{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T04:17:15Z","timestamp":1771733835045,"version":"3.50.1"},"reference-count":72,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.3892\/ijo.2017.4082","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T05:58:05Z","timestamp":1501135085000},"page":"753-759","source":"Crossref","is-referenced-by-count":14,"title":["Salinomycin's potential to eliminate glioblastoma stem cells and treat glioblastoma multiforme (Review)"],"prefix":"10.3892","volume":"51","author":[{"given":"Justin W.","family":"Magrath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"key20180107180243_b1-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N Engl J Med"},{"key":"key20180107180243_b2-ijo-51-03-0753","first-page":"357","article-title":"Treatment options and outcomes for glioblastoma in the elderly patient","volume":"9","author":"Arvold","year":"2014","journal-title":"Clin Interv Aging"},{"key":"key20180107180243_b3-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat Med"},{"key":"key20180107180243_b4-ijo-51-03-0753","first-page":"5821","article-title":"Identification of a cancer stem cell in human brain tumors","volume":"63","author":"Singh","year":"2003","journal-title":"Cancer Res"},{"key":"key20180107180243_b5-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature03128","article-title":"Identification of human brain tumour initiating cells","volume":"432","author":"Singh","year":"2004","journal-title":"Nature"},{"key":"key20180107180243_b6-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1158\/0008-5472.CAN-04-1364","article-title":"Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma","volume":"64","author":"Galli","year":"2004","journal-title":"Cancer Res"},{"key":"key20180107180243_b7-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature05236","article-title":"Glioma stem cells promote radioresistance by preferential activation of the DNA damage response","volume":"444","author":"Bao","year":"2006","journal-title":"Nature"},{"key":"key20180107180243_b8-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"109","DOI":"10.15283\/ijsc.2009.2.2.109","article-title":"Cancer stem cells and their mechanism of chemo-radiation resistance","volume":"2","author":"Kim","year":"2009","journal-title":"Int J Stem Cells"},{"key":"key20180107180243_b9-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1158\/0008-5472.CAN-07-6878","article-title":"Temozolomide preferentially depletes cancer stem cells in glioblastoma","volume":"68","author":"Beier","year":"2008","journal-title":"Cancer Res"},{"key":"key20180107180243_b10-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.canlet.2010.04.005","article-title":"Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres","volume":"296","author":"Mihaliak","year":"2010","journal-title":"Cancer Lett"},{"key":"key20180107180243_b11-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1634\/stemcells.2006-0624","article-title":"Spheres isolated from 9L gliosarcoma rat cell line possess chemoresistant and aggressive cancer stem-like cells","volume":"25","author":"Ghods","year":"2007","journal-title":"Stem Cells"},{"key":"key20180107180243_b12-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/sj.cdd.4401872","article-title":"Chemotherapy resistance of glioblastoma stem cells","volume":"13","author":"Eramo","year":"2006","journal-title":"Cell Death Differ"},{"key":"key20180107180243_b13-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1476-4598-10-128","article-title":"Chemoresistance of glioblastoma cancer stem cells - much more complex than expected","volume":"10","author":"Beier","year":"2011","journal-title":"Mol Cancer"},{"key":"key20180107180243_b14-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/0006-291X(75)90490-8","article-title":"Salinomycin: A new monovalent cation ionophore","volume":"66","author":"Mitani","year":"1975","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107180243_b15-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3382\/ps.0560933","article-title":"Anticoccidial activity of salinomycin in floor-pen experiments with broilers","volume":"56","author":"Danforth","year":"1977","journal-title":"Poult Sci"},{"key":"key20180107180243_b16-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.2174\/15672050113109990199","article-title":"Salinomycin: A novel anti-cancer agent with known anti-coccidial activities","volume":"20","author":"Zhou","year":"2013","journal-title":"Curr Med Chem"},{"key":"key20180107180243_b17-ijo-51-03-0753","first-page":"43","article-title":"Ionophores: Their use as ruminant growth promotants and impact on food safety","volume":"4","author":"Callaway","year":"2003","journal-title":"Curr Issues Intest Microbiol"},{"key":"key20180107180243_b18-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2527\/jas1985.614782x","article-title":"The efficacy of salinomycin as a growth promotant for swine from 9 to 97 kg","volume":"61","author":"Lindemann","year":"1985","journal-title":"J