{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T09:42:36Z","timestamp":1772790156051,"version":"3.50.1"},"reference-count":30,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.3892\/ijo.2017.4103","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T10:43:39Z","timestamp":1503657819000},"page":"1035-1044","source":"Crossref","is-referenced-by-count":12,"title":["Phospho-valproic acid inhibits pancreatic cancer growth in mice: Enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles"],"prefix":"10.3892","volume":"51","author":[{"given":"George","family":"Mattheolabakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basil","family":"Rigas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo G.","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,8,25]]},"reference":[{"key":"key20180107180417_b1-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"key20180107180417_b2-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1158\/0008-5472.CAN-11-2349","article-title":"Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds","volume":"71","author":"Huang","year":"2011","journal-title":"Cancer Res"},{"key":"key20180107180417_b3-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1593\/neo.131368","article-title":"A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice","volume":"15","author":"Mackenzie","year":"2013","journal-title":"Neoplasia"},{"key":"key20180107180417_b4-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1053\/j.gastro.2010.06.044","article-title":"Phospho-sulindac (OxT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice","volume":"139","author":"Mackenzie","year":"2010","journal-title":"Gastroenterology"},{"key":"key20180107180417_b5-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"e61532","DOI":"10.1371\/journal.pone.0061532","article-title":"Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice","volume":"8","author":"Mackenzie","year":"2013","journal-title":"PLoS One"},{"key":"key20180107180417_b6-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1158\/0008-5472.CAN-11-0908","article-title":"STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis","volume":"71","author":"Corcoran","year":"2011","journal-title":"Cancer Res"},{"key":"key20180107180417_b7-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ccr.2011.03.002","article-title":"Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression","volume":"19","author":"Fukuda","year":"2011","journal-title":"Cancer Cell"},{"key":"key20180107180417_b8-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ccr.2011.03.009","article-title":"Stat3\/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer","volume":"19","author":"Lesina","year":"2011","journal-title":"Cancer Cell"},{"key":"key20180107180417_b9-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0016-5085(03)01064-3","article-title":"Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer","volume":"125","author":"Scholz","year":"2003","journal-title":"Gastroenterology"},{"key":"key20180107180417_b10-ijo-51-04-1035","first-page":"945","article-title":"Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention","volume":"8","author":"Buettner","year":"2002","journal-title":"Clin Cancer Res"},{"key":"key20180107180417_b11-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/jnci\/djn470","article-title":"The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate","volume":"101","author":"Sahu","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"key20180107180417_b12-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.2217\/nnm.12.128","article-title":"Nanodelivery strategies in cancer chemotherapy: Biological rationale and pharmaceutical perspectives","volume":"7","author":"Mattheolabakis","year":"2012","journal-title":"Nanomedicine (Lond)"},{"key":"key20180107180417_b13-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(00)00339-4","article-title":"Biodegradable polymeric nanoparticles as drug delivery devices","volume":"70","author":"Soppimath","year":"2001","journal-title":"J Control Release"},{"key":"key20180107180417_b14-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0169-409X(02)00044-3","article-title":"Nanoparticles in cancer therapy and diagnosis","volume":"54","author":"Brigger","year":"2002","journal-title":"Adv Drug Deliv Rev"},{"key":"key20180107180417_b15-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ejpb.2008.09.011","article-title":"In vivo investigation of tolerance and antitumor activity of cisplatin-loaded PLGA-mPEG nanoparticles","volume":"71","author":"Mattheolabakis","year":"2009","journal-title":"Eur J Pharm Biopharm"},{"key":"key20180107180417_b16-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.onc.1206122","article-title":"Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis","volume":"22","author":"Wei","year":"2003","journal-title":"Oncogene"},{"key":"key20180107180417_b17-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/MPA.0b013e3181c15963","article-title":"Phenotype and genotype of pancreatic cancer cell lines","volume":"39","author":"Deer","year":"2010","journal-title":"Pancreas"},{"key":"key20180107180417_b18-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"8269","DOI":"10.1158\/0008-5472.CAN-08-2010","article-title":"The thioredoxin system mediates redox-induced cell death in human colon cancer cells: Implications for the mechanism of action of anticancer agents","volume":"68","author":"Sun","year":"2008","journal-title":"Cancer Res"},{"key":"key20180107180417_b19-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/ijc.23477","article-title":"Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells","volume":"123","author":"Mackenzie","year":"2008","journal-title":"Int J Cancer"},{"key":"key20180107180417_b20-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1158\/1940-6207.CAPR-15-0344","article-title":"Phospho-aspirin (MDC-22) prevents pancreatic carcinogenesis in mice","volume":"9","author":"Mattheolabakis","year":"2016","journal-title":"Cancer Prev Res"},{"key":"key20180107180417_b21-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1158\/1940-6207.CAPR-11-0067","article-title":"Phospho-sulindac (OxT-328) combined with difluoromethylornithine prevents colon cancer in mice","volume":"4","author":"Mackenzie","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"key":"key20180107180417_b22-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ejso.2003.08.001","article-title":"Suicide gene therapy with HSV-TK in pancreatic cancer has no effect in vivo in a mouse model","volume":"29","author":"Fogar","year":"2003","journal-title":"Eur J Surg Oncol"},{"key":"key20180107180417_b23-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jcp.1041650118","article-title":"Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor","volume":"165","author":"Freeman","year":"1995","journal-title":"J Cell Physiol"},{"key":"key20180107180417_b24-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1158\/1940-6207.CAPR-15-0344","article-title":"Phospho-aspirin (MDC-22) prevents pancreatic carcinogenesis in mice","volume":"9","author":"Mattheolabakis","year":"2016","journal-title":"Cancer Prev Res (Phila)"},{"key":"key20180107180417_b25-ijo-51-04-1035","first-page":"109","article-title":"Advancements in the management of pancreatic cancer","volume":"10","author":"Li","year":"2009","journal-title":"JOP"},{"key":"key20180107180417_b26-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrc2899","article-title":"KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma","volume":"10","author":"Morris","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"key20180107180417_b27-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jconrel.2009.12.020","article-title":"Cyclic RGD conjugated poly(ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect","volume":"143","author":"Zhan","year":"2010","journal-title":"J Control Release"},{"key":"key20180107180417_b28-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/mp050103u","article-title":"Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation","volume":"3","author":"Ahmed","year":"2006","journal-title":"Mol Pharm"},{"key":"key20180107180417_b29-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0168-3659(01)00275-9","article-title":"In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy","volume":"72","author":"Kim","year":"2001","journal-title":"J Control Release"},{"key":"key20180107180417_b30-ijo-51-04-1035","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1158\/2159-8290.CD-13-0593","article-title":"Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D","volume":"4","author":"Baumgart","year":"2014","journal-title":"Cancer Discov"}],"container-title":["International Journal of Oncology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T18:05:21Z","timestamp":1515348321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/ijo.2017.4103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,25]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,8,25]]},"published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.3892\/ijo.2017.4103"],"URL":"https:\/\/doi.org\/10.3892\/ijo.2017.4103","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,25]]}}}