{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:12:33Z","timestamp":1789193553043,"version":"build-2803163510"},"reference-count":32,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Oncol"],"DOI":"10.3892\/ijo.2017.4227","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T08:47:48Z","timestamp":1513154868000},"source":"Crossref","is-referenced-by-count":12,"title":["Cyclooxygenase-2 expression is induced by celecoxib treatment in lung cancer cells and is transferred to neighbor cells via exosomes"],"prefix":"10.3892","author":[{"given":"Jayoung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Anatomy and Research Center for Tumor Immunology, College of Medicine, Inje University, Busan 47392, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Woo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Research Center for Tumor Immunology, College of Medicine, Inje University, Busan 47392, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonghan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Research Center for Tumor Immunology, College of Medicine, Inje University, Busan 47392, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daejin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Research Center for Tumor Immunology, College of Medicine, Inje University, Busan 47392, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae","family":"Hur","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Research Center for Tumor Immunology, College of Medicine, Inje University, Busan 47392, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hoon","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haeundae Paik Hospital, College of Medicine, Inje University, Busan 48108, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Research Center for Tumor Immunology, College of Medicine, Inje University, Busan 47392, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,12,13]]},"reference":[{"key":"key20200713184502_b1-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1200\/JCO.2005.14.209","article-title":"Advances in the biology of lung cancer chemoprevention","volume":"23","author":"Hirsch","year":"2005","journal-title":"J Clin Oncol"},{"key":"key20200713184502_b2-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1513\/pats.201107-038MS","article-title":"Lung cancer chemoprevention","volume":"9","author":"Keith","year":"2012","journal-title":"Proc Am Thorac Soc"},{"key":"key20200713184502_b3-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.ccm.2011.09.001","article-title":"Lung cancer: Epidemiology, etiology, and prevention","volume":"32","author":"Dela Cruz","year":"2011","journal-title":"Clin Chest Med"},{"issue":"Suppl 7","key":"key20200713184502_b4-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1053\/j.seminoncol.2004.03.045","article-title":"COX-2 inhibition and lung cancer","volume":"31","author":"Sandler","year":"2004","journal-title":"Semin Oncol"},{"key":"key20200713184502_b5-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1200\/JCO.2002.11.145","article-title":"Novel targets for lung cancer therapy: Part I","volume":"20","author":"Dy","year":"2002","journal-title":"J Clin Oncol"},{"key":"key20200713184502_b6-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1741-7015-10-28","article-title":"Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: The effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab","volume":"10","author":"Chen","year":"2012","journal-title":"BMC Med"},{"key":"key20200713184502_b7-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.pharmthera.2015.07.002","article-title":"EGFR targeted therapies and radiation: Optimizing efficacy by appropriate drug scheduling and patient selection","volume":"154","author":"Cuneo","year":"2015","journal-title":"Pharmacol Ther"},{"key":"key20200713184502_b8-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1056\/NEJMra0802714","article-title":"Lung cancer","volume":"359","author":"Herbst","year":"2008","journal-title":"N Engl J Med"},{"key":"key20200713184502_b9-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/S1470-2045(03)01220-8","article-title":"Inhibitors of cyclooxygenase 2: A new class of anticancer agents?","volume":"4","author":"Gasparini","year":"2003","journal-title":"Lancet Oncol"},{"key":"key20200713184502_b10-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/00041552-200101000-00014","article-title":"Cyclooxygenase 2 and the kidney","volume":"10","author":"Breyer","year":"2001","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"key20200713184502_b11-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1530\/REP-14-0392","article-title":"Cyclooxygenase and prostaglandins in somatic cell populations of the testis","volume":"149","author":"Frungieri","year":"2015","journal-title":"Reproduction"},{"key":"key20200713184502_b12-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1517\/17460441.2014.883377","article-title":"The discovery and development of cyclooxygenase-2 inhibitors as potential anticancer therapies","volume":"9","author":"Vosooghi","year":"2014","journal-title":"Expert Opin Drug Discov"},{"key":"key20200713184502_b13-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S1734-1140(10)70262-0","article-title":"COX-2 as a target for cancer chemotherapy","volume":"62","author":"Ghosh","year":"2010","journal-title":"Pharmacol Rep"},{"key":"key20200713184502_b14-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.cca.2010.12.026","article-title":"Cyclooxygenase-2 in oncogenesis","volume":"412","author":"Rizzo","year":"2011","journal-title":"Clin Chim