Anim Sci"},{"key":"key20180107180243_b19-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2009.06.034","article-title":"Identification of selective inhibitors of cancer stem cells by high-throughput screening","volume":"138","author":"Gupta","year":"2009","journal-title":"Cell"},{"key":"key20180107180243_b20-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"13253","DOI":"10.1073\/pnas.1110431108","article-title":"Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells","volume":"108","author":"Lu","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107180243_b21-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbrc.2011.08.054","article-title":"Salinomycin-induced apoptosis of human prostate cancer cells due to accumulated reactive oxygen species and mitochondrial membrane depolarization","volume":"413","author":"Kim","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107180243_b22-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1245\/s10434-011-1561-2","article-title":"Salinomycin selectively targets 'CD133+' cell subpopulations and decreases malignant traits in colorectal cancer lines","volume":"18","author":"Dong","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"key20180107180243_b23-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/157340611794859307","article-title":"Effects of salinomycin on cancer stem cell in human lung adenocarcinoma A549 cells","volume":"7","author":"Wang","year":"2011","journal-title":"Med Chem"},{"key":"key20180107180243_b24-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1021\/mp500754r","article-title":"Co-eradication of breast cancer cells and cancer stem cells by cross-linked multilamellar liposomes enhances tumor treatment","volume":"12","author":"Kim","year":"2015","journal-title":"Mol Pharm"},{"key":"key20180107180243_b25-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.bbrc.2010.03.138","article-title":"Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells","volume":"394","author":"Fuchs","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107180243_b26-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.bbrc.2009.10.042","article-title":"Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells","volume":"390","author":"Fuchs","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107180243_b27-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13046-015-0174-1","article-title":"ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis","volume":"34","author":"Qin","year":"2015","journal-title":"J Exp Clin Cancer Res"},{"key":"key20180107180243_b28-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/j.bbamcr.2013.04.011","article-title":"Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cells","volume":"1833","author":"Jangamreddy","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"key20180107180243_b29-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.3892\/mmr.2014.3027","article-title":"Salinomycin inhibits the tumor growth of glioma stem cells by selectively suppressing glioma-initiating cells","volume":"11","author":"Chen","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180107180243_b30-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"30626","DOI":"10.18632\/oncotarget.8905","article-title":"Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma","volume":"7","author":"Xipell","year":"2016","journal-title":"Oncotarget"},{"key":"key20180107180243_b31-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/cas.12691","article-title":"Nestin as a marker of cancer stem cells","volume":"106","author":"Neradil","year":"2015","journal-title":"Cancer Sci"},{"key":"key20180107180243_b32-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jcma.2016.03.010","article-title":"Sox2, a stemness gene, regulates tumor-initiating and drug-resistant properties in CD133-positive glioblastoma stem cells","volume":"79","author":"Song","year":"2016","journal-title":"J Chin Med Assoc"},{"key":"key20180107180243_b33-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/stem.1537","article-title":"The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer- and glioma-initiating cells","volume":"32","author":"Lagadec","year":"2014","journal-title":"Stem Cells"},{"key":"key20180107180243_b34-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1354\/vp.36-2-152","article-title":"Salinomycin-induced polyneuropathy in cats: Morphologic and epidemiologic data","volume":"36","author":"van der Linde-Sipman","year":"1999","journal-title":"Vet Pathol"},{"key":"key20180107180243_b35-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/vr.121.6.126","article-title":"Salinomycin poisoning in horses","volume":"121","author":"Rollinson","year":"1987","journal-title":"Vet Rec"},{"key":"key20180107180243_b36-ijo-51-03-0753","first-page":"318","article-title":"The comparative toxicology of narasin in laboratory animals","volume":"36","author":"Novilla","year":"1994","journal-title":"Vet Hum