"},{"key":"key20180107175932_b117-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3892\/or.2015.4498","article-title":"Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R","volume":"35","author":"Li","year":"2016","journal-title":"Oncol Rep"},{"key":"key20180107175932_b118-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ygyno.2015.01.531","article-title":"The role of miR-205 in the VEGF-mediated promotion of human ovarian cancer cell invasion","volume":"137","author":"Li","year":"2015","journal-title":"Gynecol Oncol"},{"key":"key20180107175932_b119-ijo-50-05-1461","first-page":"142","article-title":"Expression and significance of VEGF, miR-205 and target protein Ezrin and Lamin A\/C in ovarian cancer","volume":"39","author":"Zhou","year":"2014","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"key20180107175932_b120-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.1007\/s13277-015-4507-7","article-title":"MicroRNA-613 inhibited ovarian cancer cell proliferation and invasion by regulating KRAS","volume":"37","author":"Fu","year":"2016","journal-title":"Tumour Biol"},{"key":"key20180107175932_b121-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.3892\/mmr.2015.3756","article-title":"MicroRNA-137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180107175932_b122-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1007\/s13277-015-4377-z","article-title":"miR-761 inhibits tumor progression by targeting MSI1 in ovarian carcinoma","volume":"37","author":"Shi","year":"2016","journal-title":"Tumour Biol"},{"key":"key20180107175932_b123-ijo-50-05-1461","first-page":"15198","article-title":"MiR181c inhibits ovarian cancer metastasis and progression by targeting PRKCD expression","volume":"8","author":"Yao","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20180107175932_b124-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"12339","DOI":"10.1007\/s13277-014-2546-0","article-title":"MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2","volume":"35","author":"Feng","year":"2014","journal-title":"Tumour Biol"},{"key":"key20180107175932_b125-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2014.04.027","article-title":"MicroRNA-181b promotes ovarian cancer cell growth and invasion by targeting LATS2","volume":"447","author":"Xia","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107175932_b126-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3892\/ijmm_00000530","article-title":"MicroRNA-21 promotes the cell proliferation, invasion and migration abilities in ovarian epithelial carcinomas through inhibiting the expression of PTEN protein","volume":"26","author":"Lou","year":"2010","journal-title":"Int J Mol Med"},{"key":"key20180107175932_b127-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"E281","DOI":"10.25011\/cim.v34i5.15671","article-title":"miR-21 down-regulation promotes apoptosis and inhibits invasion and migration abilities of OVCAR3 cells","volume":"34","author":"Lou","year":"2011","journal-title":"Clin Invest Med"},{"key":"key20180107175932_b128-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/jcb.24488","article-title":"MicroRNA-182 promotes cell growth, invasion, and chemoresis-tance by targeting programmed cell death 4 (PDCD4) in human ovarian carcinomas","volume":"114","author":"Wang","year":"2013","journal-title":"J Cell Biochem"},{"key":"key20180107175932_b129-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1158\/1535-7163.MCT-13-0982","article-title":"Anti-miR182 reduces ovarian cancer burden, invasion, and metastasis: An in vivo study in orthotopic xenografts of nude mice","volume":"13","author":"Xu","year":"2014","journal-title":"Mol Cancer Ther"},{"key":"key20180107175932_b130-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/path.4000","article-title":"MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma","volume":"228","author":"Liu","year":"2012","journal-title":"J Pathol"},{"key":"key20180107175932_b131-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3892\/ijo.2013.1935","article-title":"Loss of HOXD10 expression induced by upregulation of miR-10b accelerates the migration and invasion activities of ovarian cancer cells","volume":"43","author":"Nakayama","year":"2013","journal-title":"Int J Oncol"},{"key":"key20180107175932_b132-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/abbs\/gmq026","article-title":"miR-20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells","volume":"42","author":"Fan","year":"2010","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20180107175932_b133-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.1007\/s13277-015-3365-7","article-title":"MiR-197 induces Taxol resistance in human ovarian cancer cells by regulating NLK","volume":"36","author":"Zou","year":"2015","journal-title":"Tumour Biol"},{"key":"key20180107175932_b134-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2052-8426-2-30","article-title":"Therapeutic opportunities for targeting microRNAs in cancer","volume":"2","author":"Taylor","year":"2014","journal-title":"Mol Cell Ther"},{"key":"key20180107175932_b135-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nature04303","article-title":"Silencing of microRNAs in vivo with 'antagomirs'","volume":"438","author":"Kr\u00fctzfeldt","year":"2005","journal-title":"Nature"},{"key":"key20180107175932_b136-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/nar\/gkm1113","article-title":"Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver","volume":"36","author":"Elm\u00e9n","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"key20180107175932_b137-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1126\/science.1073827","article-title":"A microRNA in a multiple-turnover RNAi enzyme complex","volume":"297","author":"Hutv\u00e1gner","year":"2002","journal-title":"Science"},{"key":"key20180107175932_b138-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cell.2009.04.021","article-title":"Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model","volume":"137","author":"Kota","year":"2009","journal-title":"Cell"},{"key":"key20180107175932_b139-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrd3179","article-title":"Targeting microRNAs in cancer: Rationale, strategies and challenges","volume":"9","author":"Garzon","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"key20180107175932_b140-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1093\/nar\/gkn1053","article-title":"A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference","volume":"37","author":"Lu","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"key20180107175932_b141-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11523-012-0236-7","article-title":"Anticancer role of MUC1 aptamer-miR-29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation","volume":"7","author":"Dai","year":"2012","journal-title":"Target Oncol"},{"key":"key20180107175932_b142-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1158\/1535-7163.MCT-12-0463","article-title":"Restoration of miR-200c to ovarian cancer reduces tumor burden and increases sensitivity to paclitaxel","volume":"11","author":"Cittelly","year":"2012","journal-title":"Mol Cancer Ther"},{"key":"key20180107175932_b143-ijo-50-05-1461","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3892\/ijo.2016.3503","article-title":"Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: New trends in the development of miRNA therapeutic strategies in oncology (Review)","volume":"49","author":"Gambari","year":"2016","journal-title":"Int J Oncol"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/ijo.2017.3948\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T13:00:13Z","timestamp":1515330013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2017.3948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,4]]},"references-count":143,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,4,4]]},"published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.3892\/ijo.2017.3948"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2017.3948","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,4]]}}}