Acta"},{"key":"key20200713184502_b15-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1093\/jnci\/djj206","article-title":"Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors","volume":"98","author":"Gr\u00f6sch","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"key20200713184502_b16-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.canlet.2014.01.021","article-title":"Anti-tumor activity of non-steroidal anti-inflammatory drugs: Cyclooxygenase-independent targets","volume":"346","author":"Liggett","year":"2014","journal-title":"Cancer Lett"},{"key":"key20200713184502_b17-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cdp.2003.12.005","article-title":"Celecoxib: A potent cyclooxygenase-2 inhibitor in cancer prevention","volume":"28","author":"Kismet","year":"2004","journal-title":"Cancer Detect Prev"},{"key":"key20200713184502_b18-ijo-52-02-0613","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1158\/1535-7163.299.3.3","article-title":"The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells","volume":"3","author":"Wu","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"key20200713184502_b19-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.canlet.2011.01.012","article-title":"Targeting apoptosis pathways by Celecoxib in cancer","volume":"332","author":"Jendrossek","year":"2013","journal-title":"Cancer Lett"},{"key":"key20200713184502_b20-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1194\/jlr.M042283","article-title":"Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib","volume":"54","author":"Ramer","year":"2013","journal-title":"J Lipid Res"},{"key":"key20200713184502_b21-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/sji.12247","article-title":"Exosomes - structure, biogenesis and biological role in non-small-cell lung cancer","volume":"81","author":"Frydrychowicz","year":"2015","journal-title":"Scand J Immunol"},{"key":"key20200713184502_b22-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/boc.201400095","article-title":"Tumour-derived exosomes: Tiny envelopes for big stories","volume":"107","author":"Miller","year":"2015","journal-title":"Biol Cell"},{"key":"key20200713184502_b23-ijo-52-02-0613","doi-asserted-by":"crossref","first-page":"370","DOI":"10.20452\/pamw.2840","article-title":"Exosomes as mediators of intercellular communication: Clinical implications","volume":"125","author":"Nazimek","year":"2015","journal-title":"Pol Arch Med Wewn"},{"key":"key20200713184502_b24-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13045-015-0181-x","article-title":"Exosomes in cancer: Small particle, big player","volume":"8","author":"Zhang","year":"2015","journal-title":"J Hematol Oncol"},{"key":"key20200713184502_b25-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.jconrel.2015.06.029","article-title":"Exosome mediated communication within the tumor microenvironment","volume":"219","author":"Milane","year":"2015","journal-title":"J Control Release"},{"key":"key20200713184502_b26-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"14240","DOI":"10.3390\/ijms140714240","article-title":"Intercellular communication by exosome-derived microRNAs in cancer","volume":"14","author":"Hannafon","year":"2013","journal-title":"Int J Mol Sci"},{"key":"key20200713184502_b27-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.gpb.2015.02.001","article-title":"Exosome and exosomal microRNA: Trafficking, sorting, and function","volume":"13","author":"Zhang","year":"2015","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"key20200713184502_b28-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"179486","DOI":"10.1155\/2014\/179486","article-title":"Exosome in tumour microenvironment: Overview of the crosstalk between normal and cancer cells","volume":"2014","author":"Roma-Rodrigues","year":"2014","journal-title":"Biomed Res Int"},{"key":"key20200713184502_b29-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1165\/ajrcmb.17.6.2888","article-title":"Prostaglandins induce vascular endothelial growth factor in a human monocytic cell line and rat lungs via cAMP","volume":"17","author":"H\u00f6per","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20200713184502_b30-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.3892\/or.2014.3301","article-title":"Cyclooxygenase-2 inhibition as a strategy for treating gastric adenocarcinoma","volume":"32","author":"Xiang","year":"2014","journal-title":"Oncol Rep"},{"key":"key20200713184502_b31-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1158\/1055-9965.EPI-08-0261","article-title":"Altered gene expression profiles define pathways in colorectal cancer cell lines affected by celecoxib","volume":"17","author":"Fatima","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key20200713184502_b32-ijo-52-02-0613","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1475-2867-12-53","article-title":"Antitumor activity of the selective cyclo-oxygenase-2 inhibitor, celecoxib, on breast cancer in vitro and in vivo","volume":"12","author":"Dai","year":"2012","journal-title":"Cancer Cell Int"}],"container-title":["International Journal of Oncology"],"original-title":[],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T18:06:17Z","timestamp":1751133977000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/ijo.2017.4227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,13]]},"references-count":32,"URL":"https:\/\/doi.org\/10.3892\/ijo.2017.4227","relation":{},"ISSN":["1019-6439","1791-2423"],"issn-type":[{"value":"1019-6439","type":"print"},{"value":"1791-2423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,13]]}}}