Toxicol"},{"key":"key20180107180243_b37-ijo-51-03-0753","first-page":"U799","article-title":"A case of human poisoning by salinomycin, an agricultural antibiotic","volume":"117","author":"Story","year":"2004","journal-title":"N Z Med J"},{"key":"key20180107180243_b38-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1038\/cddis.2011.46","article-title":"Salinomycin induces calpain and cytochrome c-mediated neuronal cell death","volume":"2","author":"Boehmerle","year":"2011","journal-title":"Cell Death Dis"},{"key":"key20180107180243_b39-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0006-291X(86)80063-8","article-title":"Alterations in intracellular calcium activity and contractility of isolated perfused rabbit hearts by ionophores and adrenergic agents","volume":"139","author":"Lattanzio","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107180243_b40-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.canlet.2007.07.011","article-title":"Role of Wnt5a in the proliferation of human glioblastoma cells","volume":"257","author":"Yu","year":"2007","journal-title":"Cancer Lett"},{"key":"key20180107180243_b41-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/abbs\/gmr079","article-title":"Wnt\/Ca2+ signaling pathway: A brief overview","volume":"43","author":"De","year":"2011","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20180107180243_b42-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1517\/17425250903228834","article-title":"ABCG2: The key to chemoresistance in cancer stem cells?","volume":"5","author":"An","year":"2009","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"key20180107180243_b43-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10911-009-9109-9","article-title":"ABC transporters, drug resistance, and cancer stem cells","volume":"14","author":"Dean","year":"2009","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"key20180107180243_b44-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2017.04.006","article-title":"Salinomycin attenuates liver cancer stem cell motility by enhancing cell stiffness and increasing F-actin formation via the FAK-ERK1\/2 signalling pathway","volume":"384","author":"Sun","year":"2017","journal-title":"Toxicology"},{"key":"key20180107180243_b45-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"445","DOI":"10.21873\/anticanres.11336","article-title":"Salinomycin abolished STAT3 and STAT1 interactions and reduced telomerase activity in colorectal cancer cells","volume":"37","author":"Chung","year":"2017","journal-title":"Anticancer Res"},{"key":"key20180107180243_b46-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1186\/1471-2407-12-556","article-title":"Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt","volume":"12","author":"Kuo","year":"2012","journal-title":"BMC Cancer"},{"key":"key20180107180243_b47-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.apjtm.2015.06.004","article-title":"Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24","volume":"8","author":"Qu","year":"2015","journal-title":"Asian Pac J Trop Med"},{"key":"key20180107180243_b48-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.cell.2009.08.007","article-title":"Breast cancer stem cells: Eradication by differentiation therapy?","volume":"138","author":"Beug","year":"2009","journal-title":"Cell"},{"key":"key20180107180243_b49-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1186\/s12885-016-2879-8","article-title":"Salinomycin inhibits metastatic colorectal cancer growth and interferes with Wnt\/\u03b2-catenin signaling in CD133(+) human colorectal cancer cells","volume":"16","author":"Klose","year":"2016","journal-title":"BMC Cancer"},{"key":"key20180107180243_b50-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cbi.2014.12.002","article-title":"Salinomycin exerts anticancer effects on human breast carcinoma MCF-7 cancer stem cells via modulation of Hedgehog signaling","volume":"228","author":"Lu","year":"2015","journal-title":"Chem Biol Interact"},{"key":"key20180107180243_b51-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1042\/CS20140592","article-title":"The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients","volume":"129","author":"He","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"key20180107180243_b52-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrclinonc.2010.196","article-title":"Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways","volume":"8","author":"Takebe","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"key20180107180243_b53-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/cdd.2014.137","article-title":"Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015","volume":"22","author":"Galluzzi","year":"2015","journal-title":"Cell Death Differ"},{"key":"key20180107180243_b54-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2184.2012.00845.x","article-title":"Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis","volume":"45","author":"Ouyang","year":"2012","journal-title":"Cell