{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:48:42Z","timestamp":1776948522613,"version":"3.51.4"},"reference-count":27,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.3892\/ijo.2017.4081","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T09:59:49Z","timestamp":1501149589000},"page":"823-831","source":"Crossref","is-referenced-by-count":25,"title":["Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K\/AKT pathway"],"prefix":"10.3892","volume":"51","author":[{"given":"Jiaqi","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijun","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"key20180107180319_b1-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1586\/17474124.2014.943188","article-title":"The surgical management of gallbladder cancer","volume":"9","author":"Garg","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"key20180107180319_b2-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.14694\/EdBook_AM.2014.34.e165","article-title":"A review of recent data in the treatment of gallbladder cancer: what we know, what we do, and what should be done","author":"M\u00fcller","year":"2014","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"key20180107180319_b3-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"62364","DOI":"10.18632\/oncotarget.11634","article-title":"miR-223 increases gallbladder cancer cell sensitivity to docetaxel by downregulating STMN1","volume":"7","author":"Lu","year":"2016","journal-title":"Oncotarget"},{"key":"key20180107180319_b4-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/20974","article-title":"Structure and ligand of a histone acetyltransferase bromodomain","volume":"399","author":"Dhalluin","year":"1999","journal-title":"Nature"},{"key":"key20180107180319_b5-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.3390\/ijms16011928","article-title":"BRD4 inhibitor inhibits colorectal cancer growth and metastasis","volume":"16","author":"Hu","year":"2015","journal-title":"Int J Mol Sci"},{"key":"key20180107180319_b6-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.1158\/0008-5472.CAN-16-0559","article-title":"BRD4 regulates breast cancer dissemination through Jagged1\/Notch1 signaling","volume":"76","author":"Andrieu","year":"2016","journal-title":"Cancer Res"},{"key":"key20180107180319_b7-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"8758","DOI":"10.1073\/pnas.1433065100","article-title":"The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis","volume":"100","author":"Dey","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107180319_b8-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1158\/1078-0432.CCR-15-1666","article-title":"The bromodomain inhibitor JQ1 and the histone deacetylase inhibitor panobinostat synergistically reduce N-Myc expression and induce anticancer effects","volume":"22","author":"Shahbazi","year":"2016","journal-title":"Clin Cancer Res"},{"key":"key20180107180319_b9-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.molcel.2012.12.006","article-title":"Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting","volume":"49","author":"Wu","year":"2013","journal-title":"Mol Cell"},{"key":"key20180107180319_b10-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cell.2015.11.062","article-title":"Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance","volume":"164","author":"Marcotte","year":"2016","journal-title":"Cell"},{"key":"key20180107180319_b11-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1158\/1535-7163.MCT-13-0925","article-title":"BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen","volume":"13","author":"Sahai","year":"2014","journal-title":"Mol Cancer Ther"},{"key":"key20180107180319_b12-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"9491","DOI":"10.18632\/oncotarget.7068","article-title":"High level of BRD4 promotes non-small cell lung cancer progression","volume":"7","author":"Liao","year":"2016","journal-title":"Oncotarget"},{"key":"key20180107180319_b13-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1158\/1541-7786.MCR-15-0418","article-title":"Expression of ANRIL-polycomb complexes-CDKN2A\/B\/ARF genes in breast tumors: Identification of a two-gene (EZH2\/CBX7) signature with independent prognostic value","volume":"14","author":"Meseure","year":"2016","journal-title":"Mol Cancer Res"},{"key":"key20180107180319_b14-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.canlet.2016.01.008","article-title":"LASP-1 induces proliferation, metastasis and cell cycle arrest at the G2\/M phase in gallbladder cancer by down-regulating S100P via the PI3K\/AKT pathway","volume":"372","author":"Li","year":"2016","journal-title":"Cancer Lett"},{"key":"key20180107180319_b15-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"11373","DOI":"10.1523\/JNEUROSCI.23-36-11373.2003","article-title":"Apoptosis induced by p75NTR over-expression requires Jun kinase-dependent phosphorylation of Bad","volume":"23","author":"Bhakar","year":"2003","journal-title":"J Neurosci"},{"key":"key20180107180319_b16-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0092-8674(00)80405-5","article-title":"Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery","volume":"91","author":"Datta","year":"1997","journal-title":"Cell"},{"key":"key20180107180319_b17-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1158\/0008-5472.CAN-13-0122-T","article-title":"BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy","volume":"73","author":"Segura","year":"2013","journal-title":"Cancer Res"},{"key":"key20180107180319_b18-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1158\/1078-0432.CCR-12-3904","article-title":"Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer","volume":"19","author":"Shimamura","year":"2013","journal-title":"Clin Cancer Res"},{"key":"key20180107180319_b19-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1158\/1535-7163.MCT-15-0724","article-title":"Dual targeting of bromodomain and extraterminal domain proteins, and WNT or MAPK signaling, inhibits c-MYC expression and proliferation of colorectal cancer cells","volume":"15","author":"T\u00f6gel","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"key20180107180319_b20-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1158\/1535-7163.MCT-15-0750","article-title":"BRD4 regulates EZH2 transcription through upregulation of C-MYC and represents a novel therapeutic target in bladder cancer","volume":"15","author":"Wu","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"key20180107180319_b21-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1093\/nar\/gkw126","article-title":"Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition","volume":"44","author":"Chang","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"key20180107180319_b22-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"key":"key20180107180319_b23-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ccr.2014.01.028","article-title":"Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer","volume":"25","author":"Shi","year":"2014","journal-title":"Cancer Cell"},{"key":"key20180107180319_b24-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"key20180107180319_b25-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"8305","DOI":"10.1007\/s13277-015-4704-4","article-title":"Upregulated LASP-1 correlates with a malignant phenotype and its potential therapeutic role in human cholangiocarcinoma","volume":"37","author":"Zhang","year":"2016","journal-title":"Tumour Biol"},{"key":"key20180107180319_b26-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/cdd.2015.50","article-title":"The BCL-2 protein family, BH3-mimetics and cancer therapy","volume":"22","author":"Delbridge","year":"2015","journal-title":"Cell Death Differ"},{"key":"key20180107180319_b27-ijo-51-03-0823","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/sj.jcbfm.9600367","article-title":"Bad as a converging signaling molecule between survival PI3-K\/Akt and death JNK in neurons after transient focal cerebral ischemia in rats","volume":"27","author":"Kamada","year":"2007","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T17:33:26Z","timestamp":1569951206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2017.4081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,27]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,7,27]]},"published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.3892\/ijo.2017.4081"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2017.4081","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,27]]}}}