Prolif"},{"key":"key20180107180243_b55-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br J Cancer"},{"key":"key20180107180243_b56-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3322\/canjclin.55.3.178","article-title":"Targeting apoptosis pathways in cancer therapy","volume":"55","author":"Ghobrial","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"key20180107180243_b57-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev.pathmechdis.2.010506.091842","article-title":"Autophagy: Basic principles and relevance to disease","volume":"3","author":"Kundu","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"key20180107180243_b58-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc3262","article-title":"Deconvoluting the context-dependent role for autophagy in cancer","volume":"12","author":"White","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"key20180107180243_b59-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.cell.2008.12.004","article-title":"Necroptosis: A specialized pathway of programmed necrosis","volume":"135","author":"Galluzzi","year":"2008","journal-title":"Cell"},{"key":"key20180107180243_b60-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1016\/j.bbagen.2013.01.010","article-title":"Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation","volume":"1830","author":"Al Dhaheri","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"key20180107180243_b61-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1007\/s13277-015-4212-6","article-title":"Apoptotic effects of salinomycin on human ovarian cancer cell line (OVCAR-3)","volume":"37","author":"Kaplan","year":"2016","journal-title":"Tumour Biol"},{"key":"key20180107180243_b62-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"e94438","DOI":"10.1371\/journal.pone.0094438","article-title":"Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines","volume":"9","author":"Calzolari","year":"2014","journal-title":"PLoS One"},{"key":"key20180107180243_b63-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4161\/cbt.27309","article-title":"HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells","volume":"15","author":"Booth","year":"2014","journal-title":"Cancer Biol Ther"},{"key":"key20180107180243_b64-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"key20180107180243_b65-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.cell.2012.05.014","article-title":"p53 opens the mitochondrial permeability transition pore to trigger necrosis","volume":"149","author":"Vaseva","year":"2012","journal-title":"Cell"},{"key":"key20180107180243_b66-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fphys.2013.00095","article-title":"The mitochondrial permeability transition pore: A mystery solved?","volume":"4","author":"Bernardi","year":"2013","journal-title":"Front Physiol"},{"key":"key20180107180243_b67-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1093\/emboj\/18.22.6349","article-title":"Apoptosis driven by IP(3)-linked mitochondrial calcium signals","volume":"18","author":"Szalai","year":"1999","journal-title":"EMBO J"},{"key":"key20180107180243_b68-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/2212697X113019990002","article-title":"Low concentration of salinomycin prevents regrowth and partially depletes human glioma cells surviving high concentrations of alkylating agents","volume":"1","author":"Delwar","year":"2014","journal-title":"Clin Cancer Drugs"},{"key":"key20180107180243_b69-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/1074-7613(95)90057-8","article-title":"Identification and characterization of a new member of the TNF family that induces apoptosis","volume":"3","author":"Wiley","year":"1995","journal-title":"Immunity"},{"key":"key20180107180243_b70-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"12687","DOI":"10.1074\/jbc.271.22.12687","article-title":"Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family","volume":"271","author":"Pitti","year":"1996","journal-title":"J Biol Chem"},{"key":"key20180107180243_b71-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.2174\/138161207782360528","article-title":"Valproic acid as anti-cancer drug","volume":"13","author":"Michaelis","year":"2007","journal-title":"Curr Pharm Des"},{"key":"key20180107180243_b72-ijo-51-03-0753","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jbm.a.35591","article-title":"Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells","volume":"104","author":"T\u0131\u011fl\u0131 Ayd\u0131n","year":"2016","journal-title":"J Biomed Mater Res A"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T13:03:30Z","timestamp":1515330210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2017.4082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,27]]},"references-count":72,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,7,27]]},"published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.3892\/ijo.2017.4082"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2017.4082","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,27]]}}}